David Jeffries

Summary

Affiliation: Medical Research Council Laboratories
Country: The Gambia

Publications

  1. doi request reprint Analysis of flow cytometry data using an automatic processing tool
    David Jeffries
    Medical Research Council MRC Gambia, Banjul, The Gambia
    Cytometry A 73:857-67. 2008
  2. pmc Supervised learning for the automated transcription of spacer classification from spoligotype films
    David J Jeffries
    MRC Laboratories, Fajara, The Gambia
    BMC Bioinformatics 10:248. 2009
  3. pmc Maintenance of large subpopulations of differentiated CD8 T-cells two years after cytomegalovirus infection in Gambian infants
    David J C Miles
    MRC Laboratories Gambia, Banjul, The Gambia
    PLoS ONE 3:e2905. 2008
  4. pmc Field testing of different chemical combinations as odour baits for trapping wild mosquitoes in The Gambia
    Musa Jawara
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS ONE 6:e19676. 2011
  5. pmc Are plasma biomarkers of immune activation predictive of HIV progression: a longitudinal comparison and analyses in HIV-1 and HIV-2 infections?
    Samuel Nyamweya
    Medical Research Council UK, Banjul, The Gambia, West Africa
    PLoS ONE 7:e44411. 2012
  6. pmc Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia
    Irfan Zaidi
    Medical Research Council UK Unit, Fajara, The Gambia
    PLoS ONE 7:e39213. 2012
  7. pmc Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation
    David J C Miles
    MRC Laboratories Gambia, P O Box 273, Banjul, The Gambia
    J Virol 81:5766-76. 2007
  8. ncbi request reprint Innate immune responses to human malaria: heterogeneous cytokine responses to blood-stage Plasmodium falciparum correlate with parasitological and clinical outcomes
    Michael Walther
    Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Churchill Hospital, Oxford, United Kingdom
    J Immunol 177:5736-45. 2006
  9. ncbi request reprint Incidence of tuberculosis and survival after its diagnosis in patients infected with HIV-1 and HIV-2
    Marianne A B van der Sande
    London School of Hygiene and Tropical Medicine, London, UK
    AIDS 18:1933-41. 2004
  10. pmc Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia
    Maimuna E Mendy
    Medical Research Council Laboratories, Atlantic Boulevard, PO Box 273, Banjul, The Gambia
    Virol J 5:49. 2008

Collaborators

Detail Information

Publications24

  1. doi request reprint Analysis of flow cytometry data using an automatic processing tool
    David Jeffries
    Medical Research Council MRC Gambia, Banjul, The Gambia
    Cytometry A 73:857-67. 2008
    ..By applying consistent criteria to all data generated by a study, the APT can provide a level of objectivity that is difficult to match using conventional manual analysis...
  2. pmc Supervised learning for the automated transcription of spacer classification from spoligotype films
    David J Jeffries
    MRC Laboratories, Fajara, The Gambia
    BMC Bioinformatics 10:248. 2009
    ..To facilitate processing of spoligotype images we have developed tools and algorithms to automate the classification and transcription of these data directly to a database while allowing for manual editing...
  3. pmc Maintenance of large subpopulations of differentiated CD8 T-cells two years after cytomegalovirus infection in Gambian infants
    David J C Miles
    MRC Laboratories Gambia, Banjul, The Gambia
    PLoS ONE 3:e2905. 2008
    ..Here we describe a follow-up study conducted on the same infants to establish whether the differentiated subpopulations continued through the second year post-infection...
  4. pmc Field testing of different chemical combinations as odour baits for trapping wild mosquitoes in The Gambia
    Musa Jawara
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS ONE 6:e19676. 2011
    ....
  5. pmc Are plasma biomarkers of immune activation predictive of HIV progression: a longitudinal comparison and analyses in HIV-1 and HIV-2 infections?
    Samuel Nyamweya
    Medical Research Council UK, Banjul, The Gambia, West Africa
    PLoS ONE 7:e44411. 2012
    ..Their evaluation in cohort resources is therefore needed to further their development and use in HIV research...
  6. pmc Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia
    Irfan Zaidi
    Medical Research Council UK Unit, Fajara, The Gambia
    PLoS ONE 7:e39213. 2012
    ..The levels of T regulatory cells were measured using flow cytometry at baseline and all follow-up visits. Baseline cytokine levels of IL-2, IL-6, IFN-γ, TNF-α, MIP-1β, IL-1, IL-12, IL-13, and IL-10 were measured in all patients...
  7. pmc Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation
    David J C Miles
    MRC Laboratories Gambia, P O Box 273, Banjul, The Gambia
    J Virol 81:5766-76. 2007
    ....
  8. ncbi request reprint Innate immune responses to human malaria: heterogeneous cytokine responses to blood-stage Plasmodium falciparum correlate with parasitological and clinical outcomes
    Michael Walther
    Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Churchill Hospital, Oxford, United Kingdom
    J Immunol 177:5736-45. 2006
    ..Furthermore, the in vitro observations on cytokine kinetics presented here, suggest that intact schizont-stage infected RBC can trigger innate responses before rupture of the infected RBC...
  9. ncbi request reprint Incidence of tuberculosis and survival after its diagnosis in patients infected with HIV-1 and HIV-2
    Marianne A B van der Sande
    London School of Hygiene and Tropical Medicine, London, UK
    AIDS 18:1933-41. 2004
    ..HIV-2 has been associated with less immune suppression, slower disease progression and longer survival...
  10. pmc Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia
    Maimuna E Mendy
    Medical Research Council Laboratories, Atlantic Boulevard, PO Box 273, Banjul, The Gambia
    Virol J 5:49. 2008
    ..The aim of this study is to determine the natural course of HBV chronic infection, particularly in relation to sequential changes in serum HBV DNA levels and hepatitis B surface (HBsAg) antigen/hepatitis e antigen (HBeAg) status by age...
  11. pmc Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence
    Marianne A B van der Sande
    Medical Research Council Laboratories, Fajara, The Gambia
    PLoS ONE 2:e753. 2007
    ..These children are now in adolescence and approaching adulthood, when the onset of sexual activity may challenge their hepatitis B immunity. Thus a booster dose in adolescence could be important to maintain long-term protection...
  12. pmc Comparison of two interferon gamma release assays in the diagnosis of Mycobacterium tuberculosis infection and disease in The Gambia
    Ifedayo M O Adetifa
    Bacterial Diseases Programme, Medical Research Council Laboratories, Fajara, The Gambia
    BMC Infect Dis 7:122. 2007
    ..We compared the diagnostic performance of an in-house T -cell and commercial whole blood-based IGRAs for the diagnosis of LTBI and TB disease in The Gambia...
  13. doi request reprint Bioactive TGF-beta levels can be preserved in plasma samples collected into heparin but not EDTA
    Michael Walther
    Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, Gambia
    Cytokine 48:267-72. 2009
    ..Where precise measurement of latent TGF-beta in blood samples is required, samples need to be collected on ice; bioactive TGF-beta can be detected reliably in samples collected into heparin tubes even when stored at RT...
  14. pmc Comparison of electronic data capture (EDC) with the standard data capture method for clinical trial data
    Brigitte Walther
    Statistics and Data Management Department, Medical Research Council, Fajara, The Gambia
    PLoS ONE 6:e25348. 2011
    ..It was performed in a West African setting, where clinical trials involve data collection from urban, rural and often remote locations...
  15. pmc Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection?
    Nkoyo Faal
    Medical Research Council Laboratories, Fajara, Banjul, Gambia
    PLoS Med 3:e266. 2006
    ..This is essential for the successful development of a vaccine against both ocular and genital C. trachomatis infection...
  16. pmc Differential effects of frozen storage on the molecular detection of bacterial taxa that inhabit the nasopharynx
    Brenda A Kwambana
    Bacterial Diseases Programme, Medical Research Council Laboratories UK, Banjul, The Gambia
    BMC Clin Pathol 11:2. 2011
    ..abstract:..
  17. pmc Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria
    Michael Walther
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS Pathog 5:e1000364. 2009
    ..These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation...
  18. pmc Optimizing odor-baited trap methods for collecting mosquitoes during the malaria season in The Gambia
    Musa Jawara
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS ONE 4:e8167. 2009
    ..To optimize the use of counter-flow traps baited with human odor (nylon socks that had been worn for a single day) to capture wild mosquitoes in the Gambia, investigations were conducted at a field experimental site...
  19. ncbi request reprint Elevated iron status strongly predicts mortality in West African adults with HIV infection
    Joann M McDermid
    Medical Research Council International Nutrition Group, Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, England, WC1E 7HT
    J Acquir Immune Defic Syndr 46:498-507. 2007
    ..To comprehensively assess iron status and determine whether elevated iron status, like anemia, predicts mortality...
  20. doi request reprint A simple approach to test for interaction between intervention and an individual-level variable in community randomized trials
    Yin Bun Cheung
    MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 13:247-55. 2008
    ..e. small number of communities but large number of subjects per community...
  21. ncbi request reprint A relational database for management of flow cytometry and ELISpot clinical trial data
    James S Cavenaugh
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Cytometry B Clin Cytom 72:49-62. 2007
    ..Almost no published guidance exists for immunologists to design appropriate and useful data management systems...
  22. ncbi request reprint Conjunctival chlamydial 16S ribosomal RNA expression in trachoma: is chlamydial metabolic activity required for disease to develop?
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Infect Dis 42:463-70. 2006
    ..We measured chlamydial 16S ribosomal RNA (rRNA) expression, a marker of chlamydial metabolic activity, in comparison with the quantitation of a chlamydial DNA target in subjects exposed to trachoma...
  23. pmc Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
    Infect Immun 72:7352-6. 2004
    ..Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present...
  24. pmc Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation
    Helen A Fletcher
    The Centre for Infectious Diseases and International Health, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, London, UK
    Immunology 112:669-73. 2004
    ..tuberculosis induces unusual, previously unrecognized, immunological events. We tentatively hypothesize that progression to active disease might depend upon the underlying ratio of IL-4 to IL-4delta2...