Frans R J Verhey

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Olanzapine versus haloperidol in the treatment of agitation in elderly patients with dementia: results of a randomized controlled double-blind trial
    Frans R J Verhey
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 21:1-8. 2006
  2. doi request reprint Prevalence of neuropsychiatric symptoms in young-onset compared to late-onset Alzheimer's disease - part 1: findings of the two-year longitudinal NeedYD-study
    Deliane van Vliet
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 34:319-27. 2012
  3. doi request reprint Subjective forgetfulness is associated with lower quality of life in middle-aged and young-old individuals: a 9-year follow-up in older participants from the Maastricht Aging Study
    Martine E M Mol
    Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience MHeNS European Graduate School of Neuroscience Euron, The Netherlands
    Aging Ment Health 13:699-705. 2009
  4. ncbi request reprint Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part II
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 25:1-8. 2008
  5. doi request reprint The predictive value of memory strategies for Alzheimer's disease in subjects with mild cognitive impairment
    Inez H G B Ramakers
    Department of Psychiatry and Neuropsychology Alzheimer Center Limburg, School for Mental Health and Neurosciences, Maastricht University Medical Center, Maastricht, The Netherlands
    Arch Clin Neuropsychol 25:71-7. 2010
  6. doi request reprint The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA Study
    Angelique P A Vermeiren
    Caphri, Department of Social Medicine, Maastricht University, Maastricht, The Netherlands
    J Alzheimers Dis 35:241-6. 2013
  7. pmc Association between white matter microstructure, executive functions, and processing speed in older adults: the impact of vascular health
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, University Maastricht, 6200 MD Maastricht, The Netherlands
    Hum Brain Mapp 34:77-95. 2013
  8. ncbi request reprint Cognitive functioning in spousal caregivers of dementia patients: findings from the prospective MAASBED study
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Age Ageing 35:160-6. 2006
  9. doi request reprint Characteristics of help-seeking behaviour in subjects with subjective memory complaints at a memory clinic: a case-control study
    Inez H G B Ramakers
    Department of Psychiatry and Neuropsychology, Institute of Brain and Behaviour, Maastricht University, The Netherlands
    Int J Geriatr Psychiatry 24:190-6. 2009
  10. doi request reprint Neuropsychological correlates of apathy in mild cognitive impairment and Alzheimer's disease: the role of executive functioning
    Rosa L Drijgers
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    Int Psychogeriatr 23:1327-33. 2011

Detail Information

Publications82

  1. ncbi request reprint Olanzapine versus haloperidol in the treatment of agitation in elderly patients with dementia: results of a randomized controlled double-blind trial
    Frans R J Verhey
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 21:1-8. 2006
    ..They were well tolerated and had a similar side-effect pattern. Our study could not demonstrate the superiority of olanzapine, compared to haloperidol, for the treatment of agitation in patients with dementia...
  2. doi request reprint Prevalence of neuropsychiatric symptoms in young-onset compared to late-onset Alzheimer's disease - part 1: findings of the two-year longitudinal NeedYD-study
    Deliane van Vliet
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 34:319-27. 2012
    ..The aim of this study is to assess frequency parameters of neuropsychiatric symptoms in YO-AD over 2 years and investigate whether there are differences compared with late-onset Alzheimer's disease (LO-AD)...
  3. doi request reprint Subjective forgetfulness is associated with lower quality of life in middle-aged and young-old individuals: a 9-year follow-up in older participants from the Maastricht Aging Study
    Martine E M Mol
    Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience MHeNS European Graduate School of Neuroscience Euron, The Netherlands
    Aging Ment Health 13:699-705. 2009
    ..The second objective was to assess whether the association between perceived forgetfulness and quality of life changes over a 9-year follow-up period...
  4. ncbi request reprint Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part II
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 25:1-8. 2008
    ..g. dementia subtypes, dementia severity, medication use, age and gender) in a large sample of outpatients with dementia...
  5. doi request reprint The predictive value of memory strategies for Alzheimer's disease in subjects with mild cognitive impairment
    Inez H G B Ramakers
    Department of Psychiatry and Neuropsychology Alzheimer Center Limburg, School for Mental Health and Neurosciences, Maastricht University Medical Center, Maastricht, The Netherlands
    Arch Clin Neuropsychol 25:71-7. 2010
    ..Prodromal AD is characterized by a decreased use of effortful learning strategies. This finding may have implications for the early detection of AD in MCI subjects and for the development of cognitive training programs...
  6. doi request reprint The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA Study
    Angelique P A Vermeiren
    Caphri, Department of Social Medicine, Maastricht University, Maastricht, The Netherlands
    J Alzheimers Dis 35:241-6. 2013
    ..81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention...
  7. pmc Association between white matter microstructure, executive functions, and processing speed in older adults: the impact of vascular health
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, University Maastricht, 6200 MD Maastricht, The Netherlands
    Hum Brain Mapp 34:77-95. 2013
    ..This suggests that, although BP and WMSA are causally related, these differential metrics of vascular health may act via independent pathways to influence brain structure, EF and PS...
  8. ncbi request reprint Cognitive functioning in spousal caregivers of dementia patients: findings from the prospective MAASBED study
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Age Ageing 35:160-6. 2006
    ..Spousal caregivers are usually of the same age as the dementia patient and therefore at risk of age-related cognitive decline. Suboptimal cognitive functioning in caregivers may have profound implications...
  9. doi request reprint Characteristics of help-seeking behaviour in subjects with subjective memory complaints at a memory clinic: a case-control study
    Inez H G B Ramakers
    Department of Psychiatry and Neuropsychology, Institute of Brain and Behaviour, Maastricht University, The Netherlands
    Int J Geriatr Psychiatry 24:190-6. 2009
    ..Only a subset of these subjects seeks medical attention for these complaints. The aim of the present study was to investigate which factors determine why people with subjective memory complaints (SMC) seek medical attention...
  10. doi request reprint Neuropsychological correlates of apathy in mild cognitive impairment and Alzheimer's disease: the role of executive functioning
    Rosa L Drijgers
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    Int Psychogeriatr 23:1327-33. 2011
    ..The aim of the current study was to examine the association between apathy and neuropsychological functioning in patients with MCI and AD...
  11. ncbi request reprint Patterns of gray and white matter changes in individuals at risk for Alzheimer's disease
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, The Netherlands
    Curr Alzheimer Res 9:1097-105. 2012
    ..This suggests that a combination of cognitive decline and structural brain changes might be an ideal biomarker for AD pathogenesis...
  12. ncbi request reprint A prospective study of the effects of behavioral symptoms on the institutionalization of patients with dementia
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int Psychogeriatr 17:577-89. 2005
    ..The aim of the present study was to examine the impact of specific behavioral subsyndromes and caregivers' emotional reaction on NHP...
  13. ncbi request reprint Relationship between measures of dementia severity and observation of daily life functioning as measured with the Assessment of Motor and Process Skills (AMPS)
    Sharon F M Bouwens
    School for Mental Health and Neuroscience Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 25:81-7. 2008
    ..The relationship between these domains is unclear. The Assessment of Motor and Process Skills (AMPS) is a relatively unexplored instrument in people with dementia, measuring severity by direct observation...
  14. ncbi request reprint Challenging the serotonergic system in Parkinson disease patients: effects on cognition, mood, and motor performance
    Bart Scholtissen
    Institute of Brain and Behaviour, Maastricht University Hospital, Maastricht, The Netherlands
    Clin Neuropharmacol 29:276-85. 2006
    ..Multiple neurotransmitter systems, including the serotonergic system, are involved in the pathophysiology of this disease. The exact role of the serotonergic system in PD is still unclear...
  15. doi request reprint Integrated multidisciplinary diagnostic approach for dementia care: randomised controlled trial
    Claire A G Wolfs
    Department of Psychiatry and Neuropsychology, University Hospital of Maastricht Alzheimer Centre Limburg, Maastricht, The Netherlands
    Br J Psychiatry 192:300-5. 2008
    ..An integrated multidisciplinary approach to dementia is often recommended but has rarely been evaluated...
  16. doi request reprint Association between cognition and daily life functioning in dementia subtypes
    Sharon F M Bouwens
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Int J Geriatr Psychiatry 24:764-9. 2009
    ..To investigate the association between cognition and daily life functioning in dementia subtypes...
  17. doi request reprint The impact of fatigue on cognitive functioning in patients with multiple sclerosis
    Yvonne Bol
    Department of Medical Psychology and Psychiatry, Orbis Medical Centre, Sittard, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Clin Rehabil 24:854-62. 2010
    ..To study the impact of physical and mental fatigue on cognitive complaints and cognitive performance in patients with multiple sclerosis...
  18. ncbi request reprint The influence of neuropsychological functioning on neuropsychiatric problems in dementia
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, University Hospital of Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    J Neuropsychiatry Clin Neurosci 19:50-6. 2007
    ..In particular, a low level of language expression was related to higher levels of overall neuropsychiatric problems and to psychosis. Impairment of abstract reasoning was related to psychosis and aberrant motor behavior...
  19. doi request reprint Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis
    Lyzel S Elias-Sonnenschein
    School of Mental Health and Neuroscience, Alzheimer Center Limburg, Department of Psychiatry and Neuropsychology, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neurol Neurosurg Psychiatry 82:1149-56. 2011
    ..The APOE-ε4 allele is the strongest known genetic risk factor for AD. The authors performed a meta-analysis to establish the predictive accuracy of the APOE-ε4 allele for progression from MCI to AD-type dementia...
  20. doi request reprint Awareness and its association with affective symptoms in young-onset and late-onset Alzheimer disease: a prospective study
    Deliane van Vliet
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    Alzheimer Dis Assoc Disord 27:265-71. 2013
    ..The present study assesses possible differences between young-onset (YO-AD) and late-onset Alzheimer disease (LO-AD) in awareness levels and the association between awareness and affective symptoms...
  21. ncbi request reprint Predictive factors for the objective burden of informal care in people with dementia: a systematic review
    Claire A G Wolfs
    Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience MHeNS Alzheimer Centre Limburg, Maastricht, The Netherlands
    Alzheimer Dis Assoc Disord 26:197-204. 2012
    ..Several reviews have been published on the predictive factors of subjective burden; however, such a review lacks information on objective burden, which refers to the amount and/or costs of informal care...
  22. ncbi request reprint The course of neuropsychiatric symptoms in dementia. Part I: findings from the two-year longitudinal Maasbed study
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 20:523-30. 2005
    ..Although neuropsychiatric symptoms in dementia are common, there have been few large long-term prospective studies assessing the course of a broad range of neuropsychiatric symptoms in dementia...
  23. ncbi request reprint The course of neuropsychiatric symptoms in dementia. Part II: relationships among behavioural sub-syndromes and the influence of clinical variables
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 20:531-6. 2005
    ..Although several studies have mentioned associations between neuropsychiatric symptoms, there have been no prospective studies determining interrelations among behavioural sub-syndromes...
  24. doi request reprint Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker?
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
    Alzheimers Dement 9:93-7. 2013
    ..Gray matter atrophy, an important biomarker for early Alzheimer's disease, might be due to white matter changes within gray matter...
  25. ncbi request reprint Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Hospital, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 24:457-63. 2007
    ..The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD)...
  26. doi request reprint Empowered or overpowered? Service use, needs, wants and demands in elderly patients with cognitive impairments
    Claire A G Wolfs
    Department of Psychiatry and Neuropsychology, University Hospital Maastricht Alzheimer Center Limburg, Maastricht, The Netherlands
    Int J Geriatr Psychiatry 25:1006-12. 2010
    ..Examination of clinical practice reveals that current treatment options are often not sufficiently utilized by patients suffering from dementia or mild cognitive impairment...
  27. doi request reprint Economic evaluation of an integrated diagnostic approach for psychogeriatric patients: results of a randomized controlled trial
    Claire A G Wolfs
    Department of Psychiatry and Neuropsychology, University Hospital of Maastricht Alzheimer Centre Limburg, Maastricht, The Netherlands
    Arch Gen Psychiatry 66:313-23. 2009
    ..Cost-effectiveness results are relevant for decision making about new strategies in dementia care...
  28. doi request reprint Increasing the diagnostic accuracy of medial temporal lobe atrophy in Alzheimer's disease
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    J Alzheimers Dis 25:477-90. 2011
    ..Diagnosis of preclinical AD may lead to more false positive outcomes if only the MTL atrophy is considered...
  29. ncbi request reprint Impact of behavioural problems on spousal caregivers: a comparison between Alzheimer's disease and frontotemporal dementia
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 22:35-41. 2006
    ..The aim of this study was to compare caregivers' distress related to behavioural symptoms of AD and FTD...
  30. ncbi request reprint Behavioral problems in dementia patients and salivary cortisol patterns in caregivers
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University Hospital of Maastricht, The Netherlands
    J Neuropsychiatry Clin Neurosci 17:201-7. 2005
    ..Elevated morning cortisol levels could predispose caregivers to negative health consequences, with caregivers of patients with BPSD at greater risk...
  31. ncbi request reprint GP concordance with advice for treatment following a multidisciplinary psychogeriatric assessment
    Claire A G Wolfs
    Department of Clinical Epidemiology and Medical Technology Assessment, University Hospital of Maastricht, Maastricht, The Netherlands
    Int J Geriatr Psychiatry 22:233-40. 2007
    ..To evaluate the concordance of General Practitioners (GPs) with advice for treatment after a multidisciplinary psychogeriatric assessment by the Diagnostic Observation Centre for PsychoGeriatric patients (DOC-PG)...
  32. ncbi request reprint [Use of cerebrospinal fluid (CSF) biomarkers for Alzheimer's type dementia: diagnosis in mild cognitive impairment]
    Frans R J Verhey
    MUMC, Alzheimer Centrum Limburg, Maastricht, The Netherlands
    Ned Tijdschr Geneeskd 157:A5596. 2013
    ..The added value of CSF biomarkers is not yet clear in MCI patients in whom extensive clinical, neuropsychological examination or imaging have already been performed...
  33. doi request reprint Caregivers' perspectives on the pre-diagnostic period in early onset dementia: a long and winding road
    Deliane van Vliet
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    Int Psychogeriatr 23:1393-404. 2011
    ..The objectives of this study are to investigate the barriers to diagnosis and to develop a typology of the diagnosis pathway for EOD caregivers...
  34. doi request reprint Parietal cortex matters in Alzheimer's disease: an overview of structural, functional and metabolic findings
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
    Neurosci Biobehav Rev 36:297-309. 2012
    ..In this model myelin breakdown is a beginning of the chain of pathological events leading to AD pathology and an AD diagnosis...
  35. doi request reprint Neuroanatomical correlates of apathy in Parkinson's disease: A magnetic resonance imaging study using voxel-based morphometry
    Jennifer S A M Reijnders
    Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands
    Mov Disord 25:2318-25. 2010
    ..Further studies addressing the pathogenesis of apathy are needed...
  36. doi request reprint Review of goal attainment scaling as a useful outcome measure in psychogeriatric patients with cognitive disorders
    Sharon F M Bouwens
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 26:528-40. 2008
    ..Goal Attainment Scaling (GAS) seems to offer a meaningful outcome measure...
  37. ncbi request reprint Symptoms of preclinical dementia in general practice up to five years before dementia diagnosis
    Inez H G B Ramakers
    Department of Psychiatry and Neuropsychology, Institute of Brain and Behavior, Maastricht University, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 24:300-6. 2007
    ..To investigate which symptoms are indicative of preclinical dementia in general practice and whether subjects with preclinical dementia have an increased contact frequency with their general practitioner (GP)...
  38. ncbi request reprint Awareness and behavioral problems in dementia patients: a prospective study
    Pauline Aalten
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, University of Maastricht, Maastricht, The Netherlands
    Int Psychogeriatr 18:3-17. 2006
    ..Specifically, it was hypothesized that relatively intact awareness was related to affective disorders...
  39. pmc Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort
    Lyzel S Elias-Sonnenschein
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 8:e59676. 2013
    ....
  40. doi request reprint Co-occurrence of different pathologies in dementia: implications for dementia diagnosis
    Carmen Echávarri
    School for Mental Health and Neuroscience Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    J Alzheimers Dis 30:909-17. 2012
    ....
  41. doi request reprint Dynamic cerebral autoregulation in subjects with Alzheimer's disease, mild cognitive impairment, and controls: evidence for increased peripheral vascular resistance with possible predictive value
    Erik D Gommer
    Department of Clinical Neurophysiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Alzheimers Dis 30:805-13. 2012
    ..AD, p = 0.004). In conclusion, AD patients compared to MCI patients and controls have increased CVRi, whereas dCA parameters do not seem to differentiate AD patients. For MCI patients, CVRi might have predictive value in developing AD...
  42. ncbi request reprint The serotonergic hypothesis for depression in Parkinson's disease: an experimental approach
    Albert F G Leentjens
    Department of Psychiatry, Maastricht University Hospital, Maastricht, The Netherlands
    Neuropsychopharmacology 31:1009-15. 2006
    ..We could find no evidence of a specific serotonergic vulnerability of PD patients for depression. Therefore, our results do not support the serotonergic hypothesis for depression in PD...
  43. pmc Research protocol of the NeedYD-study (Needs in Young onset Dementia): a prospective cohort study on the needs and course of early onset dementia
    Deliane van Vliet
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    BMC Geriatr 10:13. 2010
    ....
  44. doi request reprint Depressive symptoms and cognitive decline in community-dwelling older adults
    Sebastian Kohler
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Am Geriatr Soc 58:873-9. 2010
    ..To examine the temporal association between depressive symptoms and cognitive functioning and estimate the effect measure modification of the apolipoprotein E (APOE) epsilon4 allele on this relationship...
  45. ncbi request reprint Behavioral problems in dementia: a factor analysis of the neuropsychiatric inventory
    Pauline Aalten
    Brain and Behavior Institute, University of Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 15:99-105. 2003
    ..Anxiety was regarded as a separate symptom. The subsyndrome mood/apathy was the most common, occurring in almost 80% of the patients, versus psychosis and hyperactivity, which occurred in 37 and 60% of the patients, respectively...
  46. ncbi request reprint Course of minimal dementia and predictors of outcome
    Pieter Jelle Visser
    Department of Psychiatry and Neuropsychology, Institute of Brain and Behavior, University of Maastricht, Maastricht, The Netherlands
    Int J Geriatr Psychiatry 17:835-41. 2002
    ..Previous studies have indicated that not all subjects who meet the CAMDEX criteria of 'minimal dementia' progress to dementia. In the present study, predictors of outcome in minimally demented subjects were tested...
  47. doi request reprint A study into the psychosocial determinants of perceived forgetfulness: implications for future interventions
    Martine E M Mol
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience EURON, Maastricht University, The Netherlands
    Aging Ment Health 12:167-76. 2008
    ..It is argued that future interventions should focus on the specified determinants to improve programme effectiveness in reducing subjective memory complaints...
  48. doi request reprint Pharmacological treatment of apathy in neurodegenerative diseases: a systematic review
    Rosa L Drijgers
    Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 28:13-22. 2009
    ..To evaluate the efficacy of pharmacological treatment of apathy in patients with neurodegenerative diseases...
  49. doi request reprint The practical use of goal attainment scaling for people with acquired brain injury who receive cognitive rehabilitation
    Sharon F M Bouwens
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    Clin Rehabil 23:310-20. 2009
    ..To examine the feasibility of and clinical experiences with goal attainment scaling when used for the evaluation of cognitive rehabilitation in people with acquired brain injury...
  50. pmc Passive movement therapy in patients with moderate to severe paratonia; study protocol of a randomised clinical trial (ISRCTN43069940)
    Johannes S M Hobbelen
    Physiotherapy Research Vitalis WoonZorg groep Eindhoven, The Netherlands
    BMC Geriatr 7:30. 2007
    ..General doubt about the beneficial effects of this widely used therapy necessitates a randomised clinical trial (RCT) to study the efficacy of PMT on the severity of paratonia and on the improvement of daily care...
  51. ncbi request reprint Higher incidence of depression preceding the onset of Parkinson's disease: a register study
    Albert F G Leentjens
    Department of Psychiatry, Maastricht University Hospital, Maastricht, The Netherlands
    Mov Disord 18:414-8. 2003
    ..4 (95% CI: 2.1-2.7). We concluded that the higher incidence of depression in patients who were later diagnosed with PD supports the hypothesis of there being a biological risk factor for depression in these patients...
  52. ncbi request reprint General and disease-specific risk factors for depression after ischemic stroke: a two-step Cox regression analysis
    Albert F G Leentjens
    Department of Psychiatry, Maastricht University Hospital, the NetherlandsInstitute of Brain and Behavior, Maastricht University, The Netherlands
    Int Psychogeriatr 18:739-48. 2006
    ..The aim of this study was to assess whether general risk factors for major depressive disorder (MDD) in the community are also risk factors for PSD, and to identify additional, stroke-related risk factors...
  53. ncbi request reprint Effects of acute tryptophan depletion on cognition, memory and motor performance in Parkinson's disease
    Bart Scholtissen
    Institute of Brain and Behaviour, Maastricht University, P O Box 616 6200 MD Maastricht, The Netherlands
    J Neurol Sci 248:259-65. 2006
    ..It is hypothesized that some of the non-motor symptoms are related to the serotonergic deficiency that is present in PD...
  54. doi request reprint A comparison of the phenomenology of pediatric, adult, and geriatric delirium
    Albert F G Leentjens
    Department of Psychiatry, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Psychosom Res 64:219-23. 2008
    ..The phenomenology of delirium in childhood is understudied...
  55. ncbi request reprint [Ethical aspects of anti-Alzheimer drugs: experiences of caregivers]
    Anna R Huizing
    Cluster Zorgwetenschappen, Sectie Verplegingswetenschap, Universiteit Maastricht, Postbus 616, 6200 MD Maastricht
    Tijdschr Gerontol Geriatr 33:246-51. 2002
    ..In the interest of a further ethical debate concerning the development and use of antidementia drugs it is important to modify these theoretical considerations...
  56. ncbi request reprint Cross-national comparisons of the Cambridge Cognitive Examination-revised: the CAMCOG-R: results from the European Harmonization Project for Instruments in Dementia
    Frans R J Verhey
    Institute Brain and Behaviour, University Hospital of Maastricht, The Netherlands
    Age Ageing 32:534-40. 2003
    ....
  57. pmc Performance of the EQ-5D and the EQ-5D+C in elderly patients with cognitive impairments
    Claire A G Wolfs
    Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Hospital, Maastricht, Netherlands
    Health Qual Life Outcomes 5:33. 2007
    ..The aim of this study was to compare the performance of the EQ-5D and the EQ-5D+C in elderly patients with cognitive impairments by assessing their construct validity and responsiveness...
  58. ncbi request reprint Diagnostic accuracy of the Preclinical AD Scale (PAS) in cognitively mildly impaired subjects
    Pieter Jelle Visser
    Department of Psychiatry and Neuropsychology, Institute of Brain and Behaviour, University of Maastricht, The Netherlands
    J Neurol 249:312-9. 2002
    ..Step-wise scoring of the PAS can reduce the number of elaborate or expensive diagnostic procedures considerably...
  59. pmc Effects of type 2 diabetes on 12-year cognitive change: results from the Maastricht Aging Study
    Peggy J J Spauwen
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Diabetes Care 36:1554-61. 2013
    ..To examine the effects of baseline and incident diabetes on change in cognitive function over 12 years...
  60. doi request reprint Resources as a protective factor for negative outcomes of frailty in elderly people
    Bart H L Ament
    CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands
    Gerontology 58:391-7. 2012
    ..Although frailty is often conceptualized in terms of deficits, the level of frailty can be perceived as a complex interplay between deficits and resources...
  61. doi request reprint Association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre, Limburg, Maastricht University, Maastricht, The Netherlands
    Neurobiol Aging 33:201.e1-8. 2012
    ....
  62. doi request reprint The psychology of fatigue in patients with multiple sclerosis: a review
    Yvonne Bol
    Department of Psychology, Maastricht University Medical Center, Maastricht, The Netherlands
    J Psychosom Res 66:3-11. 2009
    ..Conceptual issues and the relationships between MS-related fatigue and mood, anxiety, cognition, personality, and cognitive-behavioral factors are discussed, and the implications for clinical practice and research are presented...
  63. doi request reprint Development of memory clinics in the Netherlands: 1998 to 2009
    Inez H G B Ramakers
    Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, The Netherlands
    Aging Ment Health 15:34-9. 2011
    ..Memory clinics (MCs) are multidisciplinary teams involved with early diagnosis and treatment of people with dementia. The main aim of this study was to gain more insight into the development of MCs in the Netherlands since 1998...
  64. ncbi request reprint The sensitivity of somatic symptoms in post-stroke depression: a discriminant analytic approach
    Liesbeth de Coster
    Department of Psychiatry, Maastricht University Hospital, Maastricht, The Netherlands
    Int J Geriatr Psychiatry 20:358-62. 2005
    ..Somatic and neurocognitive symptoms of depression may overlap with the physical symptoms of stroke, and thus make the diagnosis of post-stroke depression difficult...
  65. ncbi request reprint Behavioural disturbances in dementia patients and quality of the marital relationship
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Int J Geriatr Psychiatry 18:149-54. 2003
    ..To investigate the relationship between behavioural problems in patients with dementia and changes in the marital relationship...
  66. doi request reprint Amyloid-β interacts with blood-brain barrier function in dementia: a systematic review
    Saartje Burgmans
    Department of Psychiatry and Neuropsychology Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    J Alzheimers Dis 35:859-73. 2013
    ..The present systematic analysis describes the available evidence for a significant interplay between amyloid-β and blood-brain barrier function in dementia...
  67. ncbi request reprint Cognitive functioning after stroke: a one-year follow-up study
    Sascha M C Rasquin
    Department of Psychiatry and Neuropsychology, University Hospital Maastricht, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 18:138-44. 2004
    ..Performance on almost all cognitive tests was improved 6 and 12 months after stroke. Thus, while the frequency of post-stroke dementia is low, the frequency of post-stroke MCI is high, but improvement of cognitive function is possible...
  68. ncbi request reprint The added value of a multidisciplinary approach in diagnosing dementia: a review
    Claire A G Wolfs
    Department of Clinical Epidemiology and Medical Technology Assessment, University Hospital Maastricht, Maastricht, The Netherlands
    Int J Geriatr Psychiatry 21:223-32. 2006
    ..The impact of dementia constitutes a major public health challenge to our society. A multidisciplinary approach to dementia is generally recommended...
  69. doi request reprint Natural progression model of cognition and physical functioning among people with mild cognitive impairment and alzheimer's disease
    Ron L H Handels
    Alzheimer Centre Limburg, School for Mental Health and NeuroScience MHeNS, University Medical Centre, Maastricht, The Netherlands
    J Alzheimers Dis 37:357-65. 2013
    ..Empirical models of the natural history of Alzheimer's disease (AD) may help to evaluate new interventions for AD...
  70. ncbi request reprint Do caregiver management strategies influence patient behaviour in dementia?
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 19:85-92. 2004
    ..However, identification of specific caregiver strategies may provide useful information on the management and manifestation of behavioural problems in dementia...
  71. ncbi request reprint Characteristics of preclinical Alzheimer's disease
    Pieter Jelle Visser
    Int J Geriatr Psychiatry 17:88-9. 2002
  72. doi request reprint Diagnosing paratonia in the demented elderly: reliability and validity of the Paratonia Assessment Instrument (PAI)
    Johannes S M Hobbelen
    Physiotherapy Research Vitalis WoonZorg Groep, Eindhoven, The Netherlands
    Int Psychogeriatr 20:840-52. 2008
    ..The aim of this study was to develop an assessment tool (the Paratonia Assessment Instrument, PAI), based on the new consensus definition of paratonia. An additional aim was to investigate the reliability and validity of the PAI...
  73. ncbi request reprint Brain lesions in patients visiting a memory clinic with postconcussional sequelae after mild to moderate brain injury
    Paul A M Hofman
    Department of Radiology, University Hospital Maastricht, The Netherlands
    J Neuropsychiatry Clin Neurosci 14:176-84. 2002
    ..Patients had a lower curve amplitude than control subjects (P=0.008). This study provides evidence of persistent traumatic brain alterations in patients who sustained a relatively mild traumatic brain injury...
  74. ncbi request reprint Disease-specific properties of the Rating Scale for Depression in patients with stroke, Alzheimer's dementia, and Parkinson's disease
    Paul Naarding
    Department of Psychiatry, University Medical Center Nijmegen, The Netherlands
    J Neuropsychiatry Clin Neurosci 14:329-34. 2002
    ..These disease-specific cutoff scores were highest in PD, lower in AD, and lowest in stroke patients...
  75. ncbi request reprint Neuropsychiatric symptoms in nursing home patients: factor structure invariance of the Dutch nursing home version of the neuropsychiatric inventory in different stages of dementia
    Sytse U Zuidema
    Department of Nursing Home Medicine, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Dement Geriatr Cogn Disord 24:169-76. 2007
    ..To examine the influence of dementia stage and psychoactive medication use on the factor structure of the Neuropsychiatric Inventory-Nursing Home version (NPI-NH) in Dutch nursing home patients...
  76. ncbi request reprint Prevalence of neuropsychiatric symptoms in a large sample of Dutch nursing home patients with dementia
    Sytse U Zuidema
    Kalorama, Beek Ubbergen, The Netherlands
    Int J Geriatr Psychiatry 22:632-8. 2007
    ..To estimate the prevalence of neuropsychiatric symptoms of dementia patients in Dutch nursing homes...
  77. ncbi request reprint Medial temporal lobe atrophy and APOE genotype do not predict cognitive improvement upon treatment with rivastigmine in Alzheimer's disease patients
    Pieter Jelle Visser
    Department of Neurology, Alzheimer Centre, VU Medisch Centrum, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 19:126-33. 2005
    ..Only a subgroup of subjects with probable AD shows cognitive improvement after treatment with cholinesterase inhibitors...
  78. ncbi request reprint Agitation in Dutch institutionalized patients with dementia: factor analysis of the Dutch version of the Cohen-Mansfield Agitation Inventory
    Sytse U Zuidema
    Department of Nursing Home Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Dement Geriatr Cogn Disord 23:35-41. 2007
    ..To establish the construct validity of the Dutch version of the Cohen-Mansfield Agitation Inventory (CMAI-D) in institutionalized patients with dementia...
  79. ncbi request reprint Antipsychotics for behavioural and psychological problems in elderly people with dementia: a systematic review of adverse events
    Marianne B van Iersel
    Department of Geriatrics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Drugs Aging 22:845-58. 2005
    ..This study systematically reviews the reporting of adverse events of antipsychotics used to treat BPSD in randomised, controlled trials (RCTs)...
  80. ncbi request reprint Do caregivers' experiences correspond with the concerns raised in the literature? Ethical issues relating to anti-dementia drugs
    Anna R Huizing
    Department of Nursing Science, Maastricht University, University Hospital of Maastricht, The Netherlands
    Int J Geriatr Psychiatry 21:869-75. 2006
    ..We interviewed caregivers of patients with dementia, focussing on issues of quality of life and the process of decision-making regarding the use of anti-dementia drugs...
  81. ncbi request reprint Grouping for behavioral and psychological symptoms in dementia: clinical and biological aspects. Consensus paper of the European Alzheimer disease consortium
    Philippe H Robert
    Centre Mémoire de Ressources and de Recherche, CHU, Hopital Pasteur, Universite de Nice Sophia Antipolis, 30, avenue de la Voie Romaine, 06002 Nice cedex 1, France
    Eur Psychiatry 20:490-6. 2005
    ..An individually tailored approach taking all these aspects into account is warranted as it may offer more, and better, pharmacological and non-pharmacological treatment opportunities...
  82. ncbi request reprint Paratonia: a Delphi procedure for consensus definition
    Johannes S M Hobbelen
    Physiotherapy Research Vitalis Zorggroep Eindhoven, Vlasmeersestraat 5, 5261 TA Vught, The Netherlands
    J Geriatr Phys Ther 29:50-6. 2006
    ..For this reason, we initiated a Delphi procedure with known experts in the field to establish an operational consensus definition of paratonia...