Simon E Fisher


Affiliation: Max Planck Institute for Psycholinguistics
Country: The Netherlands


  1. Fisher S. Human Genetics: The Evolving Story of FOXP2. Curr Biol. 2019;29:R65-R67 pubmed publisher
    ..A new study re-evaluates genomic variation at the human FOXP2 locus but finds no evidence of recent adaptive evolution. ..
  2. Gunz P, Tilot A, Wittfeld K, Teumer A, Shapland C, van Erp T, et al. Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity. Curr Biol. 2019;29:120-127.e5 pubmed publisher
    ..Our findings show how integration of fossil skull data with archaic genomics and neuroimaging can suggest developmental mechanisms that may contribute to the unique modern human endocranial shape. ..
  3. Snijders Blok L, Rousseau J, Twist J, Ehresmann S, Takaku M, Venselaar H, et al. CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language. Nat Commun. 2018;9:4619 pubmed publisher
    ..We implicate de novo CHD3 mutations in a syndrome characterized by intellectual disability, macrocephaly, and impaired speech and language. ..
  4. den Hoed J, Sollis E, Venselaar H, Estruch S, Deriziotis P, Fisher S. Functional characterization of TBR1 variants in neurodevelopmental disorder. Sci Rep. 2018;8:14279 pubmed publisher
  5. French C, Vinueza Veloz M, Zhou K, Peter S, Fisher S, Costa R, et al. Differential effects of Foxp2 disruption in distinct motor circuits. Mol Psychiatry. 2018;: pubmed publisher
    ..Our findings show that Foxp2 can modulate different aspects of motor behaviour in distinct brain regions, and uncover an unknown role for Foxp2 in the modulation of Purkinje cell activity that severely impacts skilled movements. ..
  6. Gingras B, Honing H, Peretz I, Trainor L, Fisher S. Defining the biological bases of individual differences in musicality. Philos Trans R Soc Lond B Biol Sci. 2015;370:20140092 pubmed publisher
    ..Here, we offer a synthesis of existing literatures and outline concrete suggestions for the development of comprehensive operational tools for the analysis of musical phenotypes. ..
  7. Gialluisi A, Guadalupe T, Francks C, Fisher S. Neuroimaging genetic analyses of novel candidate genes associated with reading and language. Brain Lang. 2017;172:9-15 pubmed publisher
    ..In future, this hypothesis could be tested using sufficiently large samples containing both neuroimaging data and quantitative reading/language scores from the same individuals. ..
  8. Eising E, Carrion Castillo A, Vino A, Strand E, Jakielski K, Scerri T, et al. A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development. Mol Psychiatry. 2018;: pubmed publisher
    ..This study highlights gene regulatory pathways in the developing brain that may contribute to acquisition of proficient speech. ..
  9. Tilot A, Kucera K, Vino A, Asher J, Baron Cohen S, Fisher S. Rare variants in axonogenesis genes connect three families with sound-color synesthesia. Proc Natl Acad Sci U S A. 2018;115:3168-3173 pubmed publisher
    ..These results are consistent with neuroimaging-based hypotheses about the role of hyperconnectivity in the etiology of synesthesia and offer a potential entry point into the neurobiology that organizes our sensory experiences. ..

More Information


  1. Deriziotis P, Graham S, Estruch S, Fisher S. Investigating protein-protein interactions in live cells using bioluminescence resonance energy transfer. J Vis Exp. 2014;: pubmed publisher
  2. Dias C, Estruch S, Graham S, McRae J, Sawiak S, Hurst J, et al. BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription. Am J Hum Genet. 2016;99:253-74 pubmed publisher
    ..Thus, our work implicates BCL11A haploinsufficiency in neurodevelopmental disorders and defines additional targets regulated by this gene, with broad relevance for our understanding of ID and related syndromes. ..
  3. Deriziotis P, Fisher S. Speech and Language: Translating the Genome. Trends Genet. 2017;33:642-656 pubmed publisher
    ..We consider the future of the field, highlighting the unusual challenges and opportunities associated with studying genomics of language-related traits. ..
  4. Fisher S. Evolution of language: Lessons from the genome. Psychon Bull Rev. 2017;24:34-40 pubmed publisher
    ..Of course, this endeavour remains challenging on many fronts, as I also highlight in the article. Nonetheless, such an integrated approach holds great potential for untangling the complexities of the capacities that make us human. ..