Research Topics
Genomes and Genes | Cees VermeerSummaryAffiliation: Maastricht University Country: The Netherlands Publications
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Publications
Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal womenM H J Knapen
CARIM, University of Maastricht, Maastricht, The Netherlands
Osteoporos Int 18:963-72. 2007..Results showed that K(2) improved BMC and femoral neck width, but not DXA-BMD. Hence high vitamin K(2) intake may contribute to preventing postmenopausal bone loss...
Beyond deficiency: potential benefits of increased intakes of vitamin K for bone and vascular healthCees Vermeer
Dept of Biochemistry, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
Eur J Nutr 43:325-35. 2004....- Vitamin K: lessons from the pastC Vermeer
Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
J Thromb Haemost 2:2115-7. 2004 - Bone markers during a 6-month space flight: effects of vitamin K supplementationC Vermeer
Department of Biochemistry, Maastricht University, The Netherlands
J Gravit Physiol 5:65-9. 1998..Our data suggest that increased intake of vitamin K may contribute to counteracting microgravity-induced loss of bone mass during long lasting space missions, but need confirmation in more astronauts... - Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patientsEllen C M Cranenburg
Department of Biochemistry, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Thromb Haemost 101:359-66. 2009..Since circulating ucMGP levels are significantly and inversely correlated with the extent of CAC in HD patients, ucMGP may become a tool for identifying HD patients with a high probability of cardiovascular calcification... 
Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weightMarjo H J Knapen
VitaK and Cardiovascular Research Institute CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Br J Nutr 108:1017-24. 2012..These findings demonstrate that a high vitamin K status of bone has no effect on circulating adiponectin in healthy people and long-term vitamin K supplementation does not increase weight in healthy postmenopausal women...- Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7Leon J Schurgers
VitaK and Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
Blood 109:3279-83. 2007..MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 mug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way... - Calcium scores and matrix Gla protein levels: association with vitamin K statusRoger J M W Rennenberg
Department of Internal Medicine, Maastricht University Medical Centre MUMC and Cardiovascular Research Institute Maastricht CARIM, Maastricht, The Netherlands
Eur J Clin Invest 40:344-9. 2010..We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP... - Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humansRoger J M W Rennenberg
Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
Blood 115:5121-3. 2010..We conclude that long-term use of coumarins is associated with enhanced extracoronary vascular calcification, possibly through the inhibition of MGP carboxylation... - Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcificationLeon J Schurgers
Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands
Arterioscler Thromb Vasc Biol 25:1629-33. 2005..We hypothesized that low endogenous production of MGP and impaired carboxylation of MGP may contribute to the development or the progression of vascular disease... - The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcificationEllen C M Cranenburg
VitaK, Maastricht University, Maastricht, The Netherlands
J Vasc Res 45:427-36. 2008..Here we report on the development of an ucMGP assay and the potential diagnostic utility of monitoring serum ucMGP levels... - Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in ratsLeon J Schurgers
Cardiovascular Research Institute CARIM, Maastricht University, The Netherlands
Blood 109:2823-31. 2007..Using MGP antibodies, local VK deficiency was demonstrated at sites of calcification. This is the first study in rats demonstrating that AC and the resulting decreased arterial distensibility are reversible by high-VK intake... - Matrix Gla-protein: the calcification inhibitor in need of vitamin KLeon J Schurgers
VitaK, Maastricht University, Universiteitssingel 50, Maastricht, The Netherlands
Thromb Haemost 100:593-603. 2008..These assays may have potential value for identifying patients as well as apparently healthy subjects at high risk for CVD and/or cardiovascular calcification and for monitoring the treatment of CVD and vascular calcification... - Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) speciesEllen C M Cranenburg
VitaK and Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
Thromb Haemost 104:811-22. 2010..We conclude that the different assays for particular circulating MGP species allows the assessment of various aspects of the MGP system... - Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wallH M Spronk
Department of Biochemistry, Maastricht University, Maastricht, The Netherlands
Biochem Biophys Res Commun 289:485-90. 2001..Our data demonstrate the close association between MGP and calcification. It is suggested that undercarboxylated MGP is biologically inactive and that poor vascular vitamin K status may form a risk factor for vascular calcification... - Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjectsLeon J Schurgers
Cardiovascular Research Institute Maastricht and VitaK BV, Maastricht, The Netherlands
Blood 104:2682-9. 2004.... - Role of vitamin K and vitamin K-dependent proteins in vascular calcificationL J Schurgers
Department of Biochemistry, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Z Kardiol 90:57-63. 2001..The hypothesis is put forward that undercarboxylation of MGP is a risk factor for vascular calcification and that the present RDA values are too low to ensure full carboxylation of MGP... - The role of vitamin K in soft-tissue calcificationElke Theuwissen
VitaK, Maastricht University, The Netherlands
Adv Nutr 3:166-73. 2012..More studies, both in healthy subjects and in patients at risk of vascular calcification, are required before conclusions can be drawn... - Renal handling of matrix Gla-protein in humans with moderate to severe hypertensionRoger J M W Rennenberg
Department of Internal Medicine, University Hospital Maastricht and Cardiovascular Research Institute Maastricht CARIM, P Debyelaan 25, Maastricht, The Netherlands
Hypertens Res 31:1745-51. 2008..In conclusion, we demonstrate that the kidney is able to extract matrix Gla-protein from the plasma at a constant level of 12.8%, independent of renal function in hypertensive subjects... - Vitamin K: the coagulation vitamin that became omnipotentEllen C M Cranenburg
Department of Biochemistry, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
Thromb Haemost 98:120-5. 2007.... - Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up studyLavienja A J L M Braam
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
Thromb Haemost 91:373-80. 2004..No significant differences were observed in the change of IMT between the three groups. It is concluded that a supplement containing vitamins K1 and D has a beneficial effect on the elastic properties of the arterial vessel wall... - Undercarboxylated matrix GLA protein levels are decreased in dialysis patients and related to parameters of calcium-phosphate metabolism and aortic augmentation indexMarc M H Hermans
Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, Maastricht, The Netherlands
Blood Purif 25:395-401. 2007..Vascular calcifications are related to cardiovascular mortality and morbidity in dialysis patients. Limited data exist on the role of calcification inhibitors, such as matrix-carboxyglutamic acid protein (MGP) in dialysis patients... - Vitamin K, osteoporosis and degenerative diseases of ageingCees Vermeer
VitaK, Maastricht University, Oxfordlaan 70, 6229 EV Maastricht, The Netherlands
Menopause Int 17:19-23. 2011..According to the triage theory, long-term vitamin K inadequacy is an independent, but modifiable risk factor for the development of degenerative diseases of ageing including osteoporosis and atherosclerosis... - Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young menLeon J Schurgers
Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, The Netherlands
J Lipid Res 43:878-84. 2002..The mechanism is unclear but may result from interactions of vitamin K with PUFA and/or other lipid components such as vitamin E... - Oral anticoagulant treatment: friend or foe in cardiovascular disease?Leon J Schurgers
Department of Biochemistry, Cardiovascular Research Institute, University Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
Blood 104:3231-2. 2004..These observations suggest that OACs, which are widely used for antithrombotic therapy, may induce cardiovascular calcifications as an adverse side effect... - Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjectsElke Theuwissen
VitaK and Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Oxfordlaan 70, 6229 EV Maastricht, The Netherlands
Br J Nutr 108:1652-7. 2012..Whether this improvement contributes to public health, i.e. increasing the protection against age-related diseases needs further investigation in specifically designed intervention trials... - Dietary phylloquinone intake as a potential marker for a heart-healthy dietary pattern in the Framingham Offspring cohortLavienja Braam
Cardiovascular Research Institute, University of Maastricht, Maastricht, The Netherlands
J Am Diet Assoc 104:1410-4. 2004..001). Higher phylloquinone intakes were also associated with lower triglyceride concentrations ( P <.001). In conclusion, a high phylloquinone intake may be a marker for an overall heart-healthy dietary pattern... - Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcificationL J Schurgers
Cardiovascular Research Institute Maastricht and VitaK, University of Maastricht, Universiteitssingel 50, Maastricht, The Netherlands
J Thromb Haemost 5:2503-11. 2007..In vivo, MGP has been shown to be a potent inhibitor of vascular calcification; however, the precise molecular mechanism underlying the function of MGP is not yet fully understood... - Menaquinone-4 in breast milk is derived from dietary phylloquinoneH H W Thijssen
Department of Pharmacology, University of Maastricht, The Netherlands
Br J Nutr 87:219-26. 2002..Phylloquinone supplementation to lactating mothers may be of benefit to the newborn infant, since both phylloquinone and menaquinone-4 are raised by supplementation... - Characteristics of recombinant W501S mutated human gamma-glutamyl carboxylaseB A M Soute
Cardiovascular Research Institute Maastricht, Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
J Thromb Haemost 2:597-604. 2004.... - Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated ratsH M H Spronk
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
J Vasc Res 40:531-7. 2003.... 
Total chemical synthesis of human matrix Gla proteinT M Hackeng
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, The Netherlands
Protein Sci 10:864-70. 2001..In conclusion, facile and efficient chemical synthesis in combination with native chemical ligation yielded MGP preparations that can aid in unraveling the mechanism by which MGP prevents vascular calcification...- Vitamin K intake and status are low in hemodialysis patientsEllen C M Cranenburg
VitaK and Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
Kidney Int 82:605-10. 2012..A randomized controlled trial is needed to test whether vitamin K supplementation reduces the risk of arterial calcification and mortality in hemodialysis patients... - Differential lipoprotein transport pathways of K-vitamins in healthy subjectsLeon J Schurgers
Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
Biochim Biophys Acta 1570:27-32. 2002..Moreover, the very long half-life time of MK-9 in the circulation indicates that it may form a more constant source of vitamin K than are either K1 or MK-4... - Factors affecting bone loss in female endurance athletes: a two-year follow-up studyLavienja A J L M Braam
Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
Am J Sports Med 31:889-95. 2003..Clinical Relevance: High-intensity training maintained over several years must be regarded in women as a risk factor for osteoporosis, and protocols for optimal treatment should be developed... - Characteristics and performance of an immunosorbent assay for human matrix Gla-proteinLeon J Schurgers
VitaK and Department of Biochemistry, Maastricht University, The Netherlands
Clin Chim Acta 351:131-8. 2005..CONCLUSIONS: The assay allows comparison of groups and may become a suitable marker for risk assessment or diagnosis in cardiovascular disease and osteoarthritis... - Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of ageL A J L M Braam
Department of Biochemistry, University of Maastricht, The Netherlands
Calcif Tissue Int 73:21-6. 2003..If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck... - Osteocalcin binds tightly to the gamma-glutamylcarboxylase at a site distinct from that of the other known vitamin K-dependent proteinsR J Houben
Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
Biochem J 341:265-9. 1999..From our studies we conclude that descarboxy-osteocalcin must have an internal recognition sequence that binds to gamma-glutamylcarboxylase at a site different from the propeptide-recognition site... - Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcinRoger J T J Houben
Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Biochem J 364:323-8. 2002.... - Low serum and bone vitamin K status in patients with longstanding Crohn's disease: another pathogenetic factor of osteoporosis in Crohn's disease?E J Schoon
Department of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands
Gut 48:473-7. 2001..Vitamin K is a cofactor in the carboxylation of osteocalcin, a protein essential for calcium binding to bone. A high level of circulating uncarboxylated osteocalcin is a sensitive marker of vitamin K deficiency... - Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transportL J Schurgers
Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands
J Lipid Res 42:1120-4. 2001..It is concluded that corn oil may have a mildly anticoagulant effect, the potential benefit of which is discussed... - Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotypeLeon J Schurgers
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
PLoS ONE 7:e43229. 2012.... - Abnormal bone turnover in long-standing Crohn's disease in remissionE J Schoon
Department of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands
Aliment Pharmacol Ther 15:783-92. 2001..A high prevalence of osteoporosis is found in patients with Crohn's disease. The pathogenesis of this condition seems to be multifactorial and its pathophysiology is still not completely understood... - Vitamin K-dependent and vitamin K-independent hypocoagulant effects of dietary fish oil in ratsC M Nieuwenhuys
Department of Human Biology, Maastricht University, P.O. Box 616, Maastricht 6200 MD, The Netherlands
Thromb Res 104:137-47. 2001.... - Circulating calcification inhibitors and vascular properties in children after renal transplantationMarieke J H van Summeren
Department of Pediatric Immunology, University Medical Centre Utrecht, Lundlaan 6, Room KE 04 133 1, 3584 EA Utrecht, The Netherlands
Pediatr Nephrol 23:985-93. 2008..Future prospective studies in pediatric ESRD and transplant patients are needed to learn more about the role of calcification inhibitors in relation to the prevention of vascular damage... - Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomographyShuichi Jono
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
Thromb Haemost 91:790-4. 2004..We found that serum MGP levels are inversely correlated with the severity of CAC. These data suggest a possible role for MGP in the development of vascular calcification... - Novel insights into uremic vascular calcification: role of matrix Gla protein and alpha-2-Heremans Schmid glycoprotein/fetuinMarkus Ketteler
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany
Blood Purif 20:473-6. 2002.... - Assessment of vitamin K deficiency in CF--how much sophistication is useful?Katharina Mosler
Department of Paediatrics, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
J Cyst Fibros 2:91-6. 2003..Routine supplementation of vitamin K(1) in PICF is presently subject of discussion... - Effect of calcium, vitamins K1 and D3 on bone in galactosemiaBianca Panis
Department of Pediatrics, University Hospital Maastricht, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands
Bone 39:1123-9. 2006..015). Supplementation of calcium, vitamins K(1) and D(3) given in this dose (750 mg, 1.0 mg and 10.0 mug respectively) is likely to have a role in the treatment of BMC abnormalities in galactosemia... - Pronounced elevation of undercarboxylated osteocalcin in healthy childrenMarieke van Summeren
Department of Pediatric Immunology, University Medical Centre Utrecht, 3584 EA Utrecht, The Netherlands
Pediatr Res 61:366-70. 2007..These findings suggest a pronounced low vitamin K status of bone during growth. The question remains, however, whether children would benefit from higher vitamin K intake, for instance, by improved bone health or stronger bones... - Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal womenSusanne Bugel
Department of Human Nutrition Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
Br J Nutr 97:373-80. 2007..In conclusion, while daily supplementation with 200 and 500 microg phylloquinone/d for 6 weeks increased vitamin K status in postmenopausal women, it had no effect on bone turnover... - Vitamin K supplementation during oral anticoagulation: concernsDaniel W Stafford
Blood 109:3607; author reply 3607-8. 2007 - Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patientsDealba Gheduzzi
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Lab Invest 87:998-1008. 2007..The lower ratio of Gla-MGP over Glu-MGP in pathological fibroblasts compared to controls suggests these cells may play an important role in the ectopic calcification in PXE... - Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam StudyJohanna M Geleijnse
Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
J Nutr 134:3100-5. 2004..71 (0.50, 1.00) and 0.48 (0.32, 0.71), respectively]. Phylloquinone intake was not related to any of the outcomes. These findings suggest that an adequate intake of menaquinone could be important for CHD prevention... - Lifestyle and diet as risk factors for overanticoagulationFernie J A Penning-van Beest
Pharmaco-epidemiology Unit, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
J Clin Epidemiol 55:411-7. 2002..Dietary factors were not associated with overanticoaguation. If risk factors can not be avoided, increased monitoring of INR values could prevent overanticoagulation and potential bleeding complications...