- Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycleHenk H Thijssen
Department of Pharmacology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
Thromb Haemost 92:797-802. 2004..We conclude that, the potentiation of the oral anticoagulant effect by paracetamol is likely to result from NAPQI-induced inhibition of enzymes of the vitamin K cycle, particularly VKD-carb...
- A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9Allan E Rettie
Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
Br J Clin Pharmacol 62:617-20. 2006..The study provides additional data in support of diminished CYP2C9 activity due to the presence of the rare *11 allele...