Frits R Mooi

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. pmc Bordetella pertussis strains with increased toxin production associated with pertussis resurgence
    Frits R Mooi
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 15:1206-13. 2009
  2. doi Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen
    Frits R Mooi
    Lab for Infectious Diseases and Screening, Netherlands Centre for Infectious Diseases Control, Natl Institute for Public Health and the Environment, RIVM, PO Box 1, 3720 BA Bilthoven, Netherlands
    Infect Genet Evol 10:36-49. 2010
  3. pmc Comparative genomics of prevaccination and modern Bordetella pertussis strains
    Marieke J Bart
    Laboratory for Infectious Diseases and Screening, Netherlands Centre for Infectious Diseases Control, RIVM, Bilthoven, Netherlands
    BMC Genomics 11:627. 2010
  4. pmc Multiple-locus variable-number tandem repeat analysis of Dutch Bordetella pertussis strains reveals rapid genetic changes with clonal expansion during the late 1990s
    Leo M Schouls
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Bacteriol 186:5496-505. 2004
  5. pmc Studies on Prn variation in the mouse model and comparison with epidemiological data
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 6:e18014. 2011
  6. pmc SNP-based typing: a useful tool to study Bordetella pertussis populations
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 6:e20340. 2011
  7. pmc Small mutations in Bordetella pertussis are associated with selective sweeps
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 7:e46407. 2012
  8. pmc Differentially expressed genes in Bordetella pertussis strains belonging to a lineage which recently spread globally
    Daan de Gouw
    Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 9:e84523. 2014
  9. doi Characterization of Bordetella holmesii isolates from patients with pertussis-like illness in The Netherlands
    Frits R Mooi
    National Institute of Public Health and the Environment RIVM, Centre for Infectious Diseases Control CIb, Laboratory for Infectious Diseases and Perinatal Screening LIS, Bilthoven, The Netherlands
    FEMS Immunol Med Microbiol 64:289-91. 2012
  10. pmc Comparative genomic profiling of Dutch clinical Bordetella pertussis isolates using DNA microarrays: identification of genes absent from epidemic strains
    Audrey J King
    Laboratory for Infectious Diseases and Screening Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    BMC Genomics 9:311. 2008

Collaborators

Detail Information

Publications37

  1. pmc Bordetella pertussis strains with increased toxin production associated with pertussis resurgence
    Frits R Mooi
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 15:1206-13. 2009
    ..pertussis that may have driven this adaptation. Our results underline the importance of Ptx in transmission, suggest that vaccination may select for increased virulence, and indicate ways to control pertussis more effectively...
  2. doi Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen
    Frits R Mooi
    Lab for Infectious Diseases and Screening, Netherlands Centre for Infectious Diseases Control, Natl Institute for Public Health and the Environment, RIVM, PO Box 1, 3720 BA Bilthoven, Netherlands
    Infect Genet Evol 10:36-49. 2010
    ..pertussis populations has not only increased our understanding of pathogen evolution, but also suggests way to improve pertussis vaccines, underlining the public health significance of population-based studies of pathogens...
  3. pmc Comparative genomics of prevaccination and modern Bordetella pertussis strains
    Marieke J Bart
    Laboratory for Infectious Diseases and Screening, Netherlands Centre for Infectious Diseases Control, RIVM, Bilthoven, Netherlands
    BMC Genomics 11:627. 2010
    ..To elucidate how B. pertussis has adapted to vaccination, we compared genome sequences of two ptxP3 strains with four strains isolated before and after the introduction vaccination...
  4. pmc Multiple-locus variable-number tandem repeat analysis of Dutch Bordetella pertussis strains reveals rapid genetic changes with clonal expansion during the late 1990s
    Leo M Schouls
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Bacteriol 186:5496-505. 2004
    ..Using this genotyping, we have been able to show that B. pertussis is much more dynamic than expected...
  5. pmc Studies on Prn variation in the mouse model and comparison with epidemiological data
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 6:e18014. 2011
    ..Therefore other factors may have contributed to the predominance of Prn2 in vaccinated populations. The mouse model may be useful to assess and predict changes in the B. pertussis population due to vaccination...
  6. pmc SNP-based typing: a useful tool to study Bordetella pertussis populations
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 6:e20340. 2011
    ..Two predominant ptxP3 SNP types were identified which spread worldwide. The widespread use of SNP typing will enhance our understanding of the evolution and global epidemiology of B. pertussis...
  7. pmc Small mutations in Bordetella pertussis are associated with selective sweeps
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 7:e46407. 2012
    ..Further, this work shows that small mutations, even single SNPs, can drive large changes in the populations of bacterial pathogens within a time span of six to 19 years...
  8. pmc Differentially expressed genes in Bordetella pertussis strains belonging to a lineage which recently spread globally
    Daan de Gouw
    Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 9:e84523. 2014
    ..Identification of genes differentially expressed between ptxP1 and ptxP3 strains may elucidate how B. pertussis has adapted to vaccination and allow the improvement of pertussis vaccines by identifying novel vaccine candidates. ..
  9. doi Characterization of Bordetella holmesii isolates from patients with pertussis-like illness in The Netherlands
    Frits R Mooi
    National Institute of Public Health and the Environment RIVM, Centre for Infectious Diseases Control CIb, Laboratory for Infectious Diseases and Perinatal Screening LIS, Bilthoven, The Netherlands
    FEMS Immunol Med Microbiol 64:289-91. 2012
    ..All isolates contained a locus involved in iron uptake, previously suggested to originate from B. pertussis. The causes for the apparent increase in the isolation of B. holmesii are discussed...
  10. pmc Comparative genomic profiling of Dutch clinical Bordetella pertussis isolates using DNA microarrays: identification of genes absent from epidemic strains
    Audrey J King
    Laboratory for Infectious Diseases and Screening Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    BMC Genomics 9:311. 2008
    ..In the Netherlands, the resurgence of pertussis is associated with the rise of B. pertussis strains with an altered promoter region for pertussis toxin (ptxP3)...
  11. doi An investigation into the cause of the 1983 whooping cough epidemic in the Netherlands
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 27:1898-903. 2009
    ..Further, we show that MLVA and fimbrial serotyping of strains can be used as early warning for pertussis epidemics...
  12. ncbi Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Vaccine 25:2346-60. 2007
    ..In summary, after challenge vaccination increased lung pathology, TNF-alpha expression (only WCV), and IH parameters. Th1 cells were critical for clearance...
  13. pmc The role of Toll-like receptor-4 in pertussis vaccine-induced immunity
    Sander Banus
    Health Protection Research, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    BMC Immunol 9:21. 2008
    ..Here we analyze the effects of wP and aP vaccination and B. pertussis challenge, in Tlr4-deficient C3H/HeJ and wild-type C3H/HeOuJ mice. aP consists of Ptx, filamentous hemagglutinin (FHA), and pertactin (Prn)...
  14. ncbi Changes in the Dutch Bordetella pertussis population in the first 20 years after the introduction of whole-cell vaccines
    Inge H M Van Loo
    Laboratory for Infectious Diseases Research LIO, National Institute of Public Health and Environment, 3720 BA Bilthoven, The Netherlands
    Microbiology 148:2011-8. 2002
    ..This adaptation had very little, if any, effect on mortality, however...
  15. ncbi Antibody responses to defined regions of the Bordetella pertussis virulence factor pertactin
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Scand J Infect Dis 40:94-104. 2008
    ..It also suggests that the amount of pertactin type-specific antibodies will not be very large and that the variation in pertactin probably will not constitute a problem in highly immune individuals...
  16. ncbi The role of peptide loops of the Bordetella pertussis protein P.69 pertactin in antibody recognition
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 25:5902-14. 2007
    ..69 Prn. The results presented here provide a better understanding of the structure and function of variable loops and their role in the persistence of pathogens in immunologically primed populations...
  17. ncbi The Bordetella pertussis virulence factor P.69 pertactin retains its immunological properties after overproduction in Escherichia coli
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Protein Expr Purif 41:106-12. 2005
    ..Here, we describe the procedure to clone, express, and purify up to 0.1mg P.69 pertactin and its derivatives per 1 ml Escherichia coli culture...
  18. doi Pertussis in the Netherlands, is the current vaccination strategy sufficient to reduce disease burden in young infants?
    Nicoline A T van der Maas
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, 3720BA Bilthoven, The Netherlands Electronic address
    Vaccine 31:4541-7. 2013
    ..Nevertheless, a large outbreak occurred in 2011-2012...
  19. pmc Seroprevalence of pertussis in The Netherlands: evidence for increased circulation of Bordetella pertussis
    Sabine C de Greeff
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 5:e14183. 2010
    ..We determined whether the increase in reported pertussis in the last decade is associated with an increase in the number of infections...
  20. doi Estimation of household transmission rates of pertussis and the effect of cocooning vaccination strategies on infant pertussis
    Sabine C de Greeff
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiology 23:852-60. 2012
    ..Despite >50 years of universal vaccination, pertussis remains the most prevalent vaccine-preventable infectious disease in developed countries. Pertussis is often mild in adults, but can run a severe course in young infants...
  21. pmc Two-component cluster analysis of a large serodiagnostic database for specificity of increases of IgG antibodies against pertussis toxin in paired serum samples and of absolute values in single serum samples
    Sabine C de Greeff
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Clin Vaccine Immunol 19:1452-6. 2012
    ..2%). Given the methodology of this study, estimates of sensitivity probably are overrated (because pertussis patients without IgG-Ptx response are not detected), but estimates of specificities can be considered very accurate...
  22. pmc Multilocus sequence typing of Bordetella pertussis based on surface protein genes
    Inge H M Van Loo
    Laboratory for Infectious Diseases Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 40:1994-2001. 2002
    ..These types may represent newly emerged, successful clones. The identification of highly successful clones may shed light on the question of how B. pertussis is able to maintain itself in vaccinated populations...
  23. doi Economic analysis of pertussis illness in the Dutch population: implications for current and future vaccination strategies
    Sabine C de Greeff
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 27:1932-7. 2009
    ..The effectiveness of universal adolescent or adult booster strategies -- to prevent pertussis in infants -- should also be considered from an economical point of view before being implemented...
  24. ncbi [Pertussis in the Netherlands]
    Sabine C de Greeff
    RIVM, Centrum voor Infectieziektebestrijding, afd Epidemiologie en Surveillance, Bilthoven, The Netherlands
    Ned Tijdschr Geneeskd 154:A1383. 2010
    ..Targeting vaccination at adults and health care workers who are in close contact with infants may prevent transmission of pertussis to infants...
  25. doi Pertussis: a matter of immune modulation
    Daan de Gouw
    Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    FEMS Microbiol Rev 35:441-74. 2011
    ..Based on these insights, we delineate ideas for the rational design of improved vaccines that can target the 'weak spots' in the pathogenesis of this highly successful pathogen...
  26. ncbi Cost-effectiveness of targeted vaccination to protect new-borns against pertussis: comparing neonatal, maternal, and cocooning vaccination strategies
    Anna K Lugnér
    Epidemiology and Surveillance Unit, National Institute for Public Health and the Environment, Bilthoven, The Netherlands Electronic address
    Vaccine 31:5392-7. 2013
    ..Specifically, with a persistent epidemic as seen in 2012, there is need for reconsidering the vaccination schedules against pertussis in order to increase protection of the vulnerable new-borns. ..
  27. pmc Epitope structure of the Bordetella pertussis protein P.69 pertactin, a major vaccine component and protective antigen
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health, Antonie van Leeuwenhoek Laan 1, P O Box 1, Bilthoven, The Netherlands
    Infect Immun 72:3716-23. 2004
    ..69 pertactin. This may explain why the variation in P.69 pertactin is so effective, despite the fact that it is limited to only two small segments of the molecule...
  28. ncbi A novel strategy to mimic discontinuous protective epitopes using a synthetic scaffold
    Marcel Hijnen
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Antonie van Leeuwenhoeklaan 1, PO Box 1, Bilthoven, The Netherlands
    Vaccine 25:6807-17. 2007
    ..This approach opens up the possibility to the design of new and fully synthetic vaccines that can induce protective antibodies...
  29. ncbi Characterization of Bordetella pertussis clinical isolates that do not express the tracheal colonization factor
    Marjolein van Gent
    Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    FEMS Immunol Med Microbiol 51:149-54. 2007
    ..Irreversible and reversible loss occurred, respectively, by recombination between repeats leading to deletion of the tcfA gene and by mutations in a polymorphic G-track. These phenomena may reflect adaptation to distinct niches...
  30. pmc Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection
    Sander Banus
    Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Microbiol 7:88. 2007
    ..pertussis inoculation. Twelve and a half percent of the genomes of these mice are from a different genetic background...
  31. doi Impact of acellular pertussis preschool booster vaccination on disease burden of pertussis in The Netherlands
    Sabine C de Greeff
    Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Pediatr Infect Dis J 27:218-23. 2008
    ..An acellular preschool booster vaccination against pertussis has been included in the National Immunization Programme in The Netherlands, since November 2001. We studied the impact of this preschool booster on the epidemiology of pertussis...
  32. pmc Effects of a diphtheria-tetanus-acellular pertussis vaccine on immune responses in murine local lymph node and lung allergy models
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Clin Vaccine Immunol 14:211-9. 2007
    ..Vaccination failed to modulate these parameters. In conclusion, although DTaP vaccination may affect the LLNA response, we found no evidence of an effect on lung allergy...
  33. doi Pertussis in infancy and the association with respiratory and cognitive disorders at toddler age
    Sabine C de Greeff
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 29:8275-8. 2011
    ..We found an association between severe pertussis in infancy and respiratory symptoms on toddler age. The mechanisms that may underlie this association require further investigation...
  34. ncbi Estimation of the serial interval of pertussis in Dutch households
    Dennis E Te Beest
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, The Netherlands
    Epidemics 7:1-6. 2014
    ..If preventive measures such as social distancing or antimicrobial treatment are taken promptly they could decrease the probability of infection of the infant. ..
  35. ncbi The case for maternal vaccination against pertussis
    Frits R Mooi
    Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, Netherlands
    Lancet Infect Dis 7:614-24. 2007
    ..Maternal vaccination might be an effective way to decrease morbidity and mortality caused by pertussis in newborn babies...
  36. ncbi Association of Bordetella pertussis with host immune cells in the mouse lung
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Microb Pathog 35:19-29. 2003
    ..These results suggest that Fim does not affect bacterial localisation in the mouse lung, but does influence host immune mechanisms. Possibly, Fim may exert an anti-inflammatory function and thereby inhibit killing by macrophages...
  37. ncbi Preclinical and clinical safety studies on DNA vaccines
    Johanna A C Schalk
    Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Hum Vaccin 2:45-53. 2006
    ..We conclude that the potential risks of DNA vaccines are minimal. However, their safety issues may differ case-by-case, and they should be treated accordingly...