Yasin Temel

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Role of the brain in the control of erection
    Yasin Temel
    Department of Neuro Surgery, European Graduate School of Neuroscience EURON, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, Netherlands
    Asian J Androl 8:259-64. 2006
  2. ncbi request reprint Targets for deep brain stimulation in Parkinson's disease
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, P Debyelaan 25, 6202 AZ, Maastricht, The Netherlands
    Expert Opin Ther Targets 10:355-62. 2006
  3. ncbi request reprint Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neurosci Lett 406:138-41. 2006
  4. ncbi request reprint Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance
    Yasin Temel
    Departments of Neurosurgery and Cellular Neuroscience, European Graduate School of Neuroscience EURON, University Hospital Maastricht, PO Box 5800, 6202, AZ, Maastricht, The Netherlands
    Exp Brain Res 169:389-99. 2006
  5. ncbi request reprint The functional role of the subthalamic nucleus in cognitive and limbic circuits
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, University of Maastricht, The Netherlands
    Prog Neurobiol 76:393-413. 2005
  6. ncbi request reprint The supraspinal network in the control of erection
    Yasin Temel
    University Hospital Maastricht, Department of Neurosurgery, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Expert Opin Ther Targets 9:941-54. 2005
  7. ncbi request reprint Protection of nigral cell death by bilateral subthalamic nucleus stimulation
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division of Cellular Neurosciences, Maastricht University, and Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
    Brain Res 1120:100-5. 2006
  8. ncbi request reprint Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division Cellular Neurosciences, European Graduate School of Neuroscience EURON, The Netherlands
    Exp Neurol 193:43-52. 2005
  9. doi request reprint Single electrode and multiple electrode guided electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, and European Graduate School of Neuroscience, Maastricht, The Netherlands
    Neurosurgery 61:346-55; discussion 355-7. 2007
  10. doi request reprint Saccadometry: a novel clinical tool for quantification of the motor effects of subthalamic nucleus stimulation in Parkinson's disease
    Yasin Temel
    Maastricht Institute for Neuromodulative Development MIND, Maastricht, The Netherlands
    Exp Neurol 216:481-9. 2009

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Role of the brain in the control of erection
    Yasin Temel
    Department of Neuro Surgery, European Graduate School of Neuroscience EURON, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, Netherlands
    Asian J Androl 8:259-64. 2006
    ..Within the brain circuit of erection, the thalamus serves as a gate-controller in which all relevant information is evaluated and further processed to higher and lower centres...
  2. ncbi request reprint Targets for deep brain stimulation in Parkinson's disease
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, P Debyelaan 25, 6202 AZ, Maastricht, The Netherlands
    Expert Opin Ther Targets 10:355-62. 2006
    ..In this review, the authors give an overview of the targets that have been used for DBS in PD and discuss patient-specific targeting...
  3. ncbi request reprint Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neurosci Lett 406:138-41. 2006
    ..This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD...
  4. ncbi request reprint Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance
    Yasin Temel
    Departments of Neurosurgery and Cellular Neuroscience, European Graduate School of Neuroscience EURON, University Hospital Maastricht, PO Box 5800, 6202, AZ, Maastricht, The Netherlands
    Exp Brain Res 169:389-99. 2006
    ..The STN seems to be an important modulator of cognitive processing and STN DBS can differentially affect motor and associative circuits...
  5. ncbi request reprint The functional role of the subthalamic nucleus in cognitive and limbic circuits
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, University of Maastricht, The Netherlands
    Prog Neurobiol 76:393-413. 2005
    ..In conclusion, it can be stated that the STN has anatomically a central position within the basal ganglia thalamocortical associative and limbic circuits and is functionally a potent regulator of these pathways...
  6. ncbi request reprint The supraspinal network in the control of erection
    Yasin Temel
    University Hospital Maastricht, Department of Neurosurgery, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Expert Opin Ther Targets 9:941-54. 2005
    ..Subsequently, the neuromediators involved in erection are summarised. Finally, these data are discussed in the light of therapeutic possibilities in the management of erectile dysfunction by targeting the supraspinal system...
  7. ncbi request reprint Protection of nigral cell death by bilateral subthalamic nucleus stimulation
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division of Cellular Neurosciences, Maastricht University, and Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
    Brain Res 1120:100-5. 2006
    ..These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD...
  8. ncbi request reprint Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division Cellular Neurosciences, European Graduate School of Neuroscience EURON, The Netherlands
    Exp Neurol 193:43-52. 2005
    ....
  9. doi request reprint Single electrode and multiple electrode guided electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, and European Graduate School of Neuroscience, Maastricht, The Netherlands
    Neurosurgery 61:346-55; discussion 355-7. 2007
    ....
  10. doi request reprint Saccadometry: a novel clinical tool for quantification of the motor effects of subthalamic nucleus stimulation in Parkinson's disease
    Yasin Temel
    Maastricht Institute for Neuromodulative Development MIND, Maastricht, The Netherlands
    Exp Neurol 216:481-9. 2009
    ..Saccadic latency, that reflects the operation of central decision-making mechanisms, is increasingly being used as a way of obtaining quantitative, objective information about cerebral performance in general...
  11. doi request reprint Subthalamic nucleus stimulation in Parkinson's disease: the other side of the medallion
    Yasin Temel
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Exp Neurol 211:321-3. 2008
  12. ncbi request reprint Cognitive and limbic effects of deep brain stimulation in preclinical studies
    Yasin Temel
    Departments of Neurosurgery and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Front Biosci (Landmark Ed) 14:1891-901. 2009
    ..In this review, we will discuss the limbic and cognitive effects of DBS in preclinical studies...
  13. ncbi request reprint Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: a systematic review
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, P Debyelaan 25, Maastricht, The Netherlands
    Parkinsonism Relat Disord 12:265-72. 2006
    ..The extent to which these changes occur has not yet been established. The aim of the present study was to systematically analyse behavioural changes of bilateral STN DBS...
  14. doi request reprint A combined in vivo neurochemical and electrophysiological analysis of the effect of high-frequency stimulation of the subthalamic nucleus on 5-HT transmission
    Sonny K H Tan
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Exp Neurol 233:145-53. 2012
    ..These data provide neurochemical evidence for an inhibition of 5-HT neurotransmission by STN HFS, which may contribute to its psychiatric side effects and guide therapeutic options...
  15. doi request reprint Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, Faculty of Health, Medicine and Life Sciences, Maastricht, The Netherlands
    Exp Neurol 226:293-300. 2010
    ..These results suggest that the fear-like response, which was observed 12 h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms...
  16. doi request reprint Bilateral high frequency stimulation of the subthalamic nucleus normalizes COX activity in the substantia nigra of Parkinsonian rats
    Rinske Vlamings
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Brain Res 1288:143-8. 2009
    ..These results show that STN HFS decreased the overall activity of the basal ganglia output nucleus in dopamine-depleted rats...
  17. doi request reprint Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in rats
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, The Netherlands
    Behav Brain Res 218:301-7. 2011
    ..In conclusion, the present study clearly demonstrated that PA or escape response activates the HPA axis and it remains difficult to anticipate the mechanism underlying HPA axis during PAs and its relationship with 5-HT drugs...
  18. ncbi request reprint Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel
    Chunyan Cao
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 170:257-61. 2006
    ..These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD...
  19. doi request reprint Mild dopaminergic lesions are accompanied by robust changes in subthalamic nucleus activity
    Marcus L F Janssen
    Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Neurosci Lett 508:101-5. 2012
    ..These findings indicate that the early increase in STN burst activity is a compensatory mechanism to maintain the dopamine homeostasis in the basal ganglia...
  20. doi request reprint Double-blind clinical trial of thalamic stimulation in patients with Tourette syndrome
    Linda Ackermans
    Department of Neurosurgery, Maastricht University Medical Centre, Oxfordlaan 10, 6202 AZ Maastricht, The Netherlands
    Brain 134:832-44. 2011
    ..Further randomized controlled trials on other targets are urgently needed since the search for the optimal one is still ongoing...
  21. pmc Periaqueductal grey stimulation induced panic-like behaviour is accompanied by deactivation of the deep cerebellar nuclei
    Véronique M P Moers-Hornikx
    Department of Neuroscience, Maastricht University, The Netherlands
    Cerebellum 10:61-9. 2011
    ..We suggest that the cerebellum plays a role in the selection of relevant information, and that deactivation of the cerebellar nuclei is required to allow inappropriate behaviour to occur, such as panic attacks...
  22. doi request reprint Subthalamic neuronal responses to cortical stimulation
    Marcus L F Janssen
    Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Mov Disord 27:435-8. 2012
    ..The aim of this study was to identify the motor part of the subthalamic nucleus to reduce stimulation-induced behavioral side effects, by using motor cortex stimulation...
  23. doi request reprint Motor and non-motor behaviour in experimental Huntington's disease
    Dagmar H Zeef
    Department of Neuroscience, Maastricht University Medical School, Maastricht, The Netherlands
    Behav Brain Res 226:435-9. 2012
    ..Our data suggest that hyperkinetic features and reduced-anxiety in the tgHD rats are associated behaviours and are seen in the earlier stages of the disease...
  24. doi request reprint Hyperdopaminergic status in experimental Huntington disease
    Ali Jahanshahi
    Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neuropathol Exp Neurol 69:910-7. 2010
    ..The findings implicate increased dopamine input from these nuclei in the pathogenesis of chorea in Huntington disease...
  25. doi request reprint Effect of buspirone on the behavioral regulation of rats in low versus high anxiety conditions
    Lee Wei Lim
    Department of Neuroscience, Faculty of Medicine, Health and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Arzneimittelforschung 58:269-76. 2008
    ....
  26. doi request reprint Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Chem Neuroanat 38:83-96. 2009
    ..In conclusion, we have shown that deep brain stimulation of the dlPAG produced a distinctive pattern of neuronal activation across forebrain regions as compared to the sham and control animals...
  27. doi request reprint Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus?
    Sonny K H Tan
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropharmacology 61:387-99. 2011
    ..This review provides an overview of 5-HT alterations in PD and a discussion of how these changes might combine with altered basal ganglia network activity to increase depression vulnerability...
  28. doi request reprint Deep brain stimulation of the nucleus accumbens core and shell: opposite effects on impulsive action
    Thibaut Sesia
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Exp Neurol 214:135-9. 2008
    ..However, different behavioral effects resulting from stimulation of the subterritories should be taken into account...
  29. ncbi request reprint Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease: a four year follow-up study
    Veerle Visser-Vandewalle
    Department of Neurosurgery, Academic Hospital Maastricht, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Parkinsonism Relat Disord 11:157-65. 2005
    ..The stimulation induced behavioural changes need special consideration...
  30. doi request reprint Neuromodulation in psychiatric disorders
    Yasin Temel
    Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Int Rev Neurobiol 107:283-314. 2012
    ..Here, we review the clinical data on neuromodulation in the major psychiatric disorders. Relevant data from animal models will also be discussed to explain the neurobiological basis of the therapy...
  31. pmc Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    Proc Natl Acad Sci U S A 104:17087-92. 2007
    ..More generally, the powerful interaction between the STN and 5-HT system uncovered here offers insights into the high level of comorbidity of basal ganglia disease and mood disorder...
  32. doi request reprint Memory deficits in the transgenic rat model of Huntington's disease
    Dagmar H Zeef
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Behav Brain Res 227:194-8. 2012
    ..Since HD patients are known to be impaired in both types of memory, these results confirm the validity of this tgHD rat as a model for the human HD phenotype...
  33. doi request reprint High frequency stimulation of the subthalamic nucleus increases c-fos immunoreactivity in the dorsal raphe nucleus and afferent brain regions
    Sonny K H Tan
    Department of Neuroscience, Maastricht University, The Netherlands
    J Psychiatr Res 45:1307-15. 2011
    ..Collectively, these findings support a role for circuitry involving DRN GABA neurons, as well as DRN afferents from the lateral habenula nucleus and medial prefrontal cortex, in the mood effects of HFS of the STN...
  34. ncbi request reprint Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude and frequency dependent
    Lieve Desbonnet
    Department of Neuroscience, European Graduate School of Neuroscience EURON, Maastricht, The Netherlands
    Brain Res 1008:198-204. 2004
    ..Furthermore, the overall effects of DBS on neuronal cells cannot be classified simply as being "inhibitory" and evidently mediates its effects by more complex mechanisms than lesions of the same brain area...
  35. doi request reprint High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fails to inhibit panic-like behaviour
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Behav Brain Res 193:197-203. 2008
    ..The neuronal activation pattern resulting from dlPAG and VMH DBS was similar. These findings suggest that DBS of the dlPAG and VMH induces panic-related behaviours even at higher frequencies...
  36. doi request reprint Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of rats
    Ali Jahanshahi
    Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Neurosci Lett 473:136-40. 2010
    ..Our findings suggest that buspirone treatment affects not only the intracellular content of 5-HT but also nNOS and TH. Therefore, the cellular effect of buspirone is more complex than thought...
  37. pmc Neurostimulatory and ablative treatment options in major depressive disorder: a systematic review
    Pablo Andrade
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    Acta Neurochir (Wien) 152:565-77. 2010
    ..Major depressive disorder is one of the most disabling and common diagnoses amongst psychiatric disorders, with a current worldwide prevalence of 5-10% of the general population and up to 20-25% for the lifetime period...
  38. doi request reprint Unchanged expression of the ceramide transfer protein in the acute 6-OHDA neurodegenerative model
    Chiara Mencarelli
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Neurosci Lett 506:39-43. 2012
    ..No difference in the striatal expression levels of GPBP/CERT proteins was found between diseased and control animals, suggesting that the expression pattern of GPBP/CERT in the striatum is not affected in the 6-OHDA rat model of PD...
  39. doi request reprint Cerebellar nuclei are activated by high-frequency stimulation of the subthalamic nucleus
    Véronique M P Moers-Hornikx
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neurosci Lett 496:111-5. 2011
    ..The connection between the cerebellum and the basal ganglia may imply a role for the cerebellum in behavioural aspects of disorders of the basal ganglia...
  40. doi request reprint Long-term outcome of thalamic deep brain stimulation in two patients with Tourette syndrome
    Linda Ackermans
    Department of Neurosurgery, Maastricht University Medical Centre, Oxfordlaan 10, Maastricht, The Netherlands
    J Neurol Neurosurg Psychiatry 81:1068-72. 2010
    ..In this follow-up study, the authors report on the long-term (6 and 10 years) outcome in terms of tic reduction, cognition, mood and side effects of medial thalamic deep brain stimulation in two previously described Tourette patients...
  41. ncbi request reprint Long-term motor effect of unilateral pallidal stimulation in 26 patients with advanced Parkinson disease
    Veerle Visser-Vandewalle
    Department of Neurosurgery, Academic Hospital Maastricht, The Netherlands
    J Neurosurg 99:701-7. 2003
    ..The aim of this study was to evaluate the long-term effects of unilateral pallidal stimulation on motor function in selected patients with advanced Parkinson disease (PD)...
  42. ncbi request reprint Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation
    Rob Hameleers
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 185:65-7. 2007
    ..p.) reduced the behavioural activity of the animals and that STN HFS reversed these effects. This study provides the first evidence that the therapeutic effect of STN HFS may also be mediated by a 5-HT-dependent mechanism...
  43. doi request reprint Metabolic and electrophysiological changes in the basal ganglia of transgenic Huntington's disease rats
    Rinske Vlamings
    Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Neurobiol Dis 48:488-94. 2012
    ..Altogether, our results suggest that the globus pallidus and subthalamic nucleus play a role in the neurobiology of HD and can be potential targets for therapeutic interventions...
  44. ncbi request reprint Monopolar versus bipolar high frequency stimulation in the rat subthalamic nucleus: differences in histological damage
    Yasin Temel
    Department of Neuroscience, European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neurosci Lett 367:92-6. 2004
    ..This can be achieved by decreasing the present current densities to a level comparable to the human situation...
  45. ncbi request reprint Deep brain stimulation in Tourette's syndrome: two targets?
    Linda Ackermans
    Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
    Mov Disord 21:709-13. 2006
    ..These data show that bilateral DBS of the thalamus as well as of the GPi can have a good effect on tics and behavioral symptoms in patients suffering from intractable TS...
  46. ncbi request reprint Electrical stimulation of the motor cortex enhances progenitor cell migration in the adult rat brain
    Ali Jahanshahi
    Departments of Neuroscience and Neurosurgery, Maastricht University Medical Center MUMC, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    Exp Brain Res 231:165-77. 2013
    ..It is known that such an increase can promote formation of new cells in the SVZ. Our findings suggest that epidural MC stimulation influences neurogenesis-related processes in animal models...
  47. doi request reprint Surgery for Tourette syndrome
    Linda Ackermans
    Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands MIND Maastricht Institute for Neuromodulative Development, Maastricht, The Netherlands
    World Neurosurg 80:S29.e15-22. 2013
    ..A strict patient selection is absolutely mandatory. There is a need for double-blinded multicenter trials with inclusion of more patients. ..
  48. doi request reprint Deep brain stimulation of the forniceal area enhances memory functions in experimental dementia: the role of stimulation parameters
    Sarah Hescham
    Department of Neuroscience, Maastricht University Medical Center, Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Brain Stimul 6:72-7. 2013
    ..DBS of this region, using tailored stimulation parameters, has the potential to improve memory functions in conditions characterised by memory impairment...
  49. pmc Lessons learned from the transgenic Huntington's disease rats
    Rinske Vlamings
    Department of Neuroscience, Maastricht University Medical Center, 6229 ER Maastricht, The Netherlands
    Neural Plast 2012:682712. 2012
    ..We have been using this animal model in our research and review here our experience with the behavioural, neurophysiological, and histopathological phenotype of the transgenic Huntington's disease rats with relevant literature...
  50. doi request reprint Cerebellar nuclei are involved in impulsive behaviour
    Véronique M P Moers-Hornikx
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Behav Brain Res 203:256-63. 2009
    ..The present study demonstrates that impulsive behaviour involves the cerebellar nuclei, possibly through a decreased selective attention caused by a disruption of the cerebello-thalamo-cortical pathways through the MD thalamic nucleus...
  51. ncbi request reprint Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: surgical technique, tips, tricks and complications
    Ersoy Kocabiçak
    Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey Departments of Neurosurgery and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands Electronic address
    Clin Neurol Neurosurg 115:2318-23. 2013
    ..Tips and tricks, complications and their management are the main elements of this article. In addition, we provide scientific information from our research and other groups in specific sections. ..
  52. doi request reprint Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats
    Yasin Temel
    Department of Neuroscience, Maastricht University, The Netherlands
    Behav Brain Res 233:322-5. 2012
    ..In conclusion, our findings indicate that the inhibition of this subpopulation of hippocampal parvalbumin-positive interneurons induced a long lasting anxiety- or fear-like behaviour...
  53. ncbi request reprint Bilateral high-frequency stimulation of the subthalamic nucleus in patients with multiple system atrophy--parkinsonism. Report of four cases
    Veerle Visser-Vandewalle
    Department of Neurosurgery, Academic Hospital Maastricht, Maastricht, The Netherlands
    J Neurosurg 98:882-7. 2003
    ..There was a beneficial effect of STN HFS in these four patients on both a short-term and a long-term basis. A larger prospective study is justified...
  54. doi request reprint Impulse control and related disorders in Parkinson's disease patients treated with bilateral subthalamic nucleus stimulation: a review
    Martijn Broen
    Department of Neurology, Maastricht University Medical Center, P Debyelaan 25, 6202 AZ Maastricht, The Netherlands
    Parkinsonism Relat Disord 17:413-7. 2011
    ..Moreover, STN DBS can also reveal or even induce ICD. Possible explanations for this variability are proposed and suggestions for clinical management are given...
  55. ncbi request reprint Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome. Report of three cases
    Veerle Visser-Vandewalle
    Department of Neurosurgery, Academic Hospital Maastricht, The Netherlands
    J Neurosurg 99:1094-100. 2003
    ..Chronic thalamic HFS may be an effective and safe treatment for medically intractable TS in adult patients. Unwanted stimulation-induced side effects may occur...
  56. doi request reprint An experimental model for Huntington's chorea?
    Dagmar H Zeef
    Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands European Graduate School of Neuroscience EURON, The Netherlands
    Behav Brain Res 262:31-4. 2014
    ..These findings suggest that the hyperkinetic movements observed in this animal model can be considered as a choreiform movement disorder. This makes these animals unique and provides opportunities for chorea-research. ..
  57. ncbi request reprint Delivery of DNA into the Central Nervous System via Electroporation
    Jochen De Vry
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands
    Methods Mol Biol 1121:157-63. 2014
    ..This allows altering gene expression in very-well-defined areas of the brain while inducing minimal tissue damage. ..
  58. ncbi request reprint Vertical gaze palsy after thalamic stimulation for Tourette syndrome: case report
    Linda Ackermans
    Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
    Neurosurgery 61:E1100; discussion E1100. 2007
    ..We describe a patient who developed a vertical gaze paralysis after deep brain stimulation performed for intractable Tourette syndrome due to a small deep bleeding in the upper mesencephalon...
  59. doi request reprint Limbic effects of high-frequency stimulation of the subthalamic nucleus
    Yasin Temel
    Department of Neuroscience and Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Vitam Horm 82:47-63. 2010
    ..The STN is interconnected not only with motor areas, but also with associative and limbic regions. In this chapter, the author discusses relevant articles, provides anatomical details, and presents an integrated view...
  60. doi request reprint The neurosurgical treatment of addiction
    Bianca M L Stelten
    Maastricht Institute for Neuromodulative Development, Maastricht University and Medical Centre, Maastricht, The Netherlands
    Neurosurg Focus 25:E5. 2008
    ..With the expanding knowledge of the neurobiology of addiction, deep brain stimulation could be a future option in the treatment arsenal of addiction...
  61. ncbi request reprint Surgery in Tourette syndrome
    Yasin Temel
    Department of Neurosurgery, Academic Hospital Maastricht, Maastricht, The Netherlands
    Mov Disord 19:3-14. 2004
    ..To date, 3 patients have been reported who underwent bilateral thalamic stimulation, with promising results on tics and obsessive-compulsive symptoms...
  62. ncbi request reprint The subthalamic nucleus: From response selection to execution
    Sonny K H Tan
    Department of Psychiatry and Neuropsychology, Division Cellular Neurosciences, Maastricht University, Maastricht, The Netherlands
    J Chem Neuroanat 31:155-61. 2006
    ..In the present review, we discuss the findings of these preclinical studies on cognitive parameters and outline the anatomical and functional place of the STN in the basal ganglia cognitive circuit...
  63. doi request reprint Deep brain stimulation in Tourette's Syndrome
    Linda Ackermans
    Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
    Neurotherapeutics 5:339-44. 2008
    ..Since then, multiple targets have been used in a small number of patients, including the globus pallidus pars interna and the nucleus accumbens. Inclusion and exclusion criteria have been formulated to identify good candidates for DBS...
  64. doi request reprint Close communication between the subependymal serotonergic plexus and the neurogenic subventricular zone
    Ali Jahanshahi
    Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Chem Neuroanat 42:297-303. 2011
    ..Here, we review the literature and propose that subependymal plexus is part of an intrinsic brain mechanism which controls the subventricular zone cell proliferative capacity by modulating 5-HT release...
  65. doi request reprint Experimental deep brain stimulation in animal models
    Sonny Kh Tan
    Department of Neuroscience, Maastricht University, Department of Neurosurgery, Maastricht University Medical Center, European Graduate School of Neuroscience EURON, Maastricht Institute of Neuromodulative Development MIND, Maastricht, The Netherlands
    Neurosurgery 67:1073-9; discussion1080. 2010
    ..These are discussed in detail. Experimental DBS in freely moving animals is an adequate tool to explore new indications for DBS and to refine DBS technology...
  66. ncbi request reprint History of the corpus luysii: 1865-1995
    Rob Hameleers
    Department of Neurosurgery, University Hospital Maastricht, European Graduate School of Neuroscience, P Debyelaan 25, 6202 AZ Maastricht, The Netherlands
    Arch Neurol 63:1340-2. 2006
  67. ncbi request reprint The microanatomical environment of the subthalamic nucleus. Technical note
    Kim Rijkers
    Department of Neurosurgery, Maastricht University Hospital, Maastricht, The Netherlands
    J Neurosurg 107:198-201. 2007
    ..The images allow an optimal analysis of the microenvironment of the STN in the three orthogonal planes and can be used for 3D reconstructions of this area with possible clinical applications in the future...
  68. pmc Effect of serotonin depletion on the neuronal, endocrine and behavioural responses to corticotropin-releasing factor in the rat
    Yasin Temel
    Department of Neurosurgery, Academic Hospital Maastricht, Maastricht, The Netherlands
    Neurosci Lett 338:139-42. 2003
    ..Adequate and specific depletion of serotonin using 5,7-DHT did not alter these CRF-induced changes. These data suggest that acute responses induced by i.c.v. CRF are independent of basal levels of serotonin...
  69. doi request reprint Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: similar improvements in saccadic and manual responses
    Chrystalina A Antoniades
    Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, UK
    Neuroreport 23:179-83. 2012
    ....
  70. doi request reprint Imaging of the subthalamic nucleus for deep brain stimulation: a systematic review
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
    Neuromodulation 11:8-12. 2008
    ....
  71. doi request reprint In vivo electroporation of the central nervous system: a non-viral approach for targeted gene delivery
    Jochen De Vry
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Prog Neurobiol 92:227-44. 2010
    ..Improving the knowledge about in vivo electroporation will pave the way for electroporation-enhanced gene therapy to treat brain carcinomas, as well as CNS disorders such as Alzheimer's disease, Parkinson's disease, and depression...
  72. doi request reprint Saccadic latency during electrical stimulation of the human subthalamic nucleus
    Yasin Temel
    Curr Biol 18:R412-4. 2008
  73. doi request reprint Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats
    Ahmet H Kaya
    Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey
    Brain Res 1221:93-7. 2008
    ..These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain...
  74. ncbi request reprint Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats
    Orsolya Kántor
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Neurobiol Dis 22:538-47. 2006
    ..No alterations in mean total numbers of striatal neurons were found in 6-month-old animals. Testing 14-month-old animals in a choice reaction time task indicated impaired striatal function of tgHD rats compared with controls...
  75. ncbi request reprint Automatic trajectory planning for deep brain stimulation: a feasibility study
    Ellen J L Brunenberg
    Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
    Med Image Comput Comput Assist Interv 10:584-92. 2007
    ..A qualitative evaluation has shown that automatic avoidance of critical structures is feasible. The participating neurosurgeons estimate the time gain to be around 30 minutes...
  76. ncbi request reprint Deep brain stimulation in Gilles de la Tourette's syndrome
    Veerle Visser-Vandewalle
    Neurosurgery 58:E590. 2006