Ruud van Winkel

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. pmc Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht, The Netherlands
    Schizophr Bull 34:1095-105. 2008
  2. ncbi Evidence that the impact of hearing impairment on psychosis risk is moderated by the level of complexity of the social environment
    Margriet van der Werf
    Department of Psychiatry and Neuropsychology, EURON Graduate School of Neuroscience, Maastricht University Medical Centre, PO BOX 616 VIJV, 6200MD Maastricht, The Netherlands
    Schizophr Res 122:193-8. 2010
  3. pmc Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data
    Carla Truyers
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Fam Pract 12:132. 2011
  4. ncbi MTHFR and risk of metabolic syndrome in patients with schizophrenia
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Schizophr Res 121:193-8. 2010
  5. doi REVIEW: Genome-wide findings in schizophrenia and the role of gene-environment interplay
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, The Netherlands
    CNS Neurosci Ther 16:e185-92. 2010
  6. doi MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: an observational study
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Int Clin Psychopharmacol 25:270-6. 2010
  7. pmc AKT1 moderation of cannabis-induced cognitive alterations in psychotic disorder
    Ruud van Winkel
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience EURON, South Limburg Mental Health Research and Teaching Network SEARCH, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neuropsychopharmacology 36:2529-37. 2011
  8. ncbi FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma
    Dina Collip
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Br J Psychiatry 202:261-8. 2013
  9. pmc Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study
    Ehsan Pishva
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 9:e100935. 2014
  10. doi Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
    Odette L J Peerbooms
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University, Maastricht, The Netherlands
    Brain Behav Immun 25:1530-43. 2011

Collaborators

Detail Information

Publications22

  1. pmc Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht, The Netherlands
    Schizophr Bull 34:1095-105. 2008
    ....
  2. ncbi Evidence that the impact of hearing impairment on psychosis risk is moderated by the level of complexity of the social environment
    Margriet van der Werf
    Department of Psychiatry and Neuropsychology, EURON Graduate School of Neuroscience, Maastricht University Medical Centre, PO BOX 616 VIJV, 6200MD Maastricht, The Netherlands
    Schizophr Res 122:193-8. 2010
    ....
  3. pmc Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data
    Carla Truyers
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Fam Pract 12:132. 2011
    ..Many studies are performed in specialized settings with a strong focus on schizophrenia. Somatic comorbidity after psychosis is studied, using a general practice comorbidity registration network...
  4. ncbi MTHFR and risk of metabolic syndrome in patients with schizophrenia
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Schizophr Res 121:193-8. 2010
    ..Meta-analyses have implicated polymorphisms in MTHFR, encoding a critical enzyme in folate and homocysteine metabolism, in both schizophrenia and CVD...
  5. doi REVIEW: Genome-wide findings in schizophrenia and the role of gene-environment interplay
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, The Netherlands
    CNS Neurosci Ther 16:e185-92. 2010
    ..Collaborative efforts that bring together expertise in statistics, genetics, epidemiology, experimental psychiatry, brain imaging, and clinical psychiatry will be required to succeed in this challenging task...
  6. doi MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: an observational study
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Int Clin Psychopharmacol 25:270-6. 2010
    ..A1298C allele carriers consistently displayed the most unfavorable evolution of metabolic parameters. Thus, MTHFR A1298C genotype may explain part of the individual liability to metabolic disturbances in patients with schizophrenia...
  7. pmc AKT1 moderation of cannabis-induced cognitive alterations in psychotic disorder
    Ruud van Winkel
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience EURON, South Limburg Mental Health Research and Teaching Network SEARCH, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neuropsychopharmacology 36:2529-37. 2011
    ..The results suggest that long-term changes in cognition may mediate the risk-increasing effect of the AKT1 × cannabis interaction on psychotic disorder...
  8. ncbi FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma
    Dina Collip
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Br J Psychiatry 202:261-8. 2013
    ..FK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma...
  9. pmc Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study
    Ehsan Pishva
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 9:e100935. 2014
    ..These data provide the first evidence that emotional responses to daily life stressors may be moderated by genetic variation in the genes involved in the epigenetic machinery. ..
  10. doi Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
    Odette L J Peerbooms
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University, Maastricht, The Netherlands
    Brain Behav Immun 25:1530-43. 2011
    ..This study provides evidence for shared genetic vulnerability for SZ, BPD and UDD mediated by MTHFR 677TT genotype, which is in line with epigenetic involvement in the pathophysiology of these psychiatric disorders...
  11. doi COMT Val158Met-stress interaction in psychosis: role of background psychosis risk
    Dina Collip
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands
    CNS Neurosci Ther 17:612-9. 2011
    ....
  12. pmc Psychopathological mechanisms linking childhood traumatic experiences to risk of psychotic symptoms: analysis of a large, representative population-based sample
    Martine van Nierop
    To whom correspondence should be addressed School of Mental Health and Neuroscience MHeNS, Maastricht University Medical Centre, PO Box 616 DRT 12, 6200 MD Maastricht, The Netherlands tel 0031 43 388 4077, fax 0031 43 388 4122, E mail
    Schizophr Bull 40:S123-30. 2014
    ..However, the actual specificity of these associations remains to be tested...
  13. pmc Intermediate phenotype analysis of patients, unaffected siblings, and healthy controls identifies VMAT2 as a candidate gene for psychotic disorder and neurocognition
    Claudia J P Simons
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht, The Netherlands
    Schizophr Bull 39:848-56. 2013
    ..29, 95% CI 0.92-1.81, P = .14), suggesting mediation. Genetic variation in VMAT2 may be linked to alterations in cognitive functioning underlying psychotic disorder, possibly through altered transport of monoamines into synaptic vesicles...
  14. pmc Brain-derived neurotrophic factor/FK506-binding protein 5 genotype by childhood trauma interactions do not impact on hippocampal volume and cognitive performance
    Dennis Hernaus
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands
    PLoS ONE 9:e92722. 2014
    ..The importance of appropriate statistical designs and inclusion of relevant covariates should be carefully considered. ..
  15. ncbi Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: replication and extension of a gene-environment interaction
    Mark van Winkel
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO BOX 616 DRT 10, Maastricht 6200 MD, The Netherlands Riagg Maastricht, Parallelweg 45 47, 6221 BD, Maastricht, The Netherlands Electronic address
    Eur Neuropsychopharmacol 24:930-8. 2014
    ..Further, it shows that the generation of positive affect (PA) can buffer social stress sensitivity and partially undo the genetic susceptibility. ..
  16. ncbi Childhood trauma as a cause of psychosis: linking genes, psychology, and biology
    Ruud van Winkel
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Can J Psychiatry 58:44-51. 2013
    ....
  17. ncbi Genetic variation underlying psychosis-inducing effects of cannabis: critical review and future directions
    Jeroen Decoster
    Dept of Psychiatry and Psychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, The Netherlands
    Curr Pharm Des 18:5015-23. 2012
    ..Possible strategies for future cannabis interaction studies are discussed...
  18. ncbi Genetic association study of the P300 endophenotype in schizophrenia
    Jeroen Decoster
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Schizophr Res 141:54-9. 2012
    ..This study aims to examine associations between P300 and a range of candidate genetic variants, selected from either candidate gene studies or genome-wide association studies, in a large sample of patients with schizophrenia...
  19. pmc Phenotypically continuous with clinical psychosis, discontinuous in need for care: evidence for an extended psychosis phenotype
    Martine van Nierop
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, PO BOX 616 VIJV1, 6200 MD Maastricht, The Netherlands
    Schizophr Bull 38:231-8. 2012
    ..Design: The second Netherlands Mental Health Survey and Incidence Study-2, a general population study...
  20. doi Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up
    Ruud van Winkel
    Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Arch Gen Psychiatry 68:148-57. 2011
    ..Individual differences exist in sensitivity to the psychotomimetic effect of cannabis; the molecular genetic basis underlying differential sensitivity remains elusive...
  21. pmc COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge
    Dennis Hernaus
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands
    PLoS ONE 8:e65662. 2013
    ..Implications of these results for stress-related psychopathology and models of dopaminergic functioning are discussed. ..
  22. doi CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia
    Weiping Yu
    University Psychiatric Center Campus Kortenberg, Katholieke University Leuven, Kortenberg, Belgium
    J Clin Psychopharmacol 33:186-92. 2013
    ..Further studies are needed to uncover the exact molecular basis for this association, which could provide novel treatment targets for the MetS...