Affiliation: Netherlands Institute of Ecology
Country: The Netherlands
- TCF: Lady Justice casting the final verdict on the outcome of Wnt signallingHelen Brantjes
Department of Immunology, University Hospital Utrecht, The Netherlands
Biol Chem 383:255-61. 2002..In the absence of Wnt signalling, Tcf complexes with several transcriptional repressor proteins ensuring active repression of Tcf target genes. In this review the dual role of Tcf proteins in the Wnt signalling cascade will be discussed...
- Tracking down the stem cells of the intestine: strategies to identify adult stem cellsNick Barker
Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands
Gastroenterology 133:1755-60. 2007
- You Wnt some, you lose some: oncogenes in the Wnt signaling pathwayJohan H van Es
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
Curr Opin Genet Dev 13:28-33. 2003..Collectively, this represents an important step forward in our understanding of the role of Wnt signaling in development and oncogenesis...
- WNT signaling in the normal intestine and colorectal cancerWim de Lau
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands
Front Biosci 12:471-91. 2007..The Eph/Ephrin system also operates to limit progression of colorectal cancer beyond the early stages...
- Mining the Wnt pathway for cancer therapeuticsNick Barker
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8 3584CT, Utrecht, The Netherlands
Nat Rev Drug Discov 5:997-1014. 2006..Here we provide an overview of the promise and pitfalls of current drug development strategies striving to inhibit the Wnt pathway and present new opportunities for therapeutic intervention...
- Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney developmentNick Barker
Hubrecht Institute for Developmental Biology and Stem Cell Research University Medical Centre Utrecht, Utrecht, The Netherlands
Cell Rep 2:540-52. 2012....
- Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts"Wim de Lau
Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, and University Medical Centre Utrecht, Utrecht, The Netherlands
Mol Cell Biol 32:3639-47. 2012..We conclude that RankL-induced expression of SpiB is essential for Lgr5 stem cell-derived epithelial precursors to develop into M cells...
- Tissue-resident adult stem cell populations of rapidly self-renewing organsNick Barker
Hubrecht Institute, Utrecht, The Netherlands
Cell Stem Cell 7:656-70. 2010..Here, we review recent advances in adult stem cell biology, highlighting the promise and pitfalls of the candidate biomarkers of the various stem cell populations...
- Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cellsNick Barker
Hubrecht Institute, Uppsalalaan, Utrecht, The Netherlands
Gastroenterology 138:1681-96. 2010..Further studies of these markers might reveal adult stem cell populations in additional tissues. Identification of the ligands for Lgr5 and 6 will help elucidate stem cell functions and modes of intracellular signaling...
- Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestineHugo J Snippert
Hubrecht Institute, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
Gastroenterology 136:2187-2194.e1. 2009..To determine whether there is a relationship between these markers, we investigated the intestinal expression pattern of Prom1/CD133 and created knock-in mice to visualize and trace Prom1(+) cells...
- The intestinal stem cellNick Barker
Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
Genes Dev 22:1856-64. 2008..This review attempts to provide a comprehensive overview of four decades of research on crypt stem cells...
- The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleusEwa Markiewicz
Department of Biological Science, The School of Biological and Biomedical Sciences, The University of Durham, Durham, UK
EMBO J 25:3275-85. 2006..Our results support recent findings that suggest that INM proteins can influence signalling pathways by restricting access of transcription coactivators to the nucleus...
- Functional interaction between beta-catenin and FOXO in oxidative stress signalingMarieke A G Essers
Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
Science 308:1181-4. 2005..These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress...
- Cloning and characterization of hELD/OSA1, a novel BRG1 interacting proteinAdam F L Hurlstone
University Medical Centre Utrecht, Department of Immunology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Biochem J 364:255-64. 2002..EHD1 and EHD2 also appear capable of interacting with each other. Using an antibody raised against EHD2 of hELD/OSA1, we detected Eld/Osa1 in endogenous SWI/SNF complexes derived from mouse brain...
- Identification of stem cells in small intestine and colon by marker gene Lgr5Nick Barker
Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
Nature 449:1003-7. 2007..The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers...