Cees Vermeer

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
    Leon J Schurgers
    VitaK and Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Blood 109:3279-83. 2007
  2. pmc Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
    M H J Knapen
    CARIM, University of Maastricht, Maastricht, The Netherlands
    Osteoporos Int 18:963-72. 2007
  3. ncbi request reprint Beyond deficiency: potential benefits of increased intakes of vitamin K for bone and vascular health
    Cees Vermeer
    Dept of Biochemistry, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Nutr 43:325-35. 2004
  4. ncbi request reprint Vitamin K: lessons from the past
    C Vermeer
    Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
    J Thromb Haemost 2:2115-7. 2004
  5. ncbi request reprint Bone markers during a 6-month space flight: effects of vitamin K supplementation
    C Vermeer
    Department of Biochemistry, Maastricht University, The Netherlands
    J Gravit Physiol 5:65-9. 1998
  6. ncbi request reprint Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients
    Ellen C M Cranenburg
    Department of Biochemistry, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Thromb Haemost 101:359-66. 2009
  7. doi request reprint Vitamin K intake and status are low in hemodialysis patients
    Ellen C M Cranenburg
    VitaK and Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Kidney Int 82:605-10. 2012
  8. doi request reprint The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification
    Ellen C M Cranenburg
    VitaK, Maastricht University, Maastricht, The Netherlands
    J Vasc Res 45:427-36. 2008
  9. doi request reprint Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects
    Elke Theuwissen
    VitaK and Cardiovascular Research Institute Maastricht, Maastricht University, Oxfordlaan 70, Maastricht, The Netherlands
    Br J Nutr 108:1652-7. 2012
  10. doi request reprint Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight
    Marjo H J Knapen
    VitaK and Cardiovascular Research Institute CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Nutr 108:1017-24. 2012

Detail Information

Publications55

  1. ncbi request reprint Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
    Leon J Schurgers
    VitaK and Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Blood 109:3279-83. 2007
    ..MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 mug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way...
  2. pmc Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
    M H J Knapen
    CARIM, University of Maastricht, Maastricht, The Netherlands
    Osteoporos Int 18:963-72. 2007
    ..Results showed that K(2) improved BMC and femoral neck width, but not DXA-BMD. Hence high vitamin K(2) intake may contribute to preventing postmenopausal bone loss...
  3. ncbi request reprint Beyond deficiency: potential benefits of increased intakes of vitamin K for bone and vascular health
    Cees Vermeer
    Dept of Biochemistry, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Nutr 43:325-35. 2004
    ....
  4. ncbi request reprint Vitamin K: lessons from the past
    C Vermeer
    Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
    J Thromb Haemost 2:2115-7. 2004
  5. ncbi request reprint Bone markers during a 6-month space flight: effects of vitamin K supplementation
    C Vermeer
    Department of Biochemistry, Maastricht University, The Netherlands
    J Gravit Physiol 5:65-9. 1998
    ..Our data suggest that increased intake of vitamin K may contribute to counteracting microgravity-induced loss of bone mass during long lasting space missions, but need confirmation in more astronauts...
  6. ncbi request reprint Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients
    Ellen C M Cranenburg
    Department of Biochemistry, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Thromb Haemost 101:359-66. 2009
    ..Since circulating ucMGP levels are significantly and inversely correlated with the extent of CAC in HD patients, ucMGP may become a tool for identifying HD patients with a high probability of cardiovascular calcification...
  7. doi request reprint Vitamin K intake and status are low in hemodialysis patients
    Ellen C M Cranenburg
    VitaK and Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Kidney Int 82:605-10. 2012
    ..A randomized controlled trial is needed to test whether vitamin K supplementation reduces the risk of arterial calcification and mortality in hemodialysis patients...
  8. doi request reprint The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification
    Ellen C M Cranenburg
    VitaK, Maastricht University, Maastricht, The Netherlands
    J Vasc Res 45:427-36. 2008
    ..Here we report on the development of an ucMGP assay and the potential diagnostic utility of monitoring serum ucMGP levels...
  9. doi request reprint Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects
    Elke Theuwissen
    VitaK and Cardiovascular Research Institute Maastricht, Maastricht University, Oxfordlaan 70, Maastricht, The Netherlands
    Br J Nutr 108:1652-7. 2012
    ..Whether this improvement contributes to public health, i.e. increasing the protection against age-related diseases needs further investigation in specifically designed intervention trials...
  10. doi request reprint Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight
    Marjo H J Knapen
    VitaK and Cardiovascular Research Institute CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Nutr 108:1017-24. 2012
    ..These findings demonstrate that a high vitamin K status of bone has no effect on circulating adiponectin in healthy people and long-term vitamin K supplementation does not increase weight in healthy postmenopausal women...
  11. ncbi request reprint Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification
    Leon J Schurgers
    Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1629-33. 2005
    ..We hypothesized that low endogenous production of MGP and impaired carboxylation of MGP may contribute to the development or the progression of vascular disease...
  12. doi request reprint Calcium scores and matrix Gla protein levels: association with vitamin K status
    Roger J M W Rennenberg
    Department of Internal Medicine, Maastricht University Medical Centre MUMC and Cardiovascular Research Institute Maastricht CARIM, Maastricht, The Netherlands
    Eur J Clin Invest 40:344-9. 2010
    ..We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP...
  13. doi request reprint Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans
    Roger J M W Rennenberg
    Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Blood 115:5121-3. 2010
    ..We conclude that long-term use of coumarins is associated with enhanced extracoronary vascular calcification, possibly through the inhibition of MGP carboxylation...
  14. ncbi request reprint Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats
    Leon J Schurgers
    Cardiovascular Research Institute CARIM, Maastricht University, The Netherlands
    Blood 109:2823-31. 2007
    ..Using MGP antibodies, local VK deficiency was demonstrated at sites of calcification. This is the first study in rats demonstrating that AC and the resulting decreased arterial distensibility are reversible by high-VK intake...
  15. ncbi request reprint Matrix Gla-protein: the calcification inhibitor in need of vitamin K
    Leon J Schurgers
    VitaK, Maastricht University, Universiteitssingel 50, Maastricht, The Netherlands
    Thromb Haemost 100:593-603. 2008
    ..These assays may have potential value for identifying patients as well as apparently healthy subjects at high risk for CVD and/or cardiovascular calcification and for monitoring the treatment of CVD and vascular calcification...
  16. ncbi request reprint Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects
    Leon J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK BV, Maastricht, The Netherlands
    Blood 104:2682-9. 2004
    ....
  17. doi request reprint Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species
    Ellen C M Cranenburg
    VitaK and Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Thromb Haemost 104:811-22. 2010
    ..We conclude that the different assays for particular circulating MGP species allows the assessment of various aspects of the MGP system...
  18. ncbi request reprint Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall
    H M Spronk
    Department of Biochemistry, Maastricht University, Maastricht, The Netherlands
    Biochem Biophys Res Commun 289:485-90. 2001
    ..Our data demonstrate the close association between MGP and calcification. It is suggested that undercarboxylated MGP is biologically inactive and that poor vascular vitamin K status may form a risk factor for vascular calcification...
  19. ncbi request reprint Role of vitamin K and vitamin K-dependent proteins in vascular calcification
    L J Schurgers
    Department of Biochemistry, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
    Z Kardiol 90:57-63. 2001
    ..The hypothesis is put forward that undercarboxylation of MGP is a risk factor for vascular calcification and that the present RDA values are too low to ensure full carboxylation of MGP...
  20. pmc The role of vitamin K in soft-tissue calcification
    Elke Theuwissen
    VitaK, Maastricht University, The Netherlands
    Adv Nutr 3:166-73. 2012
    ..More studies, both in healthy subjects and in patients at risk of vascular calcification, are required before conclusions can be drawn...
  21. doi request reprint Renal handling of matrix Gla-protein in humans with moderate to severe hypertension
    Roger J M W Rennenberg
    Department of Internal Medicine, University Hospital Maastricht and Cardiovascular Research Institute Maastricht CARIM, P Debyelaan 25, Maastricht, The Netherlands
    Hypertens Res 31:1745-51. 2008
    ..In conclusion, we demonstrate that the kidney is able to extract matrix Gla-protein from the plasma at a constant level of 12.8%, independent of renal function in hypertensive subjects...
  22. ncbi request reprint Vitamin K: the coagulation vitamin that became omnipotent
    Ellen C M Cranenburg
    Department of Biochemistry, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Thromb Haemost 98:120-5. 2007
    ....
  23. pmc Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype
    Leon J Schurgers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 7:e43229. 2012
    ....
  24. ncbi request reprint Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study
    Lavienja A J L M Braam
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Thromb Haemost 91:373-80. 2004
    ..No significant differences were observed in the change of IMT between the three groups. It is concluded that a supplement containing vitamins K1 and D has a beneficial effect on the elastic properties of the arterial vessel wall...
  25. doi request reprint Vitamin K, osteoporosis and degenerative diseases of ageing
    Cees Vermeer
    VitaK, Maastricht University, Oxfordlaan 70, 6229 EV Maastricht, The Netherlands
    Menopause Int 17:19-23. 2011
    ..According to the triage theory, long-term vitamin K inadequacy is an independent, but modifiable risk factor for the development of degenerative diseases of ageing including osteoporosis and atherosclerosis...
  26. ncbi request reprint Undercarboxylated matrix GLA protein levels are decreased in dialysis patients and related to parameters of calcium-phosphate metabolism and aortic augmentation index
    Marc M H Hermans
    Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, Maastricht, The Netherlands
    Blood Purif 25:395-401. 2007
    ..Vascular calcifications are related to cardiovascular mortality and morbidity in dialysis patients. Limited data exist on the role of calcification inhibitors, such as matrix-carboxyglutamic acid protein (MGP) in dialysis patients...
  27. ncbi request reprint Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men
    Leon J Schurgers
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, The Netherlands
    J Lipid Res 43:878-84. 2002
    ..The mechanism is unclear but may result from interactions of vitamin K with PUFA and/or other lipid components such as vitamin E...
  28. ncbi request reprint Oral anticoagulant treatment: friend or foe in cardiovascular disease?
    Leon J Schurgers
    Department of Biochemistry, Cardiovascular Research Institute, University Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Blood 104:3231-2. 2004
    ..These observations suggest that OACs, which are widely used for antithrombotic therapy, may induce cardiovascular calcifications as an adverse side effect...
  29. ncbi request reprint Dietary phylloquinone intake as a potential marker for a heart-healthy dietary pattern in the Framingham Offspring cohort
    Lavienja Braam
    Cardiovascular Research Institute, University of Maastricht, Maastricht, The Netherlands
    J Am Diet Assoc 104:1410-4. 2004
    ..001). Higher phylloquinone intakes were also associated with lower triglyceride concentrations ( P <.001). In conclusion, a high phylloquinone intake may be a marker for an overall heart-healthy dietary pattern...
  30. ncbi request reprint Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification
    L J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK, University of Maastricht, Universiteitssingel 50, Maastricht, The Netherlands
    J Thromb Haemost 5:2503-11. 2007
    ..In vivo, MGP has been shown to be a potent inhibitor of vascular calcification; however, the precise molecular mechanism underlying the function of MGP is not yet fully understood...
  31. pmc Total chemical synthesis of human matrix Gla protein
    T M Hackeng
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, The Netherlands
    Protein Sci 10:864-70. 2001
    ..In conclusion, facile and efficient chemical synthesis in combination with native chemical ligation yielded MGP preparations that can aid in unraveling the mechanism by which MGP prevents vascular calcification...
  32. ncbi request reprint Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats
    H M H Spronk
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    J Vasc Res 40:531-7. 2003
    ....
  33. ncbi request reprint Menaquinone-4 in breast milk is derived from dietary phylloquinone
    H H W Thijssen
    Department of Pharmacology, University of Maastricht, The Netherlands
    Br J Nutr 87:219-26. 2002
    ..Phylloquinone supplementation to lactating mothers may be of benefit to the newborn infant, since both phylloquinone and menaquinone-4 are raised by supplementation...
  34. ncbi request reprint Characteristics of recombinant W501S mutated human gamma-glutamyl carboxylase
    B A M Soute
    Cardiovascular Research Institute Maastricht, Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
    J Thromb Haemost 2:597-604. 2004
    ....
  35. ncbi request reprint Differential lipoprotein transport pathways of K-vitamins in healthy subjects
    Leon J Schurgers
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Biochim Biophys Acta 1570:27-32. 2002
    ..Moreover, the very long half-life time of MK-9 in the circulation indicates that it may form a more constant source of vitamin K than are either K1 or MK-4...
  36. ncbi request reprint Factors affecting bone loss in female endurance athletes: a two-year follow-up study
    Lavienja A J L M Braam
    Department of Biochemistry, University of Maastricht, Maastricht, The Netherlands
    Am J Sports Med 31:889-95. 2003
    ..Low bone mass leading to stress fractures is a well-known and yet unsolved problem among female athletes...
  37. ncbi request reprint Characteristics and performance of an immunosorbent assay for human matrix Gla-protein
    Leon J Schurgers
    VitaK and Department of Biochemistry, Maastricht University, The Netherlands
    Clin Chim Acta 351:131-8. 2005
    ..Promotor polymorphisms resulting in decreased expression levels were found to be associated with an increased risk for cardiovascular disease in humans...
  38. ncbi request reprint Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age
    L A J L M Braam
    Department of Biochemistry, University of Maastricht, The Netherlands
    Calcif Tissue Int 73:21-6. 2003
    ..If co-administered with minerals and vitamin D, vitamin K1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck...
  39. pmc Osteocalcin binds tightly to the gamma-glutamylcarboxylase at a site distinct from that of the other known vitamin K-dependent proteins
    R J Houben
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Biochem J 341:265-9. 1999
    ..From our studies we conclude that descarboxy-osteocalcin must have an internal recognition sequence that binds to gamma-glutamylcarboxylase at a site different from the propeptide-recognition site...
  40. pmc Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcin
    Roger J T J Houben
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem J 364:323-8. 2002
    ....
  41. pmc Low serum and bone vitamin K status in patients with longstanding Crohn's disease: another pathogenetic factor of osteoporosis in Crohn's disease?
    E J Schoon
    Department of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands
    Gut 48:473-7. 2001
    ..Vitamin K is a cofactor in the carboxylation of osteocalcin, a protein essential for calcium binding to bone. A high level of circulating uncarboxylated osteocalcin is a sensitive marker of vitamin K deficiency...
  42. ncbi request reprint Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transport
    L J Schurgers
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Lipid Res 42:1120-4. 2001
    ..It is concluded that corn oil may have a mildly anticoagulant effect, the potential benefit of which is discussed...
  43. ncbi request reprint Abnormal bone turnover in long-standing Crohn's disease in remission
    E J Schoon
    Department of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands
    Aliment Pharmacol Ther 15:783-92. 2001
    ..A high prevalence of osteoporosis is found in patients with Crohn's disease. The pathogenesis of this condition seems to be multifactorial and its pathophysiology is still not completely understood...
  44. ncbi request reprint Vitamin K-dependent and vitamin K-independent hypocoagulant effects of dietary fish oil in rats
    C M Nieuwenhuys
    Department of Human Biology, Maastricht University, P.O. Box 616, Maastricht 6200 MD, The Netherlands
    Thromb Res 104:137-47. 2001
    ....
  45. ncbi request reprint Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography
    Shuichi Jono
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Thromb Haemost 91:790-4. 2004
    ..We found that serum MGP levels are inversely correlated with the severity of CAC. These data suggest a possible role for MGP in the development of vascular calcification...
  46. ncbi request reprint Assessment of vitamin K deficiency in CF--how much sophistication is useful?
    Katharina Mosler
    Department of Paediatrics, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    J Cyst Fibros 2:91-6. 2003
    ..Routine supplementation of vitamin K(1) in PICF is presently subject of discussion...
  47. ncbi request reprint Novel insights into uremic vascular calcification: role of matrix Gla protein and alpha-2-Heremans Schmid glycoprotein/fetuin
    Markus Ketteler
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany
    Blood Purif 20:473-6. 2002
    ....
  48. doi request reprint Circulating calcification inhibitors and vascular properties in children after renal transplantation
    Marieke J H van Summeren
    Department of Pediatric Immunology, University Medical Centre Utrecht, Lundlaan 6, Room KE 04 133 1, 3584 EA Utrecht, The Netherlands
    Pediatr Nephrol 23:985-93. 2008
    ..Future prospective studies in pediatric ESRD and transplant patients are needed to learn more about the role of calcification inhibitors in relation to the prevention of vascular damage...
  49. ncbi request reprint Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients
    Dealba Gheduzzi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Lab Invest 87:998-1008. 2007
    ..The lower ratio of Gla-MGP over Glu-MGP in pathological fibroblasts compared to controls suggests these cells may play an important role in the ectopic calcification in PXE...
  50. ncbi request reprint Effect of calcium, vitamins K1 and D3 on bone in galactosemia
    Bianca Panis
    Department of Pediatrics, University Hospital Maastricht, P Debyelaan 25, 6202 AZ Maastricht, The Netherlands
    Bone 39:1123-9. 2006
    ..015). Supplementation of calcium, vitamins K(1) and D(3) given in this dose (750 mg, 1.0 mg and 10.0 mug respectively) is likely to have a role in the treatment of BMC abnormalities in galactosemia...
  51. ncbi request reprint Pronounced elevation of undercarboxylated osteocalcin in healthy children
    Marieke van Summeren
    Department of Pediatric Immunology, University Medical Centre Utrecht, 3584 EA Utrecht, The Netherlands
    Pediatr Res 61:366-70. 2007
    ..These findings suggest a pronounced low vitamin K status of bone during growth. The question remains, however, whether children would benefit from higher vitamin K intake, for instance, by improved bone health or stronger bones...
  52. ncbi request reprint Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women
    Susanne Bugel
    Department of Human Nutrition Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Br J Nutr 97:373-80. 2007
    ..In conclusion, while daily supplementation with 200 and 500 microg phylloquinone/d for 6 weeks increased vitamin K status in postmenopausal women, it had no effect on bone turnover...
  53. ncbi request reprint Vitamin K supplementation during oral anticoagulation: concerns
    Daniel W Stafford
    Blood 109:3607; author reply 3607-8. 2007
  54. ncbi request reprint Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study
    Johanna M Geleijnse
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Nutr 134:3100-5. 2004
    ..71 (0.50, 1.00) and 0.48 (0.32, 0.71), respectively]. Phylloquinone intake was not related to any of the outcomes. These findings suggest that an adequate intake of menaquinone could be important for CHD prevention...
  55. ncbi request reprint Lifestyle and diet as risk factors for overanticoagulation
    Fernie J A Penning-van Beest
    Pharmaco epidemiology Unit, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Epidemiol 55:411-7. 2002
    ..Dietary factors were not associated with overanticoaguation. If risk factors can not be avoided, increased monitoring of INR values could prevent overanticoagulation and potential bleeding complications...