Nick Barker

Summary

Affiliation: Netherlands Institute of Ecology
Country: The Netherlands

Publications

  1. ncbi TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling
    Helen Brantjes
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Biol Chem 383:255-61. 2002
  2. ncbi Tracking down the stem cells of the intestine: strategies to identify adult stem cells
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands
    Gastroenterology 133:1755-60. 2007
  3. ncbi You Wnt some, you lose some: oncogenes in the Wnt signaling pathway
    Johan H van Es
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Curr Opin Genet Dev 13:28-33. 2003
  4. ncbi WNT signaling in the normal intestine and colorectal cancer
    Wim de Lau
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands
    Front Biosci 12:471-91. 2007
  5. ncbi Mining the Wnt pathway for cancer therapeutics
    Nick Barker
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8 3584CT, Utrecht, The Netherlands
    Nat Rev Drug Discov 5:997-1014. 2006
  6. ncbi Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research University Medical Centre Utrecht, Utrecht, The Netherlands
    Cell Rep 2:540-52. 2012
  7. ncbi Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts"
    Wim de Lau
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, and University Medical Centre Utrecht, Utrecht, The Netherlands
    Mol Cell Biol 32:3639-47. 2012
  8. ncbi Tissue-resident adult stem cell populations of rapidly self-renewing organs
    Nick Barker
    Hubrecht Institute, Utrecht, The Netherlands
    Cell Stem Cell 7:656-70. 2010
  9. ncbi Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells
    Nick Barker
    Hubrecht Institute, Uppsalalaan, Utrecht, The Netherlands
    Gastroenterology 138:1681-96. 2010
  10. ncbi Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine
    Hugo J Snippert
    Hubrecht Institute, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
    Gastroenterology 136:2187-2194.e1. 2009

Collaborators

  • Hans Clevers
  • Rodney P DeKoter
  • Hendrik C Korswagen
  • Ivan A Olave
  • Wim de Lau
  • Johan H van Es
  • Hugo J Snippert
  • Ewa Markiewicz
  • Marieke A G Essers
  • Adam F L Hurlstone
  • Helen Brantjes
  • Frans Hofhuis
  • Peter J Peters
  • Kerstin Schneeberger
  • Edward Nieuwenhuis
  • Pekka Kujala
  • Vivian S W Li
  • Anton Martens
  • Sabine Middendorp
  • Daniel E Stange
  • Harry Begthel
  • Maaike van den Born
  • Margareth Dorobek
  • Robert G Wilson
  • Juliet A Ellis
  • Katarzyna Tilgner
  • Christopher J Hutchison
  • Mark van de Wetering
  • W Matthijs Blankesteijn
  • Irena Hausmanowa-Petrusewicz
  • Georgia Salpingidou
  • Jos L V Broers
  • Frans C S Ramaekers
  • Lydia M M de Vries-Smits
  • Boudewijn M T Burgering
  • Paulien E Polderman
  • Mascha van Noort
  • Johan van Es

Detail Information

Publications15

  1. ncbi TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling
    Helen Brantjes
    Department of Immunology, University Hospital Utrecht, The Netherlands
    Biol Chem 383:255-61. 2002
    ..In the absence of Wnt signalling, Tcf complexes with several transcriptional repressor proteins ensuring active repression of Tcf target genes. In this review the dual role of Tcf proteins in the Wnt signalling cascade will be discussed...
  2. ncbi Tracking down the stem cells of the intestine: strategies to identify adult stem cells
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands
    Gastroenterology 133:1755-60. 2007
  3. ncbi You Wnt some, you lose some: oncogenes in the Wnt signaling pathway
    Johan H van Es
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Curr Opin Genet Dev 13:28-33. 2003
    ..Collectively, this represents an important step forward in our understanding of the role of Wnt signaling in development and oncogenesis...
  4. ncbi WNT signaling in the normal intestine and colorectal cancer
    Wim de Lau
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands
    Front Biosci 12:471-91. 2007
    ..The Eph/Ephrin system also operates to limit progression of colorectal cancer beyond the early stages...
  5. ncbi Mining the Wnt pathway for cancer therapeutics
    Nick Barker
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8 3584CT, Utrecht, The Netherlands
    Nat Rev Drug Discov 5:997-1014. 2006
    ..Here we provide an overview of the promise and pitfalls of current drug development strategies striving to inhibit the Wnt pathway and present new opportunities for therapeutic intervention...
  6. ncbi Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research University Medical Centre Utrecht, Utrecht, The Netherlands
    Cell Rep 2:540-52. 2012
    ....
  7. ncbi Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts"
    Wim de Lau
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, and University Medical Centre Utrecht, Utrecht, The Netherlands
    Mol Cell Biol 32:3639-47. 2012
    ..We conclude that RankL-induced expression of SpiB is essential for Lgr5 stem cell-derived epithelial precursors to develop into M cells...
  8. ncbi Tissue-resident adult stem cell populations of rapidly self-renewing organs
    Nick Barker
    Hubrecht Institute, Utrecht, The Netherlands
    Cell Stem Cell 7:656-70. 2010
    ..Here, we review recent advances in adult stem cell biology, highlighting the promise and pitfalls of the candidate biomarkers of the various stem cell populations...
  9. ncbi Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells
    Nick Barker
    Hubrecht Institute, Uppsalalaan, Utrecht, The Netherlands
    Gastroenterology 138:1681-96. 2010
    ..Further studies of these markers might reveal adult stem cell populations in additional tissues. Identification of the ligands for Lgr5 and 6 will help elucidate stem cell functions and modes of intracellular signaling...
  10. ncbi Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine
    Hugo J Snippert
    Hubrecht Institute, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
    Gastroenterology 136:2187-2194.e1. 2009
    ..To determine whether there is a relationship between these markers, we investigated the intestinal expression pattern of Prom1/CD133 and created knock-in mice to visualize and trace Prom1(+) cells...
  11. ncbi The intestinal stem cell
    Nick Barker
    Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Genes Dev 22:1856-64. 2008
    ..This review attempts to provide a comprehensive overview of four decades of research on crypt stem cells...
  12. ncbi The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus
    Ewa Markiewicz
    Department of Biological Science, The School of Biological and Biomedical Sciences, The University of Durham, Durham, UK
    EMBO J 25:3275-85. 2006
    ..Our results support recent findings that suggest that INM proteins can influence signalling pathways by restricting access of transcription coactivators to the nucleus...
  13. ncbi Functional interaction between beta-catenin and FOXO in oxidative stress signaling
    Marieke A G Essers
    Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    Science 308:1181-4. 2005
    ..These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress...
  14. ncbi Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein
    Adam F L Hurlstone
    University Medical Centre Utrecht, Department of Immunology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Biochem J 364:255-64. 2002
    ..EHD1 and EHD2 also appear capable of interacting with each other. Using an antibody raised against EHD2 of hELD/OSA1, we detected Eld/Osa1 in endogenous SWI/SNF complexes derived from mouse brain...
  15. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
    ..The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers...