Research Topics
| A H HavelaarSummaryAffiliation: National Institute for Public Health and the Environment Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
Intraspecies variability in the dose-response relationship for Salmonella Enteritidis associated with genetic differences in cellular immune responseArie Havelaar
Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
J Food Prot 67:2008-15. 2004..Successful colonization by only one or two SE clones resulted in a marked increase of neutrophil counts by a factor of two to three in both rat strains...- Towards an integrated approach in supporting microbiological food safety decisionsA H Havelaar
Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
Zoonoses Public Health 54:103-17. 2007.... - Disease burden of congenital toxoplasmosisA H Havelaar
National Institute for Public Health and the Environment, Netherlands Center for Infectious Disease Control, Bilthoven, The Netherlands
Clin Infect Dis 44:1467-74. 2007..In countries that actively screen for toxoplasmosis, such as France, there may be a lower burden of morbidity but a higher burden of mortality... 
Attribution of foodborne pathogens using structured expert elicitationArie H Havelaar
Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Foodborne Pathog Dis 5:649-59. 2008..To estimate the fraction of human cases of enterically transmitted illness by five major pathways (food, environment, direct animal contact, human-human transmission, and travel) and by 11 groups within the food pathway...- Disease burden of foodborne pathogens in the Netherlands, 2009Arie H Havelaar
Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Int J Food Microbiol 156:231-8. 2012..The burden of acute disease is a relatively small part of the total burden. In the Netherlands, the burden of foodborne pathogens is similar to the burden of upper respiratory and urinary tract infections... 
Disability Adjusted Life Years and minimal disease: application of a preference-based relevance criterion to rank enteric pathogensJuanita A Haagsma
Centre for Infectious Disease Control, National Institute of Public Health and the Environment, P, O, Box 1, Bilthoven, The Netherlands
Popul Health Metr 6:7. 2008..abstract:..- Fine-tuning Food Safety Objectives and risk assessmentArie H Havelaar
Microbiological Laboratory for Health Protection, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
Int J Food Microbiol 93:11-29. 2004..For this purpose, we propose the P-D equivalence curve, a simple graphical tool to separate "tolerable" from "non-tolerable" combinations of prevalence and concentration (dose)... - Effectiveness and efficiency of controlling Campylobacter on broiler chicken meatArie H Havelaar
National Institute for Public Health and the Environment, 3720 BA, Bilthoven, The Netherlands
Risk Anal 27:831-44. 2007..Other methods to decrease the contamination of meat of colonized flocks such as freezing and heat treatment are more expensive and/or less effective than chemical decontamination... - Future challenges to microbial food safetyArie H Havelaar
Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Diseases Control Netherlands, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
Int J Food Microbiol 139:S79-94. 2010..In addition, the increasing complexity of the global food systems necessitates improved communication between all parties involved: scientists, risk assessors and risk managers, as well as consumers... - Prioritizing emerging zoonoses in the NetherlandsArie H Havelaar
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
PLoS ONE 5:e13965. 2010..To support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the Netherlands... - Balancing the risks and benefits of drinking water disinfection: disability adjusted life-years on the scaleA H Havelaar
National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
Environ Health Perspect 108:315-21. 2000..In practice, the application of DALYs may be hampered by the substantial degree of uncertainty, as is typical for risk assessment... - A biotracing model of Salmonella in the pork production chainJ H Smid
National Institute for Public Health and the Environment, Centre for Infectious Disease Control, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands
J Food Prot 75:270-80. 2012.... - A practical framework for the construction of a biotracing model: application to Salmonella in the pork slaughter chainJ H Smid
Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Risk Anal 31:1434-50. 2011..This model, implemented as a BBN, describes the dynamics of Salmonella in a Dutch slaughterhouse and enables finding the source of contamination of specific carcasses at the end of the chain... - Assessment of the dose-response relationship of Campylobacter jejuniG J Medema
Laboratory of Water and Food Microbiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Int J Food Microbiol 30:101-11. 1996..jejuni in water, the uncertainty in the dose-response relation was insignificant compared to the uncertainty in the exposure estimate... - Disease burden in The Netherlands due to infections with Shiga toxin-producing Escherichia coli O157A H Havelaar
National Institute for Public Health and the Environment (RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
Epidemiol Infect 132:467-84. 2004..Sensitivity analysis indicates that uncertainty associated with model assumptions did not have a major effect on these estimates... - A rat model for dose-response relationships of Salmonella Enteritidis infectionA H Havelaar
Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J Appl Microbiol 91:442-52. 2001..SIGNIFICANCE AND IMPACT OF THE STUDY: The rat model allows controlled quantification of different factors related to the host, pathogen and food matrix on initial stages of infection by food-borne bacterial pathogens... - The Beta Poisson dose-response model is not a single-hit modelP F Teunis
National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Risk Anal 20:513-20. 2000..This maximum possible response curve is important for uncertainty analysis, and for risk assessment of pathogens with unknown properties... - The protective effects of temporary immunity under imposed infection pressureA N Swart
National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Epidemics 4:43-7. 2012..In a second part of the paper we relate the model parameters to the available data concerning campylobacteriosis... - Congenital toxoplasmosis and DALYs in the NetherlandsL M Kortbeek
Laboratory for Infectious Diseases and Perinatal Screening, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and Environment, BA Bilthoven, The Netherlands
Mem Inst Oswaldo Cruz 104:370-3. 2009..There is no screening program in the Netherlands; most children will be born asymptomatic and therefore will not be detected or treated... - Decreased prevalence and age-specific risk factors for Toxoplasma gondii IgG antibodies in The Netherlands between 1995/1996 and 2006/2007A Hofhuis
Epidemiology and Surveillance Unit, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
Epidemiol Infect 139:530-8. 2011..For younger participants, risk factors were keeping sheep or cattle, consumption of raw unwashed vegetables and putting sand in the mouth... - The burden of infectious intestinal disease (IID) in the community: a survey of self-reported IID in The NetherlandsY Doorduyn
Netherlands Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Epidemiol Infect 140:1185-92. 2012..This is probably largely due to the retrospective nature of the present study and, to a lesser extent, to differences in case definitions... - Strengths and weaknesses of Monte Carlo simulation models and Bayesian belief networks in microbial risk assessmentJ H Smid
RIVM, A van Leeuwenhoeklaan 9, 3720 BA Bilthoven, The Netherlands
Int J Food Microbiol 139:S57-63. 2010..An inventory is made of the strengths and weaknesses of both approaches, and an example is given showing an additional use of BBNs in biotracing problems... - Optimisation of the ISO-method on enumeration of somatic coliphages (draft ISO 10705-2)K A Mooijman
National Institute of Public Health and the Environment RIVM, Microbiological Laboratory for Health Protection MGB, PO Box 1, 3720 BA Bilthoven, The Netherlands
Water Sci Technol 43:205-8. 2001..The double agar layer method (DAL) is preferred to the single agar layer method (SAL) for performing the phage analysis as the DAL method gives higher phage counts than the SAL method... - Enumeration of bacteriophages in water by different laboratories of the European Union in two interlaboratory comparison studiesK A Mooijman
National Institute for Public Health and the Environment RIVM, Microbiological Laboratory for Health Protection MGB, P O Box 1, 3720 BA Bilthoven, The Netherlands
J Virol Methods 127:60-8. 2005..When analysing the naturally polluted samples more variation in results within and between laboratories was found (r=1.63-2.34; R=3.10-5.72), in comparison with the results obtained with the pure phage reference materials... - A comparison of risk assessments on Campylobacter in broiler meatMaarten Nauta
Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
Int J Food Microbiol 129:107-23. 2009..The purpose of such a generic model has yet to be defined at a European level and the large variety in practices between countries, especially related to consumer food preparation and consumption, complicates a unified approach... - A poultry-processing model for quantitative microbiological risk assessmentMaarten Nauta
Microbiological Laboratory for Health Protection MGB, National Institute for Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
Risk Anal 25:85-98. 2005..The effects of logistic slaughter (scheduled processing) as a risk mitigation strategy are predicted to be small. Some additional complications in applying microbiological data obtained in processing plants are discussed... - A quantitative model for neutrophil response and delayed-type hypersensitivity reaction in rats orally inoculated with various doses of Salmonella EnteritidisKatsuhisa Takumi
Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
Int Immunol 14:111-9. 2002..6 x 10(-3)). We conclude that at low inocula, infections are initiated by very small numbers of bacteria. The magnitude of the immune responses is similar whether only a few or a larger number of bacteria initiated the infection... - Release kinetics and cell trafficking in relation to bacterial growth explain the time course of blood neutrophils and monocytes during primary Salmonella infectionKatsuhisa Takumi
Microbiological Laboratory for Health Protection, National Institute for Public Health and Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
Int Immunol 17:85-93. 2005..In conclusion, we can predict time series of neutrophil and monocyte responses in low-dose and high-dose experimental infection via the oral route... - The burden of infectious diseases in Europe: a pilot studyE A van Lier
Centre for Infectious Disease Control Netherlands, Rijksinstituut voor Volksgezondheid en Milieu National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands
Euro Surveill 12:E3-4. 2007..Such a study would benefit from an approach that identifies and combines several methods of investigation, including epidemiological modelling, and it should be done in collaboration with other international efforts in this field... - Disease burden of post-infectious irritable bowel syndrome in The NetherlandsJ A Haagsma
Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Epidemiol Infect 138:1650-6. 2010..PI-IBS is a frequent sequel of IID, resulting in a considerable disease burden compared to other outcomes. If this relationship is not considered, this will result in an underestimation of the disease burden of IID... - Sedimentation of free and attached Cryptosporidium oocysts and Giardia cysts in waterG J Medema
Microbiological Laboratory of Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Appl Environ Microbiol 64:4460-6. 1998..parvum and G. lamblia. Attachment to particles influences not only sedimentation of (oo)cysts in surface water but also their behavior in drinking water treatment processes... - The certification of a reference material for the evaluation of methods for the enumeration of Bacillus cereusP H in 't Veld
Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J Appl Microbiol 86:266-74. 1999..Based on the information on homogeneity, stability and the certification study, the BCR decided to certify the material as CRM 528... - Risk factors for the presence of Campylobacter spp. in Dutch broiler flocksM Bouwknegt
Microbiological Laboratory for Health Protection, National Institute for Public Health and the Environment, PO Box 1, 3720 BA, Bilthoven, The Netherlands
Prev Vet Med 62:35-49. 2004..76) and hatchery (PAF = 0.67) had the highest impacts on campylobacter presence in Dutch broiler flocks. These factors, however, lack an easy interpretation of the mechanism behind the suggested effect... - A structured expert judgment study for a model of Campylobacter transmission during broiler-chicken processingH J Van der Fels-Klerx
National Institute for Public Health and the Environment RIVM, Microbiological Laboratory for Health Protection MGB, Bilthoven, The Netherlands
Risk Anal 25:109-24. 2005..Hence, this weighting scheme, having adequate robustness, was chosen for further processing of the results... - Cost-utility analysis to control Campylobacter on chicken meat: dealing with data limitationsMarie Josee J Mangen
National Institute for Public Health and the Environment, 3720 BA, Bilthoven, The Netherlands
Risk Anal 27:815-30. 2007..However, all three do have some clauses... - Optimisation of ISO 10705-1 on enumeration of F-specific bacteriophagesKirsten A Mooijman
National Institute of Public Health and the Environment RIVM, Microbiological Laboratory for Health Protection MGB, Bilthoven, The Netherlands
J Virol Methods 103:129-36. 2002.... - A risk assessment model for Campylobacter in broiler meatMaarten J Nauta
National Institute for Public Health and the Environment RIVM, MGB, Bilthoven, The Netherlands
Risk Anal 27:845-61. 2007..However, this uncertainty is smaller when relative risks of interventions are calculated with the model. Hence, the model can be effectively used by risk management in deciding on strategies to reduce human campylobacteriosis... - "Second-order modeling of variability and uncertainty in microbial hazard characterization," A comment on: J. Food Prot. 70(2):363-372 (2007)Arie H Havelaar
J Food Prot 70:2228-9. 2007 - Cross-contamination during food preparation: a mechanistic model applied to chicken-borne CampylobacterSido D Mylius
RIVM, National Institute for Public Health and the Environment, Epidemiology and Surveillance Unit, Bilthoven, The Netherlands
Risk Anal 27:803-13. 2007..Furthermore, we argue that especially more behavioral data on hygiene during food preparation is needed for a comprehensive Campylobacter risk assessment...