Bart P F Rutten

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. pmc Epigenetic mediation of environmental influences in major psychotic disorders
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Vijverdalseweg 1, Maastricht 6226 NB, The Netherlands
    Schizophr Bull 35:1045-56. 2009
  2. doi request reprint Caloric restriction and aging but not overexpression of SOD1 affect hippocampal volumes in mice
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neurosciences, Maastricht University, NL 6200 MD Maastricht, The Netherlands
    Mech Ageing Dev 131:574-9. 2010
  3. pmc Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice
    Bart P F Rutten
    Division Cellular Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Am J Pathol 167:161-73. 2005
  4. pmc Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction
    Leonidas Chouliaras
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neurobiol Aging 33:1672-81. 2012
  5. pmc Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction
    Leonidas Chouliaras
    School for Mental Health and NeuroScience MHeNS, Department of Psychiatry and Psychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Alzheimer Res 9:536-44. 2012
  6. ncbi request reprint Histone deacetylase 2 in the mouse hippocampus: attenuation of age-related increase by caloric restriction
    Leonidas Chouliaras
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, PO BOX 616 VIJV, 6200 MD Maastricht, The Netherlands
    Curr Alzheimer Res 10:868-76. 2013
  7. doi request reprint Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
    Leonidas Chouliaras
    School for Mental Health and NeuroScience MHeNS, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neurobiol Aging 34:2091-9. 2013
  8. pmc Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
    Christoph Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, Maastricht, The Netherlands
    Am J Pathol 164:1495-502. 2004
  9. doi request reprint Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice
    Annerieke S R Sierksma
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Neurobiol Aging 34:319-37. 2013
  10. pmc Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease
    Hisaaki Takahashi
    Department of Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands
    Brain Struct Funct 214:145-60. 2010

Collaborators

Detail Information

Publications27

  1. pmc Epigenetic mediation of environmental influences in major psychotic disorders
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Vijverdalseweg 1, Maastricht 6226 NB, The Netherlands
    Schizophr Bull 35:1045-56. 2009
    ....
  2. doi request reprint Caloric restriction and aging but not overexpression of SOD1 affect hippocampal volumes in mice
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neurosciences, Maastricht University, NL 6200 MD Maastricht, The Netherlands
    Mech Ageing Dev 131:574-9. 2010
    ..These morphometric alterations may have impact on the function of the hippocampus during aging and CR...
  3. pmc Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice
    Bart P F Rutten
    Division Cellular Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Am J Pathol 167:161-73. 2005
    ..The observation of age-related SIPB loss within SR of PS1M146L mice supports a role of mutant PS1 in neurodegeneration apart from its contribution to alterations in Abeta generation...
  4. pmc Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction
    Leonidas Chouliaras
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neurobiol Aging 33:1672-81. 2012
    ..These findings suggest a crucial role for DNA methylation in hippocampal aging and in the mediation of the beneficial effects of CR on aging...
  5. pmc Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction
    Leonidas Chouliaras
    School for Mental Health and NeuroScience MHeNS, Department of Psychiatry and Psychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Alzheimer Res 9:536-44. 2012
    ..These findings indicate that the aging process in mice is connected with changes in epigenetic machinery in the hippocampus and suggest that CR acts by influencing epigenetic regulation...
  6. ncbi request reprint Histone deacetylase 2 in the mouse hippocampus: attenuation of age-related increase by caloric restriction
    Leonidas Chouliaras
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, PO BOX 616 VIJV, 6200 MD Maastricht, The Netherlands
    Curr Alzheimer Res 10:868-76. 2013
    ....
  7. doi request reprint Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
    Leonidas Chouliaras
    School for Mental Health and NeuroScience MHeNS, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neurobiol Aging 34:2091-9. 2013
    ....
  8. pmc Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
    Christoph Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, Maastricht, The Netherlands
    Am J Pathol 164:1495-502. 2004
    ..These findings point to the potential involvement of more than one mechanism in hippocampal neuron loss in this APP/PS-1 double-transgenic mouse model of Alzheimer's disease...
  9. doi request reprint Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice
    Annerieke S R Sierksma
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Neurobiol Aging 34:319-37. 2013
    ..Moreover, given the remarkable sex differences observed, one should not overlook the impact of sex-specific responses to environmental exposures when investigating gene-environment interactions in AD...
  10. pmc Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease
    Hisaaki Takahashi
    Department of Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands
    Brain Struct Funct 214:145-60. 2010
    ..The loss of these interneurons in AD may have substantial functional repercussions on local inhibitory processes in the hippocampus...
  11. ncbi request reprint Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study
    Ehsan Pishva
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 9:e100935. 2014
    ..These data provide the first evidence that emotional responses to daily life stressors may be moderated by genetic variation in the genes involved in the epigenetic machinery. ..
  12. ncbi request reprint No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 12:110-20. 2003
    ..These data implicate that expression of beta-CTF per se is not neurotoxic, and that other mechanisms are responsible for the neurotoxic events in Alzheimer's disease brain...
  13. ncbi request reprint The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies
    Daniel L A van den Hove
    School for Mental Health and NeuroScience MHeNS, Department of Psychiatry and Psychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Alzheimer Res 9:545-9. 2012
    ....
  14. doi request reprint COMT Val158Met-stress interaction in psychosis: role of background psychosis risk
    Dina Collip
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands
    CNS Neurosci Ther 17:612-9. 2011
    ....
  15. doi request reprint Epigenetic regulation in the pathophysiology of Alzheimer's disease
    Leonidas Chouliaras
    School for Mental Health and NeuroScience MHeNS, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Prog Neurobiol 90:498-510. 2010
    ..Research on earlier stages of the disease could provide more insight into its underlying pathophysiology, possibly contributing to the establishment of early diagnosis and the development of more effective treatment strategies...
  16. pmc Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease
    Marijke A M Lemmens
    Department for Neuroscience, Faculty of Health, Medicine and Life Sciences FHML, School for Mental Health and NeuroScience MHeNS, European Graduate School of Neuroscience EURON, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Brain Struct Funct 216:227-37. 2011
    ..In conclusion, the APP/PS1KI mice provide novel insights into the regional selective vulnerability in the frontal cortex during AD that, together with previous findings in the hippocampus, are remarkably similar to the human situation...
  17. doi request reprint The environment and schizophrenia
    Jim Van Os
    European Graduate School for Neuroscience, SEARCH, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
    Nature 468:203-12. 2010
    ..Longitudinal research is needed to uncover gene-environment interplay that determines how expression of vulnerability in the general population may give rise to more severe psychopathology...
  18. ncbi request reprint The aging brain: accumulation of DNA damage or neuron loss?
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
    Neurobiol Aging 28:91-8. 2007
    ..This formerly unknown inverse relation between age-related accumulation of nDNA damage and age-related loss of neurons may reflect a fundamental process of aging in the central nervous system...
  19. doi request reprint A time-lagged momentary assessment study on daily life physical activity and affect
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Health Psychol 31:135-44. 2012
    ..The current study examined the effects of physical activity on affective state. A primary and within-study replication sample was derived from twin pairs...
  20. doi request reprint Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
    Odette L J Peerbooms
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University, Maastricht, The Netherlands
    Brain Behav Immun 25:1530-43. 2011
    ..This study provides evidence for shared genetic vulnerability for SZ, BPD and UDD mediated by MTHFR 677TT genotype, which is in line with epigenetic involvement in the pathophysiology of these psychiatric disorders...
  21. ncbi request reprint The aging brain: less neurons could be better
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, Division of Neuroscience, University of Maastricht, P O Box 616, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands
    Mech Ageing Dev 124:349-55. 2003
    ..Ultimately, the implication of this strategy may lead to the prevention of AD...
  22. doi request reprint Advanced microscopy techniques for quantitative analysis in neuromorphology and neuropathology research: current status and requirements for the future
    Marijke A M Lemmens
    Division Neuroscience, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Chem Neuroanat 40:199-209. 2010
    ..These developments will advance basic neuroscience research as well as pharmaceutical and biotechnology research and development...
  23. ncbi request reprint Epigenetic effects of electroconvulsive seizures
    Job O Z de Jong
    From the Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University Medical Centre, Maastricht Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands Department of Mood Disorders and ECT, University Psychiatric Center, Catholic University Leuven, Leuven, Belgium and Department of Psychosis Studies, Institute of Psychiatry, King s College London, King s Health Partners, London, UK
    J ECT 30:152-9. 2014
    ..These studies, however, support the notion of a robust impact of ECT on epigenetic mechanisms and set the stage for human ECT studies on the epigenetic machinery. ..
  24. ncbi request reprint The epigenome and postnatal environmental influences in psychotic disorders
    Ehsan Pishva
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 49:337-48. 2014
    ....
  25. ncbi request reprint Antioxidants and Alzheimer's disease: from bench to bedside (and back again)
    Bart P F Rutten
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 5:645-51. 2002
    ....