Wout Slob

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. pmc Statins accelerate the onset of collagen type II-induced arthritis in mice
    Rob J Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Arthritis Res Ther 14:R90. 2012
  2. doi request reprint Can current dietary exposure models handle aggregated intake from different foods? A simulation study for the case of two foods
    Wout Slob
    National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Food Chem Toxicol 48:178-86. 2010
  3. ncbi request reprint Dose-response modeling of continuous endpoints
    Wout Slob
    National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 66:298-312. 2002
  4. ncbi request reprint Probabilistic dietary exposure assessment taking into account variability in both amount and frequency of consumption
    Wout Slob
    National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Food Chem Toxicol 44:933-51. 2006
  5. ncbi request reprint A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints
    Wout Slob
    National Institute for Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 84:167-85. 2005
  6. doi request reprint A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE)
    Leo T M Van der Ven
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Toxicol Lett 179:6-14. 2008
  7. doi request reprint Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats
    Leo T M Van der Ven
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Lett 185:51-62. 2009
  8. doi request reprint Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study
    Leo T M Van der Ven
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 245:76-89. 2008
  9. ncbi request reprint A retrospective analysis of the added value of the rat two-generation reproductive toxicity study versus the rat subchronic toxicity study
    Gemma Janer
    National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Reprod Toxicol 24:103-13. 2007
  10. doi request reprint A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats
    Leo T M Van der Ven
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 245:109-22. 2008

Collaborators

Detail Information

Publications26

  1. pmc Statins accelerate the onset of collagen type II-induced arthritis in mice
    Rob J Vandebriel
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Arthritis Res Ther 14:R90. 2012
    ..Our objective was to investigate whether a causal relationship could be established for this finding...
  2. doi request reprint Can current dietary exposure models handle aggregated intake from different foods? A simulation study for the case of two foods
    Wout Slob
    National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Food Chem Toxicol 48:178-86. 2010
    ..Our results illustrate that the simulation model can be used for validating dietary exposure models, and for indicating how exposure models may be improved...
  3. ncbi request reprint Dose-response modeling of continuous endpoints
    Wout Slob
    National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 66:298-312. 2002
    ..The various applications of the proposed methodology are illustrated by real data sets...
  4. ncbi request reprint Probabilistic dietary exposure assessment taking into account variability in both amount and frequency of consumption
    Wout Slob
    National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Food Chem Toxicol 44:933-51. 2006
    ..This approach results in an estimate of the fraction of the population as a function of the fraction of days at which the exposure limit is exceeded by the individual...
  5. ncbi request reprint A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints
    Wout Slob
    National Institute for Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 84:167-85. 2005
    ..The typical 28-day study design of four dose groups with five animals (per sex) may not be adequate to assess endpoints with large residual variation (CV > or = 18%), both in assessing a benchmark dose and in assessing a NOAEL...
  6. doi request reprint A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE)
    Leo T M Van der Ven
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Toxicol Lett 179:6-14. 2008
    ..18 mg/kg bw/day). These results suggest that decaBDE may represent an as yet unreported hazard for reproductive health...
  7. doi request reprint Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats
    Leo T M Van der Ven
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Lett 185:51-62. 2009
    ..The low BMDLs of these effects may raise concern for human health, particularly when based on body burdens of HBCD, which leads to critical margins of exposure particularly for the occupational setting...
  8. doi request reprint Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study
    Leo T M Van der Ven
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 245:76-89. 2008
    ..Combined with data of human exposure to environmental TBBPA, the margin of exposure for highly exposed populations can be calculated at 2.6, and current use of TBBPA may therefore be a matter of concern for human health...
  9. ncbi request reprint A retrospective analysis of the added value of the rat two-generation reproductive toxicity study versus the rat subchronic toxicity study
    Gemma Janer
    National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Reprod Toxicol 24:103-13. 2007
    ..The consequences that these findings may have for risk assessment and risk management are discussed, especially in the context of REACH...
  10. doi request reprint A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats
    Leo T M Van der Ven
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 245:109-22. 2008
    ..5 mkd in males and 2.3 mkd in females). These results contribute to refinement of the hazard identification of pentaBDE and improved risk assessment of human exposure to this industrial chemical and environmental pollutant...
  11. doi request reprint A retrospective analysis of developmental toxicity studies in rat and rabbit: what is the added value of the rabbit as an additional test species?
    Gemma Janer
    National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 50:206-17. 2008
    ..More knowledge about the interaction between maternal and developmental effects is required before decisions on omitting the requirement for the developmental toxicity testing in a second species can be considered...
  12. doi request reprint A semi-quantitative model for risk appreciation and risk weighing
    Peter M J Bos
    National Institute for Public Health and the Environment RIVM, P O Box 1, NL 3720 BA Bilthoven, Netherlands
    Food Chem Toxicol 47:2941-50. 2009
    ..These graphs will facilitate the discussions on appropriate risk reduction measures to be taken...
  13. ncbi request reprint Quantitative extrapolation of in vitro whole embryo culture embryotoxicity data to developmental toxicity in vivo using the benchmark dose approach
    Aldert H Piersma
    National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 101:91-100. 2008
    ..Further analysis of the in vitro-in vivo correlation would therefore require high-quality in vivo data, generated by appropriate (and similar) study designs...
  14. doi request reprint Developmental immunotoxicity of methylmercury: the relative sensitivity of developmental and immune parameters
    Elisa C M Tonk
    Department of Health Risk Analysis and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Toxicol Sci 117:325-35. 2010
    ..010-0.12). These data show the relatively high sensitivity of the developing immune system and thereby illustrate the relevance of testing immune parameters in reproductive and developmental toxicity testing protocols...
  15. ncbi request reprint Deriving a data-based interspecies assessment factor using the NOAEL and the benchmark dose approach
    Bas G H Bokkers
    Institute for Risk Assessment Sciences IRAS, Utrecht, The Netherlands
    Crit Rev Toxicol 37:355-73. 2007
    ..0 when the BMDL (or BMD uncertainty distribution) is used, and around 3.4 when the NOAEL is used as a point of departure for further risk assessment...
  16. doi request reprint Risk assessment of N-nitrosodimethylamine formed endogenously after fish-with-vegetable meals
    Marco J Zeilmaker
    Centre for Substances and Integrated Risk Assessment, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Toxicol Sci 116:323-35. 2010
    ..We conclude that the combined consumption of fish and nitrate-rich vegetables appears to lead to marginal increases of additional cancer risk...
  17. ncbi request reprint Reduced intake of deoxynivalenol in The Netherlands: a risk assessment update
    Moniek N Pieters
    National Institute of Public Health and the Environment, RIVM, Centre for Substances and Integrated Risk Assessment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Lett 153:145-53. 2004
    ..Taking into account the possible (partly) reversibility of this effect we conclude that no clear adverse health effects will be associated to the exposure (February 2000-December 2002) to DON in The Netherlands...
  18. ncbi request reprint A retrospective analysis of the two-generation study: what is the added value of the second generation?
    Gemma Janer
    National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Reprod Toxicol 24:97-102. 2007
    ..These results support the proposal of replacing the current two-generation study by a one-generation study with a more extensive assessment of parameters at F(1) adulthood...
  19. ncbi request reprint Probabilistic risk characterization: an example with di(2-ethylhexyl) phthalate
    Sieto Bosgra
    National Institute of Public Health and the Environment RIVM, NL 3720 BA Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 43:104-13. 2005
    ..This information leads to a better informed conclusion on the risk of a substance, and may be very useful to define the necessary measures for risk reduction...
  20. ncbi request reprint A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats
    Leo T M Van der Ven
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 94:281-92. 2006
    ..Overall, female rats appeared to be more sensitive to HBCD than male rats, and an overall BMDL is proposed at 1.6 mkd, based on a 10% increase of the thyroid weight, which was the most sensitive parameter in the sequence of events...
  21. ncbi request reprint A comparison of three methods for calculating confidence intervals for the benchmark dose
    Mirjam Moerbeek
    Department of Methodology and Statistics, Utrecht University, Utrecht, The Netherlands
    Risk Anal 24:31-40. 2004
    ..In the context of a probabilistic risk assessment the bootstrap method has the advantage that it directly links to Monte Carlo analysis...
  22. ncbi request reprint Risk assessment of deoxynivalenol in food: concentration limits, exposure and effects
    Moniek N Pieters
    Center for Substances and Risk Assessment, National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands
    Adv Exp Med Biol 504:235-48. 2002
    ..Suppressive effects on body weights and relative liver weight were estimated at 2.2 and 2.7%. However, the large confidence intervals around these estimates indicated that the magnitudes of these effects are uncertain...
  23. ncbi request reprint A comparison of ratio distributions based on the NOAEL and the benchmark approach for subchronic-to-chronic extrapolation
    Bas G H Bokkers
    Institute for Risk Assessment Sciences IRAS, P O Box 80176, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 85:1033-40. 2005
    ..This results in more accurate, and less conservative distributions of AFs in general compared to the distributions based on NOAEL ratios that have been proposed so far...
  24. ncbi request reprint Integration of probabilistic exposure assessment and probabilistic hazard characterization
    Hilko van der Voet
    Wageningen UR, Biometris and RIKILT Institute of Food Safety, Wageningen, The Netherlands
    Risk Anal 27:351-71. 2007
    ..We show how the relative contributions from the various sources of uncertainty involved may be quantified...
  25. ncbi request reprint What is a practical threshold?
    Wout Slob
    Toxicol Pathol 35:848-9. 2007
  26. doi request reprint Risk assessment of botanicals and botanical preparations intended for use in food and food supplements: emerging issues
    Ivonne M C M Rietjens
    Division of Toxicology, Wageningen University, Tuinlaan 5, 6703HE Wageningen, The Netherlands
    Toxicol Lett 180:131-6. 2008
    ....