Frans R J Verhey

..They were well tolerated and had a similar side-effect pattern. Our study could not demonstrate the superiority of olanzapine, compared to haloperidol, for the treatment of agitation in patients with dementia...

..The second objective was to assess whether the association between perceived forgetfulness and quality of life changes over a 9-year follow-up period...

..g. dementia subtypes, dementia severity, medication use, age and gender) in a large sample of outpatients with dementia...

..Prodromal AD is characterized by a decreased use of effortful learning strategies. This finding may have implications for the early detection of AD in MCI subjects and for the development of cognitive training programs...

..The aim of the current study was to examine the association between apathy and neuropsychological functioning in patients with MCI and AD...

..Only a subset of these subjects seeks medical attention for these complaints. The aim of the present study was to investigate which factors determine why people with subjective memory complaints (SMC) seek medical attention...

..CONCLUSION: The results indicate that screening for cognitive impairment of spousal caregivers may be helpful, because suboptimal cognitive functioning may affect the ability to provide adequate care...

..To investigate the association between cognition and daily life functioning in dementia subtypes...

..An integrated multidisciplinary approach to dementia is often recommended but has rarely been evaluated...

..The relationship between these domains is unclear. The Assessment of Motor and Process Skills (AMPS) is a relatively unexplored instrument in people with dementia, measuring severity by direct observation...

..Multiple neurotransmitter systems, including the serotonergic system, are involved in the pathophysiology of this disease. The exact role of the serotonergic system in PD is still unclear...

..To study the impact of physical and mental fatigue on cognitive complaints and cognitive performance in patients with multiple sclerosis...

..In particular, a low level of language expression was related to higher levels of overall neuropsychiatric problems and to psychosis. Impairment of abstract reasoning was related to psychosis and aberrant motor behavior...

..The APOE-ε4 allele is the strongest known genetic risk factor for AD. The authors performed a meta-analysis to establish the predictive accuracy of the APOE-ε4 allele for progression from MCI to AD-type dementia...

..Future interventions need to account for the specific needs and problems of different caregiver groups...

..Several reviews have been published on the predictive factors of subjective burden; however, such a review lacks information on objective burden, which refers to the amount and/or costs of informal care...

..Different symptoms have their own specific course, most of the time show a intermittent course, but behavioural problems overall are chronically present. The data have implications for developing treatment strategies...

..The data have implications for clinicians and the nosology of neuropsychiatric symptoms in dementia...

..Elevated morning cortisol levels could predispose caregivers to negative health consequences, with caregivers of patients with BPSD at greater risk...

..To evaluate the concordance of General Practitioners (GPs) with advice for treatment after a multidisciplinary psychogeriatric assessment by the Diagnostic Observation Centre for PsychoGeriatric patients (DOC-PG)...

..Diagnosis of preclinical AD may lead to more false positive outcomes if only the MTL atrophy is considered...

..Findings from this study underscore the importance of differentiating between diagnostic groups and specific behavioural domains when focusing on caregiver reactions to problem behaviour...

..Examination of clinical practice reveals that current treatment options are often not sufficiently utilized by patients suffering from dementia or mild cognitive impairment...

..The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD)...

..Cost-effectiveness results are relevant for decision making about new strategies in dementia care...

..This suggests that a combination of cognitive decline and structural brain changes might be an ideal biomarker for AD pathogenesis...

..The aim of this study is to assess frequency parameters of neuropsychiatric symptoms in YO-AD over 2 years and investigate whether there are differences compared with late-onset Alzheimer's disease (LO-AD)...

..In this model myelin breakdown is a beginning of the chain of pathological events leading to AD pathology and an AD diagnosis...

..Further studies addressing the pathogenesis of apathy are needed...

..To investigate which symptoms are indicative of preclinical dementia in general practice and whether subjects with preclinical dementia have an increased contact frequency with their general practitioner (GP)...

..Goal Attainment Scaling (GAS) seems to offer a meaningful outcome measure...

..Specifically, it was hypothesized that relatively intact awareness was related to affective disorders...

..This suggests that, although BP and WMSA are causally related, these differential metrics of vascular health may act via independent pathways to influence brain structure, EF and PS...

..Gray matter atrophy, an important biomarker for early Alzheimer's disease, might be due to white matter changes within gray matter...

..We could find no evidence of a specific serotonergic vulnerability of PD patients for depression. Therefore, our results do not support the serotonergic hypothesis for depression in PD...

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..To examine the temporal association between depressive symptoms and cognitive functioning and estimate the effect measure modification of the apolipoprotein E (APOE) epsilon4 allele on this relationship...

..Previous studies have indicated that not all subjects who meet the CAMDEX criteria of 'minimal dementia' progress to dementia. In the present study, predictors of outcome in minimally demented subjects were tested...

..Anxiety was regarded as a separate symptom. The subsyndrome mood/apathy was the most common, occurring in almost 80% of the patients, versus psychosis and hyperactivity, which occurred in 37 and 60% of the patients, respectively...

..It is argued that future interventions should focus on the specified determinants to improve programme effectiveness in reducing subjective memory complaints...

..To evaluate the efficacy of pharmacological treatment of apathy in patients with neurodegenerative diseases...

..To examine the feasibility of and clinical experiences with goal attainment scaling when used for the evaluation of cognitive rehabilitation in people with acquired brain injury...

..4 (95% CI: 2.1-2.7). We concluded that the higher incidence of depression in patients who were later diagnosed with PD supports the hypothesis of there being a biological risk factor for depression in these patients...

..General doubt about the beneficial effects of this widely used therapy necessitates a randomised clinical trial (RCT) to study the efficacy of PMT on the severity of paratonia and on the improvement of daily care...

..The phenomenology of delirium in childhood is understudied...

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..Step-wise scoring of the PAS can reduce the number of elaborate or expensive diagnostic procedures considerably...

..It is hypothesized that some of the non-motor symptoms are related to the serotonergic deficiency that is present in PD...

..In the interest of a further ethical debate concerning the development and use of antidementia drugs it is important to modify these theoretical considerations...

..The aim of this study was to compare the performance of the EQ-5D and the EQ-5D+C in elderly patients with cognitive impairments by assessing their construct validity and responsiveness...

..The aim of this study was to assess whether general risk factors for major depressive disorder (MDD) in the community are also risk factors for PSD, and to identify additional, stroke-related risk factors...

..Although frailty is often conceptualized in terms of deficits, the level of frailty can be perceived as a complex interplay between deficits and resources...

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..Some somatic symptoms are highly sensitive for depression and should not be neglected by following an 'exclusive' or 'attributional' approach to the diagnosis of PSD...

..Conceptual issues and the relationships between MS-related fatigue and mood, anxiety, cognition, personality, and cognitive-behavioral factors are discussed, and the implications for clinical practice and research are presented...

..Memory clinics (MCs) are multidisciplinary teams involved with early diagnosis and treatment of people with dementia. The main aim of this study was to gain more insight into the development of MCs in the Netherlands since 1998...

..Intervention programmes should target relationship problems when problem behaviour, especially apathy, is present in patients with dementia...

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..AD, p = 0.004). In conclusion, AD patients compared to MCI patients and controls have increased CVRi, whereas dCA parameters do not seem to differentiate AD patients. For MCI patients, CVRi might have predictive value in developing AD...

..Disciplines within an MT complement each other in establishing a specific diagnosis, which is considered to be the added value of such a multidisciplinary team...

..Performance on almost all cognitive tests was improved 6 and 12 months after stroke. Thus, while the frequency of post-stroke dementia is low, the frequency of post-stroke MCI is high, but improvement of cognitive function is possible...

..However, identification of specific caregiver strategies may provide useful information on the management and manifestation of behavioural problems in dementia...

..To estimate the prevalence of neuropsychiatric symptoms of dementia patients in Dutch nursing homes...

..To establish the construct validity of the Dutch version of the Cohen-Mansfield Agitation Inventory (CMAI-D) in institutionalized patients with dementia...

..To examine the influence of dementia stage and psychoactive medication use on the factor structure of the Neuropsychiatric Inventory-Nursing Home version (NPI-NH) in Dutch nursing home patients...

..Patients had a lower curve amplitude than control subjects (P=0.008). This study provides evidence of persistent traumatic brain alterations in patients who sustained a relatively mild traumatic brain injury...

..Only a subgroup of subjects with probable AD shows cognitive improvement after treatment with cholinesterase inhibitors...

..An individually tailored approach taking all these aspects into account is warranted as it may offer more, and better, pharmacological and non-pharmacological treatment opportunities...

..We interviewed caregivers of patients with dementia, focussing on issues of quality of life and the process of decision-making regarding the use of anti-dementia drugs...

..The aim of this study was to develop an assessment tool (the Paratonia Assessment Instrument, PAI), based on the new consensus definition of paratonia. An additional aim was to investigate the reliability and validity of the PAI...

..Better reporting on harms in RCTs is needed to enable rational treatment decisions with respect to use of antipsychotics for BPSD...

..These disease-specific cutoff scores were highest in PD, lower in AD, and lowest in stroke patients...

..For this reason, we initiated a Delphi procedure with known experts in the field to establish an operational consensus definition of paratonia...