R F A Zwaal
Affiliation: Maastricht University
Country: The Netherlands
- Surface exposure of phosphatidylserine in pathological cellsR F A Zwaal
Dept of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, Netherlands
Cell Mol Life Sci 62:971-88. 2005..This review aims at highlighting how PS expression in different cells may complicate a variety of pathological conditions, including those that promote thromboembolic complications or produce aberrations in apoptotic cell removal...
- Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipidsRobert F A Zwaal
Cardiovascular Research Institute Maastricht, and Department of Biochemistry, Maastricht University, PO Box 616, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
Biochim Biophys Acta 1636:119-28. 2004....
- Direct inhibition of phospholipid scrambling activity in erythrocytes by potassium ionsJ L N Wolfs
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
Cell Mol Life Sci 66:314-23. 2009..Thus, opening of Ca(2+)-sensitive K(+) channels causes loss of intracellular K(+) that results in reduced intrinsic inhibitory effect of these ions on scramblase activity...
- Activated scramblase and inhibited aminophospholipid translocase cause phosphatidylserine exposure in a distinct platelet fractionJ L N Wolfs
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
Cell Mol Life Sci 62:1514-25. 2005..We conclude that, irrespective of the agonist, procoagulant platelets exhibit maximal surface exposure of PS by switching on scramblase and inhibiting translocase activity...
- Anti-prothrombin IgG from patients with anti-phospholipid antibodies inhibits the inactivation of factor Va by activated protein CMonica Galli
Department of Haematology, Ospedali Riuniti, Bergamo, Italy
Br J Haematol 129:240-7. 2005..Most, although not all, IgG containing anti-prothrombin antibodies inhibit the APC-catalysed FVa inactivation, which may contribute to the increased risk of thrombosis in patients with the anti-phospholipid syndrome...
- Quantitative determination of the binding of beta2-glycoprotein I and prothrombin to phosphatidylserine-exposing blood plateletsEdouard M Bevers
Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Biochem J 386:271-9. 2005..These findings are discussed in relation to the alleged (patho-)physiological functions of beta2GPI...
- The effect of phospholipids on the formation of immune complexes between autoantibodies and beta2-glycoprotein I or prothrombinEdouard M Bevers
Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
Clin Immunol 112:150-60. 2004..It is further proposed that the rate of desorption of immune complexes may present a better indicator for the functional properties of the antibodies than the amount of adsorbed immune complexes...
- Kinetics of prothrombin-mediated binding of lupus anticoagulant antibodies to phosphatidylserine-containing phospholipid membranes: an ellipsometric studyGeorge M Willems
Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Biochemistry 41:14357-63. 2002..The kinetics of adsorption and desorption indicate that divalent binding of LA IgG to prothrombin at the lipid membrane occurs...
- Anticoagulant and membrane-degrading effects of secretory (non-pancreatic) phospholipase A2 are inhibited in plasmaDidier Billy
Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
Thromb Haemost 87:978-84. 2002..These findings indicate that the elevated plasma sPLA2 concentrations observed in inflammatory disease will not reduce hypercoagulability in such patients...
- Comparison between Ca2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cellsDavid W C Dekkers
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Biochem J 362:741-7. 2002..We demonstrate that both the amino group and the size of the headgroup determine the kinetics of lipid scrambling, and that lipids with a ceramide backbone migrate much more slowly than glycerophospholipids with the same headgroup...
- Influence of erythrocyte shape on the rate of Ca2+-induced scrambling of phosphatidylserineJef L N Wolfs
Department of Biochemistry, Cardiovascular Research Institute Maastricht, The Netherlands
Mol Membr Biol 20:83-91. 2003..It is concluded that the rate of calcium-induced phosphatidylserine exposure (rate of lipid scrambling) in erythrocytes depends for a considerable part on the cells' ability to form microvesicles...