Marieke Wichers

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi Reduced stress-sensitivity or increased reward experience: the psychological mechanism of response to antidepressant medication
    M C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 34:923-31. 2009
  2. ncbi Disentangling the causal inter-relationship between negative life events and depressive symptoms in women: a longitudinal twin study
    M Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Psychol Med 42:1801-14. 2012
  3. ncbi The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 33:3030-6. 2008
  4. ncbi Unveiling patterns of affective responses in daily life may improve outcome prediction in depression: a momentary assessment study
    M Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    J Affect Disord 124:191-5. 2010
  5. ncbi Transition from stress sensitivity to a depressive state: longitudinal twin study
    Marieke Wichers
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Vijverdalseweg 1, Concorde Building, Maastricht, The Netherlands
    Br J Psychiatry 195:498-503. 2009
  6. ncbi Mechanisms of gene-environment interactions in depression: evidence that genes potentiate multiple sources of adversity
    M Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Psychol Med 39:1077-86. 2009
  7. ncbi The psychology of psychiatric genetics: evidence that positive emotions in females moderate genetic sensitivity to social stress associated with the BDNF Val-sup-6-sup-6Met polymorphism
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    J Abnorm Psychol 117:699-704. 2008
  8. ncbi Susceptibility to depression expressed as alterations in cortisol day curve: a cross-twin, cross-trait study
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdalseweg 1, Concorde Building, Maastricht, Netherlands
    Psychosom Med 70:314-8. 2008
  9. ncbi Genetic risk of depression and stress-induced negative affect in daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdalseweg 1, Concorde Building, Maastricht, The Netherlands
    Br J Psychiatry 191:218-23. 2007
  10. ncbi The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:120-3. 2008

Detail Information

Publications42

  1. ncbi Reduced stress-sensitivity or increased reward experience: the psychological mechanism of response to antidepressant medication
    M C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 34:923-31. 2009
    ..A search for (synergistic) antidepressant therapies specifically targeting ability to experience reward may be warranted...
  2. ncbi Disentangling the causal inter-relationship between negative life events and depressive symptoms in women: a longitudinal twin study
    M Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Psychol Med 42:1801-14. 2012
    ..Additionally, third factors influencing both phenotypes may be involved. In this work we sought to disentangle these relationships using a genetically informative longitudinal design...
  3. ncbi The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 33:3030-6. 2008
    ..Genetic moderation of ecological measures of reward experience is hypothesized to be of major relevance to the development of various behavioral disorders, including depression and addiction...
  4. ncbi Unveiling patterns of affective responses in daily life may improve outcome prediction in depression: a momentary assessment study
    M Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    J Affect Disord 124:191-5. 2010
    ..Daily life affective responses are closely linked to vulnerability and resilience in depression. Prediction of future clinical course may be improved if information on daily life emotional response patterns is taken into account...
  5. ncbi Transition from stress sensitivity to a depressive state: longitudinal twin study
    Marieke Wichers
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Vijverdalseweg 1, Concorde Building, Maastricht, The Netherlands
    Br J Psychiatry 195:498-503. 2009
    ..Daily-life stress sensitivity is associated with depression, but prospective data are lacking...
  6. ncbi Mechanisms of gene-environment interactions in depression: evidence that genes potentiate multiple sources of adversity
    M Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Psychol Med 39:1077-86. 2009
    ....
  7. ncbi The psychology of psychiatric genetics: evidence that positive emotions in females moderate genetic sensitivity to social stress associated with the BDNF Val-sup-6-sup-6Met polymorphism
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    J Abnorm Psychol 117:699-704. 2008
    ..Interdisciplinary research in psychology and psychiatric genetics may lead to the improvement of treatment choices in stress-related disorders...
  8. ncbi Susceptibility to depression expressed as alterations in cortisol day curve: a cross-twin, cross-trait study
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdalseweg 1, Concorde Building, Maastricht, Netherlands
    Psychosom Med 70:314-8. 2008
    ..Alteration of diurnal secretion of cortisol is a possible endophenotype of depression, as depressed patients show alterations in cortisol dynamics over the day...
  9. ncbi Genetic risk of depression and stress-induced negative affect in daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdalseweg 1, Concorde Building, Maastricht, The Netherlands
    Br J Psychiatry 191:218-23. 2007
    ..A bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess...
  10. ncbi The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:120-3. 2008
    ..Higher order interaction effects involving BDNF Val(66)Met, 5-HTTLPR and childhood adversity may contribute to the etiology of depressive illness...
  11. ncbi IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity
    M C Wichers
    Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    Mol Psychiatry 10:538-44. 2005
    ....
  12. ncbi Evidence that moment-to-moment variation in positive emotions buffer genetic risk for depression: a momentary assessment twin study
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Acta Psychiatr Scand 115:451-7. 2007
    ..It was investigated whether positive affect (PA) buffers negative affect (NA) reactivity in response to stress and whether PA moderates the genetic predisposition to negative affect reactivity...
  13. ncbi Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, The Netherlands
    J Psychosom Res 62:207-14. 2007
    ..Therefore, the induction of depressive symptoms by interferon-alpha (IFN-alpha) may be mediated by changes in the cytokine network and the HPA axis...
  14. ncbi Baseline immune activation as a risk factor for the onset of depression during interferon-alpha treatment
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Biol Psychiatry 60:77-9. 2006
    ..This study prospectively investigated the hypothesis that baseline level of immune activation predicts the development of depression during interferon-alpha (IFN-alpha) treatment...
  15. ncbi Early increase in vegetative symptoms predicts IFN-alpha-induced cognitive-depressive changes
    M C Wichers
    Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands
    Psychol Med 35:433-41. 2005
    ..We hypothesized that the onset of vegetative-depressive symptoms early in the treatment with the pro-inflammatory cytokine IFN-alpha in chronic hepatitis C patients would increase the risk for subsequent depressive cognitions...
  16. ncbi The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    J Psychiatry Neurosci 29:11-7. 2004
    ..Both ROS overproduction and hippocampal atrophy caused by NMDA overstimulation have been associated with depression...
  17. ncbi A time-lagged momentary assessment study on daily life physical activity and affect
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Health Psychol 31:135-44. 2012
    ..The current study examined the effects of physical activity on affective state. A primary and within-study replication sample was derived from twin pairs...
  18. ncbi Identifying at-risk states beyond positive symptoms: a brief task assessing how neurocognitive impairments impact on misrepresentation of the social world through blunted emotional appraisal
    Mariana Galdos
    Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands
    Rev Bras Psiquiatr 33:s175-96. 2011
    ..Early intervention efforts would be served by further elucidation of this mechanism...
  19. ncbi Altered transfer of momentary mental states (ATOMS) as the basic unit of psychosis liability in interaction with environment and emotions
    Johanna T W Wigman
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 8:e54653. 2013
    ....
  20. ncbi Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor?
    Gunter Kenis
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Int J Neuropsychopharmacol 14:247-53. 2011
    ..These findings suggest that the effect of IFN-α-induced immune activation on depression may be explained in part by alterations in neuroprotective capacity, reflected by decreases in serum BDNF following IFN-α treatment...
  21. ncbi FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma
    Dina Collip
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, PO BOX 616 DRT 10, 6200 MD Maastricht, The Netherlands
    Br J Psychiatry 202:261-8. 2013
    ..FK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma...
  22. ncbi Genetic and environmental causes of individual differences in daily life positive affect and reward experience and its overlap with stress-sensitivity
    Claudia Menne-Lothmann
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdal, Postbus 616, 6200 MD, Maastricht, The Netherlands
    Behav Genet 42:778-86. 2012
    ..Stress-sensitivity, indexing depression vulnerability, and reward experience were non-overlapping, suggesting that resilience traits are independent from stress-sensitivity levels in a general population sample...
  23. ncbi Early improvement in positive rather than negative emotion predicts remission from depression after pharmacotherapy
    Nicole Geschwind
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Eur Neuropsychopharmacol 21:241-7. 2011
    ..Moreover, monitoring of positive emotions in early stages of treatment may improve clinical decision making...
  24. ncbi From epidemiology to daily life: linking daily life stress reactivity to persistence of psychotic experiences in a longitudinal general population study
    Dina Collip
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 8:e62688. 2013
    ....
  25. ncbi Mindfulness training increases momentary positive emotions and reward experience in adults vulnerable to depression: a randomized controlled trial
    Nicole Geschwind
    European Graduate School for Neuroscience, SEARCH, Department of Psychiatry and Psychology, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
    J Consult Clin Psychol 79:618-28. 2011
    ..To examine whether mindfulness-based cognitive therapy (MBCT) increases momentary positive emotions and the ability to make use of natural rewards in daily life...
  26. ncbi Genetic moderation of CO2-induced fear by 5-HTTLPR genotype
    Koen Schruers
    Academic Anxiety Center, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 25:37-42. 2011
    ..These results are in line with current theories on the role of 5-HT in both panic and respiration...
  27. ncbi Risk factors predicting onset and persistence of subthreshold expression of bipolar psychopathology among youth from the community
    M J A Tijssen
    Department of Psychiatry, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Acta Psychiatr Scand 122:255-66. 2010
    ..To examine factors increasing the risk for onset and persistence of subthreshold mania and depression...
  28. ncbi Psychiatric diagnosis revisited: towards a system of staging and profiling combining nomothetic and idiographic parameters of momentary mental States
    Johanna T W Wigman
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands Department of Psychiatry, Rob Giel Research Centre, University Medical Centre Groningen, Groningen, The Netherlands
    PLoS ONE 8:e59559. 2013
    ..This paper addressed the hypothesis that connection strength and connection variability between mental states differ in the hypothesized direction across different stages of psychopathology...
  29. ncbi Efficacy of mindfulness-based cognitive therapy in relation to prior history of depression: randomised controlled trial
    Nicole Geschwind
    Department of Psychiatry and Psychology, Maastricht University Medical Centre, The Netherlands
    Br J Psychiatry 201:320-5. 2012
    ..There appears to be consensus that patients with only one or two prior depressive episodes do not benefit from treatment with mindfulness-based cognitive therapy (MBCT)...
  30. ncbi Emotional experience in negative symptoms of schizophrenia--no evidence for a generalized hedonic deficit
    Margreet Oorschot
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, Maastricht University, PO BOX 616 VIJV, 6200 MD, Maastricht, The Netherlands
    Schizophr Bull 39:217-25. 2013
    ..This study investigated emotional experience and social behavior in the realm of daily life in a sample of patients with schizophrenia and schizoaffective disorder, stratified by level of negative symptoms...
  31. ncbi The dynamic interplay between negative and positive emotions in daily life predicts response to treatment in depression: a momentary assessment study
    Marieke Wichers
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, European Graduate School of Neurosciences EURON, Maastricht University, The Netherlands
    Br J Clin Psychol 51:206-22. 2012
    ..This study examines how NA and PA dynamically influence each other in depression and how this may impact on treatment response...
  32. ncbi Affectively salient meaning in random noise: a task sensitive to psychosis liability
    Mariana Galdos
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands
    Schizophr Bull 37:1179-86. 2011
    ..The data suggest that the white noise task may be sensitive to psychometric and familial vulnerability for psychosis associated with alterations in top-down processing and/or salience attribution...
  33. ncbi The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Int J Neuropsychopharmacol 5:375-88. 2002
    ....
  34. ncbi REVIEW: Genome-wide findings in schizophrenia and the role of gene-environment interplay
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, The Netherlands
    CNS Neurosci Ther 16:e185-92. 2010
    ..Collaborative efforts that bring together expertise in statistics, genetics, epidemiology, experimental psychiatry, brain imaging, and clinical psychiatry will be required to succeed in this challenging task...
  35. ncbi Evidence that onset of clinical psychosis is an outcome of progressively more persistent subclinical psychotic experiences: an 8-year cohort study
    M D G Dominguez
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, PO BOX 616 DRT 10, 6200 MD Maastricht, The Netherlands
    Schizophr Bull 37:84-93. 2011
    ..This may be summarized descriptively as a psychosis proneness-persistence-impairment model of psychotic disorder...
  36. ncbi Mobile assessment in schizophrenia: a data-driven momentary approach
    Margreet Oorschot
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Schizophr Bull 38:405-13. 2012
    ..It is discussed how ESM, surfacing the patient's implicit knowledge about symptom patterns, may provide an excellent starting point for person-tailored psychoeducation and for choosing the most applicable therapeutic intervention...
  37. ncbi Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study
    Marijn J A Tijssen
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, The Netherlands
    Br J Psychiatry 196:102-8. 2010
    ..Although (hypo)manic symptoms are common in adolescence, transition to adult bipolar disorder is infrequent...
  38. ncbi Dynamic association between interpersonal functioning and positive symptom dimensions of psychosis over time: a longitudinal study of healthy adolescents
    Dina Collip
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Center, PO BOX 616 DRT 10, 6200 MD Maastricht, The Netherlands
    Schizophr Bull 39:179-85. 2013
    ..However, more research is needed on the development of this association over time...
  39. ncbi Cytokines and major depression
    Olga J G Schiepers
    Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 29:201-17. 2005
    ....
  40. ncbi Depressive symptoms in Crohn's disease: relationship with immune activation and tryptophan availability
    Sinan Guloksuz
    Department of Psychiatry and Psychology, Maastricht University Medical Centre, EURON, Maastricht, The Netherlands
    PLoS ONE 8:e60435. 2013
    ..Anti-TNF-α treatment in CD reduces depressive symptoms, in part independently of disease activity; there was no evidence that this effect was mediated by immune-induced changes in TRP availability...
  41. ncbi Chorion type and twin similarity for child psychiatric symptoms
    Marieke C Wichers
    Arch Gen Psychiatry 59:562-4. 2002
  42. ncbi Early prediction of major depression in chronic hepatitis C patients during peg-interferon alpha-2b treatment by assessment of vegetative-depressive symptoms after four weeks
    Geert Robaeys
    Ziekenhuis Oost Limburg, Department of Gastroenterology and Hepatology, Schiepse Bos 6, B 3600 Genk, Belgium
    World J Gastroenterol 13:5736-40. 2007
    ..To study the predictive value of the vegetative-depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon alpha-2b of chronic hepatitis C (CHC) patients...