W H Saris

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Substrate oxidation differences between high- and low-intensity exercise are compensated over 24 hours in obese men
    W H M Saris
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 28:759-65. 2004
  2. ncbi request reprint [Nutrition and health--nutrition and performance in sports]
    W H Saris
    Universiteit van Maastricht, Nutrition and Toxicology Research Institute NUTRIM, Postbus 616, 6200 MD Maastricht
    Ned Tijdschr Geneeskd 148:708-12. 2004
  3. pmc Smoking status in relation to serum folate and dietary vitamin intake
    Constantine I Vardavas
    Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Tob Induc Dis 4:8. 2008
  4. ncbi request reprint PASSCLAIM - Physical performance and fitness
    Wim H M Saris
    Maastricht University, Nutrition Research Centre, Dept of Human Biology, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Nutr 42:I50-95. 2003
  5. ncbi request reprint Functional food science and substrate metabolism
    W H Saris
    Department of Human Biology, Maastricht University, The Netherlands
    Br J Nutr 80:S47-75. 1998
  6. ncbi request reprint Fit, fat and fat free: the metabolic aspects of weight control
    W H Saris
    Nutrition and Toxicology Research Centre, University of Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 22:S15-21. 1998
  7. ncbi request reprint Very-low-calorie diets and sustained weight loss
    W H Saris
    Nutrition and Toxicology Research Institue Maastricht, Maastricht University, The Netherlands
    Obes Res 9:295S-301S. 2001
  8. ncbi request reprint How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement
    W H M Saris
    Nutrition and Toxicology Research Institute, Maastricht NUTRIM, University of Maastricht, Department of Human Biology, Maastricht, The Netherlands
    Obes Rev 4:101-14. 2003
  9. ncbi request reprint Sugars, energy metabolism, and body weight control
    Wim H M Saris
    Nutrition and Toxicology Research Institute NUTRIM, University of Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 78:850S-857S. 2003
  10. ncbi request reprint Randomized controlled trial of changes in dietary carbohydrate/fat ratio and simple vs complex carbohydrates on body weight and blood lipids: the CARMEN study. The Carbohydrate Ratio Management in European National diets
    W H Saris
    Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 24:1310-8. 2000

Detail Information

Publications166 found, 100 shown here

  1. ncbi request reprint Substrate oxidation differences between high- and low-intensity exercise are compensated over 24 hours in obese men
    W H M Saris
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 28:759-65. 2004
    ..It is however unclear what is the most beneficial exercise regime for obese people. We therefore studied the effect of either high-intensity (HI) or LI exercise on 24 h energy expenditure (24 h EE) and substrate metabolism...
  2. ncbi request reprint [Nutrition and health--nutrition and performance in sports]
    W H Saris
    Universiteit van Maastricht, Nutrition and Toxicology Research Institute NUTRIM, Postbus 616, 6200 MD Maastricht
    Ned Tijdschr Geneeskd 148:708-12. 2004
    ..Hence, in addition to a few functional sports supplements for which the value has been scientifically demonstrated, sound nutrition remains an absolute prerequisite for an optimal performance in sports...
  3. pmc Smoking status in relation to serum folate and dietary vitamin intake
    Constantine I Vardavas
    Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Tob Induc Dis 4:8. 2008
    ..The objective of this study was to investigate into the relationship between smoking status and serum and dietary micronutrient concentrations...
  4. ncbi request reprint PASSCLAIM - Physical performance and fitness
    Wim H M Saris
    Maastricht University, Nutrition Research Centre, Dept of Human Biology, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Nutr 42:I50-95. 2003
    ....
  5. ncbi request reprint Functional food science and substrate metabolism
    W H Saris
    Department of Human Biology, Maastricht University, The Netherlands
    Br J Nutr 80:S47-75. 1998
    ..Based on a critical evaluation of the existing knowledge in the literature, implications for future research in relation to functional foods are discussed...
  6. ncbi request reprint Fit, fat and fat free: the metabolic aspects of weight control
    W H Saris
    Nutrition and Toxicology Research Centre, University of Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 22:S15-21. 1998
    ..In conclusion, the amount of energy expended in physical activity, mediated by several metabolic factors, may play an important role in body weight regulation...
  7. ncbi request reprint Very-low-calorie diets and sustained weight loss
    W H Saris
    Nutrition and Toxicology Research Institue Maastricht, Maastricht University, The Netherlands
    Obes Res 9:295S-301S. 2001
    ..To review of the literature on the topic of very-low-calorie diets (VLCDs) and the long-term weight-maintenance success in the treatment of obesity...
  8. ncbi request reprint How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement
    W H M Saris
    Nutrition and Toxicology Research Institute, Maastricht NUTRIM, University of Maastricht, Department of Human Biology, Maastricht, The Netherlands
    Obes Rev 4:101-14. 2003
    ..Settings in which these environmental changes can be implemented include the urban and transportation infrastructure, schools, and workplaces.'..
  9. ncbi request reprint Sugars, energy metabolism, and body weight control
    Wim H M Saris
    Nutrition and Toxicology Research Institute NUTRIM, University of Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 78:850S-857S. 2003
    ..However, the effect of the carbohydrate source and class and of the form in which carbohydrate is consumed (solid or liquid) on body weight control requires further consideration...
  10. ncbi request reprint Randomized controlled trial of changes in dietary carbohydrate/fat ratio and simple vs complex carbohydrates on body weight and blood lipids: the CARMEN study. The Carbohydrate Ratio Management in European National diets
    W H Saris
    Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 24:1310-8. 2000
    ..To investigate the long-term effects of changes in dietary carbohydrate/fat ratio and simple vs complex carbohydrates...
  11. pmc Glucose kinetics during prolonged exercise in highly trained human subjects: effect of glucose ingestion
    A E Jeukendrup
    Nutrition Research Centre, Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Physiol 515:579-89. 1999
    ..The vast majority of glucose disappearing from the plasma is oxidized and MCR increased markedly with glucose ingestion. Glucose carbon recycling was minimal suggesting that gluconeogenesis in these conditions is negligible...
  12. ncbi request reprint Microdialysis assessment of local adipose tissue lipolysis during beta-adrenergic stimulation in upper-body-obese subjects with type II diabetes
    E E Blaak
    Department of Human Biology, Maastricht University and University Hospital, P O Box 616, 6200 MD Maastricht, The Netherlands
    Clin Sci (Lond) 97:421-8. 1999
    ..The last two findings contrast with previous data from obese subjects, indicating that the regulation of lipolysis may differ in obesity and obesity-associated type II diabetes...
  13. ncbi request reprint Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle
    E E Blaak
    Department of Human Biology, Maastricht University and Academic Hospital, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 279:E146-54. 2000
    ..We conclude that the uptake and oxidation of plasma FFA are impaired in the forearm muscles of type 2 diabetic subjects in the overnight fasted state with and without Iso stimulation...
  14. ncbi request reprint Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise
    E E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, The Netherlands
    Diabetes 49:2102-7. 2000
    ..05). It is hypothesized that these impairments in fatty acid utilization may play a role in the etiology of skeletal muscle and hepatic insulin resistance...
  15. ncbi request reprint Maximizing postexercise muscle glycogen synthesis: carbohydrate supplementation and the application of amino acid or protein hydrolysate mixtures
    L J van Loon
    From the Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 72:106-11. 2000
    ..Postexercise muscle glycogen synthesis is an important factor in determining the time needed to recover from prolonged exercise...
  16. ncbi request reprint Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation
    P Schrauwen
    Department of Human Biology, Maastricht University, The Netherlands
    Diabetes 49:640-6. 2000
    ....
  17. ncbi request reprint In vivo beta3-adrenergic stimulation of human thermogenesis and lipid use
    S L Schiffelers
    Nutrition Toxicology and Environment Research Institute Maastricht, Department of Human Biology, Maastricht University, The Netherlands
    Clin Pharmacol Ther 67:558-66. 2000
    ..To investigate the role of the human beta3-adrenergic receptor in in vivo isoproterenol (INN, isoprenaline)-induced thermogenesis and lipid use...
  18. ncbi request reprint Carbohydrate ingestion can completely suppress endogenous glucose production during exercise
    A E Jeukendrup
    Department of Human Biology, Nutrition Research Centre, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol 276:E672-83. 1999
    ..We conclude that 1) high rates of CHO ingestion can completely block EGP, 2) Ra gut may be a limiting factor for exogenous CHO oxidation, and 3) muscle glycogen oxidation was not reduced by large glucose feedings...
  19. ncbi request reprint Reduced oxidation rates of ingested glucose during prolonged exercise with low endogenous CHO availability
    A E Jeukendrup
    Department of Human Biology, University Maastricht, The Netherlands
    J Appl Physiol 81:1952-7. 1996
    ..It is concluded that glycogen-lowering exercise, performed the evening before an exercise bout, in combination with CHO restriction leads to a reduction of the oxidation rate of ingested glucose during moderate-intensity exercise...
  20. ncbi request reprint Short-term effects of weight loss with or without low-intensity exercise training on fat metabolism in obese men
    D P van Aggel-Leijssen
    Nutrition, Toxicology, and Environmental Research Institute NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 73:523-31. 2001
    ..Energy restriction is known to induce a decline in fat oxidation during the postdiet period. Reduced fat oxidation may contribute to weight regain...
  21. ncbi request reprint Weight reduction and the impaired plasma-derived free fatty acid oxidation in type 2 diabetic subjects
    E E Blaak
    Department of Human Biology, Nutrition Research Center, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 86:1638-44. 2001
    ....
  22. ncbi request reprint Energy expenditure at rest and during sleep in children with Prader-Willi syndrome is explained by body composition
    E A van Mil
    Departments of Human Biology, Pediatrics, Clinical Genetics, and Methodology and Statistics, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 71:752-6. 2000
    ..Obesity in Prader-Willi syndrome (PWS) seems to be related to a low basal metabolic rate (BMR). In addition, abnormal sleep patterns reported in PWS might affect sleeping metabolic rate (SMR)...
  23. ncbi request reprint Changes in fat oxidation in response to a high-fat diet
    P Schrauwen
    Department of Human Biology, Maastricht University, Netherlands
    Am J Clin Nutr 66:276-82. 1997
    ..05), reaching a new balance on day 13, 7 d afterward. In conclusion, when in energy balance, lean subjects are capable of adjusting fat oxidation to fat intake within 7 d of when dietary fat content is increased...
  24. ncbi request reprint Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease
    A M Schols
    Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 160:1220-6. 1999
    ..Schols AMWJ, Creutzberg EC, Buurman WA, Campfield LA, Saris WHM, Wouters EFM. Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease...
  25. ncbi request reprint Physical activity, fitness, and selected risk factors for CHD in active men and women
    A M Bovens
    Department of Human Biology, State University of Limburg, Maastricht, The Netherlands
    Med Sci Sports Exerc 25:572-6. 1993
    ..We conclude that in this relatively active and healthy population comparable associations of physical activity and cardiovascular fitness with risk factors for cardiovascular disease were found as in studies on less active populations...
  26. ncbi request reprint The effect of exercise training on beta-adrenergic stimulation of fat metabolism in obese men
    D P van Aggel-Leijssen
    Nutrition, Toxicology and Environmental Research Institute NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 25:16-23. 2001
    ..To investigate the in vivo effect of exercise training at high and low intensity on beta-adrenergic stimulated fat metabolism in obese men at rest...
  27. ncbi request reprint Effect of medium-chain triacylglycerol and carbohydrate ingestion during exercise on substrate utilization and subsequent cycling performance
    A E Jeukendrup
    Department of Human Biology, Nutrition Research Centre, Maastricht University, The Netherlands
    Am J Clin Nutr 67:397-404. 1998
    ..These data suggest that large amounts of MCTs (85 g) ingested during prolonged submaximal exercise may provoke gastrointestinal problems leading to decreased exercise performance...
  28. ncbi request reprint The effect of low-intensity exercise training on fat metabolism of obese women
    D P van Aggel-Leijssen
    Nutrition, Toxicology and Environmental Research Institute, Department of Human Biology, Maastricht University, The Netherlands
    Obes Res 9:86-96. 2001
    ..The present study investigated whether the effect of low-intensity exercise training on fat metabolism is different in UB and LB obese premenopausal women...
  29. ncbi request reprint beta-Adrenoceptor-mediated thermogenesis and lipolysis in patients with chronic obstructive pulmonary disease
    S L Schiffelers
    Department of Human Biology, Maastricht University, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 280:E357-64. 2001
    ..05). In conclusion, beta-adrenoceptor-mediated lipolysis and thermogenesis are impaired in COPD patients. This may play a role in the development or maintenance of their relatively increased fat mass...
  30. ncbi request reprint Effects of acute (-)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans
    L J van Loon
    Nutrition and Toxicology Research Institute NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 72:1445-50. 2000
    ..It has been hypothesized that HCA ingestion can reduce malonyl-CoA concentrations and consequently increase fatty acid oxidation in vivo...
  31. ncbi request reprint Beta-adrenergically stimulated fat oxidation is diminished in middle-aged compared to young subjects
    E E Blaak
    Department of Human Biology, Nutrition Research Center, University of Maastricht, The Netherlands
    J Clin Endocrinol Metab 84:3764-9. 1999
    ..This diminished fat oxidation may be an important etiological factor in the age-related increase in body fatness and obesity by favoring fat storage above oxidation...
  32. ncbi request reprint Skeletal muscle metabolic characteristics before and after energy restriction in human obesity: fibre type, enzymatic beta-oxidative capacity and fatty acid-binding protein content
    K P Kempen
    University of Maastricht, Maastricht, The Netherlands
    Eur J Clin Invest 28:1030-7. 1998
    ..The aim of the present study was to investigate the effects of energy restriction on skeletal muscle metabolic characteristics in obese women...
  33. ncbi request reprint Predictors of weight maintenance
    W J Pasman
    Department of Human Biology, Maastricht University, The Netherlands
    Obes Res 7:43-50. 1999
    ..To obtain predictors of weight maintenance after a weight-loss intervention...
  34. ncbi request reprint Dobutamine as selective beta(1)-adrenoceptor agonist in in vivo studies on human thermogenesis and lipid utilization
    S L Schiffelers
    Nutrition Toxicology and Environment Research Institute Maastricht, Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Appl Physiol 87:977-81. 1999
    ..Therefore, we conclude that dobutamine can be used as a selective beta(1)-adrenoceptor agonist at dosages </=10 microg x kg(-1) x min(-1) in in vivo studies on human thermogenesis and lipid utilization...
  35. ncbi request reprint Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects
    P Schrauwen
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 23:966-72. 1999
    ..Endurance training has been suggested to have effects on resting metabolic rate and energy efficiency. We therefore determined UCP2 and UCP3 mRNA levels in skeletal muscle of trained and untrained male subjects...
  36. ncbi request reprint Activity related energy expenditure in children and adolescents with Prader-Willi syndrome
    E G van Mil
    Department of Human Biology, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 24:429-34. 2000
    ..To measure activity related energy expenditure in Prader-Willi syndrome (PWS) corrected for body size...
  37. ncbi request reprint Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate
    L J van Loon
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 72:96-105. 2000
    ..However, the insulinotropic properties of different amino acids or protein (hydrolysates) when co-ingested with carbohydrate have not been investigated...
  38. pmc Energy metabolism in relation to body composition and gender in adolescents
    E G van Mil
    Departments of Human Biology and Paediatrics, Nutrition Toxicology and Environment Research Institute Maastricht, Maastricht University, PO Box 616, Maastricht 6200 MD, Netherlands
    Arch Dis Child 85:73-8. 2001
    ..To study the effect of body composition on average daily metabolic rate (ADMR) and basal metabolic rate (BMR) in adolescence, and to examine current BMR prediction equations...
  39. ncbi request reprint Increase in skeletal muscle fatty acid binding protein (FABPC) content is directly related to weight loss and to changes in fat oxidation following a very low calorie diet
    E E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, Maastricht, The Netherlands
    Diabetologia 44:2013-7. 2001
    ....
  40. doi request reprint Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle
    E Corpeleijn
    Department of Human Biology, The Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Obes Rev 10:178-93. 2009
    ..Lifestyle changes in dietary fat intake, physical activity and weight loss may improve metabolic flexibility in skeletal muscle, and thereby contribute to the prevention of type 2 diabetes...
  41. ncbi request reprint Lipolytic and nutritive blood flow response to beta-adrenoceptor stimulation in situ in subcutaneous abdominal adipose tissue in obese men
    S L H Schiffelers
    Department of Human Biology, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 27:227-31. 2003
    ..This study investigated whether local adipocyte beta-adrenergic sensitivity and changes in nutritive blood flow in subcutaneous abdominal adipose tissue contribute to this impaired response...
  42. ncbi request reprint The effect of body weight changes and endurance training on 24h substrate oxidation
    W J Pasman
    Maastricht University, Department of Human Biology, The Netherlands
    Int J Obes Relat Metab Disord 23:1223-32. 1999
    ..To investigate the effect of exercise training and dietary macronutrient composition on 24 h substrate oxidation in male, obese subjects...
  43. ncbi request reprint The effects of 2-week ingestion of (--)-hydroxycitrate and (--)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight
    E M Kovacs
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 25:1087-94. 2001
    ..Assessment of the effect of 2-week supplementation with (--)-hydroxycitrate (HCA) and HCA combined with medium-chain triglycerides (MCT) on satiety, fat oxidation, energy expenditure (EE) and body weight (BW) loss...
  44. ncbi request reprint beta(1)- and beta(2)-Adrenoceptor-mediated thermogenesis and lipid utilization in obese and lean men
    S L Schiffelers
    Nutrition Toxicology and Environment Research Institute Maastricht, Department of Human Biology, Maastricht University, The Netherlands
    J Clin Endocrinol Metab 86:2191-9. 2001
    ..In conclusion, these data suggest that beta(1)-adrenoceptor-mediated metabolic processes are similar in both groups, but beta(2)-adrenoceptor-mediated increases in thermogenesis and lipid utilization are impaired in the obese...
  45. ncbi request reprint The effect of addition of modified guar gum to a low-energy semisolid meal on appetite and body weight loss
    E M Kovacs
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 25:307-15. 2001
    ..To investigate the effect of addition of modified guar gum (GG) to a low-energy semisolid meal on appetite and body weight (BW) loss...
  46. ncbi request reprint Plasma free Fatty Acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes 50:2548-54. 2001
    ....
  47. ncbi request reprint The effect of an increased free fatty acid concentration on thermogenesis and substrate oxidation in obese and lean men
    S L Schiffelers
    Nutrition Toxicology and Environment Research Institute Maastricht, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 25:33-8. 2001
    ..To examine whether a certain increase in plasma free fatty acid (FFA) concentration leads to similar increases in lipid oxidation and energy expenditure in obese and lean men...
  48. ncbi request reprint Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes
    P Schrauwen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Diabetes 50:2870-3. 2001
    ..In conclusion, UCP3 content is lower in type 2 diabetic patients compared with healthy control subjects. These results are consistent with a role for UCP3 in glucose homeostasis and suggest a role for UCP3 in type 2 diabetes...
  49. ncbi request reprint An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix
    P Schrauwen
    Department of Human Biology, Maastricht University, The Netherlands
    FASEB J 15:2497-502. 2001
    ..In this way, UCP3 is involved in the protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix...
  50. ncbi request reprint Derangement in aerobic and anaerobic energy metabolism in skeletal muscle of critically ill and recovering rats
    O E Rooyackers
    Department of Human Biology, University of Limburg, Maastricht, The Netherlands
    Biochim Biophys Acta 1315:55-60. 1996
    ..This indicated that, although the maximal oxidative capacity (mitochondrial content) is decreased, no derangement in energy metabolism seems to be present in skeletal muscle of critically ill and recovering rats...
  51. ncbi request reprint The effect of free glutamine and peptide ingestion on the rate of muscle glycogen resynthesis in man
    G van Hall
    Department of Human Biology, Maastricht University, The Netherlands
    Int J Sports Med 21:25-30. 2000
    ....
  52. ncbi request reprint Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men
    M S Westerterp-Plantenga
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 74:426-34. 2001
    ....
  53. ncbi request reprint Short-term training is accompanied by a down regulation of ACC2 mRNA in skeletal muscle
    V B Schrauwen-Hinderling
    Department of Radiology, University Hospital Maastricht, Maastricht, The Netherlands
    Int J Sports Med 27:786-91. 2006
    ..The present data are in line with the hypothesis that the fat oxidative capacity might be more important than the IMCL content in determining insulin sensitivity...
  54. doi request reprint The effect of a low-fat, high-protein or high-carbohydrate ad libitum diet on weight loss maintenance and metabolic risk factors
    M Claessens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 33:296-304. 2009
    ..High-protein (HP) diets are often advocated for weight reduction and weight loss maintenance...
  55. doi request reprint Effects of dietary fat modification on skeletal muscle fatty acid handling in the metabolic syndrome
    A M J van Hees
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Int J Obes (Lond) 34:859-70. 2010
    ..The objective of this study was to examine the effects of dietary fat modification on the capacity of skeletal muscle to handle dietary and endogenous fatty acids (FAs)...
  56. ncbi request reprint The effect of caffeine on endurance performance after nonselective beta-adrenergic blockade
    M A van Baak
    NUTRIM, Department of Human Biology, Maastricht University, The Netherlands
    Med Sci Sports Exerc 32:499-503. 2000
    ....
  57. ncbi request reprint Exogenous glucose oxidation during exercise in endurance-trained and untrained subjects
    A E Jeukendrup
    Department of Human Biology, Maastricht University, The Netherlands
    J Appl Physiol 82:835-40. 1997
    ....
  58. pmc The effects of increasing exercise intensity on muscle fuel utilisation in humans
    L J van Loon
    Nutrition and Toxicology Research Institute NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    J Physiol 536:295-304. 2001
    ....
  59. ncbi request reprint [Insulin resistance: the role of intramuscular triglyceride and the importance of physical activity]
    R J Timmermans
    Universiteit Maastricht, Nutrition and Toxicology Research Institute Maastricht NUTRIM, capaciteitsgroep Humane Biologie, Postbus 616, 6200 MD Maastricht
    Ned Tijdschr Geneeskd 150:122-7. 2006
    ..Physical exercise forms an effective strategy to improve the balance between skeletal-muscle fatty-acid uptake and oxidation and, as such, can prevent the development of skeletal-muscle insulin resistance...
  60. ncbi request reprint Fat-specific satiety in humans for fat high in linoleic acid vs fat high in oleic acid
    M M Kamphuis
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 55:499-508. 2001
    ..To investigate the effect of 2 week use of oils high in linoleic (LA), gamma-linolenic (GLA) and oleic acid (OA) on energy intake (EI), macronutrient composition, parameters of appetite and taste perception...
  61. ncbi request reprint A dual-respiration chamber system with automated calibration
    P F Schoffelen
    Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Appl Physiol 83:2064-72. 1997
    ..The smallest practical interval was 15-25 min, as also found with most chamber systems described in the literature. We chose to standardize 0.5 h as the minimum measurement interval...
  62. ncbi request reprint The concept of energy homeostasis for optimal health during training
    W H Saris
    Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Can J Appl Physiol 26:S167-75. 2001
    ....
  63. ncbi request reprint The relation between calcium intake and body composition in a Dutch population: The Amsterdam Growth and Health Longitudinal Study
    N Boon
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, University of Maastricht, Maastricht, The Netherlands
    Am J Epidemiol 162:27-32. 2005
    ....
  64. ncbi request reprint Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men
    A E Jeukendrup
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Clin Sci (Lond) 98:47-55. 2000
    ..It is therefore concluded that LPS does enter the circulation after ultra-endurance exercise and may, together with muscle damage, be responsible for the increased cytokine response and hence GI complaints in these athletes...
  65. ncbi request reprint Effects of 2-week ingestion of (-)-hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake
    E M Kovacs
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Physiol Behav 74:543-9. 2001
    ..Two weeks of supplementation with HCA and HCA combined with MCT did not result in increased satiety or decreased energy intake compared to placebo in subjects losing BW...
  66. pmc A reduction in training volume and intensity for 21 days does not impair performance in cyclists
    G J Rietjens
    Department of Movement Science, Maastricht University, Maastricht, The Netherlands
    Br J Sports Med 35:431-4. 2001
    ....
  67. doi request reprint Role of stearoyl-CoA desaturases in obesity and the metabolic syndrome
    H E Popeijus
    Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands
    Int J Obes (Lond) 32:1076-82. 2008
    ..Therefore, more human studies are needed at the molecular as well as at the physiological level to understand the true role of SCD1 during the development of obesity and the MS...
  68. ncbi request reprint Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance
    E Corpeleijn
    Department of Medicine and Endocrinology, Cardiovascular Research Institute CARIM, University Hospital Maastricht, Maastricht, The Netherlands
    Diabet Med 23:907-11. 2006
    ..Genetic variation in the CD36 gene may contribute to the aetiology of diabetes...
  69. ncbi request reprint Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids
    J Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Diabetologia 49:2419-26. 2006
    ..We examined whether lipid-induced insulin resistance was associated with downregulation of expression of skeletal muscle genes involved in oxidative metabolism and mitochondrial biogenesis in humans...
  70. ncbi request reprint Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study
    E Corpeleijn
    Department of Human Biology, The Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetologia 49:2392-401. 2006
    ....
  71. doi request reprint Peptide-YY is released by the intestinal cell line STC-1
    M C P Geraedts
    Dept of Human Biology, Div of Gastroenterology and Hepatology, All Nutrition and Toxicology Research Inst Maastricht, Maastricht Univ, Maastricht, The Netherlands
    J Food Sci 74:H79-82. 2009
    ..We conclude that the STC-1 cell line provides an appropriate cell line for screening the effects of ingredients on the release of the satiety-related gut hormones CCK, GLP-1, and PYY...
  72. pmc Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    J Physiol 571:451-60. 2006
    ..Locally produced Ang II does not appear to regulate ATBF. Ang II appears to have no major effect on the postprandial enhancement of ATBF...
  73. ncbi request reprint Influence of beta(2)-adrenoceptor gene polymorphisms on diet-induced thermogenesis
    J M Oomen
    Department of Human Biology NUTRIM, Maastricht University, Maastricht, The Netherlands
    Br J Nutr 94:647-54. 2005
    ..The interindividual variation in thermogenic response to the meal was correlated with variations in the plasma adrenaline response to the meal...
  74. ncbi request reprint Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients
    L J C van Loon
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Diabetologia 48:2097-107. 2005
    ..In the present study, we investigated the consequences of adipose tissue lipolytic inhibition on skeletal muscle substrate use in type 2 diabetic patients...
  75. pmc Effect of beta-adrenergic stimulation on whole-body and abdominal subcutaneous adipose tissue lipolysis in lean and obese men
    J W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, and Department of Nuclear Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Diabetologia 51:320-7. 2008
    ..We hypothesised that the beta-adrenergically mediated effect on lipolysis in abdominal SAT is also impaired in vivo in obese humans...
  76. doi request reprint Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 33:669-79. 2009
    ..Part of the heterogeneity of the obesity phenotype may originate from genetic differences between obese individuals that may influence energy expenditure (EE)...
  77. ncbi request reprint Effect of short-term ACE inhibitor treatment on peripheral insulin sensitivity in obese insulin-resistant subjects
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, MD, Maastricht, The Netherlands
    Diabetologia 49:3009-16. 2006
    ..This study was designed to investigate the effect of short-term ACE inhibitor treatment on insulin sensitivity and to examine possible underlying metabolic and haemodynamic effects in obese insulin-resistant subjects...
  78. pmc Cold-induced vasoconstriction at forearm and hand skin sites: the effect of age
    B R M Kingma
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism of Maastricht Universitary Medical Centre, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands
    Eur J Appl Physiol 109:915-21. 2010
    ..This indicates that at hand skin the noradrenergic mechanism of vasoconstriction is maintained with age...
  79. doi request reprint Short-term beta-adrenergic regulation of leptin, adiponectin and interleukin-6 secretion in vivo in lean and obese subjects
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes Obes Metab 10:1029-38. 2008
    ....
  80. ncbi request reprint Insulin acutely upregulates protein expression of the fatty acid transporter CD36 in human skeletal muscle in vivo
    E Corpeleijn
    From the Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Physiol Pharmacol 59:77-83. 2008
    ..We conclude that also in obese humans the FAT/CD36 protein content in skeletal muscle is dynamically regulated by insulin in vivo on the short term...
  81. ncbi request reprint The effect of different protein hydrolysate/carbohydrate mixtures on postprandial glucagon and insulin responses in healthy subjects
    M Claessens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 63:48-56. 2009
    ..To study the effect of four protein hydrolysates from vegetable (pea, gluten, rice and soy) and two protein hydrolysates from animal origin (whey and egg) on glucagon and insulin responses...
  82. ncbi request reprint Study on Lifestyle Intervention and Impaired Glucose Tolerance Maastricht (SLIM): preliminary results after one year
    M Mensink
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 27:377-84. 2003
    ..The aim of this study is to evaluate the effect of a lifestyle-intervention programme on glucose tolerance in Dutch subjects with impaired glucose tolerance (IGT)...
  83. ncbi request reprint An intervention study of the effects of calcium intake on faecal fat excretion, energy metabolism and adipose tissue mRNA expression of lipid-metabolism related proteins
    N Boon
    Nutrition and Toxicology Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Int J Obes (Lond) 31:1704-12. 2007
    ..In various observational studies, an inverse relation between calcium intake and body weight has been observed. A possible explanation could be an increased calcium excretion through the faeces caused by an increased dietary calcium intake...
  84. doi request reprint Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients
    H Boon
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Diabetologia 51:1893-900. 2008
    ..In this study, we aimed to assess the impact of the AMPK activator 5-aminoimidazole-4-carboxamide riboside (AICAR) on both glucose and fatty acid metabolism in vivo in type 2 diabetic patients...
  85. ncbi request reprint Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation
    J W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 31:813-9. 2007
    ..We investigated whether polymorphisms in codon 16, 27 and 164 of the beta (2)-adrenoceptor gene (ADRB2) and exon 10 of the G protein beta (3)-subunit gene (GNB3) are associated with alterations in in vivo lipolysis and fat oxidation...
  86. ncbi request reprint The effect of guar gum addition to a semisolid meal on appetite related to blood glucose, in dieting men
    E M R Kovacs
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 56:771-8. 2002
    ..To investigate whether addition of modified guar gum (GG) to a low-energy semisolid meal might be effective on appetite by modifying the response of blood glucose and other blood parameters...
  87. ncbi request reprint Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients
    R J F Manders
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 63:121-6. 2009
    ..Evaluate the efficacy of protein hydrolysate co-ingestion as a dietary strategy to improve blood glucose homeostasis under free-living conditions in long-standing type 2 diabetes patients...
  88. ncbi request reprint Angiotensin II: a hormone that affects lipid metabolism in adipose tissue
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 31:382-4. 2007
    ..Alterations in adipose tissue lipolysis may contribute to the pathophysiology of obesity and insulin resistance. We examined the effects of angiotensin II (Ang II) on abdominal subcutaneous adipose tissue lipolysis in humans...
  89. doi request reprint Impact of 3-year lifestyle intervention on postprandial glucose metabolism: the SLIM study
    C Roumen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabet Med 25:597-605. 2008
    ....
  90. ncbi request reprint DiOGenes: a multidisciplinary offensive focused on the obesity epidemic
    W H M Saris
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Obes Rev 6:175-6. 2005
  91. ncbi request reprint beta2-adrenergic receptor polymorphisms and salbutamol-stimulated energy expenditure
    J M Oomen
    Department of Human Biology NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 90:2301-7. 2005
    ..Although this relatively small study needs confirmation, the findings support a role for this polymorphism in the development and maintenance of overweight and obesity...
  92. ncbi request reprint Angiotensin II-induced effects on adipose and skeletal muscle tissue blood flow and lipolysis in normal-weight and obese subjects
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 89:2690-6. 2004
    ..These effects were not significantly different in obese and normal-weight subjects in both tissues...
  93. ncbi request reprint Substrate source utilisation in long-term diagnosed type 2 diabetes patients at rest, and during exercise and subsequent recovery
    H Boon
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetologia 50:103-12. 2007
    ..However, data on substrate source utilisation in type 2 diabetes are inconclusive...
  94. doi request reprint Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity
    S L J Wijers
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Obes Rev 10:218-26. 2009
    ..In conjunction with recent advances on signal transduction studies, this knowledge makes manipulation of adaptive thermogenesis a more realistic option and thus a pharmacologically interesting target to treat obesity...
  95. ncbi request reprint Recombinant human lactoferrin ingestion attenuates indomethacin-induced enteropathy in vivo in healthy volunteers
    F J Troost
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Eur J Clin Nutr 57:1579-85. 2003
    ....
  96. ncbi request reprint The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects
    M M J W Kamphuis
    Department of Human Biology, Faculty of Health Sciences, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 27:840-7. 2003
    ..To study the effects of 13 weeks conjugated linoleic acid (CLA) supplementation in overweight subjects after weight loss on weight regain, body composition, resting metabolic rate, substrate oxidation, and blood plasma parameters...
  97. ncbi request reprint Subscapular skinfold thickness distinguishes between transient and persistent impaired glucose tolerance: Study on Lifestyle-Intervention and Impaired Glucose Tolerance Maastricht (SLIM)
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabet Med 20:552-7. 2003
    ..To assess whether adding anthropometric measurements to an oral glucose tolerance test (OGTT) can help to distinguish between transient and persistent impaired glucose tolerance (IGT)...
  98. ncbi request reprint Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects
    M M J W Kamphuis
    Department of Human Biology, Faculty of Health Sciences, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 57:1268-74. 2003
    ..To study the effects of 13 weeks conjugated linoleic acid (CLA) supplementation in overweight subjects on body-weight maintenance, parameters of appetite and energy intake (EI) at breakfast after weight loss...
  99. ncbi request reprint The effect of pegylated recombinant human leptin (PEG-OB) on weight loss and inflammatory status in obese subjects
    C J Hukshorn
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 26:504-9. 2002
    ..2 MJ/day)...
  100. ncbi request reprint Netherlands research programme weight gain prevention (NHF-NRG): rationale, objectives and strategies
    S P J Kremers
    Department of Health Education and Promotion, Maastricht University, The Netherlands
    Eur J Clin Nutr 59:498-507. 2005
    ....
  101. ncbi request reprint Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance
    M Mensink
    Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Diabetologia 46:1082-9. 2003
    ....