Frits R Mooi

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. ncbi The evolution of epidemic Vibrio cholerae strains
    F R Mooi
    Research Laboratory for Infectious Diseases, National Institute for Public Health and Environment, Bilthoven, The Netherlands
    Trends Microbiol 5:161-5. 1997
  2. pmc Variation in the Bordetella pertussis virulence factors pertussis toxin and pertactin in vaccine strains and clinical isolates in Finland
    F R Mooi
    Research Laboratory for Infectious Diseases, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Infect Immun 67:3133-4. 1999
  3. pmc Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection
    Sander Banus
    Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Microbiol 7:88. 2007
  4. pmc Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal trends and evidence for vaccine-driven evolution
    F R Mooi
    Research Laboratory for Infectious Diseases, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Infect Immun 66:670-5. 1998
  5. ncbi The case for maternal vaccination against pertussis
    Frits R Mooi
    Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, Netherlands
    Lancet Infect Dis 7:614-24. 2007
  6. pmc Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence?
    F R Mooi
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 7:526-8. 2001
  7. ncbi Epidemiological typing of Bordetella pertussis isolates: recommendations for a standard methodology
    F R Mooi
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Eur J Clin Microbiol Infect Dis 19:174-81. 2000
  8. pmc Bordetella pertussis strains with increased toxin production associated with pertussis resurgence
    Frits R Mooi
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 15:1206-13. 2009
  9. pmc Small mutations in Bordetella pertussis are associated with selective sweeps
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 7:e46407. 2012
  10. ncbi Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Vaccine 25:2346-60. 2007

Collaborators

Detail Information

Publications66

  1. ncbi The evolution of epidemic Vibrio cholerae strains
    F R Mooi
    Research Laboratory for Infectious Diseases, National Institute for Public Health and Environment, Bilthoven, The Netherlands
    Trends Microbiol 5:161-5. 1997
    ..Recent studies reveal that horizontal transfer of cell-wall polysaccharide genes played a central role in the emergence of this strain and that its genesis may not be as unique as initially believed...
  2. pmc Variation in the Bordetella pertussis virulence factors pertussis toxin and pertactin in vaccine strains and clinical isolates in Finland
    F R Mooi
    Research Laboratory for Infectious Diseases, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Infect Immun 67:3133-4. 1999
    ..An interesting difference between the contemporary Finnish and Dutch B. pertussis populations was found in the frequencies of pertactin variants, possibly explaining the distinct epidemiology of pertussis in the two countries...
  3. pmc Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection
    Sander Banus
    Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Microbiol 7:88. 2007
    ..pertussis inoculation. Twelve and a half percent of the genomes of these mice are from a different genetic background...
  4. pmc Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal trends and evidence for vaccine-driven evolution
    F R Mooi
    Research Laboratory for Infectious Diseases, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Infect Immun 66:670-5. 1998
    ..Our findings cast a new light on the reemergence of pertussis in highly vaccinated populations and may have major implications for the long-term efficacy of both WCVs and ACVs...
  5. ncbi The case for maternal vaccination against pertussis
    Frits R Mooi
    Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, Netherlands
    Lancet Infect Dis 7:614-24. 2007
    ..Maternal vaccination might be an effective way to decrease morbidity and mortality caused by pertussis in newborn babies...
  6. pmc Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence?
    F R Mooi
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 7:526-8. 2001
    ..Adaptation may have allowed B. pertussis to remain endemic despite widespread vaccination and may have contributed to the reemergence of pertussis in the Netherlands...
  7. ncbi Epidemiological typing of Bordetella pertussis isolates: recommendations for a standard methodology
    F R Mooi
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Eur J Clin Microbiol Infect Dis 19:174-81. 2000
    ..Comparisons may reveal whether the epidemiological differences observed between countries are due for instance to different Bordetella pertussis populations or different vaccines used...
  8. pmc Bordetella pertussis strains with increased toxin production associated with pertussis resurgence
    Frits R Mooi
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 15:1206-13. 2009
    ..pertussis that may have driven this adaptation. Our results underline the importance of Ptx in transmission, suggest that vaccination may select for increased virulence, and indicate ways to control pertussis more effectively...
  9. pmc Small mutations in Bordetella pertussis are associated with selective sweeps
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 7:e46407. 2012
    ..Further, this work shows that small mutations, even single SNPs, can drive large changes in the populations of bacterial pathogens within a time span of six to 19 years...
  10. ncbi Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Vaccine 25:2346-60. 2007
    ..In summary, after challenge vaccination increased lung pathology, TNF-alpha expression (only WCV), and IH parameters. Th1 cells were critical for clearance...
  11. pmc Comparative genomic profiling of Dutch clinical Bordetella pertussis isolates using DNA microarrays: identification of genes absent from epidemic strains
    Audrey J King
    Laboratory for Infectious Diseases and Screening Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    BMC Genomics 9:311. 2008
    ..In the Netherlands, the resurgence of pertussis is associated with the rise of B. pertussis strains with an altered promoter region for pertussis toxin (ptxP3)...
  12. doi An investigation into the cause of the 1983 whooping cough epidemic in the Netherlands
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 27:1898-903. 2009
    ..Further, we show that MLVA and fimbrial serotyping of strains can be used as early warning for pertussis epidemics...
  13. ncbi The role of peptide loops of the Bordetella pertussis protein P.69 pertactin in antibody recognition
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 25:5902-14. 2007
    ..69 Prn. The results presented here provide a better understanding of the structure and function of variable loops and their role in the persistence of pathogens in immunologically primed populations...
  14. pmc The role of Toll-like receptor-4 in pertussis vaccine-induced immunity
    Sander Banus
    Health Protection Research, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    BMC Immunol 9:21. 2008
    ..Here we analyze the effects of wP and aP vaccination and B. pertussis challenge, in Tlr4-deficient C3H/HeJ and wild-type C3H/HeOuJ mice. aP consists of Ptx, filamentous hemagglutinin (FHA), and pertactin (Prn)...
  15. ncbi The Bordetella pertussis virulence factor P.69 pertactin retains its immunological properties after overproduction in Escherichia coli
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Protein Expr Purif 41:106-12. 2005
    ..Here, we describe the procedure to clone, express, and purify up to 0.1mg P.69 pertactin and its derivatives per 1 ml Escherichia coli culture...
  16. pmc Comparative genomics of prevaccination and modern Bordetella pertussis strains
    Marieke J Bart
    Laboratory for Infectious Diseases and Screening, Netherlands Centre for Infectious Diseases Control, RIVM, Bilthoven, Netherlands
    BMC Genomics 11:627. 2010
    ..To elucidate how B. pertussis has adapted to vaccination, we compared genome sequences of two ptxP3 strains with four strains isolated before and after the introduction vaccination...
  17. pmc Seroprevalence of pertussis in The Netherlands: evidence for increased circulation of Bordetella pertussis
    Sabine C de Greeff
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 5:e14183. 2010
    ..We determined whether the increase in reported pertussis in the last decade is associated with an increase in the number of infections...
  18. ncbi Antibody responses to defined regions of the Bordetella pertussis virulence factor pertactin
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Scand J Infect Dis 40:94-104. 2008
    ..It also suggests that the amount of pertactin type-specific antibodies will not be very large and that the variation in pertactin probably will not constitute a problem in highly immune individuals...
  19. pmc Multiple-locus variable-number tandem repeat analysis of Dutch Bordetella pertussis strains reveals rapid genetic changes with clonal expansion during the late 1990s
    Leo M Schouls
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Bacteriol 186:5496-505. 2004
    ..Using this genotyping, we have been able to show that B. pertussis is much more dynamic than expected...
  20. doi Estimation of household transmission rates of pertussis and the effect of cocooning vaccination strategies on infant pertussis
    Sabine C de Greeff
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiology 23:852-60. 2012
    ..Despite >50 years of universal vaccination, pertussis remains the most prevalent vaccine-preventable infectious disease in developed countries. Pertussis is often mild in adults, but can run a severe course in young infants...
  21. pmc Two-component cluster analysis of a large serodiagnostic database for specificity of increases of IgG antibodies against pertussis toxin in paired serum samples and of absolute values in single serum samples
    Sabine C de Greeff
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Clin Vaccine Immunol 19:1452-6. 2012
    ..2%). Given the methodology of this study, estimates of sensitivity probably are overrated (because pertussis patients without IgG-Ptx response are not detected), but estimates of specificities can be considered very accurate...
  22. pmc Epitope structure of the Bordetella pertussis protein P.69 pertactin, a major vaccine component and protective antigen
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health, Antonie van Leeuwenhoek Laan 1, P O Box 1, Bilthoven, The Netherlands
    Infect Immun 72:3716-23. 2004
    ..69 pertactin. This may explain why the variation in P.69 pertactin is so effective, despite the fact that it is limited to only two small segments of the molecule...
  23. pmc SNP-based typing: a useful tool to study Bordetella pertussis populations
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 6:e20340. 2011
    ..Two predominant ptxP3 SNP types were identified which spread worldwide. The widespread use of SNP typing will enhance our understanding of the evolution and global epidemiology of B. pertussis...
  24. ncbi [Pertussis in the Netherlands]
    Sabine C de Greeff
    RIVM, Centrum voor Infectieziektebestrijding, afd Epidemiologie en Surveillance, Bilthoven, The Netherlands
    Ned Tijdschr Geneeskd 154:A1383. 2010
    ..Targeting vaccination at adults and health care workers who are in close contact with infants may prevent transmission of pertussis to infants...
  25. doi Economic analysis of pertussis illness in the Dutch population: implications for current and future vaccination strategies
    Sabine C de Greeff
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 27:1932-7. 2009
    ..The effectiveness of universal adolescent or adult booster strategies -- to prevent pertussis in infants -- should also be considered from an economical point of view before being implemented...
  26. pmc Studies on Prn variation in the mouse model and comparison with epidemiological data
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 6:e18014. 2011
    ..Therefore other factors may have contributed to the predominance of Prn2 in vaccinated populations. The mouse model may be useful to assess and predict changes in the B. pertussis population due to vaccination...
  27. ncbi Role of the polymorphic region 1 of the Bordetella pertussis protein pertactin in immunity
    A J King
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Microbiology 147:2885-95. 2001
    ..An mAb directed against a linear conserved epitope conferred cross-immunity against isolates with distinct pertactin variants. The results indicate an important role of region 1 of pertactin in immunity...
  28. ncbi Cost-effectiveness of targeted vaccination to protect new-borns against pertussis: comparing neonatal, maternal, and cocooning vaccination strategies
    Anna K Lugnér
    Epidemiology and Surveillance Unit, National Institute for Public Health and the Environment, Bilthoven, The Netherlands Electronic address
    Vaccine 31:5392-7. 2013
    ..Specifically, with a persistent epidemic as seen in 2012, there is need for reconsidering the vaccination schedules against pertussis in order to increase protection of the vulnerable new-borns. ..
  29. ncbi A novel strategy to mimic discontinuous protective epitopes using a synthetic scaffold
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Antonie van Leeuwenhoeklaan 1, PO Box 1, Bilthoven, The Netherlands
    Vaccine 25:6807-17. 2007
    ..This approach opens up the possibility to the design of new and fully synthetic vaccines that can induce protective antibodies...
  30. pmc DNA fingerprinting of Vibrio cholerae strains with a novel insertion sequence element: a tool to identify epidemic strains
    E M Bik
    Molecular Microbiology Unit, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 34:1453-61. 1996
    ..cholerae strain carrying non-O1 antigens. This study underlines the importance of genotypic methods for the differentiation of V. cholerae strains and for recognition of strains with epidemic potential...
  31. doi Impact of acellular pertussis preschool booster vaccination on disease burden of pertussis in The Netherlands
    Sabine C de Greeff
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Pediatr Infect Dis J 27:218-23. 2008
    ..An acellular preschool booster vaccination against pertussis has been included in the National Immunization Programme in The Netherlands, since November 2001. We studied the impact of this preschool booster on the epidemiology of pertussis...
  32. ncbi Characterization of Bordetella pertussis clinical isolates that do not express the tracheal colonization factor
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    FEMS Immunol Med Microbiol 51:149-54. 2007
    ..Irreversible and reversible loss occurred, respectively, by recombination between repeats leading to deletion of the tcfA gene and by mutations in a polymorphic G-track. These phenomena may reflect adaptation to distinct niches...
  33. pmc Effects of a diphtheria-tetanus-acellular pertussis vaccine on immune responses in murine local lymph node and lung allergy models
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Clin Vaccine Immunol 14:211-9. 2007
    ..Vaccination failed to modulate these parameters. In conclusion, although DTaP vaccination may affect the LLNA response, we found no evidence of an effect on lung allergy...
  34. doi Pertussis in infancy and the association with respiratory and cognitive disorders at toddler age
    Sabine C de Greeff
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 29:8275-8. 2011
    ..We found an association between severe pertussis in infancy and respiratory symptoms on toddler age. The mechanisms that may underlie this association require further investigation...
  35. pmc Multilocus sequence typing of Bordetella pertussis based on surface protein genes
    Inge H M Van Loo
    Laboratory for Infectious Diseases Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 40:1994-2001. 2002
    ..These types may represent newly emerged, successful clones. The identification of highly successful clones may shed light on the question of how B. pertussis is able to maintain itself in vaccinated populations...
  36. doi Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen
    Frits R Mooi
    Lab for Infectious Diseases and Screening, Netherlands Centre for Infectious Diseases Control, Natl Institute for Public Health and the Environment, RIVM, PO Box 1, 3720 BA Bilthoven, Netherlands
    Infect Genet Evol 10:36-49. 2010
    ..pertussis populations has not only increased our understanding of pathogen evolution, but also suggests way to improve pertussis vaccines, underlining the public health significance of population-based studies of pathogens...
  37. ncbi [Effect of vaccination against pertussis on the incidence of pertussis in The Netherlands, 1996-2003]
    S C de Greeff
    Centrum voor Infectieziekten Epidemiologie Rijksinstituut voor Volksgezondheid en Milieu, Postbus 1, 3720 BA Bilthoven
    Ned Tijdschr Geneeskd 149:937-43. 2005
    ..To determine whether booster vaccination of 4-year-old children with an acellular pertussis vaccine, which has been included in the national vaccination programme since October 2001, has decreased the incidence of pertussis...
  38. pmc Reemergence of pertussis in the highly vaccinated population of the Netherlands: observations on surveillance data
    H E de Melker
    Department of Infectious Disease Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 6:348-57. 2000
    ..The small immunogenicity profile of the Dutch vaccine may have resulted in greater vulnerability to antigenic changes in B. pertussis...
  39. doi Seasonal patterns in time series of pertussis
    S C de Greeff
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiol Infect 137:1388-95. 2009
    ..Studying trends offers insight into transmission dynamics and may facilitate decisions on future vaccination strategies...
  40. doi Pertussis disease burden in the household: how to protect young infants
    S C de Greeff
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Clin Infect Dis 50:1339-45. 2010
    ..We conducted a population-based, nation-wide, prospective study to identify who introduced pertussis into the household of infants aged 6 months admitted to the hospital for pertussis in the Netherlands...
  41. ncbi Structure of the Bordetella pertussis gene coding for the serotype 3 fimbrial subunit
    F R Mooi
    Laboratory of Bacteriology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
    FEMS Microbiol Lett 54:327-31. 1990
    ..Peptides derived from the conserved regions may be incorporated into a future pertussis vaccine to induce antibodies which confer protection against strains producing different fimbrial serotypes...
  42. ncbi Estimation of the serial interval of pertussis in Dutch households
    Dennis E Te Beest
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, The Netherlands
    Epidemics 7:1-6. 2014
    ..If preventive measures such as social distancing or antimicrobial treatment are taken promptly they could decrease the probability of infection of the infant. ..
  43. doi Characterization of Bordetella holmesii isolates from patients with pertussis-like illness in The Netherlands
    Frits R Mooi
    National Institute of Public Health and the Environment RIVM, Centre for Infectious Diseases Control CIb, Laboratory for Infectious Diseases and Perinatal Screening LIS, Bilthoven, The Netherlands
    FEMS Immunol Med Microbiol 64:289-91. 2012
    ..All isolates contained a locus involved in iron uptake, previously suggested to originate from B. pertussis. The causes for the apparent increase in the isolation of B. holmesii are discussed...
  44. ncbi Characterization of a Bordetella pertussis fimbrial gene cluster which is located directly downstream of the filamentous haemagglutinin gene
    R J Willems
    Molecular Microbiology Unit, National Institute of Health and Environmental Protection, Bilthoven, The Netherlands
    Mol Microbiol 6:2661-71. 1992
    ..pertussis adhesin, possibly suggesting co-operation between the two loci in the pathogenesis of pertussis...
  45. pmc Pertussis in The Netherlands: an outbreak despite high levels of immunization with whole-cell vaccine
    H E de Melker
    National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 3:175-8. 1997
    ..However, the cause of this increase has not yet been determined. Further research is directed to the severity of disease and a possible mismatch between the vaccine and the circulating Bordetella strains...
  46. ncbi Genetic organization and functional analysis of the otn DNA essential for cell-wall polysaccharide synthesis in Vibrio cholerae O139
    E M Bik
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Mol Microbiol 20:799-811. 1996
    ..Furthermore, a repeat motif was observed in extragenic regions. A number of observations suggest that these sequences may facilitate gene flow between V. cholerae strains and the assembly of clusters of functionally related genes...
  47. ncbi Mutational analysis of the Bordetella pertussis fim/fha gene cluster: identification of a gene with sequence similarities to haemolysin accessory genes involved in export of FHA
    R J Willems
    Molecular Microbiology Unit, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
    Mol Microbiol 11:337-47. 1994
    ..These results suggest that the N-terminus of FHA interacts with FhaC, and that as a result FHA is transported across the outer membrane...
  48. ncbi Efficacies of whole cell and acellular pertussis vaccines against Bordetella parapertussis in a mouse model
    Silke David
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, P O Box 1, 3720 Bilthoven, The Netherlands
    Vaccine 22:1892-8. 2004
    ..The whole cell vaccines protected significantly better than the acellular vaccines against B. parapertussis. The possible consequences of a switch from whole cell to acellular vaccines was discussed in the light of our findings...
  49. ncbi Association of Bordetella pertussis with host immune cells in the mouse lung
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Microb Pathog 35:19-29. 2003
    ..These results suggest that Fim does not affect bacterial localisation in the mouse lung, but does influence host immune mechanisms. Possibly, Fim may exert an anti-inflammatory function and thereby inhibit killing by macrophages...
  50. ncbi Adaptive evolution of the Bordetella autotransporter pertactin
    D A Diavatopoulos
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Evol Biol 19:1931-8. 2006
    ..This approach yielded 15 codons predicted to be under diversifying selection pressure. These results were interpreted in an immunological context and may help in improving future pertussis vaccines...
  51. ncbi Isolation of a putative fimbrial adhesin from Bordetella pertussis and the identification of its gene
    R J Willems
    Molecular Microbiology Unit, National Institute of Health and Environmental Protection, Bilthoven, The Netherlands
    Mol Microbiol 9:623-34. 1993
    ....
  52. ncbi Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis
    S M Hellwig
    Laboratory for Infectious Diseases National Institute of Public Health and the Environment, Bilthoven, Utrecht, The Netherlands
    J Infect Dis 183:871-9. 2001
    ..Competition between uptake via CR3 or FcgammaR may determine the outcome of natural infection...
  53. pmc Immunoglobulin A-mediated protection against Bordetella pertussis infection
    S M Hellwig
    Laboratory for Infectious Diseases Research, National Institute of Public Health and the Environment, Bilthoven, University Medical Center, Utrecht, The Netherlands
    Infect Immun 69:4846-50. 2001
    ..These data support the capacity of IgA to induce anti-B. pertussis effector functions via the myeloid IgA receptor, FcalphaRI. Increasing the amount of IgA antibodies induced by pertussis vaccines may result in higher vaccine efficacy...
  54. ncbi Preclinical and clinical safety studies on DNA vaccines
    Johanna A C Schalk
    Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Hum Vaccin 2:45-53. 2006
    ..We conclude that the potential risks of DNA vaccines are minimal. However, their safety issues may differ case-by-case, and they should be treated accordingly...
  55. pmc Characterization of a highly conserved island in the otherwise divergent Bordetella holmesii and Bordetella pertussis genomes
    D A Diavatopoulos
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Bacteriol 188:8385-94. 2006
    ..holmesii may have significantly contributed to its emergence as a human pathogen. Horizontal gene transfer between B. pertussis and B. holmesii may also explain the unusually high sequence identity of their 16S rRNA genes...
  56. pmc Host genetics of Bordetella pertussis infection in mice: significance of Toll-like receptor 4 in genetic susceptibility and pathobiology
    H A Banus
    Laboratory of Vaccine Preventable Diseases, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Infect Immun 74:2596-605. 2006
    ..Functional Tlr4 is essential for an efficient IL-1-beta, TNF-alpha, and IFN-gamma response; efficient clearance of bacteria from the lung; and reduced lung pathology...
  57. ncbi Changes in the Dutch Bordetella pertussis population in the first 20 years after the introduction of whole-cell vaccines
    Inge H M Van Loo
    Laboratory for Infectious Diseases Research LIO, National Institute of Public Health and Environment, 3720 BA Bilthoven, The Netherlands
    Microbiology 148:2011-8. 2002
    ..This adaptation had very little, if any, effect on mortality, however...
  58. pmc Antigenic divergence between Bordetella pertussis clinical isolates from Moscow, Russia, and vaccine strains
    Olga Borisova
    Russian Federal Diphtheria Reference Laboratory, G N Gabrichevsky Institute of Epidemiology and Microbiology, 10 Admiral Makarov Str, Moscow 125212, Russia
    Clin Vaccine Immunol 14:234-8. 2007
    ..The results demonstrate that the selection of B. pertussis strains for vaccine manufacturing must be based on a thorough study of the B. pertussis population...
  59. pmc Lipopolysaccharide analogs improve efficacy of acellular pertussis vaccine and reduce type I hypersensitivity in mice
    Jeroen Geurtsen
    Department of Molecular Microbiology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Clin Vaccine Immunol 14:821-9. 2007
    ..In conclusion, these results indicate that supplementation with LPS analogs forms a promising strategy that can be used to improve aP vaccines...
  60. pmc Pathogen adaptation under imperfect vaccination: implications for pertussis
    Michiel van Boven
    Animal Sciences Group, Wageningen University and Research Centre, PO Box 65, 8200 AB Lelystad, The Netherlands
    Proc Biol Sci 272:1617-24. 2005
    ..We discuss the implications of these results for the design and use of vaccines that provide temporary immunity...
  61. pmc Bordetella pertussis strains circulating in Europe in 1999 to 2004 as determined by pulsed-field gel electrophoresis
    Hans Hallander
    Department of Immunology Vaccinology, Swedish Institute for Infectious Disease Control, Solna, Sweden
    J Clin Microbiol 45:3257-62. 2007
    ..It is therefore of major interest to continue with surveillance programs of B. pertussis isolates, as both waning vaccine-derived immunity and strain variation may play a role in the persistence of pertussis...
  62. ncbi Pulsed-field gel electrophoresis analysis of Bordetella pertussis populations in various European countries with different vaccine policies
    Valerie Caro
    Institut Pasteur, Molecular Prevention and Therapy for Human Diseases Unit, Institut Pasteur, Paris, France
    Microbes Infect 7:976-82. 2005
    ..There was no evidence of geographic clustering, except that one new profile subgroup was predominantly found in one country. This study provides a baseline for continued surveillance of the B. pertussis population in Europe...
  63. pmc Bordetella pertussis isolates, Finland
    Johanna Mäkinen
    Emerg Infect Dis 11:183-4. 2005
  64. pmc Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses
    Neil K Fennelly
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    Infect Immun 76:1257-66. 2008
    ..Our findings suggest that the TTSS subverts innate and adaptive immune responses during infection of the lungs and may be a functionally important virulence factor for B. pertussis infection of humans...
  65. ncbi Crucial role of antibodies to pertactin in Bordetella pertussis immunity
    Sandra M M Hellwig
    Immunotherapy Laboratory, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    J Infect Dis 188:738-42. 2003
    ..pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection...
  66. ncbi Bordetella pertussis protein pertactin induces type-specific antibodies: one possible explanation for the emergence of antigenic variants?
    Qiushui He
    Department of Human Microbial Ecology and Inflammation, National Public Health Institute, Turku, Finland
    J Infect Dis 187:1200-5. 2003
    ..These results indicate that conformational changes have occurred in the variable region of Prn, which may offer a possible explanation for the emergence of Prn2 strains in certain countries...