Research Topics
Genomes and GenesSpecies | Yasin TemelSummaryAffiliation: Maastricht University Country: The Netherlands Publications
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Detail Information
Publications
Single electrode and multiple electrode guided electrical stimulation of the subthalamic nucleus in advanced Parkinson's diseaseYasin Temel
Department of Neurosurgery, University Hospital Maastricht, and European Graduate School of Neuroscience, Maastricht, The Netherlands
Neurosurgery 61:346-55; discussion 355-7. 2007....
Role of the brain in the control of erectionYasin Temel
Department of Neuro Surgery, European Graduate School of Neuroscience EURON, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, Netherlands
Asian J Androl 8:259-64. 2006..Within the brain circuit of erection, the thalamus serves as a gate-controller in which all relevant information is evaluated and further processed to higher and lower centres...- Targets for deep brain stimulation in Parkinson's diseaseYasin Temel
Department of Neurosurgery, University Hospital Maastricht, P Debyelaan 25, 6202 AZ, Maastricht, The Netherlands
Expert Opin Ther Targets 10:355-62. 2006..In this review, the authors give an overview of the targets that have been used for DBS in PD and discuss patient-specific targeting... - Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performanceYasin Temel
Departments of Neurosurgery and Cellular Neuroscience, European Graduate School of Neuroscience EURON, University Hospital Maastricht, PO Box 5800, 6202, AZ, Maastricht, The Netherlands
Exp Brain Res 169:389-99. 2006..The STN seems to be an important modulator of cognitive processing and STN DBS can differentially affect motor and associative circuits... - The functional role of the subthalamic nucleus in cognitive and limbic circuitsYasin Temel
Department of Neurosurgery, University Hospital Maastricht, University of Maastricht, The Netherlands
Prog Neurobiol 76:393-413. 2005..In conclusion, it can be stated that the STN has anatomically a central position within the basal ganglia thalamocortical associative and limbic circuits and is functionally a potent regulator of these pathways... - The supraspinal network in the control of erectionYasin Temel
University Hospital Maastricht, Department of Neurosurgery, PO Box 5800, 6202 AZ Maastricht, The Netherlands
Expert Opin Ther Targets 9:941-54. 2005..Subsequently, the neuromediators involved in erection are summarised. Finally, these data are discussed in the light of therapeutic possibilities in the management of erectile dysfunction by targeting the supraspinal system... - Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's diseaseYasin Temel
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
Neurosci Lett 406:138-41. 2006..This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD... - Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleusYasin Temel
Department of Psychiatry and Neuropsychology, Division Cellular Neurosciences, European Graduate School of Neuroscience EURON, The Netherlands
Exp Neurol 193:43-52. 2005.... - Saccadometry: a novel clinical tool for quantification of the motor effects of subthalamic nucleus stimulation in Parkinson's diseaseYasin Temel
Maastricht Institute for Neuromodulative Development MIND, Maastricht, The Netherlands
Exp Neurol 216:481-9. 2009..Saccadic latency, that reflects the operation of central decision-making mechanisms, is increasingly being used as a way of obtaining quantitative, objective information about cerebral performance in general... - Protection of nigral cell death by bilateral subthalamic nucleus stimulationYasin Temel
Department of Psychiatry and Neuropsychology, Division of Cellular Neurosciences, Maastricht University, and Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
Brain Res 1120:100-5. 2006..These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD... - Cognitive and limbic effects of deep brain stimulation in preclinical studiesYasin Temel
Departments of Neurosurgery and Neuroscience, Maastricht University, Maastricht, The Netherlands
Front Biosci 14:1891-901. 2009..In this review, we will discuss the limbic and cognitive effects of DBS in preclinical studies... - Subthalamic nucleus stimulation in Parkinson's disease: the other side of the medallionYasin Temel
Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
Exp Neurol 211:321-3. 2008 - Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: a systematic reviewYasin Temel
Department of Neurosurgery, University Hospital Maastricht, P Debyelaan 25, Maastricht, The Netherlands
Parkinsonism Relat Disord 12:265-72. 2006..The extent to which these changes occur has not yet been established. The aim of the present study was to systematically analyse behavioural changes of bilateral STN DBS... - A combined in vivo neurochemical and electrophysiological analysis of the effect of high-frequency stimulation of the subthalamic nucleus on 5-HT transmissionSonny K H Tan
Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
Exp Neurol 233:145-53. 2012..These data provide neurochemical evidence for an inhibition of 5-HT neurotransmission by STN HFS, which may contribute to its psychiatric side effects and guide therapeutic options... - Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal grayLee Wei Lim
Department of Neuroscience, Maastricht University, Faculty of Health, Medicine and Life Sciences, Maastricht, The Netherlands
Exp Neurol 226:293-300. 2010..These results suggest that the fear-like response, which was observed 12 h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms... - Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in ratsLee Wei Lim
Department of Neuroscience, Maastricht University, The Netherlands
Behav Brain Res 218:301-7. 2011..In conclusion, the present study clearly demonstrated that PA or escape response activates the HPA axis and it remains difficult to anticipate the mechanism underlying HPA axis during PAs and its relationship with 5-HT drugs... - Bilateral high frequency stimulation of the subthalamic nucleus normalizes COX activity in the substantia nigra of Parkinsonian ratsRinske Vlamings
Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
Brain Res 1288:143-8. 2009..These results show that STN HFS decreased the overall activity of the basal ganglia output nucleus in dopamine-depleted rats... - Double-blind clinical trial of thalamic stimulation in patients with Tourette syndromeLinda Ackermans
Department of Neurosurgery, Maastricht University Medical Centre, Oxfordlaan 10, 6202 AZ Maastricht, The Netherlands
Brain 134:832-44. 2011..Further randomized controlled trials on other targets are urgently needed since the search for the optimal one is still ongoing... - Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodelChunyan Cao
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Behav Brain Res 170:257-61. 2006..These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD... 
Periaqueductal grey stimulation induced panic-like behaviour is accompanied by deactivation of the deep cerebellar nucleiVéronique M P Moers-Hornikx
Department of Neuroscience, Maastricht University, The Netherlands
Cerebellum 10:61-9. 2011..We suggest that the cerebellum plays a role in the selection of relevant information, and that deactivation of the cerebellar nuclei is required to allow inappropriate behaviour to occur, such as panic attacks...- Subthalamic neuronal responses to cortical stimulationMarcus L F Janssen
Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
Mov Disord 27:435-8. 2012..The aim of this study was to identify the motor part of the subthalamic nucleus to reduce stimulation-induced behavioral side effects, by using motor cortex stimulation... - Motor and non-motor behaviour in experimental Huntington's diseaseDagmar H Zeef
Department of Neuroscience, Maastricht University Medical School, Maastricht, The Netherlands
Behav Brain Res 226:435-9. 2012..Our data suggest that hyperkinetic features and reduced-anxiety in the tgHD rats are associated behaviours and are seen in the earlier stages of the disease... - Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matterLee Wei Lim
Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
J Chem Neuroanat 38:83-96. 2009..In conclusion, we have shown that deep brain stimulation of the dlPAG produced a distinctive pattern of neuronal activation across forebrain regions as compared to the sham and control animals... - Effect of buspirone on the behavioral regulation of rats in low versus high anxiety conditionsLee Wei Lim
Department of Neuroscience, Faculty of Medicine, Health and Life Sciences, Maastricht University, Maastricht, The Netherlands
Arzneimittelforschung 58:269-76. 2008.... - Hyperdopaminergic status in experimental Huntington diseaseAli Jahanshahi
Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
J Neuropathol Exp Neurol 69:910-7. 2010..The findings implicate increased dopamine input from these nuclei in the pathogenesis of chorea in Huntington disease... - Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus?Sonny K H Tan
Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
Neuropharmacology 61:387-99. 2011..This review provides an overview of 5-HT alterations in PD and a discussion of how these changes might combine with altered basal ganglia network activity to increase depression vulnerability... - Deep brain stimulation of the nucleus accumbens core and shell: opposite effects on impulsive actionThibaut Sesia
Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
Exp Neurol 214:135-9. 2008..However, different behavioral effects resulting from stimulation of the subterritories should be taken into account... - Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease: a four year follow-up studyVeerle Visser-Vandewalle
Department of Neurosurgery, Academic Hospital Maastricht, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
Parkinsonism Relat Disord 11:157-65. 2005..The stimulation induced behavioural changes need special consideration... - Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleusYasin Temel
Department of Neurosurgery, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
Proc Natl Acad Sci U S A 104:17087-92. 2007..More generally, the powerful interaction between the STN and 5-HT system uncovered here offers insights into the high level of comorbidity of basal ganglia disease and mood disorder... - Memory deficits in the transgenic rat model of Huntington's diseaseDagmar H Zeef
Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
Behav Brain Res 227:194-8. 2012..Since HD patients are known to be impaired in both types of memory, these results confirm the validity of this tgHD rat as a model for the human HD phenotype... - High frequency stimulation of the subthalamic nucleus increases c-fos immunoreactivity in the dorsal raphe nucleus and afferent brain regionsSonny K H Tan
Department of Neuroscience, Maastricht University, The Netherlands
J Psychiatr Res 45:1307-15. 2011..Collectively, these findings support a role for circuitry involving DRN GABA neurons, as well as DRN afferents from the lateral habenula nucleus and medial prefrontal cortex, in the mood effects of HFS of the STN... - High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fails to inhibit panic-like behaviourLee Wei Lim
Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
Behav Brain Res 193:197-203. 2008..The neuronal activation pattern resulting from dlPAG and VMH DBS was similar. These findings suggest that DBS of the dlPAG and VMH induces panic-related behaviours even at higher frequencies... - Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of ratsAli Jahanshahi
Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
Neurosci Lett 473:136-40. 2010..Our findings suggest that buspirone treatment affects not only the intracellular content of 5-HT but also nNOS and TH. Therefore, the cellular effect of buspirone is more complex than thought... - Neurostimulatory and ablative treatment options in major depressive disorder: a systematic reviewPablo Andrade
Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
Acta Neurochir (Wien) 152:565-77. 2010..DISCUSSION: We reviewed the literature from the beginning of the twentieth century until July 2009 and described the early clinical effects and main reported complications of these methods... - Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude and frequency dependentLieve Desbonnet
Department of Neuroscience, European Graduate School of Neuroscience (EURON, Maastricht, The Netherlands
Brain Res 1008:198-204. 2004..Furthermore, the overall effects of DBS on neuronal cells cannot be classified simply as being "inhibitory" and evidently mediates its effects by more complex mechanisms than lesions of the same brain area... - Unchanged expression of the ceramide transfer protein in the acute 6-OHDA neurodegenerative modelChiara Mencarelli
Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
Neurosci Lett 506:39-43. 2012..No difference in the striatal expression levels of GPBP/CERT proteins was found between diseased and control animals, suggesting that the expression pattern of GPBP/CERT in the striatum is not affected in the 6-OHDA rat model of PD... - Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulationRob Hameleers
Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Behav Brain Res 185:65-7. 2007..p.) reduced the behavioural activity of the animals and that STN HFS reversed these effects. This study provides the first evidence that the therapeutic effect of STN HFS may also be mediated by a 5-HT-dependent mechanism... - Cerebellar nuclei are activated by high-frequency stimulation of the subthalamic nucleusVéronique M P Moers-Hornikx
Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
Neurosci Lett 496:111-5. 2011..The connection between the cerebellum and the basal ganglia may imply a role for the cerebellum in behavioural aspects of disorders of the basal ganglia... - Long-term motor effect of unilateral pallidal stimulation in 26 patients with advanced Parkinson diseaseVeerle Visser-Vandewalle
Department of Neurosurgery, Academic Hospital Maastricht, The Netherlands
J Neurosurg 99:701-7. 2003..The aim of this study was to evaluate the long-term effects of unilateral pallidal stimulation on motor function in selected patients with advanced Parkinson disease (PD)... - Long-term outcome of thalamic deep brain stimulation in two patients with Tourette syndromeLinda Ackermans
Department of Neurosurgery, Maastricht University Medical Centre, Oxfordlaan 10, Maastricht, The Netherlands
J Neurol Neurosurg Psychiatry 81:1068-72. 2010..In this follow-up study, the authors report on the long-term (6 and 10 years) outcome in terms of tic reduction, cognition, mood and side effects of medial thalamic deep brain stimulation in two previously described Tourette patients... - Monopolar versus bipolar high frequency stimulation in the rat subthalamic nucleus: differences in histological damageYasin Temel
Department of Neuroscience, European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands
Neurosci Lett 367:92-6. 2004..This can be achieved by decreasing the present current densities to a level comparable to the human situation... - Deep brain stimulation in Tourette's syndrome: two targets?Linda Ackermans
Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
Mov Disord 21:709-13. 2006..These data show that bilateral DBS of the thalamus as well as of the GPi can have a good effect on tics and behavioral symptoms in patients suffering from intractable TS... - Lessons learned from the transgenic Huntington's disease ratsRinske Vlamings
Department of Neuroscience, Maastricht University Medical Center, 6229 ER Maastricht, The Netherlands
Neural Plast 2012:682712. 2012..We have been using this animal model in our research and review here our experience with the behavioural, neurophysiological, and histopathological phenotype of the transgenic Huntington's disease rats with relevant literature... - Mild dopaminergic lesions are accompanied by robust changes in subthalamic nucleus activityMarcus L F Janssen
Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
Neurosci Lett 508:101-5. 2012..These findings indicate that the early increase in STN burst activity is a compensatory mechanism to maintain the dopamine homeostasis in the basal ganglia... - Cerebellar nuclei are involved in impulsive behaviourVéronique M P Moers-Hornikx
Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
Behav Brain Res 203:256-63. 2009..The present study demonstrates that impulsive behaviour involves the cerebellar nuclei, possibly through a decreased selective attention caused by a disruption of the cerebello-thalamo-cortical pathways through the MD thalamic nucleus... - Deep brain stimulation of the forniceal area enhances memory functions in experimental dementia: The role of stimulation parametersSarah Hescham
Department of Neuroscience, Maastricht University Medical Center, Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands European Graduate School of Neuroscience EURON, The Netherlands
Brain Stimul 6:72-7. 2013..DBS of this region, using tailored stimulation parameters, has the potential to improve memory functions in conditions characterised by memory impairment... - Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of ratsYasin Temel
Department of Neuroscience, Maastricht University, The Netherlands
Behav Brain Res 233:322-5. 2012..In conclusion, our findings indicate that the inhibition of this subpopulation of hippocampal parvalbumin-positive interneurons induced a long lasting anxiety- or fear-like behaviour... - Neuromodulation in psychiatric disordersYasin Temel
Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands
Int Rev Neurobiol 107:283-314. 2012..Here, we review the clinical data on neuromodulation in the major psychiatric disorders. Relevant data from animal models will also be discussed to explain the neurobiological basis of the therapy... - Metabolic and electrophysiological changes in the basal ganglia of transgenic Huntington's disease ratsRinske Vlamings
Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
Neurobiol Dis 48:488-94. 2012..Altogether, our results suggest that the globus pallidus and subthalamic nucleus play a role in the neurobiology of HD and can be potential targets for therapeutic interventions... - Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome. Report of three casesVeerle Visser-Vandewalle
Department of Neurosurgery, Academic Hospital Maastricht, The Netherlands
J Neurosurg 99:1094-100. 2003..Chronic thalamic HFS may be an effective and safe treatment for medically intractable TS in adult patients. Unwanted stimulation-induced side effects may occur... - Bilateral high-frequency stimulation of the subthalamic nucleus in patients with multiple system atrophy--parkinsonism. Report of four casesVeerle Visser-Vandewalle
Department of Neurosurgery, Academic Hospital Maastricht, Maastricht, The Netherlands
J Neurosurg 98:882-7. 2003..There was a beneficial effect of STN HFS in these four patients on both a short-term and a long-term basis. A larger prospective study is justified... - Impulse control and related disorders in Parkinson's disease patients treated with bilateral subthalamic nucleus stimulation: a reviewMartijn Broen
Department of Neurology, Maastricht University Medical Center, P Debyelaan 25, 6202 AZ Maastricht, The Netherlands
Parkinsonism Relat Disord 17:413-7. 2011..Moreover, STN DBS can also reveal or even induce ICD. Possible explanations for this variability are proposed and suggestions for clinical management are given... - Surgery in Tourette syndromeYasin Temel
Department of Neurosurgery, Academic Hospital Maastricht, Maastricht, The Netherlands
Mov Disord 19:3-14. 2004..To date, 3 patients have been reported who underwent bilateral thalamic stimulation, with promising results on tics and obsessive-compulsive symptoms... - Limbic effects of high-frequency stimulation of the subthalamic nucleusYasin Temel
Department of Neuroscience and Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands
Vitam Horm 82:47-63. 2010..The STN is interconnected not only with motor areas, but also with associative and limbic regions. In this chapter, the author discusses relevant articles, provides anatomical details, and presents an integrated view... - The subthalamic nucleus: From response selection to executionSonny K H Tan
Department of Psychiatry and Neuropsychology, Division Cellular Neurosciences, Maastricht University, Maastricht, The Netherlands
J Chem Neuroanat 31:155-61. 2006..In the present review, we discuss the findings of these preclinical studies on cognitive parameters and outline the anatomical and functional place of the STN in the basal ganglia cognitive circuit... - Vertical gaze palsy after thalamic stimulation for Tourette syndrome: case reportLinda Ackermans
Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
Neurosurgery 61:E1100; discussion E1100. 2007..We describe a patient who developed a vertical gaze paralysis after deep brain stimulation performed for intractable Tourette syndrome due to a small deep bleeding in the upper mesencephalon... - The neurosurgical treatment of addictionBianca M L Stelten
Maastricht Institute for Neuromodulative Development, Maastricht University and Medical Centre, Maastricht, The Netherlands
Neurosurg Focus 25:E5. 2008..With the expanding knowledge of the neurobiology of addiction, deep brain stimulation could be a future option in the treatment arsenal of addiction... - Deep brain stimulation in Tourette's SyndromeLinda Ackermans
Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
Neurotherapeutics 5:339-44. 2008..Since then, multiple targets have been used in a small number of patients, including the globus pallidus pars interna and the nucleus accumbens. Inclusion and exclusion criteria have been formulated to identify good candidates for DBS... - Experimental deep brain stimulation in animal modelsSonny Kh Tan
Department of Neuroscience, Maastricht University, Department of Neurosurgery, Maastricht University Medical Center, European Graduate School of Neuroscience EURON, Maastricht Institute of Neuromodulative Development MIND, Maastricht, The Netherlands
Neurosurgery 67:1073-9; discussion1080. 2010..These are discussed in detail. Experimental DBS in freely moving animals is an adequate tool to explore new indications for DBS and to refine DBS technology... - Close communication between the subependymal serotonergic plexus and the neurogenic subventricular zoneAli Jahanshahi
Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
J Chem Neuroanat 42:297-303. 2011..Here, we review the literature and propose that subependymal plexus is part of an intrinsic brain mechanism which controls the subventricular zone cell proliferative capacity by modulating 5-HT release... - History of the corpus luysii: 1865-1995Rob Hameleers
Department of Neurosurgery, University Hospital Maastricht, European Graduate School of Neuroscience, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands
Arch Neurol 63:1340-2. 2006 - The microanatomical environment of the subthalamic nucleus. Technical noteKim Rijkers
Department of Neurosurgery, Maastricht University Hospital, Maastricht, The Netherlands
J Neurosurg 107:198-201. 2007..The images allow an optimal analysis of the microenvironment of the STN in the three orthogonal planes and can be used for 3D reconstructions of this area with possible clinical applications in the future... - Effect of serotonin depletion on the neuronal, endocrine and behavioural responses to corticotropin-releasing factor in the ratYasin Temel
Department of Neurosurgery, Academic Hospital Maastricht, Maastricht, The Netherlands
Neurosci Lett 338:139-42. 2003..Adequate and specific depletion of serotonin using 5,7-DHT did not alter these CRF-induced changes. These data suggest that acute responses induced by i.c.v. CRF are independent of basal levels of serotonin... - Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: similar improvements in saccadic and manual responsesChrystalina A Antoniades
Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, UK
Neuroreport 23:179-83. 2012.... - In vivo electroporation of the central nervous system: a non-viral approach for targeted gene deliveryJochen De Vry
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
Prog Neurobiol 92:227-44. 2010..Improving the knowledge about in vivo electroporation will pave the way for electroporation-enhanced gene therapy to treat brain carcinomas, as well as CNS disorders such as Alzheimer's disease, Parkinson's disease, and depression... - Imaging of the subthalamic nucleus for deep brain stimulation: a systematic reviewYasin Temel
Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
Neuromodulation 11:8-12. 2008.... - Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic ratsOrsolya Kántor
Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
Neurobiol Dis 22:538-47. 2006..No alterations in mean total numbers of striatal neurons were found in 6-month-old animals. Testing 14-month-old animals in a choice reaction time task indicated impaired striatal function of tgHD rats compared with controls... - Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian ratsAhmet H Kaya
Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey
Brain Res 1221:93-7. 2008..These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain... - Saccadic latency during electrical stimulation of the human subthalamic nucleusYasin Temel
Curr Biol 18:R412-4. 2008 - Automatic trajectory planning for deep brain stimulation: a feasibility studyEllen J L Brunenberg
Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
Med Image Comput Comput Assist Interv 10:584-92. 2007..A qualitative evaluation has shown that automatic avoidance of critical structures is feasible. The participating neurosurgeons estimate the time gain to be around 30 minutes... - Deep brain stimulation in Gilles de la Tourette's syndromeVeerle Visser-Vandewalle
Neurosurgery 58:E590. 2006