Hein Sprong


Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands


  1. Hofmeester T, Krawczyk A, van Leeuwen A, Fonville M, Montizaan M, Van den Berge K, et al. Role of mustelids in the life-cycle of ixodid ticks and transmission cycles of four tick-borne pathogens. Parasit Vectors. 2018;11:600 pubmed publisher
    ..Interestingly, all four mustelid species carried all stages of I. hexagonus, potentially maintaining enzootic cycles of this tick species apart from the cycle involving hedgehogs as main host species. ..
  2. Szekeres S, Coipan E, Rigó K, Majoros G, Jahfari S, Sprong H, et al. Eco-epidemiology of Borrelia miyamotoi and Lyme borreliosis spirochetes in a popular hunting and recreational forest area in Hungary. Parasit Vectors. 2015;8:309 pubmed publisher
    ..Our results highlight the possible risk of infection with relapsing fever and Lyme borreliosis spirochetes in forest habitats especially in the high-risk groups of hunters, forestry workers and hikers. ..
  3. Franssen F, Bilska ZajÄ…c E, Deksne G, Sprong H, Pozio E, Rosenthal B, et al. Genetic evidence of interspecies introgression of mitochondrial genomes between Trichinella spiralis and Trichinella britovi under natural conditions. Infect Genet Evol. 2015;36:323-332 pubmed publisher
    ..To our knowledge, this is the first report of interspecies hybridisation between T. spiralis and T. britovi under field conditions. ..
  4. Krawczyk A, van Leeuwen A, Jacobs Reitsma W, Wijnands L, Bouw E, Jahfari S, et al. Presence of zoonotic agents in engorged ticks and hedgehog faeces from Erinaceus europaeus in (sub) urban areas. Parasit Vectors. 2015;8:210 pubmed publisher
    ..To what extent can hedgehogs maintain the enteric zoonotic agents in natural cycles, and the role of (spill-back from) humans remains to be investigated. ..
  5. Takumi K, Cacciò S, van der Giessen J, Xiao L, Sprong H. Hypothesis: Cryptosporidium genetic diversity mirrors national disease notification rate. Parasit Vectors. 2015;8:308 pubmed publisher
    ..Genetic diversity of C. hominis and C. parvum may therefore be an independent and complementary measure for quantifying disease incidence, for which only a moderate number of stool samples from each nation are sufficient data input. ..
  6. Szekeres S, Claudia Coipan E, Rigó K, Majoros G, Jahfari S, Sprong H, et al. Candidatus Neoehrlichia mikurensis and Anaplasma phagocytophilum in natural rodent and tick communities in Southern Hungary. Ticks Tick Borne Dis. 2015;6:111-6 pubmed publisher
    ..ricinus nymph removed from a male A. flavicollis with A. phagocytophilum infection. Our study provides new data on the occurrence of these pathogens in rodent tissue samples, questing ticks and engorged ticks in Southern Hungary. ..
  7. de Bruin A, van Leeuwen A, Jahfari S, Takken W, Földvári M, Dremmel L, et al. Vertical transmission of Bartonella schoenbuchensis in Lipoptena cervi. Parasit Vectors. 2015;8:176 pubmed publisher
    ..cervi is a vector for B. schoenbuchensis. Lipoptena cervi is probably not a vector for A. phagocytophilum, Rickettsia species, and Candidatus N. mikurensis. ..
  8. Koetsveld J, Tijsse Klasen E, Herremans T, Hovius J, Sprong H. Serological and molecular evidence for spotted fever group Rickettsia and Borrelia burgdorferi sensu lato co-infections in The Netherlands. Ticks Tick Borne Dis. 2016;7:371-7 pubmed publisher
    ..Whether SFG rickettsiae actually cause disease, and whether co-infections alter the clinical course of Lyme borreliosis, is not clear from our data, and warrants further investigation. ..
  9. Sprong H, Azagi T, Hoornstra D, Nijhof A, Knorr S, Baarsma M, et al. Control of Lyme borreliosis and other Ixodes ricinus-borne diseases. Parasit Vectors. 2018;11:145 pubmed publisher
    ..To facilitate this, communication and collaboration between experts from different fields, which may include patient representatives, should be promoted. ..

More Information


  1. van Duijvendijk G, Coipan C, Wagemakers A, Fonville M, Ersöz J, Oei A, et al. Larvae of Ixodes ricinus transmit Borrelia afzelii and B. miyamotoi to vertebrate hosts. Parasit Vectors. 2016;9:97 pubmed publisher
    ..As a result, B. afzelii can cycle between larvae through rodents. Our findings further imply that larval bites on humans, which easily go unnoticed, can cause Lyme borreliosis and Borrelia miyamotoi disease. ..
  2. van Duijvendijk G, Sprong H, Takken W. Multi-trophic interactions driving the transmission cycle of Borrelia afzelii between Ixodes ricinus and rodents: a review. Parasit Vectors. 2015;8:643 pubmed publisher
    ..Better understanding of the processes involved in the development and aggregation of ticks results in more precise estimates of the density of infected nymphs, and hence predictions of Lyme borreliosis risk. ..
  3. Sprong H, Caccio S, van der Giessen J. Identification of zoonotic genotypes of Giardia duodenalis. PLoS Negl Trop Dis. 2009;3:e558 pubmed publisher
    ..duodenalis is evident, evidence on the contribution and frequency is (still) lacking. This newly developed molecular database has the potential to tackle intricate epidemiological questions concerning protozoan diseases...
  4. Wagemakers A, Jahfari S, De Wever B, Spanjaard L, Starink M, de Vries H, et al. Borrelia miyamotoi in vectors and hosts in The Netherlands. Ticks Tick Borne Dis. 2017;8:370-374 pubmed publisher
    ..A prospective study focused on acute febrile illness after a tick bite could provide insight into the incidence and clinical manifestations of B. miyamotoi infection in The Netherlands. ..
  5. Jahfari S, Sarksyan D, Kolyasnikova N, Hovius J, Sprong H, Platonov A. Evaluation of a serological test for the diagnosis of Borrelia miyamotoi disease in Europe. J Microbiol Methods. 2017;136:11-16 pubmed publisher
    ..miyamotoi infection in 44% to 94% of the PCR-positive BMD patients (95% confidence interval). Thus, sensitive serological assays should not solely rely on rGlpQ, to support the diagnosis of acute BMD. ..
  6. Jahfari S, Ruyts S, Frazer Mendelewska E, Jaarsma R, Verheyen K, Sprong H. Melting pot of tick-borne zoonoses: the European hedgehog contributes to the maintenance of various tick-borne diseases in natural cycles urban and suburban areas. Parasit Vectors. 2017;10:134 pubmed publisher
    ..The extent to which hedgehogs can independently maintain these agents in natural cycles, and the role of other hosts (rodents and birds) remain to be investigated. ..
  7. Estrada Peña A, D Amico G, Palomar A, Dupraz M, Fonville M, Heylen D, et al. A comparative test of ixodid tick identification by a network of European researchers. Ticks Tick Borne Dis. 2017;8:540-546 pubmed publisher
    ..Results also showed that a combination of certain genes may adequately identify the target species of ticks. ..
  8. Ruyts S, Tack W, Ampoorter E, Coipan E, Matthysen E, Heylen D, et al. Year-to-year variation in the density of Ixodes ricinus ticks and the prevalence of the rodent-associated human pathogens Borrelia afzelii and B. miyamotoi in different forest types. Ticks Tick Borne Dis. 2018;9:141-145 pubmed publisher
    ..The risk for rodent-associated tick-borne diseases also varied between forest types. We stress the need to elucidate the contribution of the host community composition to tick-borne disease risk. ..
  9. Sprong H, Tijsse Klasen E, Langelaar M, de Bruin A, Fonville M, Gassner F, et al. Prevalence of Coxiella burnetii in ticks after a large outbreak of Q fever. Zoonoses Public Health. 2012;59:69-75 pubmed publisher
    ..burnetii infected goat farms and to assess whether C. burnetii can be transmitted transovarially and transstadially in I. ricinus ticks...