Anne S Kienhuis

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. doi request reprint Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis
    Anne S Kienhuis
    Center for Health Protection, National Institute for Public Health and the Environment RIVM, 3720 BA, Bilthoven, The Netherlands
    Toxicol Lett 221:225-36. 2013
  2. doi request reprint Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
    Anne S Kienhuis
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Toxicol Sci 107:544-52. 2009
  3. doi request reprint A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo
    Anne S Kienhuis
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Toxicol In Vitro 23:1163-9. 2009
  4. doi request reprint Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study
    Anne S Kienhuis
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 250:96-107. 2011
  5. doi request reprint Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling
    Marja Driessen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA, Bilthoven, The Netherlands
    Arch Toxicol 87:807-23. 2013
  6. doi request reprint Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes
    Karen Mathijs
    Department of Health Risk Analyses and Toxicology, Maastricht University, Maastricht, The Netherlands
    Drug Metab Dispos 37:1305-11. 2009
  7. ncbi request reprint Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BL/6 female mice
    Simone G J van Breda
    Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands
    J Nutr 135:1879-88. 2005

Collaborators

Detail Information

Publications7

  1. doi request reprint Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis
    Anne S Kienhuis
    Center for Health Protection, National Institute for Public Health and the Environment RIVM, 3720 BA, Bilthoven, The Netherlands
    Toxicol Lett 221:225-36. 2013
    ..We conclude that the applicability of in vitro models for hepatotoxicity testing fully depends on a solid in vivo phenotype anchored analysis. ..
  2. doi request reprint Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
    Anne S Kienhuis
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Toxicol Sci 107:544-52. 2009
    ..The present study is the first that used a toxicogenomics-based parallelogram approach, extrapolating in vitro to in vivo and interspecies, to reveal relevant mechanisms indicative of APAP-induced liver toxicity in humans in vivo...
  3. doi request reprint A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo
    Anne S Kienhuis
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Toxicol In Vitro 23:1163-9. 2009
    ....
  4. doi request reprint Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study
    Anne S Kienhuis
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 250:96-107. 2011
    ..The challenge herein is to assess which toxicogenomic responses are relevant for induction of the apical effect and whether perturbations are sufficient for the induction of downstream events, eventually causing toxicity...
  5. doi request reprint Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling
    Marja Driessen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA, Bilthoven, The Netherlands
    Arch Toxicol 87:807-23. 2013
    ..This supports the applicability of the whole ZFE model for compound-induced hepatotoxicity screening...
  6. doi request reprint Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes
    Karen Mathijs
    Department of Health Risk Analyses and Toxicology, Maastricht University, Maastricht, The Netherlands
    Drug Metab Dispos 37:1305-11. 2009
    ..These results indicate that the sandwich-cultured primary mouse hepatocyte system is robust and seems to maintain its metabolic competence better than that of the rat hepatocyte system...
  7. ncbi request reprint Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BL/6 female mice
    Simone G J van Breda
    Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands
    J Nutr 135:1879-88. 2005
    ..These genes are of particular interest because they were consistently affected and could be involved in the prevention of CRC by vegetable consumption...