Research Topics
| D van SoolingenSummaryAffiliation: National Institute for Public Health and the Environment Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
[Findings and ongoing research in the molecular epidemiology of tuberculosis]Dick van Soolingen
National Institute for Public Health and the Environment, BA Bilthoven, The Netherlands
Kekkaku 84:83-9. 2009..While in The Netherlands the organization of tuberculosis (TB) control in the era of elimination is being discussed, worldwide TB is still a major problem...
Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiologyKarine Brudey
, Institut Pasteur de Guadeloupe, Guadeloupe
BMC Microbiol 6:23. 2006..The building and mining of extended MTC polymorphic genetic databases is in progress...- M. tuberculosis genotypic diversity and drug susceptibility pattern in HIV-infected and non-HIV-infected patients in northern TanzaniaGibson S Kibiki
Department of Internal Medicine, Endoscopy Unit, Kilimanjaro Christian Medical Centre, Tumaini University, Moshi, Tanzania
BMC Microbiol 7:51. 2007..TB positive culture, BAL fluid or sputum samples from 130 patients were collected and genotyped. The spoligotypes were correlated with anti-tuberculous drug susceptibility in HIV-infected and non-HIV patients from Tanzania... - The use of microbead-based spoligotyping for Mycobacterium tuberculosis complex to evaluate the quality of the conventional method: providing guidelines for Quality Assurance when working on membranesEdgar Abadia
Institute of Genetics and Microbiology UMR8621, CNRS Université Paris Sud 11 Universud, Campus d Orsay, F 91405 Orsay cedex, France
BMC Infect Dis 11:110. 2011..Nine hundred and twenty-seven isolates were analyzed totaling 39,861 data points. Samples were received from 11 international laboratories with a worldwide distribution... - Molecular epidemiology of tuberculosis and other mycobacterial infections: main methodologies and achievementsD van Soolingen
Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J Intern Med 249:1-26. 2001..tuberculosis complex (atypical) mycobacteria. Important new insights that have been gained through molecular techniques into epidemiological aspects and diagnosis of mycobacterial diseases are highlighted... - Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in the NetherlandsD van Soolingen
Mycobacteria Reference Laboratory, RIVM LIS pb22, 3720 BA Bilthoven, The Netherlands
J Infect Dis 182:1788-90. 2000..Thus, aa 315 mutants lead to secondary cases of tuberculosis as often as INH-susceptible strains do... - Molecular epidemiology of tuberculosis in the Netherlands: a nationwide study from 1993 through 1997D van Soolingen
Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J Infect Dis 180:726-36. 1999..Human immunodeficiency virus infection was not an independent risk factor for active transmission. Isoniazid-resistant strains were relatively less frequently clustered, suggesting that these generated fewer secondary cases... - Diagnosis of Mycobacterium microti infections among humans by using novel genetic markersD van Soolingen
Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J Clin Microbiol 36:1840-5. 1998..microti strains isolated in The Netherlands, suggesting that geographic isolation led to divergent strains in the United Kingdom and on the continent... - IS1245 restriction fragment length polymorphism typing of Mycobacterium avium isolates: proposal for standardizationD van Soolingen
Diagnostic Laboratory of Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
J Clin Microbiol 36:3051-4. 1998..Moreover, by combining international DNA typing results of M. avium complex isolates from a broad spectrum of sources, long-lasting questions on the epidemiology of this major agent of mycobacterial infections will be answered... - Analysis of rate of change of IS6110 RFLP patterns of Mycobacterium tuberculosis based on serial patient isolatesA S de Boer
National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
J Infect Dis 180:1238-44. 1999..1-5.0). The main implication of this study is that the rate of change of IS6110-based RFLP of M. tuberculosis supports the use of IS6110 typing in epidemiologic studies of recent transmission of tuberculosis... - Genetic heterogeneity in Mycobacterium tuberculosis isolates reflected in IS6110 restriction fragment length polymorphism patterns as low-intensity bandsA S de Boer
Department of Infectious Disease Epidemiology, National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
J Clin Microbiol 38:4478-84. 2000..tuberculosis to changes in the environmental conditions during the dormant state or reactivation thereafter... - Comparison of methods based on different molecular epidemiological markers for typing of Mycobacterium tuberculosis complex strains: interlaboratory study of discriminatory power and reproducibilityK Kremer
Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
J Clin Microbiol 37:2607-18. 1999..tuberculosis strains. Several separate genotype families within the M. tuberculosis complex could be recognized on the basis of the genetic markers used... - Exogenous re-infection as a cause of recurrent tuberculosis in a low-incidence areaA S de Boer
Centre for Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Int J Tuberc Lung Dis 7:145-52. 2003..Surveillance data from the National Tuberculosis Register for the period 1993-1997 complemented with DNA fingerprinting results of Mycobacterium tuberculosis isolates... - Clinical Mycobacterium conspicuum isolation from two immunocompetent patients in The NetherlandsJ van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Clin Microbiol 45:4075-6. 2007 - Second-line drug resistance in multidrug-resistant tuberculosis cases of various origins in the NetherlandsJ van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Int J Tuberc Lung Dis 12:1295-9. 2008..The Netherlands... 
Clinical relevance of non-tuberculous mycobacteria isolated in the Nijmegen-Arnhem region, The NetherlandsJ van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Thorax 64:502-6. 2009..The frequency of clinical isolation of non-tuberculous mycobacteria (NTM) in the Netherlands is increasing, but its clinical relevance is often uncertain...- Clinical relevance of Mycobacterium simiae in pulmonary samplesJ van Ingen
Dept of Pulmonary Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Eur Respir J 31:106-9. 2008..simiae infection. Further studies are required in order to improve diagnostic criteria and treatment regimens... - Environmental sources of rapid growing nontuberculous mycobacteria causing disease in humansJ van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Clin Microbiol Infect 15:888-93. 2009..Furthermore, studies should focus on the actual sites of the active replication of RGM; their presence may not indicate their natural habitat... - Re-analysis of 178 previously unidentifiable Mycobacterium isolates in the Netherlands in 1999-2007J van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Microbiol Infect 16:1470-4. 2010..The number of NTM species in the environment is probably so high that unidentifiable clinical isolates should be given a separate species status only if this is clinically meaningful... - The changing pattern of clinical Mycobacterium avium isolation in the NetherlandsJ van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Int J Tuberc Lung Dis 14:1176-80. 2010..National Mycobacteria Reference Laboratory, The Netherlands... - Proposal to elevate Mycobacterium avium complex ITS sequevar MAC-Q to Mycobacterium vulneris sp. novJ van Ingen
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Int J Syst Evol Microbiol 59:2277-82. 2009..avium complex strains sharing this 16S gene and MAC-Q ITS sequence to separate species status, for which the name Mycobacterium vulneris sp. nov. is proposed. The type strain is NLA000700772T (=DSM 45247T=CIP 109859T)... - [Nontuberculous mycobacteria: clinically relevant]Jakko van Ingen
Radboud Universiteit Nijmegen Medisch Centrum, afd Longziekten, Nijmegen, en Universitair Centrum voor Chronische Ziekten Dekkerswald, Groesbeek, The Netherlands
Ned Tijdschr Geneeskd 154:A1178. 2010..Therefore, prompt consultation with one of the specialized centres of expertise is warranted. We should also consider formulating national guidelines for diagnosis and treatment... - Correlation of virulence, lung pathology, bacterial load and delayed type hypersensitivity responses after infection with different Mycobacterium tuberculosis genotypes in a BALB/c mouse modelJ Dormans
Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and Environment (RIVM, Bilthoven, The Netherlands
Clin Exp Immunol 137:460-8. 2004..A severe pathological response correlates with a high mortality and a high CFU counts in lungs, but poorly with the degree of the DTH response... - Tuberculosis seasonality in the Netherlands differs between natives and non-natives: a role for vitamin D deficiency?H Korthals Altes
Epidemiology and Surveillance, Tuberculosis and M XDR TB Programme, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Int J Tuberc Lung Dis 16:639-44. 2012..The seasonality of tuberculosis (TB) incidence suggests that the risk of infection or development of disease has a seasonal component... - Pathological and immunological effects of respirable coal fly ash in male Wistar ratsJ A Dormans
Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
Inhal Toxicol 11:51-69. 1999..Whether these observed alterations may effect the host resistance must be learned from infection studies... - The effect of age and study duration on the relationship between 'clustering' of DNA fingerprint patterns and the proportion of tuberculosis disease attributable to recent transmissionE Vynnycky
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
Epidemiol Infect 126:43-62. 2001.... - Rapid identification of mycobacteria by Raman spectroscopyP C A M Buijtels
University Medical Centre Utrecht, Department of Medical Microbiology, HP G04 614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
J Clin Microbiol 46:961-5. 2008..Raman spectroscopy provides a novel answer to the need for rapid species identification of cultured mycobacteria in a clinical diagnostic setting... - Molecular epidemiology of Mycobacterium tuberculosis in China: a nationwide random survey in 2000W M Li
Department of Bacteriology and Immunology, Beijing Tuberculosis and Thoracic Tumour Research Institute, Beijing People's Republic of China
Int J Tuberc Lung Dis 9:1314-9. 2005..CONCLUSION: The M. tuberculosis Beijing genotype has prevailed in China for at least five decades and is associated with region... - Tuberculosis contact investigation and DNA fingerprint surveillance in The Netherlands: 6 years' experience with nation-wide cluster feedback and cluster monitoringC S B Lambregts-van Weezenbeek
Royal Netherlands Tuberculosis Association KNCV, The Hague, The Netherlands
Int J Tuberc Lung Dis 7:S463-70. 2003..The Netherlands, 1995-2000... - Unique gene organization of thioredoxin and thioredoxin reductase in Mycobacterium lepraeB Wieles
Department of Immunohaematology and Blood Bank, Leiden University Hospital, The Netherlands
Mol Microbiol 16:921-9. 1995..leprae. These findings demonstrate the very unusual phenomenon of a single gene coding for both the substrate (thioredoxin) and the enzyme (thioredoxin reductase), which seems to be unique to M. leprae... - Lymphadenitis in children is caused by Mycobacterium avium hominissuis and not related to 'bird tuberculosis'L E S Bruijnesteijn van Coppenraet
Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
Eur J Clin Microbiol Infect Dis 27:293-9. 2008..avium isolates, and all belonged to the M. avium hominissuis subspecies. A relation to pet birds in the etiology of mycobacterial lymphadenitis could not be established, and the source of the infections may be environmental... - Efficient differentiation of Mycobacterium tuberculosis strains of the W-Beijing family from Russia using highly polymorphic VNTR lociO V Surikova
Pharmacogenomics Group, Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia
Eur J Epidemiol 20:963-74. 2005..VNTR typing in proposed format is powerful tool for discrimination of M. tuberculosis strains with different level of genetic relationship... - First description of Mycobacterium tuberculosis Beijing genotype in ArgentinaN Morcillo
Laboratorio de Referencia del Programa de Control de Tuberculosis de la Provincia de Buenos Aires,
Rev Argent Microbiol 37:92-5. 2005..These findings might be partially explained by the important migration phenomena occurred during the last decade. Further surveillance studies would help in the following of Beijing family strain dissemination in our community... - [An outbreak of multiresistant tuberculosis from Eastern Europe in the Netherlands]G de Vries
Gemeentelijke Gezondheidsdienst Rotterdam e o, afd Tuberculose bestrijding, Postbus 70 032, 3000 LP Rotterdam
Ned Tijdschr Geneeskd 149:1921-4. 2005..This is the first time an outbreak of multiresistant tuberculosis of this magnitude is described in the Netherlands... - The impact of nontuberculous mycobacteria on management of presumed pulmonary tuberculosisR van Crevel
Dept of Internal Medicine, University Medical Center Nijmegen, The Netherlands
Infection 29:59-63. 2001..Reliable DNA-based techniques and better communication between physicians and microbiologists may improve management of suspected mycobacterial infections... - Seventy percent of the Mycobacterium tuberculosis isolates in Hong Kong represent the Beijing genotypeM Y Chan
Tuberculosis Reference Laboratory, Department of Health, Hong Kong, Kwun Tong, Kowloon
Epidemiol Infect 127:169-71. 2001..This is the first geographical area where genetic diversity among 'Beijing' genotype of MTB strains has been observed on this scale... - Divergent effect of bacillus Calmette-Guérin (BCG) vaccination on Mycobacterium tuberculosis infection in highly related macaque species: implications for primate models in tuberculosis vaccine researchJ A Langermans
Departments of Parasitology and Animal Science, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands
Proc Natl Acad Sci U S A 98:11497-502. 2001..Comparative studies in these closely related species are likely to provide insight into mechanisms involved in protection against tuberculosis... - A new evolutionary scenario for the Mycobacterium tuberculosis complexR Brosch
, , , Institut Pasteur, 25-28 rue du Docteur Roux, 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 99:3684-9. 2002..bovis lineage separated from the M. tuberculosis lineage. This observation suggests that the common ancestor of the tubercle bacilli resembled M. tuberculosis or M. canettii and could well have been a human pathogen already... - Effect of screening of immigrants on tuberculosis transmissionS Verver
Royal Netherlands Tuberculosis Association KNCV, The Hague
Int J Tuberc Lung Dis 6:121-9. 2002..In The Netherlands all immigrants from highly endemic countries undergo obligatory entry screening by X-ray, followed by voluntary half-yearly screening for 2 years... - Predominace of a novel Mycobacterium tuberculosis genotype in the Delhi region of IndiaN Vijaya Bhanu
Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110 029, India
Tuberculosis (Edinb) 82:105-12. 2002..Future studies may disclose the genetic characteristics of strains belonging to the Delhi genotype, analogous to the recently observed virulence among the Beijing genogroup... - Improvement of differentiation and interpretability of spoligotyping for Mycobacterium tuberculosis complex isolates by introduction of new spacer oligonucleotidesA G M Van Der Zanden
Medical Microbiology and Infectious Diseases, Gelre Hospitals, Location Lukas, Apeldoorn, The Netherlands
J Clin Microbiol 40:4628-39. 2002..g., for low-copy-number IS6110 strains or for phylogenetic studies of Beijing genotype strains... - A low cost, home-made, reverse-line blot hybridisation assay for rapid detection of rifampicin resistance in Mycobacterium tuberculosisN Morcillo
Mycobacterial Regional Reference Laboratory, Tuberculosis Control Programme of Buenos Aires Province, Argentina
Int J Tuberc Lung Dis 6:959-65. 2002..In principle the test can also be applied directly to Zichl-Neelsen slides and clinical material, as has been demonstrated for another reverse-line blot-based assay for M. tuberculosis, spoligotyping... - Use of DNA extracts from Ziehl-Neelsen-stained slides for molecular detection of rifampin resistance and spoligotyping of Mycobacterium tuberculosisA G M Van Der Zanden
Medical Microbiology and Infectious Diseases, Gelre Hospitals, Location Lukas, Apeldoorn, The Netherlands
J Clin Microbiol 41:1101-8. 2003..The nature of rifampin resistance and the genotype can be determined by analysis of Ziehl-Neelsen-stained slides in a laboratory equipped for sequencing and spoligotyping without the need to ship biohazardous materials... - A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypesB Lopez
National Institute for Infectious Diseases, National Administration of Health Laboratories and Institutes Carlos G Malbrán, Buenos Aires, Argentina
Clin Exp Immunol 133:30-7. 2003..Future immunological research, particularly on candidate vaccines, should include a broad spectrum of M. tuberculosis genotypes rather than a few laboratory strains... - [Research into new methods for diagnosing, treating and preventing tuberculosis]M W Borgdorff
Academisch Medisch Centrum Universiteit van Amsterdam, Amsterdam
Ned Tijdschr Geneeskd 147:1838-41. 2003..However, new candidate vaccines are being developed and will be tested on humans in the near future... - Molecular characteristics and global spread of Mycobacterium tuberculosis with a western cape F11 genotypeThomas C Victor
MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
J Clin Microbiol 42:769-72. 2004..Careful study of dominant compared to rare strains should provide clues to their success and possibly provide new ideas for combating TB... - Analysis of genetic polymorphisms affecting the four phospholipase C (plc) genes in Mycobacterium tuberculosis complex clinical isolatesC Viana-Niero
Departamento de Microbiologia, Imunologia e Parasitologia, , Rua Botucatu, 862 3rd andar, 04023-062, , Brazil
Microbiology 150:967-78. 2004.... - Pneumonia caused by Mycobacterium kansasii in a series of patients without recognised immune defectS M Arend
Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Clin Microbiol Infect 10:738-48. 2004..kansasii infections. The identical fingerprint patterns of the isolates suggested the existence of a virulent strain of M. kansasii... - Systematic molecular characterization of multidrug-resistant Mycobacterium tuberculosis complex isolates from SpainS Samper
Servicio de Microbiologia, Hospital Universitario Miguel Servet, C Isabel la Católica 1 3, 50009 Zaragoza, Spain
J Clin Microbiol 43:1220-7. 2005..The 22 isolates in the largest cluster corresponded to the Mycobacterium bovis strain responsible for two nosocomial MDR outbreaks in Spain... - Differential pattern of cytokine expression by macrophages infected in vitro with different Mycobacterium tuberculosis genotypesR Chacón-Salinas
Department of Immunology, National School of Biological Sciences, ENCB IPN, Mexico
Clin Exp Immunol 140:443-9. 2005..Results presented in this work show that each genotype has the ability to induce different levels of cytokine expression that could be related to its pathogenesis during infection... - Mycobacterium tuberculosis Beijing genotype emerging in VietnamD D Anh
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
Emerg Infect Dis 6:302-5. 2000..Three hundred one (54%) patients were infected with Beijing genotype strains. The genotype was associated with younger age (and hence with active transmission) and with isoniazid and streptomycin resistance, but not with BCG vaccination...