R F A Zwaal

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Surface exposure of phosphatidylserine in pathological cells
    R F A Zwaal
    Dept of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, Netherlands
    Cell Mol Life Sci 62:971-88. 2005
  2. ncbi request reprint Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids
    Robert F A Zwaal
    Cardiovascular Research Institute Maastricht, and Department of Biochemistry, Maastricht University, PO Box 616, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1636:119-28. 2004
  3. doi request reprint Direct inhibition of phospholipid scrambling activity in erythrocytes by potassium ions
    J L N Wolfs
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cell Mol Life Sci 66:314-23. 2009
  4. ncbi request reprint Activated scramblase and inhibited aminophospholipid translocase cause phosphatidylserine exposure in a distinct platelet fraction
    J L N Wolfs
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cell Mol Life Sci 62:1514-25. 2005
  5. ncbi request reprint Anti-prothrombin IgG from patients with anti-phospholipid antibodies inhibits the inactivation of factor Va by activated protein C
    Monica Galli
    Department of Haematology, Ospedali Riuniti, Bergamo, Italy
    Br J Haematol 129:240-7. 2005
  6. pmc Quantitative determination of the binding of beta2-glycoprotein I and prothrombin to phosphatidylserine-exposing blood platelets
    Edouard M Bevers
    Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem J 386:271-9. 2005
  7. ncbi request reprint The effect of phospholipids on the formation of immune complexes between autoantibodies and beta2-glycoprotein I or prothrombin
    Edouard M Bevers
    Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Clin Immunol 112:150-60. 2004
  8. ncbi request reprint Kinetics of prothrombin-mediated binding of lupus anticoagulant antibodies to phosphatidylserine-containing phospholipid membranes: an ellipsometric study
    George M Willems
    Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Biochemistry 41:14357-63. 2002
  9. ncbi request reprint Anticoagulant and membrane-degrading effects of secretory (non-pancreatic) phospholipase A2 are inhibited in plasma
    Didier Billy
    Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Thromb Haemost 87:978-84. 2002
  10. pmc Comparison between Ca2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cells
    David W C Dekkers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem J 362:741-7. 2002

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Surface exposure of phosphatidylserine in pathological cells
    R F A Zwaal
    Dept of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, Netherlands
    Cell Mol Life Sci 62:971-88. 2005
    ..This review aims at highlighting how PS expression in different cells may complicate a variety of pathological conditions, including those that promote thromboembolic complications or produce aberrations in apoptotic cell removal...
  2. ncbi request reprint Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids
    Robert F A Zwaal
    Cardiovascular Research Institute Maastricht, and Department of Biochemistry, Maastricht University, PO Box 616, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1636:119-28. 2004
    ....
  3. doi request reprint Direct inhibition of phospholipid scrambling activity in erythrocytes by potassium ions
    J L N Wolfs
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cell Mol Life Sci 66:314-23. 2009
    ..Thus, opening of Ca(2+)-sensitive K(+) channels causes loss of intracellular K(+) that results in reduced intrinsic inhibitory effect of these ions on scramblase activity...
  4. ncbi request reprint Activated scramblase and inhibited aminophospholipid translocase cause phosphatidylserine exposure in a distinct platelet fraction
    J L N Wolfs
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cell Mol Life Sci 62:1514-25. 2005
    ..We conclude that, irrespective of the agonist, procoagulant platelets exhibit maximal surface exposure of PS by switching on scramblase and inhibiting translocase activity...
  5. ncbi request reprint Anti-prothrombin IgG from patients with anti-phospholipid antibodies inhibits the inactivation of factor Va by activated protein C
    Monica Galli
    Department of Haematology, Ospedali Riuniti, Bergamo, Italy
    Br J Haematol 129:240-7. 2005
    ..Most, although not all, IgG containing anti-prothrombin antibodies inhibit the APC-catalysed FVa inactivation, which may contribute to the increased risk of thrombosis in patients with the anti-phospholipid syndrome...
  6. pmc Quantitative determination of the binding of beta2-glycoprotein I and prothrombin to phosphatidylserine-exposing blood platelets
    Edouard M Bevers
    Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem J 386:271-9. 2005
    ..These findings are discussed in relation to the alleged (patho-)physiological functions of beta2GPI...
  7. ncbi request reprint The effect of phospholipids on the formation of immune complexes between autoantibodies and beta2-glycoprotein I or prothrombin
    Edouard M Bevers
    Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Clin Immunol 112:150-60. 2004
    ..It is further proposed that the rate of desorption of immune complexes may present a better indicator for the functional properties of the antibodies than the amount of adsorbed immune complexes...
  8. ncbi request reprint Kinetics of prothrombin-mediated binding of lupus anticoagulant antibodies to phosphatidylserine-containing phospholipid membranes: an ellipsometric study
    George M Willems
    Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Biochemistry 41:14357-63. 2002
    ..The kinetics of adsorption and desorption indicate that divalent binding of LA IgG to prothrombin at the lipid membrane occurs...
  9. ncbi request reprint Anticoagulant and membrane-degrading effects of secretory (non-pancreatic) phospholipase A2 are inhibited in plasma
    Didier Billy
    Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Thromb Haemost 87:978-84. 2002
    ..These findings indicate that the elevated plasma sPLA2 concentrations observed in inflammatory disease will not reduce hypercoagulability in such patients...
  10. pmc Comparison between Ca2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cells
    David W C Dekkers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem J 362:741-7. 2002
    ..We demonstrate that both the amino group and the size of the headgroup determine the kinetics of lipid scrambling, and that lipids with a ceramide backbone migrate much more slowly than glycerophospholipids with the same headgroup...
  11. ncbi request reprint Influence of erythrocyte shape on the rate of Ca2+-induced scrambling of phosphatidylserine
    Jef L N Wolfs
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, The Netherlands
    Mol Membr Biol 20:83-91. 2003
    ..It is concluded that the rate of calcium-induced phosphatidylserine exposure (rate of lipid scrambling) in erythrocytes depends for a considerable part on the cells' ability to form microvesicles...