T G Kimman

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. pmc Lung response to Bordetella pertussis infection in mice identified by gene-expression profiling
    Sander Banus
    Laboratory of Vaccine Preventable Diseases, National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Immunogenetics 59:555-64. 2007
  2. pmc Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection
    Sander Banus
    Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Microbiol 7:88. 2007
  3. pmc The role of Toll-like receptor-4 in pertussis vaccine-induced immunity
    Sander Banus
    Health Protection Research, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    BMC Immunol 9:21. 2008
  4. ncbi request reprint Genetic variation in the response to vaccination
    T G Kimman
    Laboratorie for Vaccine Preventable Diseases, National Institute of Public Health and Environment, Bilthoven, The Netherlands
    Community Genet 10:201-17. 2007
  5. ncbi request reprint [Effect of genetic polymorphisms on the susceptibility to and course of infectious diseases]
    T G Kimman
    Rijksinstituut voor Volksgezondheid en Milieu, Postbus I, 3720 BA Bilthoven
    Ned Tijdschr Geneeskd 151:519-24. 2007
  6. ncbi request reprint The polio eradication effort has been a great success--let's finish it and replace it with something even better
    Tjeerd G Kimman
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Lancet Infect Dis 6:675-8. 2006
  7. pmc Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination
    Tjeerd G Kimman
    Center for Infectious Disease Control, National Institute of Public Health and Environment, Bilthoven, The Netherlands
    PLoS ONE 3:e3665. 2008
  8. pmc Evidence-based biosafety: a review of the principles and effectiveness of microbiological containment measures
    Tjeerd G Kimman
    Center for Infectious Disease Control, RIVM National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Clin Microbiol Rev 21:403-25. 2008
  9. pmc An indirect double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) using baculovirus-expressed antigen for the detection of antibodies to glycoprotein E of pseudorabies virus and comparison of the method with blocking ELISAs
    T G Kimman
    Department of Porcine and Exotic Viral Diseases, Institute for Animal Science and Health ID DLO, Lelystad, The Netherlands
    Clin Diagn Lab Immunol 3:167-74. 1996
  10. ncbi request reprint Developing a vaccination evaluation model to support evidence-based decision making on national immunization programs
    Tjeerd G Kimman
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 24:4769-78. 2006

Collaborators

Detail Information

Publications56

  1. pmc Lung response to Bordetella pertussis infection in mice identified by gene-expression profiling
    Sander Banus
    Laboratory of Vaccine Preventable Diseases, National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Immunogenetics 59:555-64. 2007
    ..pertussis and partly nonspecific. We envisage that these data will be helpful in identifying polymorphic genes that affect the susceptibility and course of B. pertussis infection in humans...
  2. pmc Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection
    Sander Banus
    Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Microbiol 7:88. 2007
    ..pertussis inoculation. Twelve and a half percent of the genomes of these mice are from a different genetic background...
  3. pmc The role of Toll-like receptor-4 in pertussis vaccine-induced immunity
    Sander Banus
    Health Protection Research, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    BMC Immunol 9:21. 2008
    ..Here we analyze the effects of wP and aP vaccination and B. pertussis challenge, in Tlr4-deficient C3H/HeJ and wild-type C3H/HeOuJ mice. aP consists of Ptx, filamentous hemagglutinin (FHA), and pertactin (Prn)...
  4. ncbi request reprint Genetic variation in the response to vaccination
    T G Kimman
    Laboratorie for Vaccine Preventable Diseases, National Institute of Public Health and Environment, Bilthoven, The Netherlands
    Community Genet 10:201-17. 2007
    ..A better understanding of the factors that determine an effective response to vaccination may lead to the identification of specific genes and pathways as targets for the development of novel more uniformly effective vaccines...
  5. ncbi request reprint [Effect of genetic polymorphisms on the susceptibility to and course of infectious diseases]
    T G Kimman
    Rijksinstituut voor Volksgezondheid en Milieu, Postbus I, 3720 BA Bilthoven
    Ned Tijdschr Geneeskd 151:519-24. 2007
    ..Applications of knowledge about genetic variability can be found in the development of vaccines and therapeutic agents, prognostics, and the treatment of individual patients...
  6. ncbi request reprint The polio eradication effort has been a great success--let's finish it and replace it with something even better
    Tjeerd G Kimman
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Lancet Infect Dis 6:675-8. 2006
    ..Such a policy will present multiple challenges...
  7. pmc Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination
    Tjeerd G Kimman
    Center for Infectious Disease Control, National Institute of Public Health and Environment, Bilthoven, The Netherlands
    PLoS ONE 3:e3665. 2008
    ..We examined whether single nucleotide polymorphisms (SNPs) in genes of the TLR4 pathway and their interaction are associated with the response to whole-cell vaccine (WCV) pertussis vaccination in 490 one-year-old children...
  8. pmc Evidence-based biosafety: a review of the principles and effectiveness of microbiological containment measures
    Tjeerd G Kimman
    Center for Infectious Disease Control, RIVM National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Clin Microbiol Rev 21:403-25. 2008
    ..It is unknown to what extent specific measures contribute to the overall level of biosafety. We therefore recommend that the evidence base of biosafety practice be strengthened...
  9. pmc An indirect double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) using baculovirus-expressed antigen for the detection of antibodies to glycoprotein E of pseudorabies virus and comparison of the method with blocking ELISAs
    T G Kimman
    Department of Porcine and Exotic Viral Diseases, Institute for Animal Science and Health ID DLO, Lelystad, The Netherlands
    Clin Diagn Lab Immunol 3:167-74. 1996
    ..We conclude that the BacgE960 IDAS is a useful and specific additional (confirmatory) test for the detection of antibodies to gE...
  10. ncbi request reprint Developing a vaccination evaluation model to support evidence-based decision making on national immunization programs
    Tjeerd G Kimman
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 24:4769-78. 2006
    ..In the latter case one might be responsible for vaccine-preventable disease and mortality...
  11. ncbi request reprint Antigenic drift in swine influenza H3 haemagglutinins with implications for vaccination policy
    J C de Jong
    Research Laboratory of Infectious Diseases, National Institute of Public Health and the Environment RIVM, Bilthoven, Netherlands
    Vaccine 17:1321-8. 1999
    ....
  12. pmc Poliovirus-specific immunoglobulin A in persons vaccinated with inactivated poliovirus vaccine in The Netherlands
    M M Herremans
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Clin Diagn Lab Immunol 4:499-503. 1997
    ..While the presence of secretory IgA in IPV-vaccinated persons has been documented previously, our findings suggest that mucosal priming with live virus is necessary to obtain an IgA response after IPV booster vaccination...
  13. pmc Host genetics of Bordetella pertussis infection in mice: significance of Toll-like receptor 4 in genetic susceptibility and pathobiology
    H A Banus
    Laboratory of Vaccine Preventable Diseases, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Infect Immun 74:2596-605. 2006
    ..Functional Tlr4 is essential for an efficient IL-1-beta, TNF-alpha, and IFN-gamma response; efficient clearance of bacteria from the lung; and reduced lung pathology...
  14. ncbi request reprint Induction of mucosal immunity by inactivated poliovirus vaccine is dependent on previous mucosal contact with live virus
    T M Herremans
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    J Immunol 162:5011-8. 1999
    ..It is concluded that IPV vaccination alone is insufficient to induce a mucosal IgA response against poliovirus. In mucosally (OPV-) primed individuals, however, booster vaccination with IPV leads to a strong mucosal IgA response...
  15. ncbi request reprint Timing of infection and prior immunization with respiratory syncytial virus (RSV) in RSV-enhanced allergic inflammation
    M Barends
    Laboratories for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 189:1866-72. 2004
    ..In conclusion, inoculation with RSV enhances allergic disease only when the immune system has already been Th2-primed by the allergen (i.e., OVA). This RSV-enhanced allergy is not completely abrogated by prior inoculation with RSV...
  16. ncbi request reprint Pseudorabies virus infections in pigs. Role of viral proteins in virulence, pathogenesis and transmission
    W A Mulder
    Department of Pathobiology and Epidemiology, Institute for Animal Science and Health ID DLO, Lelystad, The Netherlands
    Vet Res 28:1-17. 1997
    ..Furthermore, it evaluates potential risks that are connected with the use of PRV vector strains. Special emphasis is placed upon the spread of genetically engineered vaccine strains within pigs or between pigs...
  17. ncbi request reprint Time course of the porcine cellular and humoral immune responses in vivo against pseudorabies virus after inoculation and challenge: significance of in vitro antigenic restimulation
    M G De Bruin
    Department of Mammalian Virology, Institute for Animal Science and Health ID DLO, Lelystad, Netherlands
    Vet Immunol Immunopathol 65:75-87. 1998
    ..Whether such a reservoir of PRV-specific cytolytic cells is important in clearing the virus is still unknown. In this study we demonstrated PRV-specific lymphocytes in circulation after they were restimulated in vitro with PRV...
  18. ncbi request reprint Mucosal and systemic immunity against poliovirus in mice transgenic for the poliovirus receptor: the poliovirus receptor is necessary for a virus-specific mucosal IgA response
    A M Buisman
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    J Infect Dis 181:815-23. 2000
    ..PVRtg mice are a suitable model for the study of poliovirus-specific immunity and protection against poliovirus infection...
  19. ncbi request reprint Comparison of two pseudorabies virus vaccines, that differ in capacity to reduce virus excretion after a challenge infection, in their capacity of reducing transmission of pseudorabies virus
    A Bouma
    DLO Institute of Animal Science and Health ID DLO, Lelystad, The Netherlands
    Vet Microbiol 54:113-22. 1997
    ..98) was not significantly below one, whereas R of vaccine 783 (R = 0) was significantly below one. Consequently, we cannot exclude the possibility that major outbreaks of PRV occur among pigs vaccinated with vaccine X...
  20. ncbi request reprint A mouse model to study immunity against pseudorabies virus infection: significance of CD4+ and CD8+ cells in protective immunity
    A T Bianchi
    DLO Institute of Animal Science and Health, Department of Mammalian Virology and Immunology, Lelystad, The Netherlands
    Vaccine 16:1550-8. 1998
    ..The results of our study demonstrated that CD4+, DTH like effector cells are a crucial effector mechanism for protective immunity against PRV...
  21. ncbi request reprint [Vaccination against pneumococci and hepatitis B in the Dutch National Immunisation Programme]
    H J Boot
    Rijksinstituut voor Volksgezondheid en Milieu RIVM, Centrum Infectieziektebestrijding CIb, Postbus I, 3720 BA Bilthoven
    Ned Tijdschr Geneeskd 151:172-6. 2007
    ..This will also generate greater insight into the efficacy of the different vaccination schemes and intervention programmes to prevent vertical transmission of the virus...
  22. ncbi request reprint Establishment and characterization of porcine cytolytic cell lines and clones
    M G De Bruin
    Department of Mammalian Virology, Institute for Animal Science and Health ID DLO, Lelystad, Netherlands
    Vet Immunol Immunopathol 59:337-47. 1997
    ..Two of the subsets, CD3 gamma/delta T- and the natural killer cell subset may be involved in antiviral immunity in this species...
  23. ncbi request reprint The influence of maternal immunity on the development of the in vitro lymphocyte proliferation response against pseudorabies virus in pigs
    A Bouma
    DLO Institute of Animal Science and Health ID DLO, Lelystad, The Netherlands
    Res Vet Sci 64:167-71. 1998
    ..The greater T-cell response induced by the vaccine might have contributed to the more rapid clearance of PRV in these pigs...
  24. pmc Genetic control of Bordetella pertussis infection: identification of susceptibility loci using recombinant congenic strains of mice
    H A Banus
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Infect Immun 73:741-7. 2005
    ..Two other loci, Bps-2 and Bps-3, showed genetic interaction and are located on chromosomes 5 and 11. We aim to identify the gene(s) in these regions which modify susceptibility to B. pertussis...
  25. pmc Antibody responses to antigenic sites 1 and 3 of serotype 3 poliovirus after vaccination with oral live attenuated or inactivated poliovirus vaccine and after natural exposure
    T Herremans
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Clin Diagn Lab Immunol 7:40-4. 2000
    ..01). We conclude that the immune response to serotype 3 poliovirus in humans consists of both site 1- and site 3-specific antibodies and that these responses can be induced by either OPV or recent IPV vaccination...
  26. pmc Vaccine-induced antibody responses as parameters of the influence of endogenous and environmental factors
    H van Loveren
    National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Environ Health Perspect 109:757-64. 2001
    ..An exposure-associated inhibition of a vaccination response may, however, signify a decreased host resistance to pathogens against which no vaccination had been performed...
  27. ncbi request reprint Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls
    Annemieke Schuurhof
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Pediatr Pulmonol 45:608-13. 2010
    ..Although so far a difference in IL-9 production in boys and girls has not been reported, this study may help in explaining the different risks of severe RSV bronchiolitis in boys and girls...
  28. pmc Improved detection of rhinoviruses in clinical samples by using a newly developed nested reverse transcription-PCR assay
    A C Andeweg
    Research Laboratory for Infectious Diseases LIO, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    J Clin Microbiol 37:524-30. 1999
    ..5 to 6% of the samples. This new assay should help determine the disease burden associated with rhinovirus infections...
  29. ncbi request reprint Immunity to poliomyelitis in The Netherlands
    M A Conyn-van Spaendonck
    Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Am J Epidemiol 153:207-14. 2001
    ....
  30. ncbi request reprint Induction of nasal turbinate atrophy in germ-free pigs, using Pasteurella multocida as well as bacterium-free crude and purified dermonecrotic toxin of P multocida
    E M Kamp
    Department of Bacteriology, Central Veterinary Institute, Lelystad, The Netherlands
    Am J Vet Res 49:1844-9. 1988
    ..In contrast, turbinate atrophy developed when these preparations were injected IM or when intranasal administration of DNT was preceded by inoculation of B bronchiseptica...
  31. doi request reprint Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes
    Christine L E Siezen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Pediatr Infect Dis J 28:333-5. 2009
    ....
  32. pmc Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study
    Sander Banus
    Laboratory of Vaccine Preventable Diseases, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Clin Vaccine Immunol 14:1377-80. 2007
    ..A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination...
  33. ncbi request reprint Assessing the introduction of universal human papillomavirus vaccination for preadolescent girls in The Netherlands
    Hein J Boot
    Laboratory for Infectious Diseases and Perinatal Screening, RIVM, Bilthoven, The Netherlands
    Vaccine 25:6245-56. 2007
    ....
  34. ncbi request reprint Determinants of monovalent oral polio vaccine mutagenesis in vaccinated elderly people
    Hein J Boot
    Laboratory of Vaccine Preventable Diseases, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 25:4706-14. 2007
    ..Duration of excretion appears to be the dominant factor for the accumulation of mutations in mOPV-derived strains in vaccinated elderly people...
  35. doi request reprint Preexisting poliovirus-specific IgA in the circulation correlates with protection against virus excretion in the elderly
    Anne Marie Buisman
    Center for Infectious Diseases Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 197:698-706. 2008
    ..Previously we established that memory immunity does not protect the elderly against poliovirus replication. In this study, we investigated whether preexisting immunoglobulin (Ig) A protects against poliovirus infection...
  36. pmc Respiratory syncytial virus differentially activates murine myeloid and plasmacytoid dendritic cells
    Ivette Boogaard
    Laboratory for Vaccine Preventable Diseases, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Immunology 122:65-72. 2007
    ..RSV-stimulated mDCs may have immunostimulatory effects on both Th1 and Th2 responses, while RSV-stimulated pDCs have direct antiviral activity through the release of IFN-alpha...
  37. ncbi request reprint Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes
    Riny Janssen
    Laboratory for Toxicology, Pathology, and Genetics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 196:826-34. 2007
    ..Only a proportion of children infected with RSV require hospitalization. Because known risk factors for severe disease, such as premature birth, cannot fully explain differences in disease severity, genetic factors have been implicated...
  38. pmc Identification of a common gene expression response in different lung inflammatory diseases in rodents and macaques
    Jeroen L A Pennings
    Laboratory for Health Protection Research GBO, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    PLoS ONE 3:e2596. 2008
    ..The existence of a common cluster shows that in vivo lung inflammation in response to various pathogens or exposures proceeds through shared molecular mechanisms...
  39. ncbi request reprint Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis
    Barbara Hoebee
    Laboratory of Toxicology, Pathology, and Genetics, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 189:239-47. 2004
    ..We also explored the interactions between different polymorphisms and found an interaction between the IL-4Ralpha Q551R and IL-10 C-592A polymorphisms...
  40. ncbi request reprint Respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus-induced interferon-gamma
    Marion Barends
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Med Virol 69:156-62. 2003
    ..In contrast, IL-12 is not involved in inhibiting nor increasing the RSV-enhanced allergy in 129/Sv/Ev mice...
  41. ncbi request reprint Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms
    Barbara Hoebee
    Laboratory for Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 187:2-11. 2003
    ..These results indicate that gain-of-function variants of T helper type 2 cytokine genes may play a role in increasing the severity of RSV disease, which appears more pronounced after the first half-year of life...
  42. pmc Excretion of wild-type and vaccine-derived poliovirus in the feces of poliovirus receptor-transgenic mice
    Hein J Boot
    Laboratory for Vaccine Preventable Diseases, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Virol 77:6541-5. 2003
    ..This mouse model will be helpful in elucidating the genetic determinants for the high fecal-oral transmission phenotype of cVDPV strains...
  43. ncbi request reprint Rapid RT-PCR amplification of full-length poliovirus genomes allows rapid discrimination between wild-type and recombinant vaccine-derived polioviruses
    Hein J Boot
    Laboratory of Vaccine Preventable Diseases, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    J Virol Methods 116:35-43. 2004
    ....
  44. ncbi request reprint Immunoglobulin a as a serological marker for the (silent) circulation of poliovirus in an inactivated poliovirus-vaccinated population
    Tineke Herremans
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Clin Infect Dis 34:1067-75. 2002
    ..We propose to use the detection of poliovirus-specific IgA as a tool to monitor virus circulation in IPV-vaccinated and nonvaccinated populations, to aid the poliovirus eradication process...
  45. ncbi request reprint Combining the transmission disequilibrium test and case-control methodology using generalized logistic regression
    Nico J D Nagelkerke
    Computerization and Methodological Consultancy Unit, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Eur J Hum Genet 12:964-70. 2004
    ..However, parents of cases can be independently compared to controls. Both the issue of testing for a genetic effect and the estimation of relative risks under the multiplicative model using generalized logistic regression are discussed...
  46. ncbi request reprint Evaluation of serological and virological tests in the diagnosis of clinical and subclinical measles virus infections during an outbreak of measles in The Netherlands
    Robert S van Binnendijk
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 188:898-903. 2003
    ..The results of this study emphasize the feasibility of combined detection of viral RNA and MV-specific IgM antibodies in oropharyngeal specimens for the diagnosis of clinical and subclinical MV infection...
  47. ncbi request reprint Poliovirus-specific memory immunity in seronegative elderly people does not protect against virus excretion
    Frithjofna Abbink
    Department of Infectious Disease Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 191:990-9. 2005
    ..We examined whether people with low or undetectable antibody levels are susceptible to infection and whether memory immunity provides protection against virus excretion...
  48. ncbi request reprint Assessing the introduction of universal varicella vaccination in the Netherlands
    Hein J Boot
    Laboratory of Vaccine Preventable Diseases, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 24:6288-99. 2006
    ..Despite these uncertainties it is clear that universal childhood vaccination will prevent most of the varicella related GP-visits, hospitalizations, and deaths...
  49. ncbi request reprint Identification, phenotypic analysis, and full-length nucleotide sequence of a Dutch Coxsackievirus A20 isolate
    Hein J Boot
    Laboratory of Vaccine Preventable Diseases, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Virus Genes 34:75-85. 2007
    ..On the basis of the phylogenetic analysis of the P2 and P3 region we expect that strain 89490 can act as recombination partner for the attenuated poliovirus strains of the Oral Polio Vaccine (OPV)...
  50. ncbi request reprint Preclinical and clinical safety studies on DNA vaccines
    Johanna A C Schalk
    Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Hum Vaccin 2:45-53. 2006
    ..We conclude that the potential risks of DNA vaccines are minimal. However, their safety issues may differ case-by-case, and they should be treated accordingly...
  51. ncbi request reprint Antigenic and molecular heterogeneity in recent swine influenza A(H1N1) virus isolates with possible implications for vaccination policy
    J C de Jong
    Research Laboratory of Infectious Diseases, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Vaccine 19:4452-64. 2001
    ....
  52. ncbi request reprint [Protection of children born to hepatitis-B-infected mothers]
    H J Boot
    Rijksinstituut voor Volksgezondheid en Milieu, Laboratorium voor Toetsing van het Rijksvaccinatieprogramma, Postbus 1, 3720 BA Bilthoven
    Ned Tijdschr Geneeskd 148:1816-8. 2004
    ....
  53. ncbi request reprint Respiratory syncytial virus, pneumonia virus of mice, and influenza A virus differently affect respiratory allergy in mice
    M Barends
    Laboratory of Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Clin Exp Allergy 34:488-96. 2004
    ..However, it is unclear whether the RSV-enhanced respiratory allergic response is a result of non-specific virus-induced damage of the lung, or virus-specific immune responses...
  54. ncbi request reprint Pathogenesis of poliovirus infection in PVRTg mice: poliovirus replicates in peritoneal macrophages
    A M Buisman
    Research Laboratory for Infectious Diseases, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    J Gen Virol 84:2819-28. 2003
    ..It is likely that this route is responsible for the induction of virus-specific IgA in the gut...
  55. ncbi request reprint IL-13 genetic polymorphism identifies children with late wheezing after respiratory syncytial virus infection
    Marieke J J Ermers
    Department of Paediatric Infection Diseases, Wilhelmina Children s Hospital, University Medical Centre, Utrecht, The Netherlands
    J Allergy Clin Immunol 119:1086-91. 2007
    ..The nature of wheezing after respiratory syncytial virus lower respiratory tract infection (RSV LRTI) is usually transient. However, some children will develop persistent or late wheezing...
  56. ncbi request reprint Enhanced severity of virus associated lower respiratory tract disease in asthma patients may not be associated with delayed viral clearance and increased viral load in the upper respiratory tract
    Leontine J R Van Elden
    Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Clin Virol 41:116-21. 2008
    ..However, the exact mechanism by which viruses contribute to exacerbation of asthma is unknown...