B Wilffert

Summary

Affiliation: Medical Centre Leeuwarden
Country: The Netherlands

Publications

  1. pmc From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics
    Bob Wilffert
    Department of Quality and Patientsafety, Zorggroep Noorderbreedte, P O Box 888, 8901 BR, Leeuwarden, The Netherlands
    Int J Clin Pharm 35:369-75. 2013
  2. doi request reprint Pharmacogenetics of drug-induced birth defects: what is known so far?
    Bob Wilffert
    Unit of Pharmacoepidemiology and Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen 9713AV, The Netherlands
    Pharmacogenomics 12:547-58. 2011
  3. ncbi request reprint Pharmacogenetics as a tool in the therapy of schizophrenia
    Bob Wilffert
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University Institute for Drug Exploration GUIDE, Groningen, The Netherlands corrected
    Pharm World Sci 27:20-30. 2005
  4. ncbi request reprint 4-Aminopyridine (fampridine) effectively treats amlodipine poisoning: a case report
    B Wilffert
    Department of Pharmacotherapy and Pharmaceutical Care, GUIDE, University of Groningen, Groningen, The Netherlands
    J Clin Pharm Ther 32:655-7. 2007
  5. doi request reprint From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics
    Bob Wilffert
    Department of Quality and Patientsafety, Zorggroep Noorderbreedte, PO Box 888, 8901 BR Leeuwarden, The Netherlands
    Int J Clin Pharm 33:3-9. 2011
  6. doi request reprint The role of dopamine D3, 5-HT2A and 5-HT2C receptor variants as pharmacogenetic determinants in tardive dyskinesia in African-Caribbean patients under chronic antipsychotic treatment: Curacao extrapyramidal syndromes study IX
    B Wilffert
    Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
    J Psychopharmacol 23:652-9. 2009
  7. doi request reprint Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia
    A F Y Al Hadithy
    Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 33:475-81. 2009
  8. pmc Leflunomide in active rheumatoid arthritis: a prospective study in daily practice
    E N van Roon
    Department of Hospital Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    Br J Clin Pharmacol 58:201-8. 2004
  9. doi request reprint The influence of inhaled corticosteroids and spacer devices on the growth of respiratory pathogenic microorganisms
    Tjalling W de Vries
    Department of Paediatrics, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    Am J Infect Control 37:237-40. 2009
  10. pmc Leflunomide in active rheumatoid arthritis: a prospective study in daily practice
    E N van Roon
    Department of Hospital Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    Br J Clin Pharmacol 57:790-7. 2004

Collaborators

Detail Information

Publications14

  1. pmc From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics
    Bob Wilffert
    Department of Quality and Patientsafety, Zorggroep Noorderbreedte, P O Box 888, 8901 BR, Leeuwarden, The Netherlands
    Int J Clin Pharm 35:369-75. 2013
    ..Conclusion The contribution of pharmacogenetics to tailor-made pharmacotherapy, which especially might be of value for patients deviating from the average, has not yet reached the position it seems to deserve...
  2. doi request reprint Pharmacogenetics of drug-induced birth defects: what is known so far?
    Bob Wilffert
    Unit of Pharmacoepidemiology and Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen 9713AV, The Netherlands
    Pharmacogenomics 12:547-58. 2011
    ..The usually low prevalence of drug-induced malformations impedes the demonstration of the contribution of pharmacogenetics. Large-scale studies, preferably case-control studies, are needed...
  3. ncbi request reprint Pharmacogenetics as a tool in the therapy of schizophrenia
    Bob Wilffert
    Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University Institute for Drug Exploration GUIDE, Groningen, The Netherlands corrected
    Pharm World Sci 27:20-30. 2005
    ..Polymorphisms of Cytochrome P450 isoenzymes and neurotransmitter receptors involved in the efficacy and side effects of antipsychotics are highlighted in this review...
  4. ncbi request reprint 4-Aminopyridine (fampridine) effectively treats amlodipine poisoning: a case report
    B Wilffert
    Department of Pharmacotherapy and Pharmaceutical Care, GUIDE, University of Groningen, Groningen, The Netherlands
    J Clin Pharm Ther 32:655-7. 2007
    ..The use of intravenous 4-aminopyridine is theoretically useful to treat poisoning from calcium entry blockers and was demonstrated in this case report...
  5. doi request reprint From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics
    Bob Wilffert
    Department of Quality and Patientsafety, Zorggroep Noorderbreedte, PO Box 888, 8901 BR Leeuwarden, The Netherlands
    Int J Clin Pharm 33:3-9. 2011
    ..We present by means of the examples nortriptyline, tramadol, clopidogrel, coumarins, abacavir and antipsychotics the discrepancy between available pharmacogenetic information and its implementation in daily clinical practice...
  6. doi request reprint The role of dopamine D3, 5-HT2A and 5-HT2C receptor variants as pharmacogenetic determinants in tardive dyskinesia in African-Caribbean patients under chronic antipsychotic treatment: Curacao extrapyramidal syndromes study IX
    B Wilffert
    Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
    J Psychopharmacol 23:652-9. 2009
    ....
  7. doi request reprint Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia
    A F Y Al Hadithy
    Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 33:475-81. 2009
    ..Pharmacogenetics of tardive dyskinesia and dopamine D3 (DRD3), serotonin 2A (HTR2A), and 2C (HTR2C) receptors has been examined in various populations, but not in Russians...
  8. pmc Leflunomide in active rheumatoid arthritis: a prospective study in daily practice
    E N van Roon
    Department of Hospital Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    Br J Clin Pharmacol 58:201-8. 2004
    ..We prospectively studied the efficacy, incidence of adverse drug reactions and withdrawal from leflunomide in an outpatient population with rheumatoid arthritis in a setting of care-as-usual...
  9. doi request reprint The influence of inhaled corticosteroids and spacer devices on the growth of respiratory pathogenic microorganisms
    Tjalling W de Vries
    Department of Paediatrics, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    Am J Infect Control 37:237-40. 2009
    ..Guidelines advise weekly cleansing of spacers, with one of the reasons being to prevent the spacers from becoming colonized with respiratory pathogens. Earlier work in clinical settings showed conflicting results...
  10. pmc Leflunomide in active rheumatoid arthritis: a prospective study in daily practice
    E N van Roon
    Department of Hospital Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    Br J Clin Pharmacol 57:790-7. 2004
    ..We prospectively studied the efficacy, incidence of adverse drug reactions and withdrawal from leflunomide in an outpatient population with rheumatoid arthritis in a setting of care-as-usual...
  11. doi request reprint Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African-Caribbean inpatients: differences in association with dopamine and serotonin receptors
    Asmar F Al Hadithy
    Department of Pharmacotherapy and Pharmaceutical Care, GUIDE, University of Groningen, Groningen, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:890-7. 2008
    ..41). Since AIPs subsymptoms (rigidity, bradykinesia, and rest-tremor) may differ pharmacogenetically, our data strongly support symptom-specific analysis of AIP. However, further research is warranted to confirm our findings...
  12. ncbi request reprint Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes: a systematic review on content and adherence to guidelines
    Stefan Vegter
    Groningen Research Institute of Pharmacy GRIP, University of Groningen, Groningen, The Netherlands
    Pharmacoeconomics 26:569-87. 2008
    ..For these goals, we provide a list of recommendations for good pharmacoeconomic practice deemed useful in the fields of pharmacogenetics and pharmacogenomics, regardless of country and origin of the economic analysis...
  13. doi request reprint Lack of association between antipsychotic-induced Parkinsonism or its subsymptoms and rs4606 SNP of RGS2 gene in African-Caribbeans and the possible role of the medication: the Curacao extrapyramidal syndromes study X
    Asmar F Al Hadithy
    Pharmacotherapy and Pharmaceutical Care, GUIDE, University of Groningen, Groningen, The Netherlands
    Hum Psychopharmacol 24:123-8. 2009
    ....
  14. ncbi request reprint The impact of MDR1 polymorphisms on prolactin concentrations in patients treated with risperidone
    Asmar F Y Al Hadithy
    Prog Neuropsychopharmacol Biol Psychiatry 32:593-4. 2008