Paulus T V M De Jong

Summary

Affiliation: Netherlands Institute of Ecology
Country: The Netherlands

Publications

  1. doi Associations between aspirin use and aging macula disorder: the European Eye Study
    Paulus T V M De Jong
    The Netherlands Institute for Neuroscience and Academic Medical Center, Amsterdam, The Netherlands
    Ophthalmology 119:112-8. 2012
  2. ncbi Age-related macular degeneration
    Paulus T V M De Jong
    Department of Ophthalmogenetics, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    N Engl J Med 355:1474-85. 2006
  3. pmc Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration
    Dominique C Baas
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience NIN, Royal Netherlands Academy of Arts and Sciences KNAW, Amsterdam, The Netherlands
    Mol Vis 18:657-74. 2012
  4. doi Course of visual decline in relation to the Best1 genotype in vitelliform macular dystrophy
    Judith C Booij
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Ophthalmology 117:1415-22. 2010
  5. doi Pseudoxanthoma elasticum: Wide phenotypic variation in homozygotes and no signs in heterozygotes for the c.3775delT mutation in ABCC6
    Astrid S Plomp
    Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam
    Genet Med 11:852-8. 2009
  6. doi Proposal for updating the pseudoxanthoma elasticum classification system and a review of the clinical findings
    Astrid S Plomp
    Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Am J Med Genet A 152:1049-58. 2010
  7. ncbi Comparison of human retinal pigment epithelium gene expression in macula and periphery highlights potential topographic differences in Bruch's membrane
    Simone S van Soest
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences KNAW, Meibergdreef, Amsterdam, The Netherlands
    Mol Vis 13:1608-17. 2007
  8. pmc The complement component 5 gene and age-related macular degeneration
    Dominique C Baas
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences KNAW, Amsterdam, The Netherlands
    Ophthalmology 117:500-11. 2010
  9. pmc Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration
    Dominiek D G Despriet
    Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences KNAW, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 49:364-71. 2008
  10. ncbi Blood pressure, arterial stiffness, and open-angle glaucoma: the Rotterdam study
    Caroline A A Hulsman
    The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, and Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
    Arch Ophthalmol 125:805-12. 2007

Collaborators

Detail Information

Publications58

  1. doi Associations between aspirin use and aging macula disorder: the European Eye Study
    Paulus T V M De Jong
    The Netherlands Institute for Neuroscience and Academic Medical Center, Amsterdam, The Netherlands
    Ophthalmology 119:112-8. 2012
    ..To study associations between aspirin use and early and late aging macula disorder (AMD)...
  2. ncbi Age-related macular degeneration
    Paulus T V M De Jong
    Department of Ophthalmogenetics, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    N Engl J Med 355:1474-85. 2006
  3. pmc Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration
    Dominique C Baas
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience NIN, Royal Netherlands Academy of Arts and Sciences KNAW, Amsterdam, The Netherlands
    Mol Vis 18:657-74. 2012
    ..SLC2A1 regulates the bioavailability of glucose in the retinal pigment epithelium (RPE), which might influence oxidative stress-mediated AMD pathology...
  4. doi Course of visual decline in relation to the Best1 genotype in vitelliform macular dystrophy
    Judith C Booij
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Ophthalmology 117:1415-22. 2010
    ..To describe the disease course in patients with vitelliform macular dystrophy (VMD) with a Best1 mutation and to determine the association between Best1 genotype and visual prognosis...
  5. doi Pseudoxanthoma elasticum: Wide phenotypic variation in homozygotes and no signs in heterozygotes for the c.3775delT mutation in ABCC6
    Astrid S Plomp
    Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam
    Genet Med 11:852-8. 2009
    ..The purpose of this study was to check variability in expression within one genotype and look for pseudoxanthoma elasticum signs in heterozygotes...
  6. doi Proposal for updating the pseudoxanthoma elasticum classification system and a review of the clinical findings
    Astrid S Plomp
    Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Am J Med Genet A 152:1049-58. 2010
    ..We put this proposed classification forward to encourage further debate on the diagnosis of this multi-organ disorder...
  7. ncbi Comparison of human retinal pigment epithelium gene expression in macula and periphery highlights potential topographic differences in Bruch's membrane
    Simone S van Soest
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences KNAW, Meibergdreef, Amsterdam, The Netherlands
    Mol Vis 13:1608-17. 2007
    ..To describe gene expression differences between healthy, young human retinal pigment epithelium (RPE) cells from the macular area and RPE cells from two locations in the retinal periphery...
  8. pmc The complement component 5 gene and age-related macular degeneration
    Dominique C Baas
    Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences KNAW, Amsterdam, The Netherlands
    Ophthalmology 117:500-11. 2010
    ..To investigate the association between variants in the complement component 5 (C5) gene and age-related macular degeneration (AMD)...
  9. pmc Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration
    Dominiek D G Despriet
    Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences KNAW, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 49:364-71. 2008
    ..To determine whether variants in the candidate genes TLR4, CCL2, and CCR2 are associated with age-related macular degeneration (AMD)...
  10. ncbi Blood pressure, arterial stiffness, and open-angle glaucoma: the Rotterdam study
    Caroline A A Hulsman
    The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, and Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
    Arch Ophthalmol 125:805-12. 2007
    ..To investigate cross-sectional associations among blood pressures (BPs), arterial stiffness, and open-angle glaucoma (OAG)...
  11. pmc ABCC6 mutations in pseudoxanthoma elasticum: an update including eight novel ones
    Astrid S Plomp
    Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Mol Vis 14:118-24. 2008
    ..Up to now, the literature reports that there are 180 different ABCC6 mutations in PXE. The purpose of this paper is to report eight novel mutations in ABCC6 and to update the spectrum and frequency of ABCC6 mutations in PXE patients...
  12. ncbi Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum
    Theo G M F Gorgels
    Department of Molecualr and Clinical Ophthalmogenetics, The Netherlands Ophthalmic Research Institute NORI, Amsterdam, The Netherlands
    Hum Mol Genet 14:1763-73. 2005
    ..Our data support the hypothesis that PXE is in fact a systemic disease...
  13. ncbi Risk profiles for ageing macular disease
    Paulus T V M De Jong
    Department of Ophthalmogenetics, Netherlands Ophthalmic Research Institute, KNAW, Amsterdam, The Netherlands
    Ophthalmologica 218:5-16; discussion 39-41. 2004
  14. ncbi Risk factors for incident age-related macular degeneration: pooled findings from 3 continents
    Sandra C Tomany
    Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin 53726, USA
    Ophthalmology 111:1280-7. 2004
    ..To examine risk factors for incident age-related macular degeneration (AMD) after combining data from 3 population-based cohort studies...
  15. ncbi Late-onset retinoblastoma in a well-functioning fellow eye
    Paulus T V M De Jong
    Netherlands Institute for Neurosciences, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Ophthalmology 113:1040-4. 2006
    ..153211T>A (p.Tyr606X) mutation in the retinoblastoma 1 gene, whose left eye was enucleated at age 2 years for 2 retinoblastomas...
  16. ncbi A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 47:1568-75. 2006
    ..This study was designed to investigate the association between a common polymorphism (Tyr402His, rs1061170) in the complement factor H (CFH) gene and risk of coronary heart disease...
  17. doi Cataract surgery and the risk of aging macula disorder: the rotterdam study
    Lintje Ho
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 49:4795-800. 2008
    ..To investigate still-controversial associations between prior cataract surgery and aging macula disorder (AMD) in a general population...
  18. doi Sunlight exposure, antioxidants, and age-related macular degeneration
    Astrid E Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, England
    Arch Ophthalmol 126:1396-403. 2008
    ..To examine the association of sunlight exposure and antioxidant level with age-related macular degeneration (AMD)...
  19. ncbi The risk and natural course of age-related maculopathy: follow-up at 6 1/2 years in the Rotterdam study
    Redmer van Leeuwen
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Ophthalmol 121:519-26. 2003
    ..To evaluate the natural course of age-related maculopathy (ARM) and to assess the incidence and absolute risk of its final stage, age-related macular degeneration (AMD)...
  20. ncbi ABCC6 and pseudoxanthoma elasticum
    Arthur A B Bergen
    Department of Clinical and Molecular Ophthalmogenetics, Amsterdam, The Netherlands
    Pflugers Arch 453:685-91. 2007
    ..2005) 14:1763-1773; Klement et al. (2005) 25:8299-8310], which may be useful to elucidate the precise function of Abcc6 and to develop experimental therapies...
  21. ncbi Epidemiology of neurological diseases in elderly people: what did we learn from the Rotterdam Study?
    Albert Hofman
    Department of Epidemiology Biostatistics, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet Neurol 5:545-50. 2006
    ..Perhaps the most important message from the Rotterdam Study is the great potential for prevention or postponement of neurological diseases in elderly people. The time for preventive nihilism is over...
  22. ncbi Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration
    Dominiek D G Despriet
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 296:301-9. 2006
    ..Recent case-control studies demonstrated an association between the complement factor H (CFH) gene, a regulator of complement, and AMD...
  23. ncbi Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE)
    Cristina A Augood
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, England
    Arch Ophthalmol 124:529-35. 2006
    ..To estimate the prevalence of age-related maculopathy in an older population from 7 European countries...
  24. ncbi Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder
    Sharmila S Boekhoorn
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:1012-7. 2007
    ..This study was undertaken to investigate whether genetic variations in the estrogen receptor alpha (ESR1) gene are associated with incident AMD...
  25. ncbi Systemic antihypertensive medication and incident open-angle glaucoma
    Rogier P H M Müskens
    Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    Ophthalmology 114:2221-6. 2007
    ..To determine the association between systemic antihypertensive medication and incident open-angle glaucoma...
  26. ncbi Complement factor h polymorphism, inflammatory mediators, and retinal vessel diameters: the rotterdam study
    Frank Jan de Jong
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:3014-8. 2007
    ..Possible effect modification by smoking and inflammatory markers was examined...
  27. ncbi C-reactive protein level and risk of aging macula disorder: The Rotterdam Study
    Sharmila S Boekhoorn
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Ophthalmol 125:1396-401. 2007
    ..To examine whether C-reactive protein (CRP) level is a risk factor for aging macula disorder (AMD) in a general population...
  28. doi Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes: baseline results from the ADVANCE Retinal Measurements (AdRem) study
    Ronald P Stolk
    Department of Epidemiology, University Medical Center Groningen, P O Box 30 001, 9700RB Groningen, The Netherlands
    Diabetes Care 31:708-13. 2008
    ....
  29. doi Alcohol consumption and risk of aging macula disorder in a general population: the Rotterdam Study
    Sharmila S Boekhoorn
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Ophthalmol 126:834-9. 2008
    ..To investigate the possible relationship between overall or specific alcohol consumption and risk of aging macula disorder (AMD), a synonym for age-related macular degeneration, in a general population...
  30. ncbi Is there a direct association between age-related eye diseases and mortality? The Rotterdam Study
    Petra H Borger
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 110:1292-6. 2003
    ..To study mortality in subjects with age-related maculopathy (ARM), cataract, or open-angle glaucoma (OAG) in comparison with those without these disorders...
  31. ncbi Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration
    Cristina Augood
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Clin Nutr 88:398-406. 2008
    ..Fish intake, the major source of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may reduce the risk of age-related macular degeneration (AMD)...
  32. ncbi Retinal vessel diameters and risk of impaired fasting glucose or diabetes: the Rotterdam study
    M Kamran Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 55:506-10. 2006
    ..In conclusion, in our study, the risk of impaired fasting glucose and diabetes with AVR was explained by venular dilatation rather than arteriolar narrowing, warranting more focus on the causes of this dilatation...
  33. ncbi Dietary intake of antioxidants and risk of age-related macular degeneration
    Redmer van Leeuwen
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    JAMA 294:3101-7. 2005
    ..Recently, high-dose supplementation with beta carotene, vitamins C and E, and zinc was shown to slow the progression of AMD...
  34. ncbi The standard gamble between cataract extraction and AMD
    Paulus T V M De Jong
    Graefes Arch Clin Exp Ophthalmol 242:103-5. 2004
  35. ncbi Epidemiology of age-related maculopathy: a review
    Redmer van Leeuwen
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Eur J Epidemiol 18:845-54. 2003
    ..Future studies, both observational and experimental, will hopefully identify more risk factors that are amenable to prevention...
  36. ncbi A peculiar autosomal dominant macular dystrophy caused by an asparagine deletion at codon 169 in the peripherin/RDS gene
    Janneke J C van Lith-Verhoeven
    Department of Ophthalmology, University Medical Center Nijmegen, The Netherlands
    Arch Ophthalmol 121:1452-7. 2003
    ..To describe the clinical and genetic findings in a family with a peculiar autosomal dominant macular dystrophy with peripheral deposits...
  37. ncbi Relationship between refraction and prevalent as well as incident age-related maculopathy: the Rotterdam Study
    M Kamran Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 44:3778-82. 2003
    ..To study the relationship between baseline spherical equivalents (SphE) of refraction and prevalent as well as incident age-related maculopathy (pARM and iARM, respectively)...
  38. ncbi Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study
    Redmer van Leeuwen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 44:3771-7. 2003
    ..To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM)...
  39. ncbi Grading of age-related maculopathy for epidemiological studies: is digital imaging as good as 35-mm film?
    Redmer van Leeuwen
    Department of Epidemiology and Biostatistics, and EUREYE Grading Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 110:1540-4. 2003
    ..To compare stereo digital images with stereo 35-mm color transparencies as to the quality and reliability of grading age-related maculopathy (ARM) in the context of a multicenter European epidemiologic study (the EUREYE Study)...
  40. ncbi Pseudoxanthoma elasticum: a clinical, histopathological, and molecular update
    Xiaofeng Hu
    Department of Ophthalmogenetics, The Netherlands Ophthalmic Research Institute, KNAW, Amsterdam, The Netherlands
    Surv Ophthalmol 48:424-38. 2003
    ..One of these sites is Bruch's membrane. This review is an update on etiology of pseudoxanthoma elasticum, including its clinical and genetic features, pathogenesis, and biomolecular basis...
  41. ncbi Analysis of the frequent R1141X mutation in the ABCC6 gene in pseudoxanthoma elasticum
    Xiaofeng Hu
    Netherlands Ophthalmic Research Institute, Royal Netherlands Academy of Art and Sciences KNAW, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 44:1824-9. 2003
    ..To characterize the ABCC6 R1141X nonsense mutation, which is implicated in more than 25% of a cohort of patients from The Netherlands with pseudoxanthoma elasticum (PXE)...
  42. ncbi ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum
    Xiaofeng Hu
    Netherlands Ophthalmic Research Institute, KNAW, Amsterdam, The Netherlands
    Eur J Hum Genet 11:215-24. 2003
    ..The consequences of our data for the molecular pathology of PXE are discussed...
  43. ncbi A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy
    Silke Schmidt
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Ophthalmic Genet 23:209-23. 2002
    ..They also suggest that the effect of the APOE-2 allele may vary by gender, and that APOE-2 may confer an increased risk only to males...
  44. ncbi Myocilin mutations in a population-based sample of cases with open-angle glaucoma: the Rotterdam Study
    Caroline A A Hulsman
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Graefes Arch Clin Exp Ophthalmol 240:468-74. 2002
    ..To investigate the prevalence of myocilin (MYOC) mutations in a population-based sample of open-angle glaucoma (OAG) cases and to describe a family with both juvenile and adult onset OAG caused by a mutation in MYOC...
  45. ncbi Cholesterol and age-related macular degeneration: is there a link?
    Redmer van Leeuwen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Ophthalmol 137:750-2. 2004
    ..To examine the relation among serum cholesterol, apolipoprotein E genotype (APOE), and the risk of early and late age-related macular degeneration (AMD)...
  46. ncbi Prevalence of age-related macular degeneration in the United States
    David S Friedman
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:564-72. 2004
    ..To estimate the prevalence and distribution of age-related macular degeneration (AMD) in the United States by age, race/ethnicity, and gender...
  47. ncbi Retinal vessel diameters and risk of hypertension: the Rotterdam Study
    M Kamran Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 47:189-94. 2006
    ..quot; Within these strata, arteriolar narrowing was still related to incident hypertension. These data show that both retinal arteriolar and venular narrowing may precede the development of systemic hypertension...
  48. ncbi Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study
    M Kamran Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 129:182-8. 2006
    ..The mechanisms underlying venular dilatation deserve more attention, as they may provide new clues into the pathophysiology of cerebral small vessel disease...
  49. ncbi Submacular Surgery Trials
    Paulus T V M De Jong
    Ophthalmology 112:2055. 2005
  50. ncbi Reduced melanoma-related mortality in uveal melanoma by preenucleation radiotherapy
    Emine Kilic
    Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands
    Arch Ophthalmol 123:1363-7. 2005
    ..Earlier studies with a short follow-up period have not demonstrated a significant effect on survival...
  51. ncbi Incidence of open-angle glaucoma in a general elderly population: the Rotterdam Study
    Simone de Voogd
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 112:1487-93. 2005
    ..To determine the incidence of open-angle glaucoma (OAG) in a general elderly white population...
  52. ncbi Retinal vessel diameters and the risk of incident age-related macular disease: the Rotterdam Study
    M Kamran Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 112:548-52. 2005
    ..To study the relationship between retinal vessel diameters and incident age-related macular disease (iAMD)...
  53. ncbi Heterogeneity of the genetic risk in age-related macular disease: a population-based familial risk study
    Jacqueline J M Assink
    Department of Ophthalmogenetics, The Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands
    Ophthalmology 112:482-7. 2005
    ..To assess the extent of heterogeneity of the genetic risk of age-related macular disease (AMD) among families...
  54. ncbi Efficient molecular diagnostic strategy for ABCC6 in pseudoxanthoma elasticum
    Xiaofeng Hu
    Netherlands Ophthalmic Research Institute, KNAW, Amsterdam, The Netherlands
    Genet Test 8:292-300. 2004
    ..7%) out of 89 mutant alleles could be detected within a week. We conclude that this strategy leads to both reliable and time-saving screening for mutations in the ABCC6 gene in sporadic cases and in families with PXE...
  55. ncbi Causes of incident visual field loss in a general elderly population: the Rotterdam study
    Elisa Skenduli-Bala
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Arch Ophthalmol 123:233-8. 2005
    ..To determine the incidence and causes of visual field loss (VFL) in a general elderly population...
  56. ncbi Is medication use associated with the incidence of early age-related maculopathy? Pooled findings from 3 continents
    Redmer van Leeuwen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 111:1169-75. 2004
    ..To investigate whether there is an association between the use of medication and the incidence of early age-related maculopathy (ARM)...
  57. ncbi Does autosomal dominant pseudoxanthoma elasticum exist?
    Astrid S Plomp
    The Netherlands Ophthalmic Research Institute, KNAW, Amsterdam, The Netherlands
    Am J Med Genet A 126:403-12. 2004
    ..AD inheritance in PXE may exist, but is both after careful literature study and in our patient material much rarer than previously thought...
  58. ncbi Macular pigment and melanin in age-related maculopathy in a general population
    Tos T J M Berendschot
    Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
    Invest Ophthalmol Vis Sci 43:1928-32. 2002
    ..To check this, MP and melanin optical density were measured in a random population-based sample of subjects 55 years of age or older...