Wim H De Jong

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. doi request reprint Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats
    Wim H De Jong
    Centre for Health Protection, National Institute for Public Health and the Environment Rijksinstituut voor Volksgezondheid en Milieu, RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 34:8333-43. 2013
  2. pmc Drug delivery and nanoparticles:applications and hazards
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Int J Nanomedicine 3:133-49. 2008
  3. doi request reprint Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
  4. ncbi request reprint Effect of prolonged exposure to low antigen concentration for sensitization
    François M M Van Och
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 184:23-30. 2003
  5. ncbi request reprint Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mRNA expression and production in the draining lymph nodes of mice
    Rob J Vandebriel
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Toxicology 188:1-13. 2003
  6. doi request reprint Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay
    Margriet V D Z Park
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Nanotoxicology 5:168-81. 2011
  7. doi request reprint Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 261:103-11. 2009
  8. doi request reprint A quantitative approach to assess the potency of skin sensitizers in the elicitation phase
    Janine Ezendam
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, NL 3720BA Bilthoven, The Netherlands
    Toxicology 299:20-4. 2012
  9. ncbi request reprint Determination of the sensitising activity of the rubber contact sensitisers TMTD, ZDMC, MBT and DEA in a modified local lymph node assay and the effect of sodium dodecyl sulfate pretreatment on local lymph node responses
    Wim H De Jong
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Toxicology 176:123-34. 2002
  10. ncbi request reprint Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers
    François M M Van Och
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 184:46-56. 2002

Collaborators

Detail Information

Publications22

  1. doi request reprint Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats
    Wim H De Jong
    Centre for Health Protection, National Institute for Public Health and the Environment Rijksinstituut voor Volksgezondheid en Milieu, RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 34:8333-43. 2013
    ..06 mg/kg b.w.) and LPS stimulation of spleen cells (CED05 0.04 mg/kg b.w.). These results show that for nanosilver the most sensitive parameters for potential adverse responses were effects on the immune system...
  2. pmc Drug delivery and nanoparticles:applications and hazards
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Int J Nanomedicine 3:133-49. 2008
    ..So, probably additional more specific testing would be needed...
  3. doi request reprint Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
    ..The results demonstrate that tissue distribution of gold nanoparticles is size-dependent with the smallest 10nm nanoparticles showing the most widespread organ distribution...
  4. ncbi request reprint Effect of prolonged exposure to low antigen concentration for sensitization
    François M M Van Och
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 184:23-30. 2003
    ..These findings indicate that for classification of sensitizers the shorter exposure period employed in the standard LLNA is sufficient, and longer periods of exposure have no bearing on this classification...
  5. ncbi request reprint Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mRNA expression and production in the draining lymph nodes of mice
    Rob J Vandebriel
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Toxicology 188:1-13. 2003
    ..Compounds that induce cell proliferation with a low concomitant IL-4 production may thus be identified as contact allergens, although the need to positively identity such allergens remain...
  6. doi request reprint Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay
    Margriet V D Z Park
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Nanotoxicology 5:168-81. 2011
    ..Further studies are needed to reveal these mechanisms and to determine the biological relevance of the effects of these particular silica nanoparticles in vivo...
  7. doi request reprint Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 261:103-11. 2009
    ..In conclusion, the respiratory LLNA is able to identify and distinguish strong contact and respiratory sensitizers when simultaneously proliferation and cytokine production are assessed in the upper respiratory tract draining LNs...
  8. doi request reprint A quantitative approach to assess the potency of skin sensitizers in the elicitation phase
    Janine Ezendam
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, NL 3720BA Bilthoven, The Netherlands
    Toxicology 299:20-4. 2012
    ..Our results indicate that elicitation thresholds cannot be readily deduced from sensitization thresholds...
  9. ncbi request reprint Determination of the sensitising activity of the rubber contact sensitisers TMTD, ZDMC, MBT and DEA in a modified local lymph node assay and the effect of sodium dodecyl sulfate pretreatment on local lymph node responses
    Wim H De Jong
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Toxicology 176:123-34. 2002
    ..For 10% and 20% SDS, inducing approximately a SI of 20 in the LLNA, no induction of cytokines was observed...
  10. ncbi request reprint Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers
    François M M Van Och
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 184:46-56. 2002
    ..We propose that, by direct linkage of proliferation and cytokine production in a dose-response manner, distinguishing contact allergens from respiratory allergens may be improved compared to present approaches...
  11. pmc Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation
    Ilse Gosens
    Centre for Environmental Health Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Part Fibre Toxicol 7:37. 2010
    ..Uptake of gold particles in alveolar macrophages has been determined by TEM...
  12. doi request reprint Skin sensitization in chemical risk assessment: report of a WHO/IPCS international workshop focusing on dose-response assessment
    Henk Van Loveren
    National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 50:155-99. 2008
    ..It is therefore recommended that clinical data, particularly dose-response data derived from sensitized patients, be included in risk assessment...
  13. ncbi request reprint Tissue response in the rat and the mouse to degradable dextran hydrogels
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Biomed Mater Res A 83:538-45. 2007
    ..Both in mice and rats the DS5 hydrogels showed a faster degradation rate than the DS13 hydrogels...
  14. doi request reprint Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats
    Daniëlle Pk Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Nanomedicine (Lond) 6:339-49. 2011
    ..To develop and determine the safety of gold nanorods, whose aspect ratios can be tuned to obtain plasmon peaks between 650 and 850 nm, as contrast enhancing agents for diagnostic and therapeutic applications...
  15. ncbi request reprint What do we (need to) know about the kinetic properties of nanoparticles in the body?
    Werner I Hagens
    Centre for Substances and Integrated Risk Assessment SIR, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 49:217-29. 2007
    ..g. blood and organs). In this paper, the current knowledge on the kinetic properties of nanoparticles is reviewed. Moreover, knowledge gaps from a kinetic point of view (detection, dose, ADME processes) are identified...
  16. doi request reprint Considerations on the EU definition of a nanomaterial: science to support policy making
    Eric A J Bleeker
    RIVM, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Regul Toxicol Pharmacol 65:119-25. 2013
    ....
  17. doi request reprint The status of in vitro toxicity studies in the risk assessment of nanomaterials
    Margriet Vdz Park
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Nanomedicine (Lond) 4:669-85. 2009
    ..A comparative analysis of published in vitro data with nanomaterials demonstrates that there are a number of issues that need resolving before in vitro studies can play a role in the risk assessment of nanomaterials...
  18. ncbi request reprint Tissue response to partially in vitro predegraded poly-L-lactide implants
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 26:1781-91. 2005
    ..0-2.0 mm thickness should be used as these may show a more realistic representation of the resorption characteristics of the material under investigation...
  19. doi request reprint In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles
    Margriet V D Z Park
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, 3720 BA, Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 240:108-16. 2009
    ....
  20. ncbi request reprint Long-term exposure to silicone breast implants does not induce antipolymer antibodies
    Wim H De Jong
    Laboratory for Pathology and Immunobiology, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 25:1095-103. 2004
    ..Hence, we cannot recommend the use of the APA assay for diagnostic purposes in the clinical evaluation of SBI recipients with severe complaints/symptoms...
  21. ncbi request reprint Screening of xenobiotics for direct immunotoxicity in an animal study
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment Rijksinstituut voor Volksgezondheid en Milieu, RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Methods 41:3-8. 2007
    ..In vitro assays with in vivo exposed cells of the immune system may present additional information on the mechanisms involved in the observed direct immunotoxicity...
  22. ncbi request reprint Ranking of allergenic potency of rubber chemicals in a modified local lymph node assay
    Wim H De Jong
    Laboratory for Pathology and Immunobiology, National Institute for Public Health and the Environment, RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 66:226-32. 2002
    ..However, one has to be aware that besides potency, the total amount of residual chemical present in the final product is also important for allergy induction...