Ruud van Winkel

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. pmc Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht, The Netherlands
    Schizophr Bull 34:1095-105. 2008
  2. ncbi request reprint Evidence that the impact of hearing impairment on psychosis risk is moderated by the level of complexity of the social environment
    Margriet van der Werf
    Department of Psychiatry and Neuropsychology, EURON Graduate School of Neuroscience, Maastricht University Medical Centre, PO BOX 616 VIJV, 6200MD Maastricht, The Netherlands
    Schizophr Res 122:193-8. 2010
  3. pmc Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data
    Carla Truyers
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Fam Pract 12:132. 2011
  4. doi request reprint MTHFR and risk of metabolic syndrome in patients with schizophrenia
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Schizophr Res 121:193-8. 2010
  5. doi request reprint REVIEW: Genome-wide findings in schizophrenia and the role of gene-environment interplay
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, The Netherlands
    CNS Neurosci Ther 16:e185-92. 2010
  6. doi request reprint MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: an observational study
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Int Clin Psychopharmacol 25:270-6. 2010
  7. pmc AKT1 moderation of cannabis-induced cognitive alterations in psychotic disorder
    Ruud van Winkel
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience EURON, South Limburg Mental Health Research and Teaching Network SEARCH, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neuropsychopharmacology 36:2529-37. 2011
  8. doi request reprint COMT Val158Met-stress interaction in psychosis: role of background psychosis risk
    Dina Collip
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands
    CNS Neurosci Ther 17:612-9. 2011
  9. doi request reprint Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
    Odette L J Peerbooms
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University, Maastricht, The Netherlands
    Brain Behav Immun 25:1530-43. 2011
  10. ncbi request reprint Childhood trauma as a cause of psychosis: linking genes, psychology, and biology
    Ruud van Winkel
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Can J Psychiatry 58:44-51. 2013

Collaborators

Detail Information

Publications17

  1. pmc Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht, The Netherlands
    Schizophr Bull 34:1095-105. 2008
    ....
  2. ncbi request reprint Evidence that the impact of hearing impairment on psychosis risk is moderated by the level of complexity of the social environment
    Margriet van der Werf
    Department of Psychiatry and Neuropsychology, EURON Graduate School of Neuroscience, Maastricht University Medical Centre, PO BOX 616 VIJV, 6200MD Maastricht, The Netherlands
    Schizophr Res 122:193-8. 2010
    ....
  3. pmc Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data
    Carla Truyers
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Fam Pract 12:132. 2011
    ..Many studies are performed in specialized settings with a strong focus on schizophrenia. Somatic comorbidity after psychosis is studied, using a general practice comorbidity registration network...
  4. doi request reprint MTHFR and risk of metabolic syndrome in patients with schizophrenia
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Schizophr Res 121:193-8. 2010
    ..Meta-analyses have implicated polymorphisms in MTHFR, encoding a critical enzyme in folate and homocysteine metabolism, in both schizophrenia and CVD...
  5. doi request reprint REVIEW: Genome-wide findings in schizophrenia and the role of gene-environment interplay
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, The Netherlands
    CNS Neurosci Ther 16:e185-92. 2010
    ..Collaborative efforts that bring together expertise in statistics, genetics, epidemiology, experimental psychiatry, brain imaging, and clinical psychiatry will be required to succeed in this challenging task...
  6. doi request reprint MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: an observational study
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Int Clin Psychopharmacol 25:270-6. 2010
    ..A1298C allele carriers consistently displayed the most unfavorable evolution of metabolic parameters. Thus, MTHFR A1298C genotype may explain part of the individual liability to metabolic disturbances in patients with schizophrenia...
  7. pmc AKT1 moderation of cannabis-induced cognitive alterations in psychotic disorder
    Ruud van Winkel
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience EURON, South Limburg Mental Health Research and Teaching Network SEARCH, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neuropsychopharmacology 36:2529-37. 2011
    ..The results suggest that long-term changes in cognition may mediate the risk-increasing effect of the AKT1 × cannabis interaction on psychotic disorder...
  8. doi request reprint COMT Val158Met-stress interaction in psychosis: role of background psychosis risk
    Dina Collip
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands
    CNS Neurosci Ther 17:612-9. 2011
    ....
  9. doi request reprint Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
    Odette L J Peerbooms
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University, Maastricht, The Netherlands
    Brain Behav Immun 25:1530-43. 2011
    ..This study provides evidence for shared genetic vulnerability for SZ, BPD and UDD mediated by MTHFR 677TT genotype, which is in line with epigenetic involvement in the pathophysiology of these psychiatric disorders...
  10. ncbi request reprint Childhood trauma as a cause of psychosis: linking genes, psychology, and biology
    Ruud van Winkel
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Can J Psychiatry 58:44-51. 2013
    ....
  11. doi request reprint FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma
    Dina Collip
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Br J Psychiatry 202:261-8. 2013
    ..FK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma...
  12. doi request reprint Genetic association study of the P300 endophenotype in schizophrenia
    Jeroen Decoster
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Schizophr Res 141:54-9. 2012
    ..This study aims to examine associations between P300 and a range of candidate genetic variants, selected from either candidate gene studies or genome-wide association studies, in a large sample of patients with schizophrenia...
  13. ncbi request reprint Genetic variation underlying psychosis-inducing effects of cannabis: critical review and future directions
    Jeroen Decoster
    Dept of Psychiatry and Psychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, The Netherlands
    Curr Pharm Des 18:5015-23. 2012
    ..Possible strategies for future cannabis interaction studies are discussed...
  14. pmc Phenotypically continuous with clinical psychosis, discontinuous in need for care: evidence for an extended psychosis phenotype
    Martine van Nierop
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, PO BOX 616 VIJV1, 6200 MD Maastricht, The Netherlands
    Schizophr Bull 38:231-8. 2012
    ..Design: The second Netherlands Mental Health Survey and Incidence Study-2, a general population study...
  15. doi request reprint Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up
    Ruud van Winkel
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Arch Gen Psychiatry 68:148-57. 2011
    ..Individual differences exist in sensitivity to the psychotomimetic effect of cannabis; the molecular genetic basis underlying differential sensitivity remains elusive...
  16. pmc COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge
    Dennis Hernaus
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands
    PLoS ONE 8:e65662. 2013
    ..Implications of these results for stress-related psychopathology and models of dopaminergic functioning are discussed. ..
  17. doi request reprint CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia
    Weiping Yu
    University Psychiatric Center Campus Kortenberg, Katholieke University Leuven, Kortenberg, Belgium
    J Clin Psychopharmacol 33:186-92. 2013
    ..Further studies are needed to uncover the exact molecular basis for this association, which could provide novel treatment targets for the MetS...