A H Havelaar

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. ncbi Intraspecies variability in the dose-response relationship for Salmonella Enteritidis associated with genetic differences in cellular immune response
    Arie Havelaar
    Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    J Food Prot 67:2008-15. 2004
  2. ncbi Towards an integrated approach in supporting microbiological food safety decisions
    A H Havelaar
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Zoonoses Public Health 54:103-17. 2007
  3. ncbi Disease burden of congenital toxoplasmosis
    A H Havelaar
    National Institute for Public Health and the Environment, Netherlands Center for Infectious Disease Control, Bilthoven, The Netherlands
    Clin Infect Dis 44:1467-74. 2007
  4. doi Attribution of foodborne pathogens using structured expert elicitation
    Arie H Havelaar
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Foodborne Pathog Dis 5:649-59. 2008
  5. pmc Scoping the impact of changes in population age-structure on the future burden of foodborne disease in the Netherlands, 2020-2060
    Martijn Bouwknegt
    Centre for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, PO Box 1, Bilthoven NL 3720BA, The Netherlands
    Int J Environ Res Public Health 10:2888-96. 2013
  6. pmc Systematic review of general burden of disease studies using disability-adjusted life years
    Suzanne Polinder
    Department of Public Health, Erasmus MC, Rotterdam, Netherlands
    Popul Health Metr 10:21. 2012
  7. doi Disease burden of foodborne pathogens in the Netherlands, 2009
    Arie H Havelaar
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Int J Food Microbiol 156:231-8. 2012
  8. pmc Disability Adjusted Life Years and minimal disease: application of a preference-based relevance criterion to rank enteric pathogens
    Juanita A Haagsma
    Centre for Infectious Disease Control, National Institute of Public Health and the Environment, P, O, Box 1, Bilthoven, The Netherlands
    Popul Health Metr 6:7. 2008
  9. ncbi Fine-tuning Food Safety Objectives and risk assessment
    Arie H Havelaar
    Microbiological Laboratory for Health Protection, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Int J Food Microbiol 93:11-29. 2004
  10. pmc Balancing the risks and benefits of drinking water disinfection: disability adjusted life-years on the scale
    A H Havelaar
    National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Environ Health Perspect 108:315-21. 2000

Detail Information

Publications45

  1. ncbi Intraspecies variability in the dose-response relationship for Salmonella Enteritidis associated with genetic differences in cellular immune response
    Arie Havelaar
    Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    J Food Prot 67:2008-15. 2004
    ..Successful colonization by only one or two SE clones resulted in a marked increase of neutrophil counts by a factor of two to three in both rat strains...
  2. ncbi Towards an integrated approach in supporting microbiological food safety decisions
    A H Havelaar
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Zoonoses Public Health 54:103-17. 2007
    ....
  3. ncbi Disease burden of congenital toxoplasmosis
    A H Havelaar
    National Institute for Public Health and the Environment, Netherlands Center for Infectious Disease Control, Bilthoven, The Netherlands
    Clin Infect Dis 44:1467-74. 2007
    ..In countries that actively screen for toxoplasmosis, such as France, there may be a lower burden of morbidity but a higher burden of mortality...
  4. doi Attribution of foodborne pathogens using structured expert elicitation
    Arie H Havelaar
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Foodborne Pathog Dis 5:649-59. 2008
    ..To estimate the fraction of human cases of enterically transmitted illness by five major pathways (food, environment, direct animal contact, human-human transmission, and travel) and by 11 groups within the food pathway...
  5. pmc Scoping the impact of changes in population age-structure on the future burden of foodborne disease in the Netherlands, 2020-2060
    Martijn Bouwknegt
    Centre for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, PO Box 1, Bilthoven NL 3720BA, The Netherlands
    Int J Environ Res Public Health 10:2888-96. 2013
    ..Other factors, such as changes in health care systems, social clustering and food processing and preparation, could not be included in the estimates. ..
  6. pmc Systematic review of general burden of disease studies using disability-adjusted life years
    Suzanne Polinder
    Department of Public Health, Erasmus MC, Rotterdam, Netherlands
    Popul Health Metr 10:21. 2012
    ..abstract:..
  7. doi Disease burden of foodborne pathogens in the Netherlands, 2009
    Arie H Havelaar
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Int J Food Microbiol 156:231-8. 2012
    ..The burden of acute disease is a relatively small part of the total burden. In the Netherlands, the burden of foodborne pathogens is similar to the burden of upper respiratory and urinary tract infections...
  8. pmc Disability Adjusted Life Years and minimal disease: application of a preference-based relevance criterion to rank enteric pathogens
    Juanita A Haagsma
    Centre for Infectious Disease Control, National Institute of Public Health and the Environment, P, O, Box 1, Bilthoven, The Netherlands
    Popul Health Metr 6:7. 2008
    ..abstract:..
  9. ncbi Fine-tuning Food Safety Objectives and risk assessment
    Arie H Havelaar
    Microbiological Laboratory for Health Protection, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Int J Food Microbiol 93:11-29. 2004
    ..For this purpose, we propose the P-D equivalence curve, a simple graphical tool to separate "tolerable" from "non-tolerable" combinations of prevalence and concentration (dose)...
  10. pmc Balancing the risks and benefits of drinking water disinfection: disability adjusted life-years on the scale
    A H Havelaar
    National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Environ Health Perspect 108:315-21. 2000
    ..In practice, the application of DALYs may be hampered by the substantial degree of uncertainty, as is typical for risk assessment...
  11. doi Future challenges to microbial food safety
    Arie H Havelaar
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Diseases Control Netherlands, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Int J Food Microbiol 139:S79-94. 2010
    ..In addition, the increasing complexity of the global food systems necessitates improved communication between all parties involved: scientists, risk assessors and risk managers, as well as consumers...
  12. pmc Prioritizing emerging zoonoses in the Netherlands
    Arie H Havelaar
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 5:e13965. 2010
    ..To support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the Netherlands...
  13. ncbi Effectiveness and efficiency of controlling Campylobacter on broiler chicken meat
    Arie H Havelaar
    National Institute for Public Health and the Environment, 3720 BA, Bilthoven, The Netherlands
    Risk Anal 27:831-44. 2007
    ..Other methods to decrease the contamination of meat of colonized flocks such as freezing and heat treatment are more expensive and/or less effective than chemical decontamination...
  14. ncbi Estimating the true incidence of campylobacteriosis and salmonellosis in the European Union, 2009
    A H Havelaar
    National Institute for Public Health and the Environment, Centre for Infectious Disease Control, Bilthoven, The Netherlands
    Epidemiol Infect 141:293-302. 2013
    ..in broiler chickens. The incidence rate of salmonellosis in EU member states varied between 16 and 11 800/100 000 population and was significantly correlated with the prevalence of Salmonella Enteritidis in laying hens...
  15. doi A biotracing model of Salmonella in the pork production chain
    J H Smid
    National Institute for Public Health and the Environment, Centre for Infectious Disease Control, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands
    J Food Prot 75:270-80. 2012
    ....
  16. doi A practical framework for the construction of a biotracing model: application to Salmonella in the pork slaughter chain
    J H Smid
    Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Risk Anal 31:1434-50. 2011
    ..This model, implemented as a BBN, describes the dynamics of Salmonella in a Dutch slaughterhouse and enables finding the source of contamination of specific carcasses at the end of the chain...
  17. ncbi Assessment of the dose-response relationship of Campylobacter jejuni
    G J Medema
    Laboratory of Water and Food Microbiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Int J Food Microbiol 30:101-11. 1996
    ..jejuni in water, the uncertainty in the dose-response relation was insignificant compared to the uncertainty in the exposure estimate...
  18. pmc Disease burden in The Netherlands due to infections with Shiga toxin-producing Escherichia coli O157
    A H Havelaar
    National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Epidemiol Infect 132:467-84. 2004
    ..Sensitivity analysis indicates that uncertainty associated with model assumptions did not have a major effect on these estimates...
  19. doi Community incidence of pathogen-specific gastroenteritis: reconstructing the surveillance pyramid for seven pathogens in seven European Union member states
    J A Haagsma
    Centrum voor Infectieziektebestrijding, Rijksinstituut voor Volksgezondheid en Milieu, Bilthoven, The Netherlands
    Epidemiol Infect 141:1625-39. 2013
    ..and Salmonella spp. Incidence estimates resulting from the pyramid reconstruction approach are adjusted for biases due to different surveillance systems and are therefore a better basis for international comparisons than reported data...
  20. ncbi The Beta Poisson dose-response model is not a single-hit model
    P F Teunis
    National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Risk Anal 20:513-20. 2000
    ..This maximum possible response curve is important for uncertainty analysis, and for risk assessment of pathogens with unknown properties...
  21. ncbi A rat model for dose-response relationships of Salmonella Enteritidis infection
    A H Havelaar
    Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Appl Microbiol 91:442-52. 2001
    ..SIGNIFICANCE AND IMPACT OF THE STUDY: The rat model allows controlled quantification of different factors related to the host, pathogen and food matrix on initial stages of infection by food-borne bacterial pathogens...
  22. doi Decreased prevalence and age-specific risk factors for Toxoplasma gondii IgG antibodies in The Netherlands between 1995/1996 and 2006/2007
    A Hofhuis
    Epidemiology and Surveillance Unit, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Epidemiol Infect 139:530-8. 2011
    ..For younger participants, risk factors were keeping sheep or cattle, consumption of raw unwashed vegetables and putting sand in the mouth...
  23. doi The protective effects of temporary immunity under imposed infection pressure
    A N Swart
    National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Epidemics 4:43-7. 2012
    ..In a second part of the paper we relate the model parameters to the available data concerning campylobacteriosis...
  24. ncbi Congenital toxoplasmosis and DALYs in the Netherlands
    L M Kortbeek
    Laboratory for Infectious Diseases and Perinatal Screening, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and Environment, BA Bilthoven, The Netherlands
    Mem Inst Oswaldo Cruz 104:370-3. 2009
    ..There is no screening program in the Netherlands; most children will be born asymptomatic and therefore will not be detected or treated...
  25. ncbi Disease outbreaks associated with untreated recreational water use
    F M Schets
    National Institute for Public Health and the Environment, Laboratory for Zoonoses and Environmental Microbiology, Bilthoven, The Netherlands
    Epidemiol Infect 139:1114-25. 2011
    ..Identification of all possible contamination sources, awareness of changes that might negatively affect water quality, and provision of adequate information to the public are important preventive measures to protect public health...
  26. doi The burden of infectious intestinal disease (IID) in the community: a survey of self-reported IID in The Netherlands
    Y Doorduyn
    Netherlands Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiol Infect 140:1185-92. 2012
    ..This is probably largely due to the retrospective nature of the present study and, to a lesser extent, to differences in case definitions...
  27. doi Strengths and weaknesses of Monte Carlo simulation models and Bayesian belief networks in microbial risk assessment
    J H Smid
    RIVM, A van Leeuwenhoeklaan 9, 3720 BA Bilthoven, The Netherlands
    Int J Food Microbiol 139:S57-63. 2010
    ..An inventory is made of the strengths and weaknesses of both approaches, and an example is given showing an additional use of BBNs in biotracing problems...
  28. ncbi Optimisation of the ISO-method on enumeration of somatic coliphages (draft ISO 10705-2)
    K A Mooijman
    National Institute of Public Health and the Environment RIVM, Microbiological Laboratory for Health Protection MGB, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Water Sci Technol 43:205-8. 2001
    ..The double agar layer method (DAL) is preferred to the single agar layer method (SAL) for performing the phage analysis as the DAL method gives higher phage counts than the SAL method...
  29. ncbi Enumeration of bacteriophages in water by different laboratories of the European Union in two interlaboratory comparison studies
    K A Mooijman
    National Institute for Public Health and the Environment RIVM, Microbiological Laboratory for Health Protection MGB, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Virol Methods 127:60-8. 2005
    ..When analysing the naturally polluted samples more variation in results within and between laboratories was found (r=1.63-2.34; R=3.10-5.72), in comparison with the results obtained with the pure phage reference materials...
  30. ncbi A poultry-processing model for quantitative microbiological risk assessment
    Maarten Nauta
    Microbiological Laboratory for Health Protection MGB, National Institute for Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Risk Anal 25:85-98. 2005
    ..The effects of logistic slaughter (scheduled processing) as a risk mitigation strategy are predicted to be small. Some additional complications in applying microbiological data obtained in processing plants are discussed...
  31. ncbi A quantitative model for neutrophil response and delayed-type hypersensitivity reaction in rats orally inoculated with various doses of Salmonella Enteritidis
    Katsuhisa Takumi
    Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Int Immunol 14:111-9. 2002
    ..6 x 10(-3)). We conclude that at low inocula, infections are initiated by very small numbers of bacteria. The magnitude of the immune responses is similar whether only a few or a larger number of bacteria initiated the infection...
  32. doi A comparison of risk assessments on Campylobacter in broiler meat
    Maarten Nauta
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Int J Food Microbiol 129:107-23. 2009
    ..The purpose of such a generic model has yet to be defined at a European level and the large variety in practices between countries, especially related to consumer food preparation and consumption, complicates a unified approach...
  33. ncbi Release kinetics and cell trafficking in relation to bacterial growth explain the time course of blood neutrophils and monocytes during primary Salmonella infection
    Katsuhisa Takumi
    Microbiological Laboratory for Health Protection, National Institute for Public Health and Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Int Immunol 17:85-93. 2005
    ..In conclusion, we can predict time series of neutrophil and monocyte responses in low-dose and high-dose experimental infection via the oral route...
  34. ncbi Quantifying the sources of Salmonella on dressed carcasses of pigs based on serovar distribution
    J H Smid
    Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 178, 3508 TD Utrecht, The Netherlands National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control CIb, P O Box 1, 3720 BA Bilthoven, The Netherlands Electronic address
    Meat Sci 96:1425-31. 2014
    ..2012). They mostly agreed. The approach chosen by an individual slaughterhouse depends on the data that are collected. ..
  35. doi Disease burden of post-infectious irritable bowel syndrome in The Netherlands
    J A Haagsma
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiol Infect 138:1650-6. 2010
    ..PI-IBS is a frequent sequel of IID, resulting in a considerable disease burden compared to other outcomes. If this relationship is not considered, this will result in an underestimation of the disease burden of IID...
  36. ncbi The burden of infectious diseases in Europe: a pilot study
    E A van Lier
    Centre for Infectious Disease Control Netherlands, Rijksinstituut voor Volksgezondheid en Milieu National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands
    Euro Surveill 12:E3-4. 2007
    ..Such a study would benefit from an approach that identifies and combines several methods of investigation, including epidemiological modelling, and it should be done in collaboration with other international efforts in this field...
  37. pmc Sedimentation of free and attached Cryptosporidium oocysts and Giardia cysts in water
    G J Medema
    Microbiological Laboratory of Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Appl Environ Microbiol 64:4460-6. 1998
    ..parvum and G. lamblia. Attachment to particles influences not only sedimentation of (oo)cysts in surface water but also their behavior in drinking water treatment processes...
  38. ncbi The certification of a reference material for the evaluation of methods for the enumeration of Bacillus cereus
    P H in 't Veld
    Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Appl Microbiol 86:266-74. 1999
    ..Based on the information on homogeneity, stability and the certification study, the BCR decided to certify the material as CRM 528...
  39. ncbi Risk factors for the presence of Campylobacter spp. in Dutch broiler flocks
    M Bouwknegt
    Microbiological Laboratory for Health Protection, National Institute for Public Health and the Environment, PO Box 1, 3720 BA, Bilthoven, The Netherlands
    Prev Vet Med 62:35-49. 2004
    ..76) and hatchery (PAF = 0.67) had the highest impacts on campylobacter presence in Dutch broiler flocks. These factors, however, lack an easy interpretation of the mechanism behind the suggested effect...
  40. ncbi Cross-contamination during food preparation: a mechanistic model applied to chicken-borne Campylobacter
    Sido D Mylius
    RIVM, National Institute for Public Health and the Environment, Epidemiology and Surveillance Unit, Bilthoven, The Netherlands
    Risk Anal 27:803-13. 2007
    ..Furthermore, we argue that especially more behavioral data on hygiene during food preparation is needed for a comprehensive Campylobacter risk assessment...
  41. ncbi Optimisation of ISO 10705-1 on enumeration of F-specific bacteriophages
    Kirsten A Mooijman
    National Institute of Public Health and the Environment RIVM, Microbiological Laboratory for Health Protection MGB, Bilthoven, The Netherlands
    J Virol Methods 103:129-36. 2002
    ....
  42. ncbi "Second-order modeling of variability and uncertainty in microbial hazard characterization," A comment on: J. Food Prot. 70(2):363-372 (2007)
    Arie H Havelaar
    J Food Prot 70:2228-9. 2007
  43. ncbi Cost-utility analysis to control Campylobacter on chicken meat: dealing with data limitations
    Marie Josee J Mangen
    National Institute for Public Health and the Environment, 3720 BA, Bilthoven, The Netherlands
    Risk Anal 27:815-30. 2007
    ..However, all three do have some clauses...
  44. ncbi A structured expert judgment study for a model of Campylobacter transmission during broiler-chicken processing
    H J Van der Fels-Klerx
    National Institute for Public Health and the Environment RIVM, Microbiological Laboratory for Health Protection MGB, Bilthoven, The Netherlands
    Risk Anal 25:109-24. 2005
    ..Hence, this weighting scheme, having adequate robustness, was chosen for further processing of the results...
  45. ncbi A risk assessment model for Campylobacter in broiler meat
    Maarten J Nauta
    National Institute for Public Health and the Environment RIVM, MGB, Bilthoven, The Netherlands
    Risk Anal 27:845-61. 2007
    ..However, this uncertainty is smaller when relative risks of interventions are calculated with the model. Hence, the model can be effectively used by risk management in deciding on strategies to reduce human campylobacteriosis...