R A Adegbola

Summary

Affiliation: Medical Research Council Laboratories
Country: The Gambia

Publications

  1. pmc Sequence and functional analyses of Haemophilus spp. genomic islands
    Mario Juhas
    Clinical Microbiology and Infectious Diseases, NDCLS, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Genome Biol 8:R237. 2007
  2. pmc Health seeking behaviour, health system experience and tuberculosis case finding in Gambians with cough
    Yaya Kasse
    Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Public Health 6:143. 2006
  3. pmc Risk factors for pulmonary tuberculosis: a clinic-based case control study in The Gambia
    Philip C Hill
    Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Public Health 6:156. 2006
  4. pmc Seasonality and outbreak of a predominant Streptococcus pneumoniae serotype 1 clone from The Gambia: expansion of ST217 hypervirulent clonal complex in West Africa
    Martin Antonio
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Microbiol 8:198. 2008
  5. pmc Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases
    Alexander M Aiken
    Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Infect Dis 6:66. 2006
  6. pmc Molecular epidemiology of pneumococci obtained from Gambian children aged 2-29 months with invasive pneumococcal disease during a trial of a 9-valent pneumococcal conjugate vaccine
    Martin Antonio
    Medical Research Council Laboratories, Banjul, The Gambia
    BMC Infect Dis 8:81. 2008
  7. pmc Immunogenicity of antigens from the TbD1 region present in M. africanum and missing from "modern" M. tuberculosis: a cross- sectional study
    Bouke C de Jong
    Bacterial Diseases Programme, MRC Laboratories, POB 273, Banjul, The Gambia
    BMC Infect Dis 10:11. 2010
  8. pmc Comparison of two interferon gamma release assays in the diagnosis of Mycobacterium tuberculosis infection and disease in The Gambia
    Ifedayo M O Adetifa
    Bacterial Diseases Programme, Medical Research Council Laboratories, Fajara, The Gambia
    BMC Infect Dis 7:122. 2007
  9. pmc Bacteraemia in patients admitted to an urban hospital in West Africa
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Infect Dis 7:2. 2007
  10. pmc Exogenous re-infection by a novel Streptococcus pneumoniae serotype 14 as a cause of recurrent meningitis in a child from The Gambia
    Martin Antonio
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia, Africa
    Ann Clin Microbiol Antimicrob 8:3. 2009

Research Grants

  1. Genotypes of Helicobacter Pylori in West Africa
    Richard Adegbola; Fiscal Year: 2005

Detail Information

Publications64

  1. pmc Sequence and functional analyses of Haemophilus spp. genomic islands
    Mario Juhas
    Clinical Microbiology and Infectious Diseases, NDCLS, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Genome Biol 8:R237. 2007
    ..More clarity comes from this comparative analysis of seven complete sequences of the ICEHin1056 genomic island subfamily...
  2. pmc Health seeking behaviour, health system experience and tuberculosis case finding in Gambians with cough
    Yaya Kasse
    Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Public Health 6:143. 2006
    ..We aimed to study health-seeking behaviour and experience of those with cough in The Gambia and to identify whether they had tuberculosis...
  3. pmc Risk factors for pulmonary tuberculosis: a clinic-based case control study in The Gambia
    Philip C Hill
    Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Public Health 6:156. 2006
    ..We aimed to identify risk factors for pulmonary tuberculosis in those attending a general outpatients clinic in The Gambia, a sub-Saharan African country with relatively low HIV prevalence in the community and in TB patients...
  4. pmc Seasonality and outbreak of a predominant Streptococcus pneumoniae serotype 1 clone from The Gambia: expansion of ST217 hypervirulent clonal complex in West Africa
    Martin Antonio
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Microbiol 8:198. 2008
    ..This study compares the molecular epidemiology of S. pneumoniae serotype 1 causing invasive disease in The Gambia between 1996 and 2005 to those carried in the nasopharynx between 2004 and 2006...
  5. pmc Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases
    Alexander M Aiken
    Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Infect Dis 6:66. 2006
    ..We hypothesized that TB patients in The Gambia would have reduced ELISPOT counts after successful treatment...
  6. pmc Molecular epidemiology of pneumococci obtained from Gambian children aged 2-29 months with invasive pneumococcal disease during a trial of a 9-valent pneumococcal conjugate vaccine
    Martin Antonio
    Medical Research Council Laboratories, Banjul, The Gambia
    BMC Infect Dis 8:81. 2008
    ..The study describes the molecular epidemiology of Streptococcus pneumoniae causing invasive disease in Gambian children..
  7. pmc Immunogenicity of antigens from the TbD1 region present in M. africanum and missing from "modern" M. tuberculosis: a cross- sectional study
    Bouke C de Jong
    Bacterial Diseases Programme, MRC Laboratories, POB 273, Banjul, The Gambia
    BMC Infect Dis 10:11. 2010
    ..M. africanum causes up to half of TB in West- Africa and its relatively lower progression to disease suggests the presence of a large reservoir of latent infection relative to M. tuberculosis...
  8. pmc Comparison of two interferon gamma release assays in the diagnosis of Mycobacterium tuberculosis infection and disease in The Gambia
    Ifedayo M O Adetifa
    Bacterial Diseases Programme, Medical Research Council Laboratories, Fajara, The Gambia
    BMC Infect Dis 7:122. 2007
    ..We compared the diagnostic performance of an in-house T -cell and commercial whole blood-based IGRAs for the diagnosis of LTBI and TB disease in The Gambia...
  9. pmc Bacteraemia in patients admitted to an urban hospital in West Africa
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Infect Dis 7:2. 2007
    ..Few studies on bacteraemia in Africa have been published. We aimed to prospectively identify the causative organisms of bacteraemia in The Gambia and their relation to clinical diagnoses, outcome and antimicrobial susceptibility...
  10. pmc Exogenous re-infection by a novel Streptococcus pneumoniae serotype 14 as a cause of recurrent meningitis in a child from The Gambia
    Martin Antonio
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia, Africa
    Ann Clin Microbiol Antimicrob 8:3. 2009
    ..eBURST analysis revealed that isolates from the two episodes of meningitis belonged to hypervirulent ST63 and ST3321 clonal complexes respectively...
  11. ncbi request reprint Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996-2003
    Richard A Adegbola
    Bacterial Diseases Programme, Medical Research Council Laboratories, PO Box 273, Banjul, The Gambia
    Trop Med Int Health 11:1128-35. 2006
    ..To describe the characteristics of pneumococcal isolates obtained from patients with invasive pneumococcal disease in The Gambia...
  12. ncbi request reprint Elimination of Haemophilus influenzae type b (Hib) disease from The Gambia after the introduction of routine immunisation with a Hib conjugate vaccine: a prospective study
    Richard A Adegbola
    Medical Research Council Laboratories, The Gambia
    Lancet 366:144-50. 2005
    ..We investigated the effectiveness of the vaccine when delivered through the expanded programme on immunisation and the effect of national immunisation on incidence of Hib disease...
  13. ncbi request reprint Surveillance of drug-resistant Mycobacterium tuberculosis in The Gambia
    R A Adegbola
    Medical Research Council Laboratories, Banjul, The Gambia, West Africa
    Int J Tuberc Lung Dis 7:390-3. 2003
    ..tuberculosis had previously been treated for tuberculosis. Drug-resistant tuberculosis is, as yet, not common in The Gambia. Periodic surveys for drug-resistant tuberculosis are recommended to monitor changes that may emerge over time...
  14. ncbi request reprint Diagnosis of childhood pneumonia in the tropics
    R A Adegbola
    Pneumonia Research Programme, Medical Research Council Laboratories, Fajara, Banjul
    Ann Trop Med Parasitol 94:197-207. 2000
    ..There is, however, considerable scope to improve the use of the cheaper techniques, and so facilitate the development and implementation of effective control measures...
  15. ncbi request reprint Vaccination with a Haemophilus influenzae type b conjugate vaccine reduces oropharyngeal carriage of H. influenzae type b among Gambian children
    R A Adegbola
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    J Infect Dis 177:1758-61. 1998
    ..001). Hib carriage varied by year among nonvaccinated children. Hib conjugate vaccines are likely to produce a herd protective effect in underdeveloped communities, as recorded in Europe and the United States...
  16. doi request reprint Immunogenicity and serotype-specific efficacy of a 9-valent pneumococcal conjugate vaccine (PCV-9) determined during an efficacy trial in The Gambia
    M Saaka
    Medical Research Council Laboratories, Fajara, Banjul, Gambia
    Vaccine 26:3719-26. 2008
    ..3 microg/ml (95% CI: 1.0, 5.0). The PCV-9 studied was immunogenic in a Gambian population where it was also found to be efficacious...
  17. ncbi request reprint Safety and immunogenicity of a nonavalent pneumococcal vaccine conjugated to CRM197 administered simultaneously but in a separate syringe with diphtheria, tetanus and pertussis vaccines in Gambian infants
    S K Obaro
    Medical Research Council Laboratories, Fajara, The Gambia
    Pediatr Infect Dis J 19:463-9. 2000
    ..Unrelenting high morbidity and mortality have mandated that immunogenic vaccines be used to combat pneumococcal disease in infants...
  18. pmc FOXP3 gene expression in a tuberculosis case contact study
    S Burl
    Tuberculosis Division, Bacterial Diseases Programme, Medical Research Council UK Unit, Banjul, The Gambia, West Africa
    Clin Exp Immunol 149:117-22. 2007
    ..While these findings do not reveal the role, beneficial or harmful, of T(regs) in TB, they emphasize the probable importance of these cells...
  19. ncbi request reprint Clinical presentation and outcome of tuberculosis patients infected by M. africanum versus M. tuberculosis
    B C de Jong
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    Int J Tuberc Lung Dis 11:450-6. 2007
    ..A tuberculosis (TB) case contact study in the Gambia...
  20. doi request reprint Haematological values from a Gambian cohort--possible reference range for a West African population
    I M O Adetifa
    Bacterial Diseases Programme, Medical Research Council UK Laboratories, The Gambia
    Int J Lab Hematol 31:615-22. 2009
    ..006). The mean and median values of haematological parameters in The Gambia are similar to other standards but the 90% reference range for each parameter encompasses lower values when compared with Western standards...
  21. doi request reprint Transthoracic lung aspiration for the aetiological diagnosis of pneumonia: 25 years of experience from The Gambia
    R C Ideh
    Clinical Services Department, Medical Research Council Laboratories, Banjul, The Gambia
    Int J Tuberc Lung Dis 15:729-35. 2011
    ..Lung aspiration is currently the most sensitive method for diagnosing pneumonia in children. With appropriate training and precautions it can be safely used for routine diagnosis in suitable referral hospitals...
  22. doi request reprint Spatial analysis of tuberculosis in an urban west African setting: is there evidence of clustering?
    K Touray
    Bacterial Diseases Programme, MRC Laboratories, Banjul, The Gambia
    Trop Med Int Health 15:664-72. 2010
    ..To describe the pattern of tuberculosis (TB) occurrence in Greater Banjul, The Gambia with Geographical Information Systems (GIS) and Spatial Scan Statistics (SaTScan) and to determine whether there is significant TB case clustering...
  23. ncbi request reprint Rising ELISPOT count prior to the onset of symptoms of full-blown tuberculosis disease
    I M O Adetifa
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    Int J Tuberc Lung Dis 11:350-2. 2007
    ..This case illustrates the possible utility of quantitative changes in the ELISPOT count in predicting progression from M. tuberculosis infection to disease...
  24. doi request reprint Antibody and T-cell responses during acute and convalescent stages of invasive pneumococcal disease
    M O C Ota
    Bacterial Diseases Programme, Medical Research Council Laboratories, PO Box 273, Banjul, The Gambia
    Int J Infect Dis 15:e282-8. 2011
    ..To understand the pattern of immune responses to pneumococcal proteins during invasive disease as a guide to their development as vaccine candidates...
  25. ncbi request reprint Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial
    F T Cutts
    Medical Research Council Laboratories, Banjul, The Gambia
    Lancet 365:1139-46. 2005
    ..Pneumonia is estimated to cause 2 million deaths every year in children. Streptococcus pneumoniae is the most important cause of severe pneumonia. We aimed to assess the efficacy of a nine-valent pneumococcal conjugate vaccine in children...
  26. ncbi request reprint Etiology of serious infections in young Gambian infants
    E K Mulholland
    Medical Research Council Laboratories, Banjul, The Gambia
    Pediatr Infect Dis J 18:S35-41. 1999
    ..The study described in this paper was conducted to determine the bacterial and viral etiology of serious infections in Gambian infants younger than 91 days old...
  27. ncbi request reprint Evaluation of Binax now Streptococcus pneumoniae urinary antigen test in children in a community with a high carriage rate of pneumococcus
    R A Adegbola
    MRC Laboratories, Banjul, The Gambia
    Pediatr Infect Dis J 20:718-9. 2001
    ..The positive predictive value for carriage was 96%, and the negative predictive value was 22%. The test is not useful for predicting etiology of disease in populations with a high rate of nasopharyngeal carriage of pneumococci...
  28. ncbi request reprint Respiratory rate as a predictor of positive lung aspirates in young Gambian children with lobar pneumonia
    A G Falade
    Medical Research Council Laboratories, Fajara, The Gambia
    Ann Trop Paediatr 21:293-7. 2001
    ..A respiratory rate of > or = 50 breaths/min in children with radiological evidence of lobar pneumonia would support lung aspiration as a positive result is significantly more likely than in children with a lower respiratory rate...
  29. ncbi request reprint Identifying ELISPOT and skin test cut-offs for diagnosis of Mycobacterium tuberculosis infection in The Gambia
    D J Jeffries
    Medical Research Council Labs, Bacterial Diseases Programme, Banjul, The Gambia
    Int J Tuberc Lung Dis 10:192-8. 2006
    ..An urban area, The Gambia...
  30. ncbi request reprint DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans
    R Olesen
    MRC Laboratories, Banjul, The Gambia
    Genes Immun 8:456-67. 2007
    ..78, 95% CI 0.63-0.98). Our findings support previous data showing that VDR SNPs modulate the risk for TB in West Africans and suggest that variation within DC-SIGN and PTX3 also affect the disease outcome...
  31. ncbi request reprint Intracellular lipophilic inclusions of mycobacteria in vitro and in sputum
    Natalie J Garton
    Department of Microbiology and Immunology and Department of Chemistry, University of Newcastle, Newcastle upon Tyne, UK
    Microbiology 148:2951-8. 2002
    ..These findings indicate that the uptake of long-chain fatty acids and TAG biosynthetic and degradative pathways are important aspects of mycobacterial lipid metabolism, meriting further investigation...
  32. ncbi request reprint The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-gamma producing cells ex vivo
    Martin O C Ota
    Bacterial Diseases Programme, Medical Research Council, P O Box 273, Banjul, Gambia
    Vaccine 25:8861-7. 2007
    ..We conclude that BCG is immunogenic, but this effector response is short-lived and can be limited in higher pre-existing anti-mycobacterial immunity, suggesting a possible threshold beyond which BCG immunogenicity is inhibited...
  33. ncbi request reprint Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae
    Hedwig E Deubzer
    Imperial College, Faculty of Medicine, Department of Immunology, Chelsea and Westminster Hospital, London, United Kingdom
    J Infect Dis 190:1758-61. 2004
    ..In breast-feeding populations, maternal vaccination might prevent pneumococcal disease in young infants...
  34. doi request reprint Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression
    Abdulrahman S Hammond
    Bacterial and Viral Diseases Programme, Medical Research Council Laboratories, Fajara, Banjul, The Gambia, West Africa
    J Infect Dis 197:295-9. 2008
    ..This may reflect early signs of reactivation, reinfection, or a restricted, inefficient immune response to Mycobacterium tuberculosis...
  35. pmc Beyond good intentions: lessons on equipment donation from an African hospital
    Stephen R C Howie
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    Bull World Health Organ 86:52-6. 2008
    ..The concentrators broke down and were put into storage. A case study was done to find the reasons for the problem and to draw lessons to help improve both oxygen supplies and the success of future equipment donations...
  36. doi request reprint Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants: a longitudinal study
    Philip C Hill
    Bacterial Diseases Programme, MRC Laboratories, Banjul, The Gambia
    Clin Infect Dis 46:807-14. 2008
    ..To prepare for national introduction of a pneumococcal conjugate vaccine of restricted valency, we studied nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants...
  37. doi request reprint C-reactive protein and procalcitonin in the evaluation of the efficacy of a pneumococcal conjugate vaccine in Gambian children
    Yin Bun Cheung
    London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 13:603-11. 2008
    ..To determine the value of C-reactive protein (CRP) and procalcitonin in the evaluation of the efficacy of a pneumococcal conjugate vaccine in Gambian children...
  38. pmc A novel Campylobacter jejuni sequence type from a culture-negative patient in the Gambia
    Gerard A J Morris
    Bacterial Diseases Programme, Medical Research Council Laboratories, Fajara, The Gambia
    PLoS ONE 3:e1773. 2008
    ..Improvements in diagnostics are needed, and will be important not only for sick individuals but also for populations, where better measures of disease burden will contribute significantly to the improvement of public health policy...
  39. pmc Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum
    Natalie J Garton
    Department of Infection, Immunity and Inflammation, University of Leicester Medical School, Leicester, United Kingdom
    PLoS Med 5:e75. 2008
    ..A preliminary observation that Mycobacterium tuberculosis cells contain triacylglycerol lipid bodies in sputum, but not when growing in vitro, led us to investigate the extent of this phenomenon and its physiological basis...
  40. ncbi request reprint Incidence of tuberculosis and survival after its diagnosis in patients infected with HIV-1 and HIV-2
    Marianne A B van der Sande
    London School of Hygiene and Tropical Medicine, London, UK
    AIDS 18:1933-41. 2004
    ..HIV-2 has been associated with less immune suppression, slower disease progression and longer survival...
  41. ncbi request reprint Clinical predictors of bacterial meningitis in infants and young children in The Gambia
    Martin W Weber
    Medical Research Council Laboratories, Fajara, The Gambia
    Trop Med Int Health 7:722-31. 2002
    ....
  42. ncbi request reprint Pneumonia and child mortality
    Stephen R C Howie
    Lancet 368:1646. 2006
  43. ncbi request reprint Large-scale evaluation of enzyme-linked immunospot assay and skin test for diagnosis of Mycobacterium tuberculosis infection against a gradient of exposure in The Gambia
    Philip C Hill
    Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
    Clin Infect Dis 38:966-73. 2004
    ..ESAT-6/CFP-10 ELISPOT probably offers increased specificity in the diagnosis of M. tuberculosis infection in this tropical setting of endemicity, at the cost of some sensitivity...
  44. pmc Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in The Gambia
    Bouke C de Jong
    Medical Research Council Laboratories, Banjul, The Gambia
    J Infect Dis 198:1037-43. 2008
    ..There is considerable variability in the outcome of Mycobacterium tuberculosis infection. We hypothesized that Mycobacterium africanum was less likely than M. tuberculosis to transmit and progress to tuberculosis disease...
  45. ncbi request reprint Serotype-specific pneumococcal antibodies in breast milk of Gambian women immunized with a pneumococcal polysaccharide vaccine during pregnancy
    Stephen K Obaro
    Imperial College, School of Science, Technology and Medicine, Department of Immunology, Chelsea and Westminster Hospital, London, United Kingdom
    Pediatr Infect Dis J 23:1023-9. 2004
    ..In breast-feeding populations, immunization during pregnancy with pneumococcal polysaccharide offers a potentially useful approach to preventing pneumococcal disease in young infants...
  46. ncbi request reprint Molecular epidemiology of community-acquired invasive non-typhoidal Salmonella among children aged 2 29 months in rural Gambia and discovery of a new serovar, Salmonella enterica Dingiri
    Usman N Ikumapayi
    Medical Research Council Laboratories, Banjul, The Gambia, West Africa
    J Med Microbiol 56:1479-84. 2007
    ..S. Dingiri, which possesses an antigenic formula of 17:z:1,6, was sensitive to ampicillin, cefotaxime, chloramphenicol, ciprofloxacin, cotrimoxazole and tetracycline but resistant to gentamicin, and was ST338...
  47. ncbi request reprint The role of Chlamydia pneumoniae in acute respiratory tract infections in young children in The Gambia, West Africa
    Martin W Weber
    Medical Research Council Laboratories, Fajara, The Gambia
    Ann Trop Paediatr 26:87-94. 2006
    ..Little is known about the role of Chlamydia pneumoniae in the aetiology of acute respiratory tract infections (ARI) in children in developing countries...
  48. ncbi request reprint Mycobacterium africanum elicits an attenuated T cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and their household contacts
    Bouke C de Jong
    Medical Research Council Laboratories, The Gambia
    J Infect Dis 193:1279-86. 2006
    ..Mycobacterium africanum, a member of the M. tuberculosis complex that is infrequently found outside of western Africa, is the cause of up to half of the tuberculosis cases there...
  49. ncbi request reprint Pneumococcal vaccination in developing countries
    Orin S Levine
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 367:1880-2. 2006
  50. ncbi request reprint The long-term natural history of trachomatous trichiasis in the Gambia
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 47:847-52. 2006
    ..Trachoma is the leading infectious cause of blindness. However, there are few data on the natural history of trachomatous trichiasis to guide program planning or that investigate its pathogenesis...
  51. ncbi request reprint Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design
    Hannah B Ibanga
    MRC Laboratories, Fajara, The Gambia
    Lancet Infect Dis 6:522-8. 2006
    ..These issues are highly relevant to early clinical trials with all new tuberculosis vaccines in the developing world...
  52. ncbi request reprint Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    Clin Infect Dis 43:673-9. 2006
    ..To prepare for the introduction of a pneumococcal conjugate vaccine of restricted valency, we studied the nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers...
  53. ncbi request reprint Mycobacterium africanum: a new opportunistic pathogen in HIV infection?
    Bouke C de Jong
    AIDS 19:1714-5. 2005
  54. pmc ESAT-6/CFP-10 fusion protein and peptides for optimal diagnosis of mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in the Gambia
    Philip C Hill
    Tuberculosis Division, Bacterial Diseases Programme, Medical Research Council Unit, MRC Labs, P O Box 273, Banjul, The Gambia
    J Clin Microbiol 43:2070-4. 2005
    ..007). A fusion protein of ESAT-6 and CFP-10 is equivalent to overlapping peptides for the diagnosis of latent M. tuberculosis infection. Use of a combination of peptides and fusion protein offers improved sensitivity...
  55. ncbi request reprint Screening for tuberculosis among 2381 household contacts of sputum-smear-positive cases in The Gambia
    Dolly Jackson-Sillah
    Bacterial Diseases Programme, MRC Laboratories, Box 273, Banjul, The Gambia
    Trans R Soc Trop Med Hyg 101:594-601. 2007
    ..These individuals are a high-risk group, and the disease identified is less advanced than that found through passive case detection. An ELISPOT assay was relatively insensitive as a screening test for TB...
  56. ncbi request reprint Quantitative T cell assay reflects infectious load of Mycobacterium tuberculosis in an endemic case contact model
    Philip C Hill
    Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
    Clin Infect Dis 40:273-8. 2005
    ..tuberculosis infection. We evaluated the quantitative ELISPOT and PPD skin test responses to recent M. tuberculosis exposure...
  57. ncbi request reprint Bacterial infections--a major cause of death among children in Africa
    E Kim Mulholland
    N Engl J Med 352:75-7. 2005
  58. pmc Longitudinal assessment of an ELISPOT test for Mycobacterium tuberculosis infection
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia
    PLoS Med 4:e192. 2007
    ..To address this deficiency, we conducted a longitudinal assessment of the enzyme-linked immunosorbent spot test (ELISPOT) test in comparison to the standard tuberculin skin test (TST)...
  59. ncbi request reprint Comparison of enzyme-linked immunospot assay and tuberculin skin test in healthy children exposed to Mycobacterium tuberculosis
    Philip C Hill
    Tuberculosis Division, Mulago Hospital Complex, Kampala, Uganda
    Pediatrics 117:1542-8. 2006
    ..To compare the enzyme-linked immunospot (ELISPOT) assay with the tuberculin skin test (TST) in children for the diagnosis of Mycobacterium tuberculosis infection in the Gambia...
  60. ncbi request reprint Re-emergence of Haemophilus influenzae type b (Hib) disease in The Gambia following successful elimination with conjugate Hib vaccine
    Stephen R C Howie
    Bacterial Diseases Programme, Medical Research Council Laboratories, P O Box 273, Banjul, Gambia
    Vaccine 25:6305-9. 2007
    ....
  61. ncbi request reprint Bacterial infection and trachoma in the gambia: a case control study
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 48:4440-4. 2007
    ..This study was undertaken to investigate whether trachomatous trichiasis or conjunctival scarring are associated with increased prevalence of bacterial infection...
  62. pmc Incidence of tuberculosis and the predictive value of ELISPOT and Mantoux tests in Gambian case contacts
    Philip C Hill
    Bacterial Diseases Programme, Medical Research Council MRC Laboratories, Banjul, The Gambia
    PLoS ONE 3:e1379. 2008
    ..tuberculosis and the human host and for assessing new interventions and diagnostic tests. We aimed to identify the incidence rate of new TB cases among TB contacts and to relate this to their initial Mantoux and ELISPOT test results...
  63. ncbi request reprint Effectiveness of an early supplementation scheme of high-dose vitamin A versus standard WHO protocol in Gambian mothers and infants: a randomised controlled trial
    Momodou K Darboe
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 369:2088-96. 2007
    ....
  64. pmc Novel 180- and 480-base-pair insertions in African and African-American strains of Helicobacter pylori
    Shannon L McNulty
    Department of Biology, The College of William and Mary, 214 Millington Hall, Landrum Drive, Williamsburg, VA 23187, USA
    J Clin Microbiol 42:5658-63. 2004
    ..Apparent differences between African-American and Caucasian-American H. pylori gene pools may bear on our understanding of H. pylori transmission and disease outcome...

Research Grants1

  1. Genotypes of Helicobacter Pylori in West Africa
    Richard Adegbola; Fiscal Year: 2005
    ..pylori colonization in West Africa differ from those seen in industrialized nations, and enable the development of appropriate treatment strategies for communities such as The Gambia. ..