K Kremer

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. pmc Discriminatory power and reproducibility of novel DNA typing methods for Mycobacterium tuberculosis complex strains
    Kristin Kremer
    Mycobacteria Reference Unit, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 43:5628-38. 2005
  2. pmc Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America
    Elis R Dalla Costa
    State Foundation for Production and Research in Health FEPPS, Porto Alegre, Brazil
    BMC Microbiol 9:39. 2009
  3. pmc Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
    Karine Brudey
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Guadeloupe
    BMC Microbiol 6:23. 2006
  4. pmc The use of microbead-based spoligotyping for Mycobacterium tuberculosis complex to evaluate the quality of the conventional method: providing guidelines for Quality Assurance when working on membranes
    Edgar Abadia
    Institute of Genetics and Microbiology UMR8621, CNRS Université Paris Sud 11 Universud, Campus d Orsay, F 91405 Orsay cedex, France
    BMC Infect Dis 11:110. 2011
  5. pmc Validation of the GenoType MTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam
    Mai N T Huyen
    KNCV Tuberculosis Foundation, PO Box 146, 2501CC The Hague, The Netherlands
    BMC Infect Dis 10:149. 2010
  6. pmc Distinct genotypic profiles of the two major clades of Mycobacterium africanum
    Sidra E Gonçalves Vasconcellos
    Laboratory of Molecular Biology Applied to Mycobacteria, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenida Brasil 4365, Rio de Janeiro, Brazil
    BMC Infect Dis 10:80. 2010
  7. pmc Vaccine-induced immunity circumvented by typical Mycobacterium tuberculosis Beijing strains
    Kristin Kremer
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 15:335-9. 2009
  8. pmc Comparison of methods based on different molecular epidemiological markers for typing of Mycobacterium tuberculosis complex strains: interlaboratory study of discriminatory power and reproducibility
    K Kremer
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 37:2607-18. 1999
  9. pmc Diagnosis of Mycobacterium microti infections among humans by using novel genetic markers
    D van Soolingen
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 36:1840-5. 1998
  10. ncbi request reprint Molecular epidemiology of tuberculosis in the Netherlands: a nationwide study from 1993 through 1997
    D van Soolingen
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 180:726-36. 1999

Collaborators

Detail Information

Publications50

  1. pmc Discriminatory power and reproducibility of novel DNA typing methods for Mycobacterium tuberculosis complex strains
    Kristin Kremer
    Mycobacteria Reference Unit, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 43:5628-38. 2005
    ..tuberculosis and that VNTR typing is the epidemiological typing method of choice for the near future...
  2. pmc Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America
    Elis R Dalla Costa
    State Foundation for Production and Research in Health FEPPS, Porto Alegre, Brazil
    BMC Microbiol 9:39. 2009
    ..tuberculosis strains...
  3. pmc Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
    Karine Brudey
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Guadeloupe
    BMC Microbiol 6:23. 2006
    ....
  4. pmc The use of microbead-based spoligotyping for Mycobacterium tuberculosis complex to evaluate the quality of the conventional method: providing guidelines for Quality Assurance when working on membranes
    Edgar Abadia
    Institute of Genetics and Microbiology UMR8621, CNRS Université Paris Sud 11 Universud, Campus d Orsay, F 91405 Orsay cedex, France
    BMC Infect Dis 11:110. 2011
    ..Nine hundred and twenty-seven isolates were analyzed totaling 39,861 data points. Samples were received from 11 international laboratories with a worldwide distribution...
  5. pmc Validation of the GenoType MTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam
    Mai N T Huyen
    KNCV Tuberculosis Foundation, PO Box 146, 2501CC The Hague, The Netherlands
    BMC Infect Dis 10:149. 2010
    ..We assessed sensitivity and specificity of the assay by using a geographically representative set of MTB isolates from the South of Vietnam...
  6. pmc Distinct genotypic profiles of the two major clades of Mycobacterium africanum
    Sidra E Gonçalves Vasconcellos
    Laboratory of Molecular Biology Applied to Mycobacteria, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenida Brasil 4365, Rio de Janeiro, Brazil
    BMC Infect Dis 10:80. 2010
    ..One result of studies interrogating recently identified MTC phylogenetic markers has been the recognition of at least two distinct lineages of M. africanum, known as West African-1 and West African-2...
  7. pmc Vaccine-induced immunity circumvented by typical Mycobacterium tuberculosis Beijing strains
    Kristin Kremer
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 15:335-9. 2009
    ..The strains' associations with drug resistance, M. bovis BCG vaccination, and patient characteristics were assessed. BCG vaccination may have positively selected the prevalent typical Beijing strains...
  8. pmc Comparison of methods based on different molecular epidemiological markers for typing of Mycobacterium tuberculosis complex strains: interlaboratory study of discriminatory power and reproducibility
    K Kremer
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 37:2607-18. 1999
    ..tuberculosis strains. Several separate genotype families within the M. tuberculosis complex could be recognized on the basis of the genetic markers used...
  9. pmc Diagnosis of Mycobacterium microti infections among humans by using novel genetic markers
    D van Soolingen
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 36:1840-5. 1998
    ..microti strains isolated in The Netherlands, suggesting that geographic isolation led to divergent strains in the United Kingdom and on the continent...
  10. ncbi request reprint Molecular epidemiology of tuberculosis in the Netherlands: a nationwide study from 1993 through 1997
    D van Soolingen
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 180:726-36. 1999
    ..Human immunodeficiency virus infection was not an independent risk factor for active transmission. Isoniazid-resistant strains were relatively less frequently clustered, suggesting that these generated fewer secondary cases...
  11. pmc Use of variable-number tandem-repeat typing to differentiate Mycobacterium tuberculosis Beijing family isolates from Hong Kong and comparison with IS6110 restriction fragment length polymorphism typing and spoligotyping
    Kristin Kremer
    Mycobacteria Reference Unit, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 43:314-20. 2005
    ..However, VNTR-defined clusters should be subtyped with IS6110 RFLP for maximal resolution...
  12. pmc Definition of the Beijing/W lineage of Mycobacterium tuberculosis on the basis of genetic markers
    Kristin Kremer
    Mycobacteria Reference Unit, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 42:4040-9. 2004
    ..tuberculosis strains belonging to the Beijing/W lineage, as described in this work, will facilitate further studies on the spread and characterization of this widespread genotype family of M. tuberculosis strains...
  13. pmc Genetic heterogeneity in Mycobacterium tuberculosis isolates reflected in IS6110 restriction fragment length polymorphism patterns as low-intensity bands
    A S de Boer
    Department of Infectious Disease Epidemiology, National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 38:4478-84. 2000
    ..tuberculosis to changes in the environmental conditions during the dormant state or reactivation thereafter...
  14. pmc Preferential deletion events in the direct repeat locus of Mycobacterium tuberculosis
    Anita C Schürch
    Tuberculosis Reference Laboratory, National Institute for Public Health and Environment RIVM, Centre for Infectious Disease Control CIbpSH D2, Laboratory for Infectious Disease and Perinatal Screening, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 49:1318-22. 2011
    ..tuberculosis complex sequences. We conclude that preferential deletions in the DR loci of closely related strains are usually an unnoted event that interferes with clustering of closely related strains...
  15. pmc Drug susceptibility testing of Mycobacterium tuberculosis complex by use of a high-throughput, reproducible, absolute concentration method
    Bert van Klingeren
    Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    J Clin Microbiol 45:2662-8. 2007
    ..5% for isoniazid, 1.4% for rifampin, 8.5% for streptomycin, and 1.0% for ethambutol. Pyrazinamide testing was successful for 7,026 (88.3%) of the isolates and showed a resistance level of 0.8%...
  16. pmc High-resolution typing by integration of genome sequencing data in a large tuberculosis cluster
    Anita C Schürch
    Tuberculosis Reference Laboratory, National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 48:3403-6. 2010
    ..Our findings suggest that single nucleotide polymorphisms can be used to identify transmission chains in restriction fragment length polymorphism clusters...
  17. ncbi request reprint [Findings and ongoing research in the molecular epidemiology of tuberculosis]
    Dick van Soolingen
    National Institute for Public Health and the Environment, BA Bilthoven, The Netherlands
    Kekkaku 84:83-9. 2009
    ..While in The Netherlands the organization of tuberculosis (TB) control in the era of elimination is being discussed, worldwide TB is still a major problem...
  18. pmc Genetic variation and evolutionary origin of the direct repeat locus of Mycobacterium tuberculosis complex bacteria
    J D van Embden
    Department of Bacteriology of the Research Laboratory for Infectious Disease, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    J Bacteriol 182:2393-401. 2000
    ....
  19. doi request reprint The tempo and mode of molecular evolution of Mycobacterium tuberculosis at patient-to-patient scale
    Anita C Schürch
    National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control CIb LIS, pb 22, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Infect Genet Evol 10:108-14. 2010
    ..tuberculosis, the most important bacterial pathogen of humans...
  20. doi request reprint Tuberculosis seasonality in the Netherlands differs between natives and non-natives: a role for vitamin D deficiency?
    H Korthals Altes
    Epidemiology and Surveillance, Tuberculosis and M XDR TB Programme, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Int J Tuberc Lung Dis 16:639-44. 2012
    ..The seasonality of tuberculosis (TB) incidence suggests that the risk of infection or development of disease has a seasonal component...
  21. pmc Correlation of virulence, lung pathology, bacterial load and delayed type hypersensitivity responses after infection with different Mycobacterium tuberculosis genotypes in a BALB/c mouse model
    J Dormans
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and Environment RIVM, Bilthoven, The Netherlands
    Clin Exp Immunol 137:460-8. 2004
    ..A severe pathological response correlates with a high mortality and a high CFU counts in lungs, but poorly with the degree of the DTH response...
  22. pmc Characterization of ancestral Mycobacterium tuberculosis by multiple genetic markers and proposal of genotyping strategy
    Yong Jiang Sun
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 308433
    J Clin Microbiol 42:5058-64. 2004
    ..This typing strategy may be useful in areas where TbD1(+) ancestral strains are prevalent...
  23. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
    ..This 15-locus system is therefore proposed as the new standard for routine epidemiological discrimination of M. tuberculosis isolates and the 24-locus system as a high-resolution tool for phylogenetic studies...
  24. pmc Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family
    Andrea L Gibson
    Cornell University, Joan and Sanford I Weill Medical College, Department of Medicine, Division of International Medicine and Infectious Diseases, Rm A 421, 525 East 68th St, New York, NY 10065, USA
    J Clin Microbiol 46:1259-67. 2008
    ..Our provision of simple and robust molecular methods will assist the evaluation of the LAM family and the RD(Rio) sublineage...
  25. pmc Snapshot of moving and expanding clones of Mycobacterium tuberculosis and their global distribution assessed by spoligotyping in an international study
    Ingrid Filliol
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Pointe a Pitre, Guadeloupe
    J Clin Microbiol 41:1963-70. 2003
    ..Intercontinental matches of shared types among eight continents and subcontinents (Africa, North America, Central America, South America, Europe, the Middle East and Central Asia, and the Far East) are analyzed and discussed...
  26. pmc Characterization of the Manila family of Mycobacterium tuberculosis
    James T Douglas
    Department of Microbiology, University of Hawaii, Honolulu, Hawaii 96822, USA
    J Clin Microbiol 41:2723-6. 2003
    ..Comparison of the DNA fingerprint patterns with those in international databases confirmed the uniqueness of this group of isolates, which we designate the Manila family of M. tuberculosis...
  27. pmc Fast ligation-mediated PCR, a fast and reliable method for IS6110-based typing of Mycobacterium tuberculosis complex
    Florian Reisig
    Children s Hospital, University of Heidelberg, Heidelberg, Germany
    J Clin Microbiol 43:5622-7. 2005
    ..We suggest that FLiP can serve to rapidly detect chains of transmission prior to starting high-throughput analysis or standard IS6110 RFLP. It may as well serve as a secondary typing technique for other, non-IS6110-based methods...
  28. pmc Targeted hybridization of IS6110 fingerprints identifies the W-Beijing Mycobacterium tuberculosis strains among clinical isolates
    Natalia Kurepina
    TB Center, Public Health Research Institute, 225 Warren St, Newark, NJ 07103, USA
    J Clin Microbiol 43:2148-54. 2005
    ..7% and 99.7%, respectively. This study demonstrates that the W-Beijing polyprobe can accurately and reliably discriminate members of the W-Beijing phylogenetic lineage and the W-Beijing family of M. tuberculosis strains...
  29. pmc Utility of mycobacterial interspersed repetitive unit typing for differentiating multidrug-resistant Mycobacterium tuberculosis isolates of the Beijing family
    Kai Man Kam
    Tuberculosis Reference Laboratory, Public Health Laboratory Service Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, Kowloon, Hong Kong
    J Clin Microbiol 43:306-13. 2005
    ..6%) than did addition of MIRU typing to RFLP (40.0%). This supported the potential use of this method to analyze the global genetic diversity of MDR M. tuberculosis strains that may be at different levels of evolutionary divergence...
  30. doi request reprint Mapping of IS6110 insertion sites in Mycobacterium bovis isolates in relation to adaptation from the animal to human host
    Isabel Otal
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza, Spain
    Vet Microbiol 129:333-41. 2008
    ..IS6110 was inserted in a position where it might serve as a promoter in two cases. We conclude that IS6110 transpositions in M. bovis may be a driving force in the adaptation from the animal to the human host...
  31. pmc Mycobacterium microti infection (vole tuberculosis) in wild rodent populations
    Rachel Cavanagh
    Centre for Comparative Infectious Diseases, University of Liverpool, Liverpool, United Kingdom
    J Clin Microbiol 40:3281-5. 2002
    ..Thus, M. microti infection seems to be widespread in wild rodent populations, but more studies are needed to understand how M. microti might be transmitted from animals to humans and to determine better the zoonotic risk posed...
  32. ncbi request reprint Mycobacterium tuberculosis strains of the Beijing genotype are rarely observed in tuberculosis patients in South America
    Viviana Ritacco
    Instituto Nacional de Enfermedades Infecciosas ANLIS Carlos Malbrá, Buenos Aires, Argentina
    Mem Inst Oswaldo Cruz 103:489-92. 2008
    ..tuberculosis of the Beijing genotype observed presently demands efforts to define better the contribution of the virulence and lack of response to treatment to the growing spread of Beijing strains observed in other parts of the world...
  33. pmc The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis
    Maxine Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000034. 2008
    ..The study provides evidence that M. tuberculosis genotype influences clinical disease phenotype and demonstrates, for the first time, a significant interaction between host and bacterial genotypes and the development of tuberculosis...
  34. pmc Origin, spread and demography of the Mycobacterium tuberculosis complex
    Thierry Wirth
    Department of Biology, Lehrstuhl fur Zoologie und Evolutionsbiologie, University of Konstanz, Konstanz, Germany
    PLoS Pathog 4:e1000160. 2008
    ..tuberculosis lineages, which coincides with the human population explosion over the last two centuries. These findings thus unveil the dynamic dimension of the association between human host and pathogen populations...
  35. doi request reprint Tuberculosis outbreaks predicted by characteristics of first patients in a DNA fingerprint cluster
    Sandra V Kik
    KNCV Tuberculosis Foundation, PO Box 146, 2501 CC The Hague, The Netherlands
    Am J Respir Crit Care Med 178:96-104. 2008
    ..Some clusters of patients who have Mycobacterium tuberculosis isolates with identical DNA fingerprint patterns grow faster than others. It is unclear what predictors determine cluster growth...
  36. pmc Beijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitis
    Maxine Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
    J Clin Microbiol 44:3934-9. 2006
    ..001). The association of the Beijing genotype with drug resistance was independent of HIV status. This is the first report of Beijing genotype association with HIV status, which may be an association unique to tuberculous meningitis...
  37. pmc Global distribution of Mycobacterium tuberculosis spoligotypes
    Ingrid Filliol
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur, Pointe a Pitre, Guadeloupe, French West Indies
    Emerg Infect Dis 8:1347-9. 2002
    ..The 11708 spoligotypes were clustered into 813 shared types. A total of 1300 orphan patterns (clinical isolates showing a unique spoligotype) were also detected...
  38. pmc Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family
    Mina Ebrahimi-Rad
    Institut Pasteur, Paris, France
    Emerg Infect Dis 9:838-45. 2003
    ..The acquisition of mut genes may explain in part the ability of the isolates of W-Beijing type to rapidly adapt to their environment...
  39. pmc Mycobacterium tuberculosis Beijing genotype, the Netherlands
    Martien W Borgdorff
    Royal Netherlands Tuberculosis Association, PO Box 146, 2501 CC The Hague, The Netherlands
    Emerg Infect Dis 9:1310-3. 2003
  40. pmc Mycobacterium tuberculosis Beijing genotype
    Troels Lillebaek
    National Institute for Prevention and Control of Infectious Diseases and Congenital Disorders, Copenhagen, Denmark
    Emerg Infect Dis 9:1553-7. 2003
    ..The true prevalence of Beijing strains worldwide is unknown because only a fraction of global strains have been analyzed...
  41. pmc Mycobacterium tuberculosis Beijing genotype and risk for treatment failure and relapse, Vietnam
    Nguyen Thi Ngoc Lan
    Pham Ngoc Thach Tuberculosis and Lung Diseases Centre, Ho Chi Minh City, Vietnam
    Emerg Infect Dis 9:1633-5. 2003
    ..8, 95% confidence interval 1.5 to 5.2)...
  42. pmc Genome structure in the vole bacillus, Mycobacterium microti, a member of the Mycobacterium tuberculosis complex with a low virulence for humans
    Cristiane C Frota
    Division of Mycobacterial Research, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Microbiology 150:1519-27. 2004
    ..Thus, this study shows that it is difficult to ascribe virulence to any particular pattern of deletion in M. microti...
  43. ncbi request reprint Mycobacterium tuberculosis, Beijing genotype strains not associated with radiological presentation of pulmonary tuberculosis
    Martien W Borgdorff
    KNCV Tuberculosis Foundation, The Hague, Netherlands
    Tuberculosis (Edinb) 84:337-40. 2004
    ..No significant differences were detected. We conclude that the Beijing genotype is not associated with a different CXR presentation...
  44. pmc Genomic analysis distinguishes Mycobacterium africanum
    Serge Mostowy
    McGill University Health Centre, Montreal, Canada
    J Clin Microbiol 42:3594-9. 2004
    ..tuberculosis complex speciation. Furthermore, the genomic results suggest a rational framework for defining M. africanum and provide tools to accurately assess its prevalence in clinical specimens...
  45. pmc Mycobacterium heckeshornense infection in an immunocompetent patient and identification by 16S rRNA sequence analysis of culture material and a histopathology tissue specimen
    Rob van Hest
    Department of Tuberculosis Control, Municipal Health Service Rotterdam, P O Box 70032, 3000 LP Rotterdam, The Netherlands
    J Clin Microbiol 42:4386-9. 2004
    ..We performed simultaneous 16S rRNA sequence analysis of a mycobacterium culture and a histopathology specimen to determine the relevance of M. heckeshornense infection in an immunocompetent patient initially presenting with pneumothorax...
  46. pmc Tuberculosis elimination in the Netherlands
    Martien W Borgdorff
    KNCV Tuberculosis Foundation, The Hague, The Netherlands
    Emerg Infect Dis 11:597-602. 2005
    ..Under current epidemiologic conditions and control efforts, TB may not be eliminated...
  47. pmc Revisiting the evolution of Mycobacterium bovis
    Serge Mostowy
    McGill University Health Centre, Montreal, Quebec, Canada
    J Bacteriol 187:6386-95. 2005
    ..From this, a phylogenetic stratification of genotypes offers a predictive framework upon which to base future genetic and phenotypic studies of the MTC...
  48. ncbi request reprint Ecotypes of the Mycobacterium tuberculosis complex
    Noel H Smith
    TB Research Group, Veterinary Laboratories Agency, VLA, Addlestone, Surrey KT15 3NB, UK
    J Theor Biol 239:220-5. 2006
    ..Finally, we discuss the application of the ecotype concept to this series of clades and suggest that the M. tuberculosis complex may best be described as a series of host-adapted ecotypes...
  49. pmc Variable host-pathogen compatibility in Mycobacterium tuberculosis
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 103:2869-73. 2006
    ..These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development...
  50. pmc Worldwide occurrence of Beijing/W strains of Mycobacterium tuberculosis: a systematic review
    Judith R Glynn
    London School of Hygeine and Tropical Medicine, London WC1E 7HT, UK
    Emerg Infect Dis 8:843-9. 2002
    ..Although few reports have measured trends in prevalence, the ubiquity of the Beijing strains and their frequent association with outbreaks and drug resistance underline their importance...