Thushan I de Silva

Summary

Affiliation: Medical Research Council Laboratories
Country: The Gambia

Publications

  1. pmc HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form
    Thushan I de Silva
    Medical Research Council UK Laboratories, Atlantic Road, Fajara, The Gambia
    Retrovirology 7:82. 2010
  2. pmc Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa
    Balint Stewart
    Medical Research Council, Fajara, P O Box 273, Banjul, The Gambia, West Africa
    BMC Res Notes 4:561. 2011
  3. doi HIV-2: the forgotten AIDS virus
    Thushan I de Silva
    Medical Research Council Laboratories, Atlantic Road, PO Box 273, Fajara, The Gambia, West Africa
    Trends Microbiol 16:588-95. 2008
  4. doi Population dynamics of HIV-2 in rural West Africa: comparison with HIV-1 and ongoing transmission at the heart of the epidemic
    Thushan I de Silva
    Medical Research Council UK Laboratories, Fajara, The Gambia
    AIDS 27:125-34. 2013
  5. pmc Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau
    Carla van Tienen
    Virology, Medical Research Council, Fajara, The Gambia
    PLoS Negl Trop Dis 6:e1690. 2012
  6. pmc Potent autologous and heterologous neutralizing antibody responses occur in HIV-2 infection across a broad range of infection outcomes
    Thushan I de Silva
    Medical Research Council United Kingdom Laboratories, Fajara, The Gambia
    J Virol 86:930-46. 2012
  7. doi Correlates of T-cell-mediated viral control and phenotype of CD8(+) T cells in HIV-2, a naturally contained human retroviral infection
    Thushan I de Silva
    Medical Research Council United Kingdom Laboratories The Gambia, Fajara, The Gambia, West Africa
    Blood 121:4330-9. 2013
  8. pmc Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource Settings
    Kevin Peterson
    Medical Research Council UK Laboratories, Atlantic Road, P O Box 273, Fajara, Gambia
    AIDS Res Treat 2011:463704. 2011

Detail Information

Publications8

  1. pmc HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form
    Thushan I de Silva
    Medical Research Council UK Laboratories, Atlantic Road, Fajara, The Gambia
    Retrovirology 7:82. 2010
    ..Detailed local HIV-1 sequence data are essential for monitoring the HIV epidemic, for maintaining sensitive sequence-based diagnostics, and to aid in designing vaccines...
  2. pmc Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa
    Balint Stewart
    Medical Research Council, Fajara, P O Box 273, Banjul, The Gambia, West Africa
    BMC Res Notes 4:561. 2011
    ..abstract:..
  3. doi HIV-2: the forgotten AIDS virus
    Thushan I de Silva
    Medical Research Council Laboratories, Atlantic Road, PO Box 273, Fajara, The Gambia, West Africa
    Trends Microbiol 16:588-95. 2008
    ..Studies to date have suggested that both enhanced immune responses and lower viral replication could play a role. We summarize the important findings to date and highlight areas that warrant further exploration...
  4. doi Population dynamics of HIV-2 in rural West Africa: comparison with HIV-1 and ongoing transmission at the heart of the epidemic
    Thushan I de Silva
    Medical Research Council UK Laboratories, Fajara, The Gambia
    AIDS 27:125-34. 2013
    ..To compare the population dynamics of HIV-2 and HIV-1, and to characterize ongoing HIV-2 transmission in rural Guinea-Bissau...
  5. pmc Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau
    Carla van Tienen
    Virology, Medical Research Council, Fajara, The Gambia
    PLoS Negl Trop Dis 6:e1690. 2012
    ..It is not known which HTLV-1 variants are present in this community. Sequence data can provide insights in the molecular epidemiology and help to understand the origin and spread of HTLV-1...
  6. pmc Potent autologous and heterologous neutralizing antibody responses occur in HIV-2 infection across a broad range of infection outcomes
    Thushan I de Silva
    Medical Research Council United Kingdom Laboratories, Fajara, The Gambia
    J Virol 86:930-46. 2012
    ....
  7. doi Correlates of T-cell-mediated viral control and phenotype of CD8(+) T cells in HIV-2, a naturally contained human retroviral infection
    Thushan I de Silva
    Medical Research Council United Kingdom Laboratories The Gambia, Fajara, The Gambia, West Africa
    Blood 121:4330-9. 2013
    ..These data reveal the potential T-cell correlates of HIV-2 control and the detailed phenotype of virus-specific CD8(+) T cells in a naturally contained retroviral infection...
  8. pmc Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource Settings
    Kevin Peterson
    Medical Research Council UK Laboratories, Atlantic Road, P O Box 273, Fajara, Gambia
    AIDS Res Treat 2011:463704. 2011
    ..Following review of the available evidence and taking the structure and challenges of antiretroviral care in West Africa into consideration, the authors make recommendations and highlight the needs of special populations...