L J Schurgers

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Role of vitamin K and vitamin K-dependent proteins in vascular calcification
    L J Schurgers
    Department of Biochemistry, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
    Z Kardiol 90:57-63. 2001
  2. ncbi request reprint Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
    Leon J Schurgers
    VitaK and Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Blood 109:3279-83. 2007
  3. ncbi request reprint Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients
    Ellen C M Cranenburg
    Department of Biochemistry, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Thromb Haemost 101:359-66. 2009
  4. pmc Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma
    Sonja Mertsch
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    BMC Cancer 9:302. 2009
  5. ncbi request reprint Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification
    L J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK, University of Maastricht, Universiteitssingel 50, Maastricht, The Netherlands
    J Thromb Haemost 5:2503-11. 2007
  6. ncbi request reprint Matrix Gla-protein: the calcification inhibitor in need of vitamin K
    Leon J Schurgers
    VitaK, Maastricht University, Universiteitssingel 50, Maastricht, The Netherlands
    Thromb Haemost 100:593-603. 2008
  7. ncbi request reprint Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats
    Leon J Schurgers
    Cardiovascular Research Institute CARIM, Maastricht University, The Netherlands
    Blood 109:2823-31. 2007
  8. ncbi request reprint Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification
    Leon J Schurgers
    Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1629-33. 2005
  9. ncbi request reprint Oral anticoagulant treatment: friend or foe in cardiovascular disease?
    Leon J Schurgers
    Department of Biochemistry, Cardiovascular Research Institute, University Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Blood 104:3231-2. 2004
  10. ncbi request reprint Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects
    Leon J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK BV, Maastricht, The Netherlands
    Blood 104:2682-9. 2004

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Role of vitamin K and vitamin K-dependent proteins in vascular calcification
    L J Schurgers
    Department of Biochemistry, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
    Z Kardiol 90:57-63. 2001
    ..The hypothesis is put forward that undercarboxylation of MGP is a risk factor for vascular calcification and that the present RDA values are too low to ensure full carboxylation of MGP...
  2. ncbi request reprint Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
    Leon J Schurgers
    VitaK and Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Blood 109:3279-83. 2007
    ..MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 mug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way...
  3. ncbi request reprint Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients
    Ellen C M Cranenburg
    Department of Biochemistry, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Thromb Haemost 101:359-66. 2009
    ..Since circulating ucMGP levels are significantly and inversely correlated with the extent of CAC in HD patients, ucMGP may become a tool for identifying HD patients with a high probability of cardiovascular calcification...
  4. pmc Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma
    Sonja Mertsch
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    BMC Cancer 9:302. 2009
    ....
  5. ncbi request reprint Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification
    L J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK, University of Maastricht, Universiteitssingel 50, Maastricht, The Netherlands
    J Thromb Haemost 5:2503-11. 2007
    ..In vivo, MGP has been shown to be a potent inhibitor of vascular calcification; however, the precise molecular mechanism underlying the function of MGP is not yet fully understood...
  6. ncbi request reprint Matrix Gla-protein: the calcification inhibitor in need of vitamin K
    Leon J Schurgers
    VitaK, Maastricht University, Universiteitssingel 50, Maastricht, The Netherlands
    Thromb Haemost 100:593-603. 2008
    ..These assays may have potential value for identifying patients as well as apparently healthy subjects at high risk for CVD and/or cardiovascular calcification and for monitoring the treatment of CVD and vascular calcification...
  7. ncbi request reprint Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats
    Leon J Schurgers
    Cardiovascular Research Institute CARIM, Maastricht University, The Netherlands
    Blood 109:2823-31. 2007
    ..Using MGP antibodies, local VK deficiency was demonstrated at sites of calcification. This is the first study in rats demonstrating that AC and the resulting decreased arterial distensibility are reversible by high-VK intake...
  8. ncbi request reprint Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification
    Leon J Schurgers
    Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1629-33. 2005
    ..We hypothesized that low endogenous production of MGP and impaired carboxylation of MGP may contribute to the development or the progression of vascular disease...
  9. ncbi request reprint Oral anticoagulant treatment: friend or foe in cardiovascular disease?
    Leon J Schurgers
    Department of Biochemistry, Cardiovascular Research Institute, University Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Blood 104:3231-2. 2004
    ..These observations suggest that OACs, which are widely used for antithrombotic therapy, may induce cardiovascular calcifications as an adverse side effect...
  10. ncbi request reprint Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects
    Leon J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK BV, Maastricht, The Netherlands
    Blood 104:2682-9. 2004
    ....
  11. pmc Low serum and bone vitamin K status in patients with longstanding Crohn's disease: another pathogenetic factor of osteoporosis in Crohn's disease?
    E J Schoon
    Department of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands
    Gut 48:473-7. 2001
    ..Vitamin K is a cofactor in the carboxylation of osteocalcin, a protein essential for calcium binding to bone. A high level of circulating uncarboxylated osteocalcin is a sensitive marker of vitamin K deficiency...
  12. ncbi request reprint Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall
    H M Spronk
    Department of Biochemistry, Maastricht University, Maastricht, The Netherlands
    Biochem Biophys Res Commun 289:485-90. 2001
    ..Our data demonstrate the close association between MGP and calcification. It is suggested that undercarboxylated MGP is biologically inactive and that poor vascular vitamin K status may form a risk factor for vascular calcification...
  13. ncbi request reprint Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats
    H M H Spronk
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    J Vasc Res 40:531-7. 2003
    ....
  14. ncbi request reprint Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transport
    L J Schurgers
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Lipid Res 42:1120-4. 2001
    ..It is concluded that corn oil may have a mildly anticoagulant effect, the potential benefit of which is discussed...
  15. doi request reprint Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans
    Roger J M W Rennenberg
    Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    Blood 115:5121-3. 2010
    ..We conclude that long-term use of coumarins is associated with enhanced extracoronary vascular calcification, possibly through the inhibition of MGP carboxylation...
  16. doi request reprint Calcium scores and matrix Gla protein levels: association with vitamin K status
    Roger J M W Rennenberg
    Department of Internal Medicine, Maastricht University Medical Centre MUMC and Cardiovascular Research Institute Maastricht CARIM, Maastricht, The Netherlands
    Eur J Clin Invest 40:344-9. 2010
    ..We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP...
  17. doi request reprint Role of vitamin K-dependent proteins in the arterial vessel wall
    M L L Chatrou
    Dept of Biochemistry, Maastricht University, Maastricht, The Netherlands
    Hamostaseologie 31:251-7. 2011
    ..This review focuses on the effect of vitamin K-dependent proteins in vascular disease...
  18. doi request reprint Circulating matrix γ-carboxyglutamate protein (MGP) species are refractory to vitamin K treatment in a new case of Keutel syndrome
    E C M Cranenburg
    VitaK and Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Thromb Haemost 9:1225-35. 2011
    ..The purpose of this study was (i) to investigate the phenotype and the underlying MGP mutation of a newly identified KS patient, and (ii) to investigate MGP species and the effect of vitamin K supplements in KS patients...
  19. doi request reprint The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification
    Ellen C M Cranenburg
    VitaK, Maastricht University, Maastricht, The Netherlands
    J Vasc Res 45:427-36. 2008
    ..Here we report on the development of an ucMGP assay and the potential diagnostic utility of monitoring serum ucMGP levels...
  20. ncbi request reprint Menadione is a metabolite of oral vitamin K
    Henk H W Thijssen
    Department of Pharmacology, Cardiovascular Research Institute Maastricht, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Nutr 95:260-6. 2006
    ..The observations make it likely that part of the menaquinone-4 in tissues results from uptake and prenylation of circulating menadione...
  21. ncbi request reprint Abnormal bone turnover in long-standing Crohn's disease in remission
    E J Schoon
    Department of Gastroenterology and Hepatology, University Hospital Maastricht, Maastricht, The Netherlands
    Aliment Pharmacol Ther 15:783-92. 2001
    ..A high prevalence of osteoporosis is found in patients with Crohn's disease. The pathogenesis of this condition seems to be multifactorial and its pathophysiology is still not completely understood...
  22. ncbi request reprint Undercarboxylated matrix GLA protein levels are decreased in dialysis patients and related to parameters of calcium-phosphate metabolism and aortic augmentation index
    Marc M H Hermans
    Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, Maastricht, The Netherlands
    Blood Purif 25:395-401. 2007
    ..Vascular calcifications are related to cardiovascular mortality and morbidity in dialysis patients. Limited data exist on the role of calcification inhibitors, such as matrix-carboxyglutamic acid protein (MGP) in dialysis patients...
  23. doi request reprint Renal handling of matrix Gla-protein in humans with moderate to severe hypertension
    Roger J M W Rennenberg
    Department of Internal Medicine, University Hospital Maastricht and Cardiovascular Research Institute Maastricht CARIM, P Debyelaan 25, Maastricht, The Netherlands
    Hypertens Res 31:1745-51. 2008
    ..In conclusion, we demonstrate that the kidney is able to extract matrix Gla-protein from the plasma at a constant level of 12.8%, independent of renal function in hypertensive subjects...
  24. ncbi request reprint Vitamin K: the coagulation vitamin that became omnipotent
    Ellen C M Cranenburg
    Department of Biochemistry, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Thromb Haemost 98:120-5. 2007
    ....
  25. pmc Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells
    K Schutters
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht 6200 MD, The Netherlands
    Cell Death Differ 20:49-56. 2013
    ..We conclude that targeting cell surface-expressed PS is an attractive strategy for treatment of inflammatory diseases and that the rationally designed RGD-anxA5 is a promising therapeutic agent...
  26. doi request reprint Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers
    E Theuwissen
    VitaK and Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Thromb Haemost 11:1085-92. 2013
    ....
  27. doi request reprint Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization
    J M E M Cosemans
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht, The Netherlands
    J Thromb Haemost 8:1797-808. 2010
    ..Interaction of murine Gas6 with the platelet Gas6 receptors Tyro3, Axl and Mer (TAM) plays an important role in arterial thrombus formation. However, a role for Gas6 in human platelet activation has been questioned...
  28. pmc Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
    M H J Knapen
    CARIM, University of Maastricht, Maastricht, The Netherlands
    Osteoporos Int 18:963-72. 2007
    ..Results showed that K(2) improved BMC and femoral neck width, but not DXA-BMD. Hence high vitamin K(2) intake may contribute to preventing postmenopausal bone loss...
  29. ncbi request reprint Differential lipoprotein transport pathways of K-vitamins in healthy subjects
    Leon J Schurgers
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Biochim Biophys Acta 1570:27-32. 2002
    ..Moreover, the very long half-life time of MK-9 in the circulation indicates that it may form a more constant source of vitamin K than are either K1 or MK-4...
  30. ncbi request reprint Characteristics and performance of an immunosorbent assay for human matrix Gla-protein
    Leon J Schurgers
    VitaK and Department of Biochemistry, Maastricht University, The Netherlands
    Clin Chim Acta 351:131-8. 2005
    ..Promotor polymorphisms resulting in decreased expression levels were found to be associated with an increased risk for cardiovascular disease in humans...
  31. doi request reprint Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice
    Kristof Vanschoonbeek
    Department of Biochemistry, CARIM and NUTRIM, Maastricht University, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 28:2023-9. 2008
    ..Using APOE2 knock-in mice, the relation of these fish-oil effects with altered gene expression was investigated...
  32. ncbi request reprint Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men
    Leon J Schurgers
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, The Netherlands
    J Lipid Res 43:878-84. 2002
    ..The mechanism is unclear but may result from interactions of vitamin K with PUFA and/or other lipid components such as vitamin E...
  33. ncbi request reprint Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study
    Johanna M Geleijnse
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Nutr 134:3100-5. 2004
    ..71 (0.50, 1.00) and 0.48 (0.32, 0.71), respectively]. Phylloquinone intake was not related to any of the outcomes. These findings suggest that an adequate intake of menaquinone could be important for CHD prevention...
  34. ncbi request reprint Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD
    Joanne L Reynolds
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Soc Nephrol 15:2857-67. 2004
    ..These vesicles contain mineralization inhibitors derived from VSMC and serum, and perturbation of the production or function of these inhibitors would lead to accelerated vascular calcification...
  35. ncbi request reprint Identification of differentially expressed genes in human varicose veins: involvement of matrix gla protein in extracellular matrix remodeling
    Chrystelle Cario-Toumaniantz
    INSERM, U533, Universite de Nantes, Faculte des Sciences et Techniques, l institut du thorax, Nantes, France
    J Vasc Res 44:444-59. 2007
    ..Further study of these genes will provide insights into their specific roles in the etiology of venous disease...
  36. doi request reprint Circulating calcification inhibitors and vascular properties in children after renal transplantation
    Marieke J H van Summeren
    Department of Pediatric Immunology, University Medical Centre Utrecht, Lundlaan 6, Room KE 04 133 1, 3584 EA Utrecht, The Netherlands
    Pediatr Nephrol 23:985-93. 2008
    ..Future prospective studies in pediatric ESRD and transplant patients are needed to learn more about the role of calcification inhibitors in relation to the prevention of vascular damage...
  37. pmc Pseudoxanthoma elasticum: reduced gamma-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6-/-)
    Qiaoli Li
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA 19107, USA
    Biochem Biophys Res Commun 364:208-13. 2007
    ..These results suggest that MGP in Abcc6-/- mice is largely in inactive form and is unable to prevent the unwanted mineralization of connective tissues in PXE...
  38. ncbi request reprint Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients
    Dealba Gheduzzi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Lab Invest 87:998-1008. 2007
    ..The lower ratio of Gla-MGP over Glu-MGP in pathological fibroblasts compared to controls suggests these cells may play an important role in the ectopic calcification in PXE...
  39. ncbi request reprint Glia-induced neuronal differentiation by transcriptional regulation
    Christian Goritz
    Department of Neurotransmission Neuroendocrine Secretion, Institute of Cellular and Integrative Neurosciences INCI UMR7168 LC2 CNRS ULP, Strasbourg, France
    Glia 55:1108-22. 2007
    ..Together, our results suggest that glial cells promote different aspects of neuronal differentiation by regulating transcription of distinct classes of genes...