Henk H Thijssen

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle
    Henk H Thijssen
    Department of Pharmacology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Thromb Haemost 92:797-802. 2004
  2. pmc A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9
    Allan E Rettie
    Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
    Br J Clin Pharmacol 62:617-20. 2006

Detail Information

Publications2

  1. ncbi request reprint Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle
    Henk H Thijssen
    Department of Pharmacology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Thromb Haemost 92:797-802. 2004
    ..We conclude that, the potentiation of the oral anticoagulant effect by paracetamol is likely to result from NAPQI-induced inhibition of enzymes of the vitamin K cycle, particularly VKD-carb...
  2. pmc A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9
    Allan E Rettie
    Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
    Br J Clin Pharmacol 62:617-20. 2006
    ..The study provides additional data in support of diminished CYP2C9 activity due to the presence of the rare *11 allele...