Kim M Smits

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. doi request reprint Genetic and epigenetic alterations in the von hippel-lindau gene: the influence on renal cancer prognosis
    Kim M Smits
    Departmens of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Clin Cancer Res 14:782-7. 2008
  2. doi request reprint The influence of 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients
    Kim M Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Psychiatr Genet 18:184-90. 2008
  3. ncbi request reprint Polymorphisms in genes related to activation or detoxification of carcinogens might interact with smoking to increase renal cancer risk: results from The Netherlands Cohort Study on diet and cancer
    Kim M Smits
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    World J Urol 26:103-10. 2008
  4. ncbi request reprint Does pretreatment testing for serotonin transporter polymorphisms lead to earlier effects of drug treatment in patients with major depression? A decision-analytic model
    Kim M Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Clin Ther 29:691-702. 2007
  5. ncbi request reprint Serotonin transporter polymorphisms and the occurrence of adverse events during treatment with selective serotonin reuptake inhibitors
    Kim Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Int Clin Psychopharmacol 22:137-43. 2007
  6. ncbi request reprint A review on the design and reporting of studies on drug-gene interaction
    Kim M Smits
    Department of Epidemiology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Epidemiol 58:651-4. 2005
  7. doi request reprint Body mass index and von Hippel-Lindau gene mutations in clear-cell renal cancer: Results of the Netherlands Cohort Study on diet and cancer
    Kim M Smits
    Department of Epidemiology, Maastricht University, The Netherlands
    Ann Epidemiol 20:401-4. 2010
  8. ncbi request reprint Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review
    K M Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Mol Psychiatry 9:433-41. 2004
  9. doi request reprint N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer
    Veerle Melotte
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    J Natl Cancer Inst 101:916-27. 2009
  10. doi request reprint A let-7 microRNA SNP in the KRAS 3'UTR is prognostic in early-stage colorectal cancer
    Kim M Smits
    Departments of Pathology and Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Cancer Res 17:7723-31. 2011

Collaborators

Detail Information

Publications22

  1. doi request reprint Genetic and epigenetic alterations in the von hippel-lindau gene: the influence on renal cancer prognosis
    Kim M Smits
    Departmens of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Clin Cancer Res 14:782-7. 2008
    ..We have evaluated the influence of (epi)genetic alterations in VHL on cause-specific survival in clear-cell renal cell cancer (ccRCC) in a large, population-based group of cases...
  2. doi request reprint The influence of 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients
    Kim M Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Psychiatr Genet 18:184-90. 2008
    ..This study evaluates the influence of two polymorphisms (5-HTTLPR and STin2) on SSRI treatment outcome in depression...
  3. ncbi request reprint Polymorphisms in genes related to activation or detoxification of carcinogens might interact with smoking to increase renal cancer risk: results from The Netherlands Cohort Study on diet and cancer
    Kim M Smits
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    World J Urol 26:103-10. 2008
    ..This could indicate that RCC risk among smokers might be more increased with the CYP1A1*2C genotype, GSTmicro1 null, or both a CYP1A1 variant and GSTmicro1 null...
  4. ncbi request reprint Does pretreatment testing for serotonin transporter polymorphisms lead to earlier effects of drug treatment in patients with major depression? A decision-analytic model
    Kim M Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Clin Ther 29:691-702. 2007
    ..Serotonin transporter gene (SLC6A4) variations have been reported to account for differences in the way individuals respond to SSRI treatment...
  5. ncbi request reprint Serotonin transporter polymorphisms and the occurrence of adverse events during treatment with selective serotonin reuptake inhibitors
    Kim Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Int Clin Psychopharmacol 22:137-43. 2007
    ..Our findings indicate that patients with the 5-HTTLPR s/s or s/l genotype have an increased risk of developing adverse events during selective serotonin reuptake inhibitor treatment...
  6. ncbi request reprint A review on the design and reporting of studies on drug-gene interaction
    Kim M Smits
    Department of Epidemiology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Epidemiol 58:651-4. 2005
    ..The essence of these studies lies within the concept of effect modification...
  7. doi request reprint Body mass index and von Hippel-Lindau gene mutations in clear-cell renal cancer: Results of the Netherlands Cohort Study on diet and cancer
    Kim M Smits
    Department of Epidemiology, Maastricht University, The Netherlands
    Ann Epidemiol 20:401-4. 2010
    ..We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which comprises 120,852 persons...
  8. ncbi request reprint Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review
    K M Smits
    Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    Mol Psychiatry 9:433-41. 2004
    ..In view of the scarcity and heterogeneity of the studies, however, current information is insufficiently reliable as a basis for implementing genetic testing in the diagnostic work-up of the depressive patient...
  9. doi request reprint N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer
    Veerle Melotte
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    J Natl Cancer Inst 101:916-27. 2009
    ..Here we examined the role of N-Myc downstream-regulated gene 4 (NDRG4) as a novel tumor suppressor and biomarker in colorectal cancer...
  10. doi request reprint A let-7 microRNA SNP in the KRAS 3'UTR is prognostic in early-stage colorectal cancer
    Kim M Smits
    Departments of Pathology and Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Cancer Res 17:7723-31. 2011
    ..Effects in early-stage CRC are however unknown. We studied KRAS-LCS6 genotype, hypothesizing that it might identify early-stage cases with a poor prognosis, and could potentially be used in therapy decision-making...
  11. doi request reprint The CpG island methylator phenotype in colorectal cancer: progress and problems
    Laura A E Hughes
    Dept of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200MD Maastricht, The Netherlands
    Biochim Biophys Acta 1825:77-85. 2012
    ....
  12. doi request reprint Different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von Hippel-Lindau gene
    Marcella M Baldewijns
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Cell Oncol 31:371-82. 2009
    ....
  13. doi request reprint Promoter CpG island methylation markers in colorectal cancer: the road ahead
    Muriel X G Draht
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Epigenomics 4:179-94. 2012
    ..This review summarizes the current knowledge of hypermethylation biomarkers for CRC detection, progression and treatment outcome...
  14. pmc Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma
    Iris J H van Vlodrop
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Pathol 176:575-84. 2010
    ..59, respectively). The strong correlation between GREM1 region iii promoter methylation and increased malignancy and its correlation with active angiogenesis indicates a role for GREM1 in ccRCC carcinogenesis and tumor angiogenesis...
  15. ncbi request reprint Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
    Kim M Smits
    University Maastricht, Maastricht, The Netherlands
    Int J Cancer 110:266-70. 2004
    ..No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected...
  16. doi request reprint Pharmacoepigenomics in colorectal cancer: a step forward in predicting prognosis and treatment response
    Kim M Smits
    Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, The Netherlands
    Pharmacogenomics 9:1903-16. 2008
    ..This review describes the current knowledge on the prognostic and predictive value of epigenetic markers in colorectal cancer...
  17. doi request reprint Colorectal cancer epigenetics: complex simplicity
    Manon van Engeland
    GROW School for Oncology and Developmental Biology, PO Box 616, 6200 Maastricht, The Netherlands
    J Clin Oncol 29:1382-91. 2011
    ..This review integrates recent data on epigenetic regulation of gene expression in CRC and describes how the understanding of these processes will alter the management of CRC...
  18. doi request reprint GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer
    Debby M E I Hellebrekers
    Departments of Pathology and Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Cancer Res 15:3990-7. 2009
    ..Here, we evaluated GATA4/5 promoter methylation as potential biomarkers for noninvasive colorectal cancer detection, and investigated the role of GATA4/5 in colorectal cancer...
  19. ncbi request reprint Methodologic ramifications of paying attention to sex and gender differences in clinical research
    Martin H Prins
    Department of Epidemiology, University of Maastricht, Maastricht, The Netherlands
    Gend Med 4:S106-10. 2007
    ..The essence of these studies lies within the concept of effect modification...
  20. doi request reprint Loss of SerpinA5 protein expression is associated with advanced-stage serous ovarian tumors
    Ingrid T G W Bijsmans
    Department of Pathology, GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Mod Pathol 24:463-70. 2011
    ....
  21. ncbi request reprint K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study
    Mirian Brink
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Epidemiology, Maastricht University, PO Box 616, The Netherlands
    Carcinogenesis 24:703-10. 2003
    ....
  22. doi request reprint Modified UroVysion scoring criteria increase the urothelial carcinoma detection rate in cases of equivocal urinary cytology
    Clément J R Huysentruyt
    Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Histopathology 58:1048-53. 2011
    ..The modification comprised the addition of a cytological prescreening technique and different evaluation criteria...