Research Topics
Species | C SchmitzSummaryAffiliation: Maastricht University Country: The Netherlands Publications
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Publications
Altered spatial arrangement of layer V pyramidal cells in the mouse brain following prenatal low-dose X-irradiation. A stereological study using a novel three-dimensional analysis method to estimate the nearest neighbor distance distributions of cells in Christoph Schmitz
Department of Anatomy and Cell Biology, RWTH University of Aachen, Germany
Cereb Cortex 12:954-60. 2002..5% and a more dispersed spatial arrangement of these neurons. Considering the recent literature, it seems reasonable to consider abnormal neuronal migration as the potential basic cause of this finding...- Design-based stereology in neuroscienceC Schmitz
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, P O Box 616, NL 6200 MD Maastricht, Netherlands
Neuroscience 130:813-31. 2005..These characteristics establish the advantages of design-based stereologic methods in quantitative neuromorphology... - Prenatal protracted irradiation at very low dose rate induces severe neuronal loss in rat hippocampus and cerebellumC Schmitz
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, P O Box 616, NL 6200 MD Maastricht, Netherlands
Neuroscience 130:935-48. 2005.... - Autism: neuropathology, alterations of the GABAergic system, and animal modelsChristoph Schmitz
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience Maastricht University, The Netherlands
Int Rev Neurobiol 71:1-26. 2005 - The neuropathology of autism: where do we stand?C Schmitz
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
Neuropathol Appl Neurobiol 34:4-11. 2008..In this respect, more concerted efforts are required to examine the various aspects of cellular pathology affecting the brain in autism. This paper briefly highlights four key areas that warrant further evaluation... 
Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortexKimmo A Michelsen
Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
BMC Neurosci 8:107. 2007..The aim of this study was to reveal putative PS- and/or CMS-related changes in basal spine morphology and density of pyramidal neurons in the rat medial prefrontal cortex (mPFC)...- Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's diseaseChristoph Schmitz
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, Maastricht, The Netherlands
Am J Pathol 164:1495-502. 2004..These findings point to the potential involvement of more than one mechanism in hippocampal neuron loss in this APP/PS-1 double-transgenic mouse model of Alzheimer's disease... - Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic miceBart P F Rutten
Division Cellular Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
Am J Pathol 167:161-73. 2005..The observation of age-related SIPB loss within SR of PS1M146L mice supports a role of mutant PS1 in neurodegeneration apart from its contribution to alterations in Abeta generation... - No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragmentBart P F Rutten
Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
Neurobiol Dis 12:110-20. 2003..These data implicate that expression of beta-CTF per se is not neurotoxic, and that other mechanisms are responsible for the neurotoxic events in Alzheimer's disease brain... - Perinatal asphyxia induced neuronal loss by apoptosis in the neonatal rat striatum: a combined TUNEL and stereological studyWilma D J van de Berg
Department of Pediatrics, Maastricht University, Maastricht, The Netherlands
Exp Neurol 174:29-36. 2002..These data show that asphyxia causes exaggerated apoptotic cell death during the first week of life and as a consequence a small amount of neuron loss in the neostriatum... - Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodelChunyan Cao
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Behav Brain Res 170:257-61. 2006..These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD... 
Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's diseaseKimmo A Michelsen
Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Brain Res 1316:139-44. 2010..These results might indicate a previously unknown action of mutations in PS1 on DNA integrity, which might be involved in the pathophysiologic processes of mutant PS1 in Alzheimer's disease...- Impact of perinatal asphyxia on the GABAergic and locomotor systemW D J Van de Berg
Department of Pediatrics, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
Neuroscience 117:83-96. 2003..Despite a considerable loss of striatal neurons, only minor deficits in motor performance were found after perinatal asphyxia... - Caloric restriction and aging but not overexpression of SOD1 affect hippocampal volumes in miceBart P F Rutten
Department of Psychiatry and Neuropsychology, School for Mental Health and Neurosciences, Maastricht University, NL 6200 MD Maastricht, The Netherlands
Mech Ageing Dev 131:574-9. 2010..These morphometric alterations may have impact on the function of the hippocampus during aging and CR... - Gene regulation by hypoxia and the neurodevelopmental origin of schizophreniaRainald Schmidt-Kastner
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands
Schizophr Res 84:253-71. 2006.... - Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's diseaseHisaaki Takahashi
Department of Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands
Brain Struct Funct 214:145-60. 2010..The loss of these interneurons in AD may have substantial functional repercussions on local inhibitory processes in the hippocampus... - Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's diseaseYasin Temel
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
Neurosci Lett 406:138-41. 2006..This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD... - Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleusYasin Temel
Department of Psychiatry and Neuropsychology, Division Cellular Neurosciences, European Graduate School of Neuroscience EURON, The Netherlands
Exp Neurol 193:43-52. 2005.... - Protection of nigral cell death by bilateral subthalamic nucleus stimulationYasin Temel
Department of Psychiatry and Neuropsychology, Division of Cellular Neurosciences, Maastricht University, and Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
Brain Res 1120:100-5. 2006..These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD... - Advanced microscopy techniques for quantitative analysis in neuromorphology and neuropathology research: current status and requirements for the futureMarijke A M Lemmens
Division Neuroscience, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
J Chem Neuroanat 40:199-209. 2010..These developments will advance basic neuroscience research as well as pharmaceutical and biotechnology research and development... - Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-hydroxydopamine lesioned ratsBart Scholtissen
Department of Psychiatry and Neuropsychology, Maastricht University, EURON, P O Box 616, 6200 MD Maastricht, The Netherlands
Pharmacol Biochem Behav 83:175-85. 2006..Taken together, since serotonergic ligands have the same effect as dopaminergic ligands on reaction time responding indicated that 5-HT and DA release are agonistically linked in control and 6-OHDA lesioned rats... - Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampusL Chouliaras
School for Mental Health and NeuroScience MHeNS, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, P O Box 616, 6200 MD Maastricht, The Netherlands
Brain Behav Immun 25:616-23. 2011..These changes in Dnmt3a levels in the mouse hippocampus may have a significant impact on gene expression and associated cognitive functioning... 
Detection of amyloid beta aggregates in the brain of BALB/c mice after Chlamydia pneumoniae infectionEllen Boelen
Department of Medical Microbiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
Acta Neuropathol 114:255-61. 2007..However, future studies are required to resolve these differences and to investigate whether Cpn is indeed an etiological factor in AD pathogenesis...- Altered gene expression and neuropathology in Alzheimer's diseaseIvona Brasnjevic
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
Neurobiol Aging 27:1081-3. 2006 - Perinatal asphyxia results in changes in presynaptic bouton number in striatum and cerebral cortex-a stereological and behavioral analysisW D Van de Berg
Department of Pediatrics, Maastricht University, P Debyelaan 25, PO Box 5800, 6212 AZ, Maastricht, The Netherlands
J Chem Neuroanat 20:71-82. 2000..These results suggest that perinatal asphyxia induced neuronal loss, which is compensated for by an increase in presynaptic bouton numbers... - Volume, neuron density and total neuron number in five subcortical regions in schizophreniaPawel Kreczmanski
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
Brain 130:678-92. 2007.... - Stereological studies of capillary length density in the frontal cortex of schizophrenicsPawel Kreczmanski
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
Acta Neuropathol (Berl) 109:510-8. 2005..Compromised brain metabolism and occurrence of oxidative stress in the brain of schizophrenics are likely caused by other mechanisms... - Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseasesIvona Brasnjevic
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
DNA Repair (Amst) 7:1087-97. 2008.... - Microvessel length density, total length, and length per neuron in five subcortical regions in schizophreniaPawel Kreczmanski
Division of Cellular Neuroscience, School for Mental Health and Neurosciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
Acta Neuropathol 117:409-21. 2009.... - Antioxidants and Alzheimer's disease: from bench to bedside (and back again)Bart P F Rutten
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, The Netherlands
Curr Opin Clin Nutr Metab Care 5:645-51. 2002..Furthermore, for the future one might expect balanced upregulation of both exogenous and endogenous antioxidants as one of the best treatment strategies for preventing or at least slowing down the progression of Alzheimer's disease... - The aging brain: accumulation of DNA damage or neuron loss?Bart P F Rutten
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
Neurobiol Aging 28:91-8. 2007..This formerly unknown inverse relation between age-related accumulation of nDNA damage and age-related loss of neurons may reflect a fundamental process of aging in the central nervous system... - The aging brain: less neurons could be betterBart P F Rutten
Department of Psychiatry and Neuropsychology, Division of Neuroscience, University of Maastricht, P.O. Box 616, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands
Mech Ageing Dev 124:349-55. 2003..Ultimately, the implication of this strategy may lead to the prevention of AD... - Neurons in the fusiform gyrus are fewer and smaller in autismImke A J van Kooten
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
Brain 131:987-99. 2008.... - The dorsal raphe nucleus--from silver stainings to a role in depressionKimmo A Michelsen
Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
Brain Res Rev 55:329-42. 2007..Starting with a historical perspective, this essay describes the morphology, ascending projections and multitransmitter nature of the DRN, and stresses its role as a key target for depression research... - Neuronal distribution in the neocortex of schizophrenic patientsManuel F Casanova
Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
Psychiatry Res 158:267-77. 2008..The findings suggest an alteration in the modulatory systems innervating the cell minicolumn. Furthermore, the lack of variation in core columnarity parameters argues in favor of a defect post-dating the formation of the cell minicolumn... - Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic modelCaty Casas
Department of Central Nervous System Alzheimer Disease, Aventis Pharma Paris Research Center, Vitry sur Seine, France
Am J Pathol 165:1289-300. 2004..Thus, APP(SL)PS1KI mice further confirm the critical role of intraneuronal Abeta(42) in neuronal loss and provide an excellent tool to investigate therapeutic strategies designed to prevent AD neurodegeneration... - Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALSErik Storkebaum
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven B 3000, Belgium
Nat Neurosci 8:85-92. 2005..On i.c.v. delivery, Vegf is anterogradely transported and preserves neuromuscular junctions in SOD1(G93A) rats. Our findings in preclinical rodent models of ALS may have implications for treatment of neurodegenerative disease in general... - Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic ratsOrsolya Kántor
Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
Neurobiol Dis 22:538-47. 2006..No alterations in mean total numbers of striatal neurons were found in 6-month-old animals. Testing 14-month-old animals in a choice reaction time task indicated impaired striatal function of tgHD rats compared with controls... - Neuroglobin mRNA expression after transient global brain ischemia and prolonged hypoxia in cell cultureRainald Schmidt-Kastner
Department of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA
Brain Res 1103:173-80. 2006..Therefore, it is unlikely that neuroglobin is instrumental in the acute response of neurons to hypoxic or ischemic insults, for which the mammalian brain is not adapted... - Three-dimensional printing creates models for surgical planning of aortic valve replacement after previous coronary bypass graftingRalf Sodian
Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany
Ann Thorac Surg 85:2105-8. 2008..Thus, we are exploring the effect of using rapid prototyping techniques for surgical planning and intraoperative orientation during aortic valve replacement after previous coronary artery bypass grafting (CABG)... - Minicolumnar abnormalities in autismManuel F Casanova
Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, Louisville, KY 40292, USA
Acta Neuropathol 112:287-303. 2006..A reduction in both somatic and nucleolar cross sections could reflect a bias towards shorter connecting fibers, which favors local computation at the expense of inter-areal and callosal connectivity... - Mean cell spacing abnormalities in the neocortex of patients with schizophreniaManuel F Casanova
Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, A Building, Room 217, Louisville, KY 40292, USA
Psychiatry Res 133:1-12. 2005..The lack of variation in the columnarity index argues in favor of a defect postdating the formation of the cell minicolumn... - Moderate loss of cerebellar Purkinje cells after chronic bilateral common carotid artery occlusion in ratsOrsolya Kántor
Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
Acta Neuropathol 113:549-58. 2007..Remodeling of the basilar artery indicated that secondary vascular perturbations might be responsible for the effects of BCCAO on the cerebellar Purkinje cells... - Extracorporeal shockwave application to the distal femur of rabbits diminishes the number of neurons immunoreactive for substance P in dorsal root ganglia L5Jorg Hausdorf
Department of Orthopedic Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Brain Res 1207:96-101. 2008..These data might further contribute to our understanding of the molecular and cellular mechanisms in the induction of long-term analgesia by extracorporeal shockwave application to the musculoskeletal system... - Neuropathological findings in autismSaskia J M C Palmen
Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Brain 127:2572-83. 2004.... - Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout miceKristina Sennvik
Experimental Genetics Group, Department Human Genetics, KULeuven Campus Gasthuisberg ON1 06 602, B 3000 Leuven, Belgium
FASEB J 21:2149-61. 2007..We suggest that the tau-4R isoform essentially contributes to hippocampal development by controlling proliferation and differentiation of neuronal precursors... - Cellular cardiomyoplasty in a transgenic mouse modelWilhelm Roell
Department of Cardiac Surgery, University of Bonn, 53105 Bonn, Germany
Transplantation 73:462-5. 2002..The aim of the present study was to develop a novel surgical approach that allows standardized cellular cardiomyoplasty in mouse with low-perioperative mortality... - The developmental neurobiology of autism spectrum disorderEmanuel DiCicco-Bloom
Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
J Neurosci 26:6897-906. 2006