P Hoogerhout

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. ncbi request reprint Solid-phase synthesis and application of double-fluorescent-labeled lipopeptides, containing a CTL-epitope from the measles fusion protein
    P Hoogerhout
    RIVM, National Institute of Public Health and the Environment, Laboratory for Vaccine Research, Bilthoven, The Netherlands
    J Pept Res 54:436-43. 1999
  2. pmc A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques
    Peter Hoogerhout
    Department of Vaccinology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    PLoS ONE 6:e19110. 2011
  3. ncbi request reprint In vitro processing and presentation of a lipidated cytotoxic T-cell epitope derived from measles virus fusion protein
    K J Stittelaar
    Laboratory for Vaccine Research, National Institute of Public Health and the Environment, 3720 BA, Bilthoven, The Netherlands
    Vaccine 20:249-61. 2001
  4. ncbi request reprint Role of the polymorphic region 1 of the Bordetella pertussis protein pertactin in immunity
    A J King
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Microbiology 147:2885-95. 2001
  5. pmc Topology of outer membrane porins in pathogenic Neisseria spp
    P van der Ley
    National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
    Infect Immun 59:2963-71. 1991
  6. ncbi request reprint Sequence variability of FrpB, a major iron-regulated outer-membrane protein in the pathogenic neisseriae
    P van der Ley
    Laboratory of Vaccine Development and Immune Mechanisms, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Microbiology 142:3269-74. 1996
  7. pmc Functional activity of antibodies against the recombinant OpaJ protein from Neisseria meningitidis
    M I de Jonge
    Laboratory of Vaccine Research, National Institute of Public Health and the Environment RIVM Bilthoven, Bilthoven, The Netherlands
    Infect Immun 71:2331-40. 2003
  8. ncbi request reprint Epitope specificity of murine and human bactericidal antibodies against PorA P1.7,16 induced with experimental meningococcal group B vaccines
    E M Rouppe van der Voort
    Laboratory of Vaccine Development and Immune Mechanisms, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    FEMS Immunol Med Microbiol 17:139-48. 1997
  9. ncbi request reprint Immunogenicity of Streptococcus pneumoniae type 6B and 14 polysaccharide-tetanus toxoid conjugates and the effect of uncoupled polysaccharide on the antigen-specific immune response
    M E Rodriguez
    Laboratory of Vaccine Development and Immune Mechanisms, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 16:1941-9. 1998

Collaborators

  • J T Poolman
  • M Virji
  • M E Rodriguez
  • J E Heckels
  • Elly M Hol
  • Frits R Mooi
  • P van der Ley
  • M I de Jonge
  • A J King
  • K J Stittelaar
  • E M Rouppe van der Voort
  • H H Van Dijken
  • G Vidarsson
  • J Dankert
  • L van Alphen
  • E J Wiertz
  • A D Osterhaus
  • W Ovaa
  • R R van Binnendijk
  • P Roholl
  • H F van Oirschot
  • C A van Els
  • M C Poelen
  • G Berbers
  • K Knipping
  • L M van Unen
  • H A Timmermans
  • B Kuipers
  • H F Brugghe
  • R Sutmuller
  • J van der Biezen

Detail Information

Publications9

  1. ncbi request reprint Solid-phase synthesis and application of double-fluorescent-labeled lipopeptides, containing a CTL-epitope from the measles fusion protein
    P Hoogerhout
    RIVM, National Institute of Public Health and the Environment, Laboratory for Vaccine Research, Bilthoven, The Netherlands
    J Pept Res 54:436-43. 1999
    ..It appeared that the double-fluorescent-labeled lipopeptide was able to induce antigen-specific cytotoxicity. Furthermore, preliminary confocal microscopical studies indicated that this lipopeptide is observed intracellularly...
  2. pmc A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques
    Peter Hoogerhout
    Department of Vaccinology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    PLoS ONE 6:e19110. 2011
    ..We propose that the cyclic peptide conjugate might provide a lead towards a vaccine that could be administered before the onset of AD symptoms. Further investigation of this hypothesis requires immunization of transgenic AD model mice...
  3. ncbi request reprint In vitro processing and presentation of a lipidated cytotoxic T-cell epitope derived from measles virus fusion protein
    K J Stittelaar
    Laboratory for Vaccine Research, National Institute of Public Health and the Environment, 3720 BA, Bilthoven, The Netherlands
    Vaccine 20:249-61. 2001
    ....
  4. ncbi request reprint Role of the polymorphic region 1 of the Bordetella pertussis protein pertactin in immunity
    A J King
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Microbiology 147:2885-95. 2001
    ..An mAb directed against a linear conserved epitope conferred cross-immunity against isolates with distinct pertactin variants. The results indicate an important role of region 1 of pertactin in immunity...
  5. pmc Topology of outer membrane porins in pathogenic Neisseria spp
    P van der Ley
    National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
    Infect Immun 59:2963-71. 1991
    ..These results suggest that the longest loops are immunodominant, provide the binding sites for bactericidal antibodies, and display the greatest variation among different strains...
  6. ncbi request reprint Sequence variability of FrpB, a major iron-regulated outer-membrane protein in the pathogenic neisseriae
    P van der Ley
    Laboratory of Vaccine Development and Immune Mechanisms, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Microbiology 142:3269-74. 1996
    ..The frpB genes from five additional meningococcal strains were cloned and sequenced in this region. Pairwise comparisons showed different degrees of similarity...
  7. pmc Functional activity of antibodies against the recombinant OpaJ protein from Neisseria meningitidis
    M I de Jonge
    Laboratory of Vaccine Research, National Institute of Public Health and the Environment RIVM Bilthoven, Bilthoven, The Netherlands
    Infect Immun 71:2331-40. 2003
    ..Sera raised against purified OpaJ and against OpaJ-containing meningococcal OMCs also blocked the nonopsonic interaction of Opa-expressing meningococci with human polymorphonuclear leukocytes...
  8. ncbi request reprint Epitope specificity of murine and human bactericidal antibodies against PorA P1.7,16 induced with experimental meningococcal group B vaccines
    E M Rouppe van der Voort
    Laboratory of Vaccine Development and Immune Mechanisms, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    FEMS Immunol Med Microbiol 17:139-48. 1997
    ..7,16) as a target strain. Bactericidal activities could be inhibited with both monomeric and multimeric peptides derived from epitopes P1.7 and P1.16...
  9. ncbi request reprint Immunogenicity of Streptococcus pneumoniae type 6B and 14 polysaccharide-tetanus toxoid conjugates and the effect of uncoupled polysaccharide on the antigen-specific immune response
    M E Rodriguez
    Laboratory of Vaccine Development and Immune Mechanisms, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Vaccine 16:1941-9. 1998
    ..However, unlike admixture of the low molecular weight PS6B, addition of the high molecular weight PS6B leads to a rather persistent state of unresponsiveness...