A M Schols

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Body composition and mortality in chronic obstructive pulmonary disease
    Annemie M W J Schols
    Department of Respiratory Medicine, University of Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 82:53-9. 2005
  2. ncbi request reprint Nutritional and metabolic modulation in chronic obstructive pulmonary disease management
    A M W J Schols
    Department of Respiratory Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht
    Eur Respir J Suppl 46:81s-86s. 2003
  3. doi request reprint The pathophysiology of cachexia in chronic obstructive pulmonary disease
    Annemie M W J Schols
    Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Curr Opin Support Palliat Care 3:282-7. 2009
  4. ncbi request reprint Different effects of corticosteroid-induced muscle wasting compared with undernutrition on rat diaphragm energy metabolism
    E Koerts-de Lang
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Eur J Appl Physiol 82:493-8. 2000
  5. ncbi request reprint Nutritional abnormalities and supplementation in chronic obstructive pulmonary disease
    A M Schols
    Department of Pulmonology, University Hospital Maastricht, Maastricht, Netherlands
    Clin Chest Med 21:753-62. 2000
  6. ncbi request reprint Pulmonary cachexia
    Annemie M W J Schols
    Department of Pulmonology, University Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Int J Cardiol 85:101-10. 2002
  7. ncbi request reprint Nutritional modulation as part of the integrated management of chronic obstructive pulmonary disease
    Annemie Schols
    Department of Respiratory Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Proc Nutr Soc 62:783-91. 2003
  8. ncbi request reprint Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease
    A M Schols
    Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 160:1220-6. 1999
  9. ncbi request reprint Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease
    M P Engelen
    Department of Pulmonology, University Hospital Maastricht and the Asthma Centre Hornerheide, Horn, Netherlands
    Am J Clin Nutr 71:733-8. 2000
  10. ncbi request reprint Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology, Surgery, and Clinical Chemistry, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 72:1480-7. 2000

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Body composition and mortality in chronic obstructive pulmonary disease
    Annemie M W J Schols
    Department of Respiratory Medicine, University of Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 82:53-9. 2005
    ..Survival studies have consistently shown significantly greater mortality rates in underweight and normal-weight patients with chronic obstructive pulmonary disease (COPD) than in overweight and obese COPD patients...
  2. ncbi request reprint Nutritional and metabolic modulation in chronic obstructive pulmonary disease management
    A M W J Schols
    Department of Respiratory Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht
    Eur Respir J Suppl 46:81s-86s. 2003
    ....
  3. doi request reprint The pathophysiology of cachexia in chronic obstructive pulmonary disease
    Annemie M W J Schols
    Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Curr Opin Support Palliat Care 3:282-7. 2009
    ..The focus of this review is on translation of putative mechanisms of altered energy metabolism and muscle maintenance in cachexia to clinical comparative and intervention studies on chronic obstructive pulmonary disease (COPD)...
  4. ncbi request reprint Different effects of corticosteroid-induced muscle wasting compared with undernutrition on rat diaphragm energy metabolism
    E Koerts-de Lang
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Eur J Appl Physiol 82:493-8. 2000
    ..25 mg/kg per day i.m.) causes a decrease in muscle energy status together with a mismatch between glycolysis and oxidative metabolism...
  5. ncbi request reprint Nutritional abnormalities and supplementation in chronic obstructive pulmonary disease
    A M Schols
    Department of Pulmonology, University Hospital Maastricht, Maastricht, Netherlands
    Clin Chest Med 21:753-62. 2000
    ..Nutritional or pharmacologic modulation of the catabolic response may further enhance the response in the near future...
  6. ncbi request reprint Pulmonary cachexia
    Annemie M W J Schols
    Department of Pulmonology, University Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Int J Cardiol 85:101-10. 2002
    ..Poor response was related to the effects of systemic inflammation on dietary intake and catabolism. The effectiveness of anticatabolic modulation requires further investigation...
  7. ncbi request reprint Nutritional modulation as part of the integrated management of chronic obstructive pulmonary disease
    Annemie Schols
    Department of Respiratory Medicine, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Proc Nutr Soc 62:783-91. 2003
    ..Patients responding to this treatment even demonstrated a decreased mortality. The effectiveness of anti-catabolic modulation requires further investigation...
  8. ncbi request reprint Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease
    A M Schols
    Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 160:1220-6. 1999
    ..Schols AMWJ, Creutzberg EC, Buurman WA, Campfield LA, Saris WHM, Wouters EFM. Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease...
  9. ncbi request reprint Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease
    M P Engelen
    Department of Pulmonology, University Hospital Maastricht and the Asthma Centre Hornerheide, Horn, Netherlands
    Am J Clin Nutr 71:733-8. 2000
    ..Skeletal muscle weakness is a prominent problem in many patients with chronic obstructive pulmonary disease (COPD)...
  10. ncbi request reprint Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology, Surgery, and Clinical Chemistry, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 72:1480-7. 2000
    ....
  11. ncbi request reprint Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema
    M P Engelen
    Departments of Pulmonology and Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 161:98-103. 2000
    ..61; p < 0.001), but not with Gln. This study illustrates that reduced Glu levels in skeletal muscle of patients with emphysema are possibly related to an enhanced glycolytic activity and associated with decreased GSH levels...
  12. ncbi request reprint Characterization of nonresponse to high caloric oral nutritional therapy in depleted patients with chronic obstructive pulmonary disease
    E C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 161:745-52. 2000
    ..Further research is needed to investigate whether these factors contribute to eventual disturbances in intermediary metabolism as reflected by the increased glucose concentration and ECW/ICW ratio...
  13. doi request reprint Pre-cachexia in patients with stages I-III non-small cell lung cancer: systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system
    C M Op den Kamp
    Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Lung Cancer 76:112-7. 2012
    ..The absence of muscular NF-κB-dependent inflammatory signaling supports the notion that transition of systemic to local inflammation is required to initiate UPS-dependent muscle wasting characteristic for (experimental) cachexia...
  14. ncbi request reprint Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives
    H R Gosker
    Departments of Pulmonology and Physiology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 71:1033-47. 2000
    ....
  15. doi request reprint Peroxisome proliferator-activated receptors: a therapeutic target in COPD?
    A H Remels
    Dept of Respiratory Medicine, University of Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 31:502-8. 2008
    ..Proposed mechanisms will be outlined in the present article, as well as the therapeutic potential of peroxisome proliferator-activated receptor modulation in the treatment of skeletal muscle dysfunction...
  16. ncbi request reprint Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB
    R C Langen
    Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    FASEB J 15:1169-80. 2001
    ..These results demonstrate that inflammatory cytokines may contribute to muscle wasting through the inhibition of myogenic differentiation via a NF-kappaB-dependent pathway...
  17. ncbi request reprint Disturbances in leptin metabolism are related to energy imbalance during acute exacerbations of chronic obstructive pulmonary disease
    E C Creutzberg
    Department of Pulmonology, Heart and Lung Function Laboratory, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1239-45. 2000
    ..Evidence was found that the elevated leptin concentrations were in turn under control of the systemic inflammatory response, and, presumably, the high-dose systemic glucocorticosteroid treatment...
  18. ncbi request reprint Exercise-induced lactate increase in relation to muscle substrates in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology and Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1697-704. 2000
    ..However, factors other than physical inactivity, such as Pa(O(2)) or DL(CO), play a role in the different La responses during exercise in subjects with different subtypes of COPD...
  19. ncbi request reprint Acute effects of nebulized salbutamol on resting energy expenditure in patients with chronic obstructive pulmonary disease and in healthy subjects
    E C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Respiration 65:375-80. 1998
    ..The metabolic effects of salbutamol were however not sufficient to explain totally the elevated REE seen in these patients...
  20. ncbi request reprint Effects of exercise on amino acid metabolism in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 163:859-64. 2001
    ..01 and 21%, p < 0.01, respectively), suggesting enhanced nitrogen efflux. This study shows that exercise alters amino acid (intermediary) metabolism in patients with COPD and independent of the presence of FFM wasting...
  21. pmc Systemic anti-inflammatory mediators in COPD: increase in soluble interleukin 1 receptor II during treatment of exacerbations
    M A Dentener
    Department of Pulmonology and Surgery, Maastricht University, Nutrition and Toxicology Research Institute Maastricht NUTRIM, 6202 AZ Maastricht, The Netherlands
    Thorax 56:721-6. 2001
    ..The aim of this study was to test the hypothesis that the chronic inflammatory process present in chronic obstructive pulmonary disease (COPD) is due to a defective endogenous anti-inflammatory mechanism...
  22. ncbi request reprint Enhanced levels of whole-body protein turnover in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology and Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1488-92. 2000
    ..The present study reveals elevated levels for protein turnover in patients with COPD, and indicates that infusion of the Leu tracer gives a reflection of Leu metabolism but not of whole-body protein metabolism in these patients...
  23. doi request reprint Short- and long-term efficacy of a community-based COPD management programme in less advanced COPD: a randomised controlled trial
    C R van Wetering
    Department of Respiratory Medicine, Maxima Medical Centre, Veldhoven, The Netherlands
    Thorax 65:7-13. 2010
    ..The effectiveness of pulmonary rehabilitation in advanced COPD is well established, but few data are available in less advanced disease...
  24. ncbi request reprint Acute effects of different nutritional supplements on symptoms and functional capacity in patients with chronic obstructive pulmonary disease
    M A Vermeeren
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Am J Clin Nutr 73:295-301. 2001
    ..Use of nutritional supplements in depleted patients with chronic obstructive pulmonary disease (COPD) requires optimization between positive effects on outcome and potential acute adverse effects on metabolism and exercise performance...
  25. ncbi request reprint Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease
    M P Engelen
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Am J Clin Nutr 68:1298-303. 1998
    ..Depletion of fat-free mass (FFM) occurs in a considerable number of patients with chronic obstructive pulmonary disease (COPD)...
  26. ncbi request reprint Anabolic steroids
    E C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 2:243-53. 1999
    ..The present review discusses the rationale for anabolic steroid treatment in acute and chronic disease, their mechanistic actions, the available clinical trials in acute and chronic disease and their side-effects...
  27. ncbi request reprint Analysis of body water compartments in relation to tissue depletion in clinically stable patients with chronic obstructive pulmonary disease
    E M Baarends
    Department of Pulmonology, University of Limburg, Maastricht, Netherlands
    Am J Clin Nutr 65:88-94. 1997
    ..66 +/- 0.12, P < 0.05); this was most pronounced in women. In conclusion, it was found that COPD patients with extreme FFM wasting are characterized by an increased ECW-ICW ratio despite a relatively spared fat mass...
  28. ncbi request reprint Nutritional support in patients with chronic obstructive pulmonary disease during hospitalization for an acute exacerbation; a randomized controlled feasibility trial
    M A P Vermeeren
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Clin Nutr 23:1184-92. 2004
    ..The aim of the study was to investigate the feasibility and effectiveness of energy- and protein-rich nutritional supplements during hospitalization for an acute exacerbation in nutritionally depleted COPD patients...
  29. doi request reprint Synergistic stimulation of myogenesis by glucocorticoid and IGF-I signaling
    N A Pansters
    Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Appl Physiol (1985) 114:1329-39. 2013
    ....
  30. pmc The effects of treatment with chemotherapy on energy metabolism and inflammatory mediators in small-cell lung carcinoma
    A J Staal van den Brekel
    Department of Pulmonology, University Hospital, Maastricht, The Netherlands
    Br J Cancer 76:1630-5. 1997
    ..No correlation, however, existed between the decrease in REE and the decrease in the acute-phase proteins. In conclusion, chemotherapeutic treatment attenuates the tumour-related metabolic derangements and acute-phase response...
  31. ncbi request reprint beta-Adrenoceptor-mediated thermogenesis and lipolysis in patients with chronic obstructive pulmonary disease
    S L Schiffelers
    Department of Human Biology, Maastricht University, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 280:E357-64. 2001
    ..05). In conclusion, beta-adrenoceptor-mediated lipolysis and thermogenesis are impaired in COPD patients. This may play a role in the development or maintenance of their relatively increased fat mass...
  32. ncbi request reprint Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease
    H R Gosker
    Dept of Pulmonology, Nutrition Toxicology and Environment Research Institute Maastricht, Maastricht, The Netherlands
    Eur Respir J 22:280-5. 2003
    ..Also, in this group of clinically and weight stable chronic obstructive pulmonary disease patients, apoptosis appeared not to be involved in muscle pathology...
  33. doi request reprint Obesity and the lung: 5. Obesity and COPD
    F M E Franssen
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Thorax 63:1110-7. 2008
    ..The potential interaction between abnormal adipose tissue function, systemic inflammation and COPD may provide more insight into the pathogenesis and reversibility of systemic pathology in this disease...
  34. ncbi request reprint Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD
    H R Gosker
    Dept of Respiratory Medicine, Maastricht University, Nutrition and Toxicology Research Institute Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur Respir J 30:73-9. 2007
    ....
  35. ncbi request reprint Leptin as local inflammatory marker in COPD
    R Broekhuizen
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Respir Med 99:70-4. 2005
    ....
  36. pmc Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease
    R Broekhuizen
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Thorax 60:376-82. 2005
    ..The aim of this study was to investigate the effect of PUFA modulation on systemic inflammation, reversal of muscle wasting, and functional status in COPD...
  37. ncbi request reprint Skeletal muscle fibre-type shifting and metabolic profile in patients with chronic obstructive pulmonary disease
    H R Gosker
    Dept of Pulmonology, University of Maastricht, The Netherlands
    Eur Respir J 19:617-25. 2002
    ..Low oxidative capacity is closely related to the proportion of type-I fibres, but an additional reduction of oxidative enzyme activity is present within IIA fibres. Fibre-type abnormalities may be aggravated in emphysema...
  38. pmc Raised CRP levels mark metabolic and functional impairment in advanced COPD
    R Broekhuizen
    Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Thorax 61:17-22. 2006
    ..A study was undertaken to investigate the discriminative value of high sensitivity CRP in COPD with respect to markers of local and systemic impairment, disability, and handicap...
  39. ncbi request reprint Glutathione and glutamate levels in the diaphragm of patients with chronic obstructive pulmonary disease
    M P K J Engelen
    Dept of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 23:545-51. 2004
    ..Glutamate and reduced glutathione levels are strongly interrelated in both muscles, independent of fibre type distribution and fibre size...
  40. doi request reprint Whole-body resting and exercise-induced lipolysis in sarcopenic [corrected] patients with COPD
    F M E Franssen
    Dept of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Hospital, Maastricht, The Netherlands
    Eur Respir J 32:1466-71. 2008
    ..Altered regulation of muscle protein turnover seems to be the trigger in the body compositional shift observed in these patients...
  41. ncbi request reprint Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD
    H R Gosker
    Dept of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Eur Respir J 22:88-93. 2003
    ..The low uncoupling protein-3 content is independent of the loss of oxidative capacity observed in these patients...
  42. doi request reprint Regulation of mitochondrial biogenesis during myogenesis
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Mol Cell Endocrinol 315:113-20. 2010
    ..In particular, PGC-1alpha and PPAR-alpha may be involved in the regulation of mitochondrial biogenesis during myogenesis...
  43. doi request reprint PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle
    A H V Remels
    Department of Respiratory Medicine, Maastricht University, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 297:E174-83. 2009
    ..These findings demonstrate that muscle-specific inhibition of NF-kappaB activation may be an interesting therapeutic avenue for treatment of several inflammation-associated skeletal muscle abnormalities...
  44. ncbi request reprint Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD
    A H Remels
    Department of Respiratory Medicine, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 30:245-52. 2007
    ..Therefore, a disturbed expression of these regulatory factors may well underlie the disturbed skeletal muscle functioning in chronic obstructive pulmonary disease...
  45. ncbi request reprint Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals
    F M van Dielen
    Department of General Surgery, University Hospital, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 25:1759-66. 2001
    ..The BMI independent relationship between leptin and both soluble TNF-receptors is consistent with a regulatory role for leptin in the inflammatory state in morbidly obese subjects...
  46. ncbi request reprint Prevalence of nutritional depletion in a large out-patient population of patients with COPD
    M A P Vermeeren
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Respir Med 100:1349-55. 2006
    ....
  47. ncbi request reprint The contribution of starvation, deconditioning and ageing to the observed alterations in peripheral skeletal muscle in chronic organ diseases
    F M E Franssen
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Clin Nutr 21:1-14. 2002
    ..Unravelling the relative contributions of these external factors to the observed alterations in the various diseases may contribute to targeted intervention strategies to improve muscle function in selected groups of patients...
  48. doi request reprint TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    FASEB J 24:5052-62. 2010
    ..In conclusion, these results demonstrate that TNF-α impairs muscle oxphen in a NF-κB-dependent manner...
  49. ncbi request reprint Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation
    Ramon C J Langen
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 35:689-96. 2006
    ....
  50. ncbi request reprint Effect of glutamate ingestion on whole-body glutamate turnover in healthy elderly and patients with chronic obstructive pulmonary disease
    Erica P A Rutten
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Nutrition 22:496-503. 2006
    ....
  51. ncbi request reprint Metabolic effects of glutamine and glutamate ingestion in healthy subjects and in persons with chronic obstructive pulmonary disease
    Erica P A Rutten
    Department of Respiratory Medicine, University of Maastricht, Maastricht, The Netherlands
    Am J Clin Nutr 83:115-23. 2006
    ..However, the metabolic effects of glutamate supplementation have never been compared with those of glutamine supplementation...
  52. ncbi request reprint Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease
    Erica P A Rutten
    Department of Respiratory Medicine, Maastricht University, PO Box 5800, 6202 AZ Maastricht, Netherlands
    Am J Clin Nutr 83:829-34. 2006
    ..Experimental studies indicate that greater skeletal muscle protein breakdown is a trigger for the cachexia that often is prevalent in chronic obstructive pulmonary disease (COPD)...
  53. pmc Cellular protein breakdown and systemic inflammation are unaffected by pulmonary rehabilitation in COPD
    Charlotte E Bolton
    Department of Respiratory Medicine, Wales College of Medicine, Cardiff University, Academic Centre, Llandough Hospital, Vale of Glamorgan, Cardiff, UK
    Thorax 62:109-14. 2007
    ..Pulmonary rehabilitation can improve the functional capacity, but has a variable effect on the low fat-free mass (FFM) in patients with chronic obstructive pulmonary disease...
  54. doi request reprint Metabolic and functional effects of glutamate intake in patients with chronic obstructive pulmonary disease (COPD)
    Erica P A Rutten
    Department of Respiratory Medicine, University of Maastricht, Maastricht, The Netherlands
    Clin Nutr 27:408-15. 2008
    ..We hypothesized that an increased availability of glutamate via glutamate ingestion increases muscle glutamate concentration leading to acute improvements in skeletal muscle energy metabolism and function...
  55. ncbi request reprint Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3beta
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Maastricht University PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Cell Physiol 292:C1636-44. 2007
    ....
  56. pmc Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis
    Harry R Gosker
    Department of Respiratory Medicine, NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Thorax 62:944-9. 2007
    ..A study was conducted to determine whether vastus lateralis muscle fibre type proportions are associated with COPD disease severity and to provide reference values for the proportions of fibre types in the vastus lateralis in COPD...
  57. ncbi request reprint Glycogen synthase kinase 3 suppresses myogenic differentiation through negative regulation of NFATc3
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6202 AZ Maastricht, The Netherlands
    J Biol Chem 283:358-66. 2008
    ..Inhibition of GSK-3beta may be a potential strategy in prevention or treatment of muscle atrophy...
  58. ncbi request reprint Muscle atrophy and hypertrophy signaling pathways in COPD: a role in muscle remodeling?
    Ramon C J Langen
    Am J Respir Crit Care Med 177:122; author reply 122-3. 2008
  59. ncbi request reprint Muscle metabolic modulation by chronic hypoxia
    Harry R Gosker
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Proteome Res 6:3400-1. 2007
    ..Proteome Res. 2007, 6(5), 1974-1984). For this, relatively young animals were used. In our communication, we note that, based on other literature, it is likely that the adaptive response of skeletal muscle to hypoxia attenuates with age...
  60. ncbi request reprint De novo glutamine synthesis induced by corticosteroids in vivo in rats is secondary to weight loss
    Ivo de Blaauw
    Department of Surgery, Maastricht University, The Netherlands
    Clin Nutr 23:1035-42. 2004
    ..Corticosteroid treatment affects muscle protein and glutamine metabolism. In the present study we aimed to clarify to what extent anorexia, weight loss and corticosteroids determine protein and glutamine metabolism in muscle...
  61. ncbi request reprint Exercise training restores uncoupling protein-3 content in limb muscles of patients with chronic obstructive pulmonary disease
    Harry R Gosker
    Dept of Respiratory Medicine, Maastricht Univ, Nutrition and Toxicology Research Institute Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 290:E976-81. 2006
    ..We conclude that exercise-training can restore muscle UCP3 protein level in COPD, and the nature of this response complies with the hypothesis that UCP3 may protect against lipotoxicity...
  62. ncbi request reprint Measuring body composition in chronic heart failure: a comparison of methods
    Nicole H M K Uszko-Lencer
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Eur J Heart Fail 8:208-14. 2006
    ....
  63. ncbi request reprint Efficacy of nutritional supplementation therapy in depleted patients with chronic obstructive pulmonary disease
    Eva C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Nutrition 19:120-7. 2003
    ..Maintenance systemic glucocorticosteroids, prescribed in a substantial number of patients, further contribute to muscle weakness. We investigated the efficacy of oral nutritional supplementation therapy in depleted patients with COPD...
  64. ncbi request reprint Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease
    Harry R Gosker
    Department of Pulmonology, University of Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 76:113-9. 2002
    ..Although the loss of peripheral muscle mass has been shown convincingly in chronic obstructive pulmonary disease (COPD), the underlying pathogenesis remains unclear...
  65. ncbi request reprint Striking similarities in systemic factors contributing to decreased exercise capacity in patients with severe chronic heart failure or COPD
    Harry R Gosker
    Department of Pulmonology, University of Maastricht, The Netherlands
    Chest 123:1416-24. 2003
    ....
  66. ncbi request reprint Effects of whole-body exercise training on body composition and functional capacity in normal-weight patients with COPD
    Frits M E Franssen
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, Germany
    Chest 125:2021-8. 2004
    ..Skeletal muscle wasting is related to muscle dysfunction, exercise intolerance, and increased mortality risk in patients with COPD...
  67. ncbi request reprint Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways
    Ramon C J Langen
    Department of Pulmonology, Maastricht University, The Netherlands
    Am J Physiol Cell Physiol 283:C714-21. 2002
    ..Our observations suggest that the inhibitory effects of TNF-alpha on myogenesis can be uncoupled in a redox-sensitive component affecting myotube formation and a redox independent component affecting myogenic protein expression...
  68. ncbi request reprint Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization
    Ramon C J Langen
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    FASEB J 18:227-37. 2004
    ..These results implicate that TNFalpha inhibits myogenic differentiation through destabilizing MyoD protein in a NF-kappaB-dependent manner, which interferes with skeletal muscle regeneration and may contribute to muscle wasting...
  69. ncbi request reprint Arm mechanical efficiency and arm exercise capacity are relatively preserved in chronic obstructive pulmonary disease
    Frits M E Franssen
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Med Sci Sports Exerc 34:1570-6. 2002
    ....
  70. ncbi request reprint Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD
    Karin H Groenewegen
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Chest 124:459-67. 2003
    ..As yet, little information is available about the long-term outcome of patients who have been hospitalized with acute exacerbations, although high mortality rates have been reported...
  71. ncbi request reprint A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial
    Eva C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Chest 124:1733-42. 2003
    ..Anabolic steroids could be an additional mode of intervention to improve outcome of pulmonary rehabilitation by increasing physiologic functioning, possibly mediated by increasing erythropoietic function...
  72. ncbi request reprint Enhanced myogenic differentiation by extracellular matrix is regulated at the early stages of myogenesis
    Ramon C J Langen
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    In Vitro Cell Dev Biol Anim 39:163-9. 2003
    ..This protocol may aid studies aimed at elucidating mechanisms of myogenic differentiation, where a homogeneous population of myotubes is preferred...
  73. ncbi request reprint Systemic effects in COPD
    Emil F M Wouters
    Department of Pulmonary Diseases, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Chest 121:127S-130S. 2002
    ....
  74. ncbi request reprint Bioelectrical impedance analysis--part I: review of principles and methods
    Ursula G Kyle
    Geneva University Hospital, Switzerland
    Clin Nutr 23:1226-43. 2004
    ..ESPEN guidelines for the clinical use of BIA measurements are described in a paper to appear soon in Clinical Nutrition...
  75. ncbi request reprint Energy balance in depleted ambulatory patients with chronic obstructive pulmonary disease: the effect of physical activity and oral nutritional supplementation
    Annelies H C Goris
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Br J Nutr 89:725-31. 2003
    ..These results suggest that knowledge about the individual physical activity level is necessary for the estimation of the energy need of the COPD patient...
  76. ncbi request reprint Decreased whole-body and splanchnic glutamate metabolism in healthy elderly men and patients with chronic obstructive pulmonary disease in the postabsorptive state and in response to feeding
    Erica P A Rutten
    Department of Respiratory Medicine, University Hospital, Maastricht, The Netherlands
    J Nutr 135:2166-70. 2005
    ..COPD does not affect postabsorptive WB glutamate metabolism but may influence splanchnic glutamate metabolism during feeding...
  77. ncbi request reprint Altered interorgan response to feeding in patients with chronic obstructive pulmonary disease
    Marielle P K J Engelen
    Department of Respiratory Medicine and Surgery, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 82:366-72. 2005
    ..Previously, we reported increased values for whole-body protein turnover in patients with chronic obstructive pulmonary disease (COPD) in the postabsorptive state...
  78. ncbi request reprint Rehabilitation decreases exercise-induced oxidative stress in chronic obstructive pulmonary disease
    Evi M Mercken
    Department of Respiratory Medicine, University of Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 172:994-1001. 2005
    ..In addition, pulmonary rehabilitation increased exercise capacity and was associated with reduced exercise-induced oxidative stress...
  79. ncbi request reprint Optimizing oral nutritional drink supplementation in patients with chronic obstructive pulmonary disease
    Roelinka Broekhuizen
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Br J Nutr 93:965-71. 2005
    ..This study illustrates that there might be an optimum for the portion size of nutritional drink supplements in chronic obstructive pulmonary disease and that more is not always better...
  80. ncbi request reprint Similarities in skeletal muscle strength and exercise capacity between renal transplant and hemodialysis patients
    Eugénie C H van den Ham
    Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Transplant 5:1957-65. 2005
    ..In RTx patients, muscle strength and PAL are highly related to exercise capacity. Renal function appears to be a significant predictor of LBM, and through the LBM, of muscle strength and exercise capacity...
  81. ncbi request reprint Altered antioxidant status in peripheral skeletal muscle of patients with COPD
    Harry R Gosker
    Department of Respiratory Medicine, Nutrition Toxicology and Environment Research Institute, Maastricht University, Maastricht, The Netherlands
    Respir Med 99:118-25. 2005
    ....
  82. ncbi request reprint Limb muscle dysfunction in COPD: effects of muscle wasting and exercise training
    Frits M E Franssen
    Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Med Sci Sports Exerc 37:2-9. 2005
    ....
  83. ncbi request reprint Response of whole-body protein and urea turnover to exercise differs between patients with chronic obstructive pulmonary disease with and without emphysema
    Marielle P K J Engelen
    Department of Respiratory Medicine, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 77:868-74. 2003
    ..Exercise is known to improve physical capacity and muscle mass in patients with chronic obstructive pulmonary disease (COPD). However, recent evidence suggests that exercise may also negatively influence metabolism in COPD...
  84. ncbi request reprint Skeletal muscle glutamate metabolism in health and disease: state of the art
    Erica P A Rutten
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 8:41-51. 2005
    ..Furthermore, several options for modulating muscle glutamate concentration in order to improve glutamate metabolism are discussed...
  85. ncbi request reprint Altered amino acid metabolism in chronic obstructive pulmonary disease: new therapeutic perspective?
    Marielle P K J Engelen
    Department of Pulmonology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 6:73-8. 2003
    ..This review aims at summarizing and critically evaluating the available clinical studies examining alterations in amino acid profile in plasma and skeletal muscle of patients with chronic obstructive pulmonary disease...
  86. ncbi request reprint The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles vs. lower limb muscle dysfunction vs. dynamic hyperinflation. Missing pieces
    Harry R Gosker
    Department of Respiratory Medicine, Maastricht University, The Netherlands
    J Appl Physiol 105:761. 2008
  87. ncbi request reprint ACE Gene Polymorphism in COPD
    Harry R Gosker
    Am J Respir Crit Care Med 170:572; author reply 572-3. 2004
  88. ncbi request reprint The functional, metabolic, and anabolic responses to exercise training in renal transplant and hemodialysis patients
    Eugénie C H van den Ham
    Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Transplantation 83:1059-68. 2007
    ..The aim of the study was to compare intrinsic muscular parameters between HD and RTx patients and controls, and to assess the response to exercise training on exercise capacity and muscular structure and function in these groups...
  89. ncbi request reprint Supplementation of soy protein with branched-chain amino acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease
    Marielle P K J Engelen
    Department of Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 85:431-9. 2007
    ..It is often suggested that chronic wasting diseases [eg, chronic obstructive pulmonary disease (COPD)] may benefit from branched-chain amino acid (BCAA) administration via improved protein metabolism...
  90. ncbi request reprint Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Am J Physiol Cell Physiol 290:C453-62. 2006
    ..Therefore, this study identifies GSK-3beta as a potential target for pharmacological stimulation of muscle growth...