Research Topics
Genomes and Genes | H van SteegSummaryAffiliation: National Institute for Public Health and the Environment Country: The Netherlands Publications
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Publications
MPHASYS: a mouse phenotype analysis systemR Brent Calder
Buck Institute for Age Research, Novato, California, USA
BMC Bioinformatics 8:183. 2007..Additionally, the lack of integrated, standardized ontologies and methodologies for data exchange has inhibited scientific collaboration and discovery...
Use of DNA repair-deficient XPA transgenic mice in short-term carcinogenicity testingH van Steeg
Laboratory of Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Toxicol Pathol 26:742-9. 1998....- Xeroderma pigmentosum and the role of UV-induced DNA damage in skin cancerH van Steeg
National Institute of Public Health and the Environment, Dept of Carcinogenesis, Mutagenesis and Genetics, Bilthoven, The Netherlands
Mol Med Today 5:86-94. 1999..The recently developed animal models that mimic the human phenotypes of XP, CS and TTD will contribute to a better understanding of the etiology of these diseases and the role of UV-induced DNA damage in the development of skin cancer... - DNA repair-deficient Xpa and Xpa/p53+/- knock-out mice: nature of the modelsH van Steeg
National Institute of Public Health and the Environment RIVM, Department of Carcinogenesis, Mutagenesis and Genetics, Bilthoven, The Netherlands
Toxicol Pathol 29:109-16. 2001.... - The role of nucleotide excision repair and loss of p53 in mutagenesis and carcinogenesisH van Steeg
National Institute of Public Health and the Environment, Laboratory of Health Effects Research, RIVM LEO pb12, P O Box 1, 3720 BA, Bilthoven, The Netherlands
Toxicol Lett 120:209-19. 2001..Surprisingly, however, the effect of a heterozygous loss of p53 appeared to be tissue-restricted, being apparent in the bladder but absent in liver and spleen... - Xpa and Xpa/p53+/- knockout mice: overview of available dataC F van Kreijl
RIVM, Laboratory of Health Effects Research, Bilthoven, The Netherlands
Toxicol Pathol 29:117-27. 2001..In general. the XPA/p53 model appears to be more sensitive to carcinogens than the XPA model... - Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA miceC T van Oostrom
National Institute of Public Health and the Environment RIVM, Laboratory of Health Effects Research, Department of Carcinogenesis, Mutagenesis and Genetics, Bilthoven, The Netherlands
Environ Mol Mutagen 34:124-30. 1999.... - Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out miceH van Steeg
Laboratory of Health Effects Research, National Institute of Public Health and the Environment, RIVM LEO, pb12 P O Box 1, 3720 BA, Eindhoven, Netherlands
Mutat Res 450:167-80. 2000..In this work, we review these results and discuss the applicability and reliability of enhanced gene mutant frequencies as early indicators of tumorigenesis... - Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- miceJ C Klein
Laboratory of Health Effects Research, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
Carcinogenesis 22:619-26. 2001..At 10 p.p.m. only lymphomas were found, whereas at 25 p.p.m. some intestinal tumours (adenomas and adenocarcinomas) were also observed... - Xpa knockout miceA de Vries
Department of Carcinogenesis, Mutagenesis and Genetics, National Institute of Public Health and Environment, Bilthoven, The Netherlands
Semin Cancer Biol 7:229-40. 1996..Furthermore, the possible use of Xpa- and other nucleotide excision repair deficient mice in cancer research will be outlined in more detail... - Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppressionJ Garssen
Laboratory for Pathology and Immunobiology and Laboratory of Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J Immunol 164:6199-205. 2000.... 
Cloning and characterization of the mouse XPAC geneC T van Oostrom
National Institute of Public Health and Environmental Protection, Laboratory of Carcinogenesis and Mutagenesis, Bilthoven, The Netherlands
Nucleic Acids Res 22:11-4. 1994..However, it contains an unique polypyrimidine-rich box, which is so far only found in genes encoding DNA repair enzymes. The function of this box in the regulation of transcription is still unclear...
Genotoxic exposure: novel cause of selection for a functional ΔN-p53 isoformJ P M Melis
Laboratory for Health Protection Research, National Institute of Public Health and the Environment, Bilthoven, Utrecht, The Netherlands
Oncogene 30:1764-72. 2011....- The rat N-ras gene; interference of pseudogenes with the detection of activating point mutationsH J van Kranen
Laboratory of Carcinogenesis and Mutagenesis, National Institute of Public Health and Environmental Protection, RIVM, Bilthoven, The Netherlands
Carcinogenesis 15:307-11. 1994..Taken together, our results demonstrate that intron-specific amplification is a prerequisite for the unambiguous detection of activating point mutations in the N-ras gene of the rat... - Subchronic inhalation of mixtures of cigarette smoke constituents in Xpa-/-p53+/- knock-out mice: a comparison of intermittent with semi-continuous exposure to acetaldehyde, formaldehyde, and acroleinF R Cassee
Centre for Environmental Health Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Food Chem Toxicol 46:527-36. 2008.... - The translation in vitro of rat ornithine decarboxylase mRNA is blocked by its 5' untranslated region in a polyamine-independent wayH van Steeg
National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
Biochem J 274:521-6. 1991..From this we conclude that the well-documented negative feedback control of intracellular polyamines on ODC expression is not regulated by effects of polyamines on the secondary structure of the 5' UTR of ODC mRNA... - The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient Cockayne syndrome group B miceS W Wijnhoven
Department of Radiation Genetics and Chemical Mutagetesis MGC, Leiden University Medical Center, The Netherlands
Cancer Res 60:5681-7. 2000..Thus, the global genome repair pathway of NER appears to play an important role in the prevention of cancer... - Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosityH Rebel
Department of Dermatology, University Medical Center Utrectht, The Netherlands
Cancer Res 61:977-83. 2001..Therefore, the frequency of p53+ foci appears to correlate well with UVB-induced tumor risk... - Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predispositionG T van der Horst
Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands
Cell 89:425-35. 1997..Further, they suggest that the lack of cancer predisposition in CS patients is attributable to a global genome repair process that in humans is more effective than in rodents... - Relative susceptibilities of XPA knockout mice and their heterozygous and wild-type littermates to UVB-induced skin cancerR J Berg
Department of Dermatology, University Hospital Utrecht, The Netherlands
Cancer Res 57:581-4. 1997..Deficient nucleotide excision repair appears to have a more dramatic impact on skin cancer susceptibility than on sensitivity to acute UV effects... - Differential ultraviolet-B-induced immunomodulation in XPA, XPC, and CSB DNA repair-deficient miceA Boonstra
Department of Immunology, Erasmus University and University Hospital Rotterdam, The Netherlands
J Invest Dermatol 117:141-6. 2001.... - Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPAA de Vries
Department of Immunology, University of Utrecht, The Netherlands
Nature 377:169-73. 1995..We conclude that the XPA-deficient mice strongly mimic the phenotype of humans with xeroderma pigmentosum... - Transgenic tumor models for carcinogen identification: the heterozygous Trp53-deficient and RasH2 mouse linesR D Storer
Department of Genetic and Cellular Toxicology, Merck Research Laboratories, WP45 311, West Point, PA 19486, USA
Mutat Res 540:165-76. 2003.... - Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repairS W Wijnhoven
Department of Radiation Genetics and Chemical Mutagenesis MGC, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
Oncogene 19:5034-7. 2000..In contrast to current models, the elevated mutation rate in Xpc-/- mice does not lead to an increased tumour incidence or premature ageing. Oncogene (2000) 19, 5034 - 5037.. - Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermisM van Oosten
Department of Radiation Genetics and Chemical Mutagenesis MGC, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
Proc Natl Acad Sci U S A 97:11268-73. 2000..G(2) arrest is manifest only under conditions of proficient TCR in combination with deficient GGR, indicating that epidermal cells become arrested in the G(2) phase as a result of persisting damage in their genome... - Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin CM L Dronkert
Department of Cell Biology and Genetics, Centre for Biomedical Genetics, Erasmus University Rotterdam, The Netherlands
Mol Cell Biol 20:4553-61. 2000..However, they were sensitive to mitomycin C. The ICL sensitivity of the mammalian SNM1 mutant suggests that SNM1 function and, by implication, ICL repair are at least partially conserved between S. cerevisiae and mammals... - Ultraviolet-B induced hyperplasia and squamous cell carcinomas in the cornea of XPA-deficient miceA de Vries
Department of Immunology, University of Utrecht, The Netherlands
Exp Eye Res 67:53-9. 1998..In addition, they suggest that the XPA-deficient mouse is a suitable animal model for the study of XPA ocular disorders... - A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophyJ de Boer
MGC Department of Cell Biology and Genetics Erasmus University, Rotterdam, The Netherlands
Mol Cell 1:981-90. 1998..The cutaneous symptoms are associated with reduced transcription of a skin-specific gene strongly supporting the concept of TTD as a human disease due to inborn defects in basal transcription and DNA repair... - Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPAH Giese
Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
Oncogene 18:1257-60. 1999..This is in keeping with a higher incidence of spontaneous liver tumors reported earlier for XPA-/- mice after about 15 months of age... - XPA-deficiency in hairless mice causes a shift in skin tumor types and mutational target genes after exposure to low doses of U.V.BA de Vries
Department of Immunology, University of Utrecht, The Netherlands
Oncogene 16:2205-12. 1998..V.B.-induced skin carcinogenesis... - Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predispositionJ de Boer
MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
Cancer Res 59:3489-94. 1999..These findings have important implications for the etiology of the human disorder and for the impact of NER on carcinogenesis... - Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour developmentA de Vries
University of Utrecht, Department of Immunology, The Netherlands
Carcinogenesis 18:2327-32. 1997..Interestingly, as we established in a previously performed carcinogenicity assay, the same oral treatment with benzo[a]pyrene induced lymphomas residing in the spleen of XPA-deficient mice... - Homologous and non-homologous recombination differentially affect DNA damage repair in miceJ Essers
Department of Cell Biology and Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam
EMBO J 19:1703-10. 2000.... - Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescenceG Weeda
Department of Cell Biology and Genetics, Medical Genetics Center, Erasmus University, Rotterdam P O Box 1738, 3000 DR, Rotterdam, The Netherlands
Curr Biol 7:427-39. 1997.... - Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient miceA de Vries
Department of Immunology, University of Utrecht, The Netherlands
Mol Carcinog 19:46-53. 1997..Our results show for the first time that XPA-deficient mice also displayed an increased sensitivity to developing tumors other than tumors of the skin... - Elevated frequencies of benzo(a)pyrene-induced Hprt mutations in internal tissue of XPA-deficient miceS A Bol
J A Cohen Institute, Inter University Institute for Radiopathology and Radiation Protection, Leiden, The Netherlands
Cancer Res 58:2850-6. 1998..These results provide the first direct evidence in mammals that deficient NER leads to enhanced mutagenesis in endogenous genes in internal tissue after exposure to relevant environmental mutagens, such as benzo(a)pyrene... - Deoxyribonucleic acid damage and spontaneous mutagenesis in the thyroid gland of rats and miceJ Maier
III Medical Department, University of Leipzig, Inselstrasse 22, D-04103 Leipzig, Germany
Endocrinology 147:3391-7. 2006..This is also supported by the spectrum of somatic mutations in the TSHR because more frequent base changes could stem from oxidized base adducts that we detected in the comet assay and with immunohistochemistry... - Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and miceJ Maier
III Medical Department, Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
Biochim Biophys Acta 1773:990-9. 2007..However, the absence of increased SMR would argue for more efficient DNA repair in response to iodine restriction... - Subunit II of yeast QH2:cytochrome-c oxidoreductase. Nucleotide sequence of the gene and features of the proteinP Oudshoorn
Eur J Biochem 163:97-103. 1987..5% of that of wild type). The implications of this finding for the possible role of subunit II in the complex are discussed...