Research Topics
| P F TeunisSummaryAffiliation: National Institute for Public Health and the Environment Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
Infectious disease transmission as a forensic problem: who infected whom?Peter Teunis
Epidemiology and Surveillance Unit, RIVM, Bilthoven, The Netherlands
J R Soc Interface 10:20120955. 2013..This illustrates that the proposed method can be used to accurately reconstruct transmission networks, enhancing our understanding of outbreak dynamics and possibly leading to new insights into how to prevent outbreaks...- Time-course of antibody responses against Coxiella burnetii following acute Q feverP F M Teunis
Centre for Infectious Disease Control, Epidemiology and Surveillance Unit, RIVM, Bilthoven, The Netherlands
Epidemiol Infect 141:62-73. 2013..When combining the results of mixture analysis into an odds score, it is concluded that not only high IgG phase 1 may be predictive for chronic Q fever, but also that high IgG phase 2 may aid in detecting such putative chronic cases... - Biomarker dynamics: estimating infection rates from serological dataP F M Teunis
Centre for Infectious Disease Control, Epidemiology and Surveillance Unit, RIVM, PO Box 1, 3720BA Bilthoven, The Netherlands
Stat Med 31:2240-8. 2012.... 
Hierarchical dose response of E. coli O157:H7 from human outbreaks incorporating heterogeneity in exposureP F M Teunis
National Institute of Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
Epidemiol Infect 136:761-70. 2008..Monte Carlo parameter samples (alpha, beta of the Beta-Poisson model) can be readily incorporated in risk assessment models built using tools such as S-plus and @ Risk...- Characterization of drinking water treatment for virus risk assessmentP F M Teunis
National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands
Water Res 43:395-404. 2009..The processes characterized in this paper may be used as reference for waterborne virus risk assessment, to check against location specific data, and in case no such data are available, to use as defaults... - Usefulness of sero-surveillance for Trichinella infections in animal populationsP F M Teunis
EMI, RIVM, Bilthoven, The Netherlands
Vet Parasitol 159:345-9. 2009..The properties of the serological test were also compared to the conventional digestion assay, which is highly specific but considerably less sensitive... 
Mixed plaques: statistical evidence how plaque assays may underestimate virus concentrationsP F M Teunis
RIVM, dept IMA, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands
Water Res 39:4240-50. 2005....- A reconsideration of the Campylobacter dose-response relationP Teunis
Computerization and Methodological Consultancy Unit, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Epidemiol Infect 133:583-92. 2005..This not only provides new information on the illness dose-response relation for Campylobacter, but also amends the infection dose-response relation because of their conditional dependence... - Enteric virus infection risk from intrusion of sewage into a drinking water distribution networkP F M Teunis
Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, RIVM National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Environ Sci Technol 44:8561-6. 2010..The spatial distribution of infection risk is highly heterogeneous. The presence of a chlorine residual reduces the infection risk... - High infectivity and pathogenicity of influenza A virus via aerosol and droplet transmissionPeter F M Teunis
Centre for Infectious Disease Control, Epidemiology and Surveillance Unit, RIVM, Anthonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, Netherlands
Epidemics 2:215-22. 2010..More studies are needed to clarify the role of different modes of transmission in other settings... - Dose response for infection by Escherichia coli O157:H7 from outbreak dataPeter Teunis
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Risk Anal 24:401-7. 2004..In particular, we demonstrate how the high infectivity limits the uncertainty in the low-dose region... - Human beings are highly susceptible to low doses of Trichinella sppP F M Teunis
Centre for Infectious Disease Control, RIVM National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Epidemiol Infect 140:210-8. 2012..Humans appear to be highly susceptible: exposure to low doses (few larvae) is associated with a considerable risk of infection. As a consequence, levels of Trichinella in meat must be low to maintain acceptable health risks... - Cryptosporidium dose-response studies: variation between hostsPeter F M Teunis
National Institute for Public Health and the Environment, BA Bilthoven, The Netherlands
Risk Anal 22:475-85. 2002..Using such an approach provides first insights into the variation of susceptibility to infection in the general population... - Cryptosporidium dose response studies: variation between isolatesPeter F M Teunis
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Risk Anal 22:175-83. 2002..This finding is of great importance for quantitative risk assessment as it provides strong evidence for heterogeneity in infectivity among isolates of the same species... - The Beta Poisson dose-response model is not a single-hit modelP F Teunis
National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Risk Anal 20:513-20. 2000..This maximum possible response curve is important for uncertainty analysis, and for risk assessment of pathogens with unknown properties... - Norwalk virus: how infectious is it?Peter F M Teunis
RIVM, Bilthoven, The Netherlands
J Med Virol 80:1468-76. 2008..Norwalk virus is a valuable model system to study virulence because genetic factors are known for both complete and partial protection; the latter can be quantitatively described as heterogeneity in dose response models... - Assessment of the dose-response relationship of Campylobacter jejuniG J Medema
Laboratory of Water and Food Microbiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Int J Food Microbiol 30:101-11. 1996..jejuni in water, the uncertainty in the dose-response relation was insignificant compared to the uncertainty in the exposure estimate... - Feasibility of quantitative environmental surveillance in poliovirus eradication strategiesW J Lodder
National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Appl Environ Microbiol 78:3800-5. 2012..This enables the detection of circulating poliovirus by environmental surveillance, supporting its feasibility as an early warning system... - Balancing the risks and benefits of drinking water disinfection: disability adjusted life-years on the scaleA H Havelaar
National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
Environ Health Perspect 108:315-21. 2000..In practice, the application of DALYs may be hampered by the substantial degree of uncertainty, as is typical for risk assessment... - Evidence for an increasing presence of Echinococcus multilocularis in foxes in The NetherlandsKatsuhisa Takumi
Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and Environment RIVM, Antonie van Leeuwenhoeklaan 9, 3720 BA, Bilthoven, The Netherlands
Int J Parasitol 38:571-8. 2008..We conclude that E. multilocularis is an emerging parasite in The Netherlands and thus in the western part of Europe. Control will be very difficult given the current high fox population density... - Base line prevalence and spatial distribution of Echinococcus multilocularis in a newly recognized endemic area in the NetherlandsJoke W B van der Giessen
Microbiological Laboratory for Health Protection, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, P O Box 1, 3720 BA Bilthoven, The Netherlands
Vet Parasitol 119:27-35. 2004..These results suggest that the border areas in the Netherlands are the most margin of E. multilocularis territory... - Combining the transmission disequilibrium test and case-control methodology using generalized logistic regressionNico J D Nagelkerke
Computerization and Methodological Consultancy Unit, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
Eur J Hum Genet 12:964-70. 2004..However, parents of cases can be independently compared to controls. Both the issue of testing for a genetic effect and the estimation of relative risks under the multiplicative model using generalized logistic regression are discussed... - Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measuresJacco Wallinga
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Am J Epidemiol 160:509-16. 2004..In controlling SARS outbreaks, timely alerts have been essential: Delaying the institution of control measures by 1 week would have nearly tripled the epidemic size and would have increased the expected epidemic duration by 4 weeks... - Evaluation of ELISA test characteristics and estimation of Toxoplasma gondii seroprevalence in Dutch sheep using mixture modelsMarieke Opsteegh
National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
Prev Vet Med 96:232-40. 2010..The seroprevalence in sheep was high, and as sheep with antibodies usually carry tissue cysts, this indicates that undercooked lamb and mutton may indeed be important sources of human toxoplasmosis in The Netherlands... - Transmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxisMichiel van Boven
Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
PLoS ONE 5:e11442. 2010..These are widely believed to be key in supporting propagating spread, and it is therefore of importance to assess the transmission levels of the virus in such settings... - Within-host dynamics of Trichinella spiralis predict persistent parasite transmission in rat populationsKatsuhisa Takumi
National Institute for Public Health and the Environment RIVM Bilthoven, The Netherlands
Int J Parasitol 40:1317-24. 2010..In conclusion, T. spiralis transmission persists in a population of rats when they cannibalize their own species. Rats should be included in the minimal set of wildlife species that maintain the life cycle of T. spiralis... - Bordetella pertussis strains with increased toxin production associated with pertussis resurgenceFrits R Mooi
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Emerg Infect Dis 15:1206-13. 2009..pertussis that may have driven this adaptation. Our results underline the importance of Ptx in transmission, suggest that vaccination may select for increased virulence, and indicate ways to control pertussis more effectively... - Transmission risk of human trichinellosisKatsuhisa Takumi
Dept LZO, National Institute of Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
Vet Parasitol 159:324-7. 2009..In the absence of rodent control near the farm, a low infection pressure from wildlife presents a relatively high risk of human trichinellosis via consumption of uncooked pork meat... - Using data on social contacts to estimate age-specific transmission parameters for respiratory-spread infectious agentsJacco Wallinga
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Am J Epidemiol 164:936-44. 2006..These findings have important implications for controlling future outbreaks of novel respiratory-spread infectious agents... - Professional and home-made face masks reduce exposure to respiratory infections among the general populationMarianne Van Der Sande
National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
PLoS ONE 3:e2618. 2008..Therefore they need data to assess the possible impact of interventions. Face-masks worn by the general population could be an accessible and affordable intervention, if effective when worn under routine circumstances... - Low predictive value of seroprevalence of Toxoplasma gondii in cattle for detection of parasite DNAMarieke Opsteegh
Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
Int J Parasitol 41:343-54. 2011..Demonstrating parasitic DNA in seronegative cattle and not in seropositive cattle suggests that only recent infections are detectable. Whether beef from these PCR-positive cattle is infectious to humans remains to be studied... - Sedimentation of free and attached Cryptosporidium oocysts and Giardia cysts in waterG J Medema
Microbiological Laboratory of Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Appl Environ Microbiol 64:4460-6. 1998..parvum and G. lamblia. Attachment to particles influences not only sedimentation of (oo)cysts in surface water but also their behavior in drinking water treatment processes... - Enhanced hygiene measures and norovirus transmission during an outbreakJanneke C M Heijne
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Emerg Infect Dis 15:24-30. 2009..This reduction was unexpectedly large but still below the reduction needed to contain a norovirus outbreak. Even more stringent control measures are required to break the chain of transmission of norovirus... - The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveysHester E de Melker
Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J Infect 53:106-13. 2006..Mathematical modeling could explore what booster vaccination strategies are most effective in reducing severe disease among not (completely) vaccinated infants...