Paul G A Volders

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. doi request reprint Novel insights into the role of the sympathetic nervous system in cardiac arrhythmogenesis
    Paul G A Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Heart Rhythm 7:1900-6. 2010
  2. pmc Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis
    Jordi Heijman
    Department of Knowledge Engineering, Maastricht University, Maastricht, The Netherlands
    PLoS Comput Biol 9:e1003202. 2013
  3. doi request reprint Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation
    Daniel M Johnson
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    Circ Res 112:246-56. 2013
  4. doi request reprint Reduced ventricular proarrhythmic potential of the novel combined ion-channel blocker AZD1305 versus dofetilide in dogs with remodeled hearts
    Daniel M Johnson
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Circ Arrhythm Electrophysiol 5:201-9. 2012
  5. doi request reprint Measurement of action potential generation in isolated canine left ventricular midmyocardial myocytes
    Daniel M Johnson
    Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Protoc Pharmacol . 2011
  6. ncbi request reprint Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation
    Paul G A Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, Netherlands
    Circulation 107:2753-60. 2003
  7. doi request reprint Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1
    Jordi Heijman
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Circ Res 110:211-9. 2012
  8. pmc Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient
    Jordi Heijman
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Mol Cell Cardiol 50:863-71. 2011
  9. pmc Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes
    Milan Stengl
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, The Netherlands
    J Physiol 551:777-86. 2003
  10. ncbi request reprint Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation
    Milan Stengl
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University and Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    Cardiovasc Res 72:90-100. 2006

Collaborators

Detail Information

Publications19

  1. doi request reprint Novel insights into the role of the sympathetic nervous system in cardiac arrhythmogenesis
    Paul G A Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Heart Rhythm 7:1900-6. 2010
    ..Actual questions are listed per topic, and viewpoints are expressed...
  2. pmc Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis
    Jordi Heijman
    Department of Knowledge Engineering, Maastricht University, Maastricht, The Netherlands
    PLoS Comput Biol 9:e1003202. 2013
    ....
  3. doi request reprint Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation
    Daniel M Johnson
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    Circ Res 112:246-56. 2013
    ..Excessive beat-to-beat variability of repolarization duration (BVR) is a proarrhythmic marker. Previous research has shown that BVR is increased during intense β-adrenergic stimulation, leading to SCR...
  4. doi request reprint Reduced ventricular proarrhythmic potential of the novel combined ion-channel blocker AZD1305 versus dofetilide in dogs with remodeled hearts
    Daniel M Johnson
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Circ Arrhythm Electrophysiol 5:201-9. 2012
    ..We investigated the electrophysiological and proarrhythmic effects of AZD1305 versus dofetilide in dogs with chronic complete atrioventricular block and myocardial hypertrophic remodeling...
  5. doi request reprint Measurement of action potential generation in isolated canine left ventricular midmyocardial myocytes
    Daniel M Johnson
    Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Protoc Pharmacol . 2011
    ..This protocol can be used at a later stage of the drug discovery process to assess proarrhythmic potential...
  6. ncbi request reprint Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation
    Paul G A Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, Netherlands
    Circulation 107:2753-60. 2003
    ..In large mammals and humans, the contribution of IKs to ventricular repolarization is still incompletely understood...
  7. doi request reprint Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1
    Jordi Heijman
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Circ Res 110:211-9. 2012
    ....
  8. pmc Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient
    Jordi Heijman
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Mol Cell Cardiol 50:863-71. 2011
    ....
  9. pmc Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes
    Milan Stengl
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, The Netherlands
    J Physiol 551:777-86. 2003
    ..Block of IKs, however, led to a reverse rate-dependent prolongation of APD indicating that IKs does not have a dominant role at short cycle lengths...
  10. ncbi request reprint Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation
    Milan Stengl
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University and Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    Cardiovasc Res 72:90-100. 2006
    ....
  11. doi request reprint Arrhythmogenic mechano-electric heterogeneity in the long-QT syndrome
    Rachel M A Ter Bekke
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Prog Biophys Mol Biol 110:347-58. 2012
    ..Future long-QT research should focus on the intact beating heart with preserved autonomic input to examine these arrhythmogenic mechanisms...
  12. ncbi request reprint Electrophysiological safety of sertindole in dogs with normal and remodeled hearts
    Morten B Thomsen
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, P O Box 5800, NL 6202 AZ, Maastricht, The Netherlands
    J Pharmacol Exp Ther 307:776-84. 2003
    ..v. doses sertindole can pose a serious proarrhythmic risk when electrical remodeling of the ventricles is present. At clinically relevant doses, however, sertindole does not cause TdP in anesthetized dogs with normal or remodeled hearts...
  13. pmc Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation
    Marketa Bebarova
    Dept of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, 6202 AZ, Maastricht, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H48-58. 2008
    ..The late slow-upstroke action potentials at the subepicardium produce T-wave inversion in the computed ECG waveform, in line with the clinical ECG...
  14. ncbi request reprint Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs
    Morten B Thomsen
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
    Circulation 110:2453-9. 2004
    ..The predictive value of different repolarization parameters, including beat-to-beat variability of repolarization (BVR), was compared in this serial investigation in dogs with chronic AV block...
  15. doi request reprint Right-ventricular enlargement in arrhythmogenic right-ventricular cardiomyopathy is associated with decreased QRS amplitudes and T-wave negativity
    Robbert Zusterzeel
    Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands
    Ann Noninvasive Electrocardiol 18:555-63. 2013
    ....
  16. doi request reprint Realistic training data improve noninvasive reconstruction of heart-surface potentials
    Matthijs J M Cluitmans
    Department of Cardiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Conf Proc IEEE Eng Med Biol Soc 2012:6373-6. 2012
    ..01) and in vivo (p<0.05). Thus, we demonstrate that the novel concept of applying electrophysiological data might be useful to improve noninvasive reconstruction of electrical heart activity...
  17. doi request reprint I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation
    Daniel M Johnson
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Mol Cell Cardiol 48:122-30. 2010
    ..Loss of I(Ks) plus overriding of Ca(2+)-dependent membrane currents, including inward Na(+)-Ca(2)(+) exchange current, conspire to proarrhythmic BVR under these conditions...
  18. ncbi request reprint Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium
    Dirk W Donker
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Heart Circ Physiol 292:H2324-32. 2007
    ..Subsequent cytoskeletal reorganization coincides with the upregulation of melusin, P-Akt, P-GSK3beta, and MLP, indicating a strong drive to compensated hypertrophy...
  19. ncbi request reprint Serial left-ventricular biopsy sampling using a minimally invasive trans-thoracic approach in adult dogs
    Dirk W Donker
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht and Maastricht University, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Pflugers Arch 454:1043-51. 2007
    ..The technique is safe and has no long-term effects on cardiac function or structure...