Rob J Vandebriel

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. doi Non-animal sensitization testing: state-of-the-art
    Rob J Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Crit Rev Toxicol 40:389-404. 2010
  2. pmc Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats
    Rob J Vandebriel
    Centre for Health Protection, National Institute for Public Health and the Environment, PO Box 1, Bilthoven, BA 3720, The Netherlands
    Part Fibre Toxicol 11:21. 2014
  3. pmc Dendritic cell-based in vitro assays for vaccine immunogenicity
    Rob Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Hum Vaccin Immunother 8:1323-5. 2012
  4. pmc Statins accelerate the onset of collagen type II-induced arthritis in mice
    Rob J Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Arthritis Res Ther 14:R90. 2012
  5. doi Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation
    Rob Vandebriel
    National Institute of Public Health and Environment, Bilthoven, The Netherlands
    Toxicol In Vitro 25:1251-8. 2011
  6. ncbi Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds
    Rob J Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Toxicol Sci 117:81-9. 2010
  7. pmc The role of Toll-like receptor-4 in pertussis vaccine-induced immunity
    Sander Banus
    Health Protection Research, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    BMC Immunol 9:21. 2008
  8. ncbi Effect of prolonged exposure to low antigen concentration for sensitization
    François M M Van Och
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 184:23-30. 2003
  9. ncbi Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mRNA expression and production in the draining lymph nodes of mice
    Rob J Vandebriel
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Toxicology 188:1-13. 2003
  10. pmc Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection
    Sander Banus
    Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Microbiol 7:88. 2007

Collaborators

Detail Information

Publications28

  1. doi Non-animal sensitization testing: state-of-the-art
    Rob J Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Crit Rev Toxicol 40:389-404. 2010
    ..Integrating multiple assays in a decision tree or integrated testing system is a next step, but has yet to be developed. Adequate risk assessment, however, is likely to require significantly more time and efforts...
  2. pmc Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats
    Rob J Vandebriel
    Centre for Health Protection, National Institute for Public Health and the Environment, PO Box 1, Bilthoven, BA 3720, The Netherlands
    Part Fibre Toxicol 11:21. 2014
    ..Several immune parameters were affected: reduced thymus weight, increased spleen weight and spleen cell number, a strongly reduced NK cell activity, and reduced IFN-γ production were observed...
  3. pmc Dendritic cell-based in vitro assays for vaccine immunogenicity
    Rob Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Hum Vaccin Immunother 8:1323-5. 2012
    ..In this commentary, this proposition is illustrated by several examples in which the maturation of human DC was successfully used to test for vaccine and adjuvant immunogenicity...
  4. pmc Statins accelerate the onset of collagen type II-induced arthritis in mice
    Rob J Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Arthritis Res Ther 14:R90. 2012
    ..Our objective was to investigate whether a causal relationship could be established for this finding...
  5. doi Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation
    Rob Vandebriel
    National Institute of Public Health and Environment, Bilthoven, The Netherlands
    Toxicol In Vitro 25:1251-8. 2011
    ..Experimental research should be targeted to (i) QSAR-type approaches to relate potential as a respiratory sensitizer to its chemical structure, (ii) in vitro models and (iii) in vitro-in vivo extrapolation/validation...
  6. ncbi Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds
    Rob J Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Toxicol Sci 117:81-9. 2010
    ..Moreover, our data suggest that contact sensitizers induce the oxidative stress pathway in KC...
  7. pmc The role of Toll-like receptor-4 in pertussis vaccine-induced immunity
    Sander Banus
    Health Protection Research, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    BMC Immunol 9:21. 2008
    ..Here we analyze the effects of wP and aP vaccination and B. pertussis challenge, in Tlr4-deficient C3H/HeJ and wild-type C3H/HeOuJ mice. aP consists of Ptx, filamentous hemagglutinin (FHA), and pertactin (Prn)...
  8. ncbi Effect of prolonged exposure to low antigen concentration for sensitization
    François M M Van Och
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 184:23-30. 2003
    ..These findings indicate that for classification of sensitizers the shorter exposure period employed in the standard LLNA is sufficient, and longer periods of exposure have no bearing on this classification...
  9. ncbi Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mRNA expression and production in the draining lymph nodes of mice
    Rob J Vandebriel
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Toxicology 188:1-13. 2003
    ..Compounds that induce cell proliferation with a low concomitant IL-4 production may thus be identified as contact allergens, although the need to positively identity such allergens remain...
  10. pmc Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection
    Sander Banus
    Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Microbiol 7:88. 2007
    ..pertussis inoculation. Twelve and a half percent of the genomes of these mice are from a different genetic background...
  11. ncbi Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Vaccine 25:2346-60. 2007
    ..In summary, after challenge vaccination increased lung pathology, TNF-alpha expression (only WCV), and IH parameters. Th1 cells were critical for clearance...
  12. pmc Statin use and markers of immunity in the Doetinchem cohort study
    Hilda J I de Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands Department of Toxicogenomics, Maastricht University Medical Centre, Maastricht, the Netherlands Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Sciences, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 8:e77587. 2013
    ..We postulate that the observed decreased inflammatory response during statin therapy may be important but is insufficient to induce loss of self-tolerance. ..
  13. ncbi Determination of the sensitising activity of the rubber contact sensitisers TMTD, ZDMC, MBT and DEA in a modified local lymph node assay and the effect of sodium dodecyl sulfate pretreatment on local lymph node responses
    Wim H De Jong
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Toxicology 176:123-34. 2002
    ..For 10% and 20% SDS, inducing approximately a SI of 20 in the LLNA, no induction of cytokines was observed...
  14. pmc Effects of a diphtheria-tetanus-acellular pertussis vaccine on immune responses in murine local lymph node and lung allergy models
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Clin Vaccine Immunol 14:211-9. 2007
    ..Vaccination failed to modulate these parameters. In conclusion, although DTaP vaccination may affect the LLNA response, we found no evidence of an effect on lung allergy...
  15. ncbi In vitro assessment of sensitizing activity of low molecular weight compounds
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 207:142-8. 2005
    ..Additional studies are required to establish whether KC or DC, or combinations thereof, are most suitable for in vitro identification and potency assessment of sensitizers...
  16. ncbi Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line
    François M M Van Och
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 210:95-109. 2005
    ..In conclusion, to assess the potency of allergens the murine keratinocyte cell line HEL-30 may be a useful in vitro test system, alternative to in vivo models, although this requires further testing using a much wider range of compounds...
  17. pmc Statin-associated polymyalgia rheumatica. An analysis using WHO global individual case safety database: a case/non-case approach
    Hilda J I de Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 7:e41289. 2012
    ..To assess whether there is an association between statin use and the occurrence of polymyalgia rheumatic (PMR) in the spontaneous reporting database of the World Health Organisation (WHO)...
  18. ncbi Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers
    François M M Van Och
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 184:46-56. 2002
    ..We propose that, by direct linkage of proliferation and cytokine production in a dose-response manner, distinguishing contact allergens from respiratory allergens may be improved compared to present approaches...
  19. doi Association between statin use and lupus-like syndrome using spontaneous reports
    Hilda J I de Jong
    Laboratory for Health Protection Research, National Institute for Public Health and Environment, Bilthoven, Netherlands
    Semin Arthritis Rheum 41:373-81. 2011
    ..However, data on the association between statin use and lupus-like syndrome are scarce. We assessed whether there was an association between statin use and the occurrence of lupus-like syndrome...
  20. doi Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and the risk of developing rheumatoid arthritis in antihypertensive drug users
    Hilda J I de Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Pharmacoepidemiol Drug Saf 21:835-43. 2012
    ..Therefore, we determined in the current study the association between ACE inhibitor and ARB use and incident rheumatoid arthritis (RA)...
  21. ncbi Gene polymorphisms within the immune system that may underlie drug allergy
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, P O Box 1, 3720, BA Bilthoven, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 369:125-32. 2004
    ..Therefore, these polymorphisms and their associations with asthma will be discussed. These studies on asthma provide us with lessons on how to conduct such studies on drug allergy...
  22. ncbi Toxicogenomics in the assessment of immunotoxicity
    Kirsten A Baken
    Nutrition and Toxicology Research Institute Maastricht, Department of Health Risk Analysis and Toxicology GRAT, Maastricht University, Maastricht, The Netherlands
    Methods 41:132-41. 2007
    ....
  23. ncbi Association of Bordetella pertussis with host immune cells in the mouse lung
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Microb Pathog 35:19-29. 2003
    ..These results suggest that Fim does not affect bacterial localisation in the mouse lung, but does influence host immune mechanisms. Possibly, Fim may exert an anti-inflammatory function and thereby inhibit killing by macrophages...
  24. doi Response of MUTZ-3 dendritic cells to the different components of the Haemophilus influenzae type B conjugate vaccine: towards an in vitro assay for vaccine immunogenicity
    Marcel H N Hoefnagel
    Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 29:5114-21. 2011
    ..The potential of this cell line as (part of) an in vitro immunogenicity assay should be further explored...
  25. doi Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats
    Wim H De Jong
    Centre for Health Protection, National Institute for Public Health and the Environment Rijksinstituut voor Volksgezondheid en Milieu, RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 34:8333-43. 2013
    ..06 mg/kg b.w.) and LPS stimulation of spleen cells (CED05 0.04 mg/kg b.w.). These results show that for nanosilver the most sensitive parameters for potential adverse responses were effects on the immune system...
  26. pmc Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study
    Sander Banus
    Laboratory of Vaccine Preventable Diseases, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Clin Vaccine Immunol 14:1377-80. 2007
    ..A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination...
  27. ncbi Ranking of allergenic potency of rubber chemicals in a modified local lymph node assay
    Wim H De Jong
    Laboratory for Pathology and Immunobiology, National Institute for Public Health and the Environment, RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 66:226-32. 2002
    ..However, one has to be aware that besides potency, the total amount of residual chemical present in the final product is also important for allergy induction...