C Schmitz

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Altered spatial arrangement of layer V pyramidal cells in the mouse brain following prenatal low-dose X-irradiation. A stereological study using a novel three-dimensional analysis method to estimate the nearest neighbor distance distributions of cells in
    Christoph Schmitz
    Department of Anatomy and Cell Biology, RWTH University of Aachen, Germany
    Cereb Cortex 12:954-60. 2002
  2. ncbi request reprint Design-based stereology in neuroscience
    C Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, P O Box 616, NL 6200 MD Maastricht, Netherlands
    Neuroscience 130:813-31. 2005
  3. ncbi request reprint Prenatal protracted irradiation at very low dose rate induces severe neuronal loss in rat hippocampus and cerebellum
    C Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, P O Box 616, NL 6200 MD Maastricht, Netherlands
    Neuroscience 130:935-48. 2005
  4. ncbi request reprint Autism: neuropathology, alterations of the GABAergic system, and animal models
    Christoph Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience Maastricht University, The Netherlands
    Int Rev Neurobiol 71:1-26. 2005
  5. ncbi request reprint The neuropathology of autism: where do we stand?
    C Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropathol Appl Neurobiol 34:4-11. 2008
  6. pmc Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex
    Kimmo A Michelsen
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    BMC Neurosci 8:107. 2007
  7. pmc Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
    Christoph Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, Maastricht, The Netherlands
    Am J Pathol 164:1495-502. 2004
  8. pmc Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice
    Bart P F Rutten
    Division Cellular Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Am J Pathol 167:161-73. 2005
  9. ncbi request reprint No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 12:110-20. 2003
  10. ncbi request reprint Perinatal asphyxia induced neuronal loss by apoptosis in the neonatal rat striatum: a combined TUNEL and stereological study
    Wilma D J van de Berg
    Department of Pediatrics, Maastricht University, Maastricht, The Netherlands
    Exp Neurol 174:29-36. 2002

Detail Information

Publications48

  1. ncbi request reprint Altered spatial arrangement of layer V pyramidal cells in the mouse brain following prenatal low-dose X-irradiation. A stereological study using a novel three-dimensional analysis method to estimate the nearest neighbor distance distributions of cells in
    Christoph Schmitz
    Department of Anatomy and Cell Biology, RWTH University of Aachen, Germany
    Cereb Cortex 12:954-60. 2002
    ..5% and a more dispersed spatial arrangement of these neurons. Considering the recent literature, it seems reasonable to consider abnormal neuronal migration as the potential basic cause of this finding...
  2. ncbi request reprint Design-based stereology in neuroscience
    C Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, P O Box 616, NL 6200 MD Maastricht, Netherlands
    Neuroscience 130:813-31. 2005
    ..These characteristics establish the advantages of design-based stereologic methods in quantitative neuromorphology...
  3. ncbi request reprint Prenatal protracted irradiation at very low dose rate induces severe neuronal loss in rat hippocampus and cerebellum
    C Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, P O Box 616, NL 6200 MD Maastricht, Netherlands
    Neuroscience 130:935-48. 2005
    ....
  4. ncbi request reprint Autism: neuropathology, alterations of the GABAergic system, and animal models
    Christoph Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience Maastricht University, The Netherlands
    Int Rev Neurobiol 71:1-26. 2005
  5. ncbi request reprint The neuropathology of autism: where do we stand?
    C Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropathol Appl Neurobiol 34:4-11. 2008
    ..In this respect, more concerted efforts are required to examine the various aspects of cellular pathology affecting the brain in autism. This paper briefly highlights four key areas that warrant further evaluation...
  6. pmc Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex
    Kimmo A Michelsen
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    BMC Neurosci 8:107. 2007
    ..The aim of this study was to reveal putative PS- and/or CMS-related changes in basal spine morphology and density of pyramidal neurons in the rat medial prefrontal cortex (mPFC)...
  7. pmc Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
    Christoph Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, Maastricht, The Netherlands
    Am J Pathol 164:1495-502. 2004
    ..These findings point to the potential involvement of more than one mechanism in hippocampal neuron loss in this APP/PS-1 double-transgenic mouse model of Alzheimer's disease...
  8. pmc Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice
    Bart P F Rutten
    Division Cellular Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Am J Pathol 167:161-73. 2005
    ..The observation of age-related SIPB loss within SR of PS1M146L mice supports a role of mutant PS1 in neurodegeneration apart from its contribution to alterations in Abeta generation...
  9. ncbi request reprint No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 12:110-20. 2003
    ..These data implicate that expression of beta-CTF per se is not neurotoxic, and that other mechanisms are responsible for the neurotoxic events in Alzheimer's disease brain...
  10. ncbi request reprint Perinatal asphyxia induced neuronal loss by apoptosis in the neonatal rat striatum: a combined TUNEL and stereological study
    Wilma D J van de Berg
    Department of Pediatrics, Maastricht University, Maastricht, The Netherlands
    Exp Neurol 174:29-36. 2002
    ..These data show that asphyxia causes exaggerated apoptotic cell death during the first week of life and as a consequence a small amount of neuron loss in the neostriatum...
  11. ncbi request reprint Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel
    Chunyan Cao
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 170:257-61. 2006
    ..These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD...
  12. doi request reprint Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease
    Kimmo A Michelsen
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Brain Res 1316:139-44. 2010
    ..These results might indicate a previously unknown action of mutations in PS1 on DNA integrity, which might be involved in the pathophysiologic processes of mutant PS1 in Alzheimer's disease...
  13. ncbi request reprint Impact of perinatal asphyxia on the GABAergic and locomotor system
    W D J Van de Berg
    Department of Pediatrics, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
    Neuroscience 117:83-96. 2003
    ..Despite a considerable loss of striatal neurons, only minor deficits in motor performance were found after perinatal asphyxia...
  14. doi request reprint Caloric restriction and aging but not overexpression of SOD1 affect hippocampal volumes in mice
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neurosciences, Maastricht University, NL 6200 MD Maastricht, The Netherlands
    Mech Ageing Dev 131:574-9. 2010
    ..These morphometric alterations may have impact on the function of the hippocampus during aging and CR...
  15. ncbi request reprint Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia
    Rainald Schmidt-Kastner
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands
    Schizophr Res 84:253-71. 2006
    ....
  16. pmc Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease
    Hisaaki Takahashi
    Department of Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands
    Brain Struct Funct 214:145-60. 2010
    ..The loss of these interneurons in AD may have substantial functional repercussions on local inhibitory processes in the hippocampus...
  17. ncbi request reprint Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neurosci Lett 406:138-41. 2006
    ..This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD...
  18. ncbi request reprint Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division Cellular Neurosciences, European Graduate School of Neuroscience EURON, The Netherlands
    Exp Neurol 193:43-52. 2005
    ....
  19. ncbi request reprint Protection of nigral cell death by bilateral subthalamic nucleus stimulation
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division of Cellular Neurosciences, Maastricht University, and Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
    Brain Res 1120:100-5. 2006
    ..These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD...
  20. doi request reprint Advanced microscopy techniques for quantitative analysis in neuromorphology and neuropathology research: current status and requirements for the future
    Marijke A M Lemmens
    Division Neuroscience, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Chem Neuroanat 40:199-209. 2010
    ..These developments will advance basic neuroscience research as well as pharmaceutical and biotechnology research and development...
  21. ncbi request reprint Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-hydroxydopamine lesioned rats
    Bart Scholtissen
    Department of Psychiatry and Neuropsychology, Maastricht University, EURON, P O Box 616, 6200 MD Maastricht, The Netherlands
    Pharmacol Biochem Behav 83:175-85. 2006
    ..Taken together, since serotonergic ligands have the same effect as dopaminergic ligands on reaction time responding indicated that 5-HT and DA release are agonistically linked in control and 6-OHDA lesioned rats...
  22. doi request reprint Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus
    L Chouliaras
    School for Mental Health and NeuroScience MHeNS, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, P O Box 616, 6200 MD Maastricht, The Netherlands
    Brain Behav Immun 25:616-23. 2011
    ..These changes in Dnmt3a levels in the mouse hippocampus may have a significant impact on gene expression and associated cognitive functioning...
  23. pmc Detection of amyloid beta aggregates in the brain of BALB/c mice after Chlamydia pneumoniae infection
    Ellen Boelen
    Department of Medical Microbiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Acta Neuropathol 114:255-61. 2007
    ..However, future studies are required to resolve these differences and to investigate whether Cpn is indeed an etiological factor in AD pathogenesis...
  24. ncbi request reprint Altered gene expression and neuropathology in Alzheimer's disease
    Ivona Brasnjevic
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
    Neurobiol Aging 27:1081-3. 2006
  25. ncbi request reprint Perinatal asphyxia results in changes in presynaptic bouton number in striatum and cerebral cortex-a stereological and behavioral analysis
    W D Van de Berg
    Department of Pediatrics, Maastricht University, P Debyelaan 25, PO Box 5800, 6212 AZ, Maastricht, The Netherlands
    J Chem Neuroanat 20:71-82. 2000
    ..These results suggest that perinatal asphyxia induced neuronal loss, which is compensated for by an increase in presynaptic bouton numbers...
  26. ncbi request reprint Volume, neuron density and total neuron number in five subcortical regions in schizophrenia
    Pawel Kreczmanski
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
    Brain 130:678-92. 2007
    ....
  27. ncbi request reprint Stereological studies of capillary length density in the frontal cortex of schizophrenics
    Pawel Kreczmanski
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Acta Neuropathol 109:510-8. 2005
    ..Compromised brain metabolism and occurrence of oxidative stress in the brain of schizophrenics are likely caused by other mechanisms...
  28. pmc Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases
    Ivona Brasnjevic
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    DNA Repair (Amst) 7:1087-97. 2008
    ....
  29. doi request reprint Microvessel length density, total length, and length per neuron in five subcortical regions in schizophrenia
    Pawel Kreczmanski
    Division of Cellular Neuroscience, School for Mental Health and Neurosciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Acta Neuropathol 117:409-21. 2009
    ....
  30. ncbi request reprint Antioxidants and Alzheimer's disease: from bench to bedside (and back again)
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 5:645-51. 2002
    ....
  31. ncbi request reprint The aging brain: accumulation of DNA damage or neuron loss?
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
    Neurobiol Aging 28:91-8. 2007
    ..This formerly unknown inverse relation between age-related accumulation of nDNA damage and age-related loss of neurons may reflect a fundamental process of aging in the central nervous system...
  32. ncbi request reprint The aging brain: less neurons could be better
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, Division of Neuroscience, University of Maastricht, P O Box 616, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands
    Mech Ageing Dev 124:349-55. 2003
    ..Ultimately, the implication of this strategy may lead to the prevention of AD...
  33. doi request reprint Neurons in the fusiform gyrus are fewer and smaller in autism
    Imke A J van Kooten
    Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    Brain 131:987-99. 2008
    ....
  34. ncbi request reprint The dorsal raphe nucleus--from silver stainings to a role in depression
    Kimmo A Michelsen
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Brain Res Rev 55:329-42. 2007
    ..Starting with a historical perspective, this essay describes the morphology, ascending projections and multitransmitter nature of the DRN, and stresses its role as a key target for depression research...
  35. doi request reprint Neuronal distribution in the neocortex of schizophrenic patients
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
    Psychiatry Res 158:267-77. 2008
    ..The findings suggest an alteration in the modulatory systems innervating the cell minicolumn. Furthermore, the lack of variation in core columnarity parameters argues in favor of a defect post-dating the formation of the cell minicolumn...
  36. pmc Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model
    Caty Casas
    Department of Central Nervous System Alzheimer Disease, Aventis Pharma Paris Research Center, Vitry sur Seine, France
    Am J Pathol 165:1289-300. 2004
    ..Thus, APP(SL)PS1KI mice further confirm the critical role of intraneuronal Abeta(42) in neuronal loss and provide an excellent tool to investigate therapeutic strategies designed to prevent AD neurodegeneration...
  37. ncbi request reprint Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    Erik Storkebaum
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven B 3000, Belgium
    Nat Neurosci 8:85-92. 2005
    ..On i.c.v. delivery, Vegf is anterogradely transported and preserves neuromuscular junctions in SOD1(G93A) rats. Our findings in preclinical rodent models of ALS may have implications for treatment of neurodegenerative disease in general...
  38. ncbi request reprint Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats
    Orsolya Kántor
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Neurobiol Dis 22:538-47. 2006
    ..No alterations in mean total numbers of striatal neurons were found in 6-month-old animals. Testing 14-month-old animals in a choice reaction time task indicated impaired striatal function of tgHD rats compared with controls...
  39. ncbi request reprint Neuroglobin mRNA expression after transient global brain ischemia and prolonged hypoxia in cell culture
    Rainald Schmidt-Kastner
    Department of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA
    Brain Res 1103:173-80. 2006
    ..Therefore, it is unlikely that neuroglobin is instrumental in the acute response of neurons to hypoxic or ischemic insults, for which the mammalian brain is not adapted...
  40. doi request reprint Three-dimensional printing creates models for surgical planning of aortic valve replacement after previous coronary bypass grafting
    Ralf Sodian
    Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany
    Ann Thorac Surg 85:2105-8. 2008
    ..Thus, we are exploring the effect of using rapid prototyping techniques for surgical planning and intraoperative orientation during aortic valve replacement after previous coronary artery bypass grafting (CABG)...
  41. ncbi request reprint Minicolumnar abnormalities in autism
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, Louisville, KY 40292, USA
    Acta Neuropathol 112:287-303. 2006
    ..A reduction in both somatic and nucleolar cross sections could reflect a bias towards shorter connecting fibers, which favors local computation at the expense of inter-areal and callosal connectivity...
  42. ncbi request reprint Mean cell spacing abnormalities in the neocortex of patients with schizophrenia
    Manuel F Casanova
    Department of Psychiatry and Behavioral Sciences, University of Louisville, 500 South Preston Street, A Building, Room 217, Louisville, KY 40292, USA
    Psychiatry Res 133:1-12. 2005
    ..The lack of variation in the columnarity index argues in favor of a defect postdating the formation of the cell minicolumn...
  43. ncbi request reprint Moderate loss of cerebellar Purkinje cells after chronic bilateral common carotid artery occlusion in rats
    Orsolya Kántor
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    Acta Neuropathol 113:549-58. 2007
    ..Remodeling of the basilar artery indicated that secondary vascular perturbations might be responsible for the effects of BCCAO on the cerebellar Purkinje cells...
  44. doi request reprint Extracorporeal shockwave application to the distal femur of rabbits diminishes the number of neurons immunoreactive for substance P in dorsal root ganglia L5
    Jorg Hausdorf
    Department of Orthopedic Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Brain Res 1207:96-101. 2008
    ..These data might further contribute to our understanding of the molecular and cellular mechanisms in the induction of long-term analgesia by extracorporeal shockwave application to the musculoskeletal system...
  45. ncbi request reprint Neuropathological findings in autism
    Saskia J M C Palmen
    Rudolf Magnus Institute of Neuroscience, Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain 127:2572-83. 2004
    ....
  46. ncbi request reprint Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice
    Kristina Sennvik
    Experimental Genetics Group, Department Human Genetics, KULeuven Campus Gasthuisberg ON1 06 602, B 3000 Leuven, Belgium
    FASEB J 21:2149-61. 2007
    ..We suggest that the tau-4R isoform essentially contributes to hippocampal development by controlling proliferation and differentiation of neuronal precursors...
  47. ncbi request reprint Cellular cardiomyoplasty in a transgenic mouse model
    Wilhelm Roell
    Department of Cardiac Surgery, University of Bonn, 53105 Bonn, Germany
    Transplantation 73:462-5. 2002
    ..The aim of the present study was to develop a novel surgical approach that allows standardized cellular cardiomyoplasty in mouse with low-perioperative mortality...
  48. ncbi request reprint The developmental neurobiology of autism spectrum disorder
    Emanuel DiCicco-Bloom
    Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 26:6897-906. 2006