M O C Ota

Summary

Affiliation: Medical Research Council Laboratories
Country: The Gambia

Publications

  1. pmc Factors affecting immunogenicity of BCG in infants, a study in Malawi, The Gambia and the UK
    Yun Gyoung Hur
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine London WC1E 7HT, UK
    BMC Infect Dis 14:184. 2014
  2. doi Human immune responses to vaccines in the first year of life: biological, socio-economic and ethical issues - a viewpoint
    M O C Ota
    Vaccinology Theme, Medical Research Council MRC Unit, Banjul, Gambia
    Vaccine 31:2483-8. 2013
  3. pmc Pneumococcal antibody concentrations of subjects in communities fully or partially vaccinated with a seven-valent pneumococcal conjugate vaccine
    Martin O C Ota
    Medical Research Council Unit, Banjul, The Gambia
    PLoS ONE 7:e42997. 2012
  4. pmc Immunogenicity of antigens from the TbD1 region present in M. africanum and missing from "modern" M. tuberculosis: a cross- sectional study
    Bouke C de Jong
    Bacterial Diseases Programme, MRC Laboratories, POB 273, Banjul, The Gambia
    BMC Infect Dis 10:11. 2010
  5. doi The immunogenicity and impact on nasopharyngeal carriage of fewer doses of conjugate pneumococcal vaccine immunization schedule
    Martin O Ota
    Medical Research Council Laboratories, Banjul, Gambia
    Vaccine 29:2999-3007. 2011
  6. doi Antibody and T-cell responses during acute and convalescent stages of invasive pneumococcal disease
    M O C Ota
    Bacterial Diseases Programme, Medical Research Council Laboratories, PO Box 273, Banjul, The Gambia
    Int J Infect Dis 15:e282-8. 2011
  7. doi Immunogenicity of the tuberculosis vaccine MVA85A is reduced by coadministration with EPI vaccines in a randomized controlled trial in Gambian infants
    Martin O C Ota
    Bacterial Diseases Programme, Medical Research Council Unit, P O Box 273, Banjul, The Gambia
    Sci Transl Med 3:88ra56. 2011
  8. ncbi The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-gamma producing cells ex vivo
    Martin O C Ota
    Bacterial Diseases Programme, Medical Research Council, P O Box 273, Banjul, Gambia
    Vaccine 25:8861-7. 2007
  9. ncbi Maternal HIV-1 and HIV-2 infection and child survival in The Gambia
    M O Ota
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    AIDS 14:435-9. 2000
  10. ncbi The influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental transfer of antibodies and IgG subclasses in a rural West African population
    B J Okoko
    Vaccine Trial Unit, Medical Research Council, Fajara, Banjul, The Gambia, West Africa
    J Infect Dis 184:627-32. 2001

Collaborators

Detail Information

Publications19

  1. pmc Factors affecting immunogenicity of BCG in infants, a study in Malawi, The Gambia and the UK
    Yun Gyoung Hur
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine London WC1E 7HT, UK
    BMC Infect Dis 14:184. 2014
    ..In this study, the influence of geographical location, season of birth, timing of vaccination, micronutrient status (zinc) and inflammatory status (C-reactive protein, CRP) were assessed...
  2. doi Human immune responses to vaccines in the first year of life: biological, socio-economic and ethical issues - a viewpoint
    M O C Ota
    Vaccinology Theme, Medical Research Council MRC Unit, Banjul, Gambia
    Vaccine 31:2483-8. 2013
    ..Recognition and understanding of these determinants are crucial in planning interventions and for logical interpretations of results...
  3. pmc Pneumococcal antibody concentrations of subjects in communities fully or partially vaccinated with a seven-valent pneumococcal conjugate vaccine
    Martin O C Ota
    Medical Research Council Unit, Banjul, The Gambia
    PLoS ONE 7:e42997. 2012
    ..We measured pneumococcal polysaccharide antibody concentrations in this trial to understand further the mechanisms underlying the observed changes...
  4. pmc Immunogenicity of antigens from the TbD1 region present in M. africanum and missing from "modern" M. tuberculosis: a cross- sectional study
    Bouke C de Jong
    Bacterial Diseases Programme, MRC Laboratories, POB 273, Banjul, The Gambia
    BMC Infect Dis 10:11. 2010
    ..M. africanum causes up to half of TB in West- Africa and its relatively lower progression to disease suggests the presence of a large reservoir of latent infection relative to M. tuberculosis...
  5. doi The immunogenicity and impact on nasopharyngeal carriage of fewer doses of conjugate pneumococcal vaccine immunization schedule
    Martin O Ota
    Medical Research Council Laboratories, Banjul, Gambia
    Vaccine 29:2999-3007. 2011
    ....
  6. doi Antibody and T-cell responses during acute and convalescent stages of invasive pneumococcal disease
    M O C Ota
    Bacterial Diseases Programme, Medical Research Council Laboratories, PO Box 273, Banjul, The Gambia
    Int J Infect Dis 15:e282-8. 2011
    ..To understand the pattern of immune responses to pneumococcal proteins during invasive disease as a guide to their development as vaccine candidates...
  7. doi Immunogenicity of the tuberculosis vaccine MVA85A is reduced by coadministration with EPI vaccines in a randomized controlled trial in Gambian infants
    Martin O C Ota
    Bacterial Diseases Programme, Medical Research Council Unit, P O Box 273, Banjul, The Gambia
    Sci Transl Med 3:88ra56. 2011
    ....
  8. ncbi The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-gamma producing cells ex vivo
    Martin O C Ota
    Bacterial Diseases Programme, Medical Research Council, P O Box 273, Banjul, Gambia
    Vaccine 25:8861-7. 2007
    ..We conclude that BCG is immunogenic, but this effector response is short-lived and can be limited in higher pre-existing anti-mycobacterial immunity, suggesting a possible threshold beyond which BCG immunogenicity is inhibited...
  9. ncbi Maternal HIV-1 and HIV-2 infection and child survival in The Gambia
    M O Ota
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    AIDS 14:435-9. 2000
    ..To compare the survival of children born to HIV-1 or HIV-2 seropositive mothers with that of children born to HIV-seronegative mothers and to evaluate risk factors for mortality...
  10. ncbi The influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental transfer of antibodies and IgG subclasses in a rural West African population
    B J Okoko
    Vaccine Trial Unit, Medical Research Council, Fajara, Banjul, The Gambia, West Africa
    J Infect Dis 184:627-32. 2001
    ..62 and P=.59, respectively). Placental malaria infection and maternal hypergammaglobulinemia were associated with reduction in the transplacental transfer of these specific antibodies, IgG1, and IgG2 in this Gambian population...
  11. doi A new TB vaccine, MVA85A, induces durable antigen-specific responses 14 months after vaccination in African infants
    A A Odutola
    Vaccinology Theme, Medical Research Council Unit, Banjul, The Gambia
    Vaccine 30:5591-4. 2012
    ..All the children had negligible evidence of latent infection with M. tuberculosis (Mtb), suggesting that deploying a prophylactic vaccine against Mtb infection at this age could still be effective in this setting...
  12. pmc Plasmodium falciparum infection of the placenta affects newborn immune responses
    J Ismaili
    MRC Laboratories, Fajara near Banjul, The Gambia
    Clin Exp Immunol 133:414-21. 2003
    ..Taken together, these data show that placental infection with P. falciparum affects Th1 differentiation and sCD30 priming of neonatal lymphocytes and that the probable mode of action is via APC...
  13. ncbi Peripheral gangrene complicating Salmonella typhi septicaemia in a Gambian infant
    B J Okoko
    Medical Research Council, Fajara, The Gambia, West Africa
    J Trop Pediatr 47:250-1. 2001
    ..A high index of suspicion and prompt treatment is highly critical in the treatment of septicaemia in young children...
  14. ncbi Electrolyte derangement in cerebral malaria: a case for a more aggressive approach to the management of hyponatraemia
    G C Enwere
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    Ann Trop Med Parasitol 94:541-7. 2000
    ..In addition, children admitted with cerebral malaria should have their electrolyte status monitored to identify new or ongoing hyponatraemia. When hyponatraemia is discovered, it should be quickly and actively corrected...
  15. ncbi Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination
    A Marchant
    Medical Research Council Laboratories, Fajara, The Gambia
    J Immunol 163:2249-55. 1999
    ..This study demonstrates that human newborns can be immunized against pathogens controlled by a Th1 immune response...
  16. ncbi Absence of association between delayed type hypersensitivity to tuberculin and atopy in children in The Gambia
    M O C Ota
    Medical Research Council Laboratories, The Gambia
    Clin Exp Allergy 33:731-6. 2003
    ..An inverse association between delayed type hypersensitivity to tuberculin and atopy has been observed in children, suggesting that exposure to mycobacteria may influence the immune response to allergens...
  17. ncbi Influence of placental malaria infection and maternal hypergammaglobulinaemia on materno-foetal transfer of measles and tetanus antibodies in a rural west African population
    B J Okoko
    Medical Research Council Laboratories, PO Box 273, Banjul, The Gambia, West Africa
    J Health Popul Nutr 19:59-65. 2001
    ..It is concluded that the combined influence of placental malaria infection and maternal hypergammaglobulinaemia is significantly associated with the transfer of impaired measles antibody in this population...
  18. ncbi Neonatal bacillus Calmette-Guérin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes
    J Vekemans
    Medical Research Council Laboratories, The Gambia
    Eur J Immunol 31:1531-5. 2001
    ..This study demonstrates that the human neonatal immune response to BCG is not biased towards Th2 and is characterized by the predominant production of IFN-gamma by CD4+ T lymphocytes...
  19. ncbi The host response in malaria and depression of defence against tuberculosis
    G C Enwere
    Medical Research Council Laboratories, Fajara, The Gambia
    Ann Trop Med Parasitol 93:669-78. 1999
    ..Could malarial infection be one of the reasons for the persistence of tuberculosis in malaria-endemic regions?..