Jan Rosing

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. doi request reprint Protein S is a cofactor for tissue factor pathway inhibitor
    J Rosing
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Thromb Res 122:S60-3. 2008
  2. ncbi request reprint Venous thrombosis and oral contraceptives: current status
    Svetlana Tchaikovski
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Womens Health (Lond Engl) 2:761-72. 2006
  3. ncbi request reprint Factor V activation and inactivation by venom proteases
    J Rosing
    Department of Biochemistry, Cardiovascular Research Institute, University of Maastricht, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Haemostasis 31:241-6. 2001
  4. ncbi request reprint Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study
    J Rosing
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Netherlands
    Lancet 354:2036-40. 1999
  5. ncbi request reprint Oral contraceptives, thrombosis and haemostasis
    J Rosing
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 95:193-7. 2001
  6. ncbi request reprint Effect of oral contraceptives on the anticoagulant activity of protein S in plasma
    Rory R Koenen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, The Netherlands
    Thromb Haemost 93:853-9. 2005
  7. doi request reprint Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms
    Connie Duckers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Blood 115:879-86. 2010
  8. doi request reprint Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera
    Marina Marchetti
    Department of Internal Medicine, Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Blood 112:4061-8. 2008
  9. pmc Inhibition of thrombin formation by active site mutated (S360A) activated protein C
    Gerry A F Nicolaes
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6200MD Maastricht, The Netherlands
    J Biol Chem 285:22890-900. 2010
  10. ncbi request reprint Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation
    Lisbeth F A Maurissen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
    Blood 111:3034-41. 2008

Collaborators

Detail Information

Publications52

  1. doi request reprint Protein S is a cofactor for tissue factor pathway inhibitor
    J Rosing
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Thromb Res 122:S60-3. 2008
    ..These assays show that the activity of the TFPI/protein S system is greatly impaired in oral contraceptive users...
  2. ncbi request reprint Venous thrombosis and oral contraceptives: current status
    Svetlana Tchaikovski
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Womens Health (Lond Engl) 2:761-72. 2006
    ..The changes in hemostatic parameters can explain why women who use oral contraceptives are exposed to an increased risk of venous thrombosis and why the risk is further increased in third-generation oral contraceptive users...
  3. ncbi request reprint Factor V activation and inactivation by venom proteases
    J Rosing
    Department of Biochemistry, Cardiovascular Research Institute, University of Maastricht, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Haemostasis 31:241-6. 2001
    ..In this review, the structural and functional properties of animal venom factor V activators and inactivators is described...
  4. ncbi request reprint Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study
    J Rosing
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Netherlands
    Lancet 354:2036-40. 1999
    ..We aimed to overcome these sources of bias by doing a cycle-controlled randomised cross-over trial...
  5. ncbi request reprint Oral contraceptives, thrombosis and haemostasis
    J Rosing
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 95:193-7. 2001
    ....
  6. ncbi request reprint Effect of oral contraceptives on the anticoagulant activity of protein S in plasma
    Rory R Koenen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, The Netherlands
    Thromb Haemost 93:853-9. 2005
    ..Functional impairment of protein S as a result of hormonal influence may, at least in part, contribute to the thrombotic risk of OC users...
  7. doi request reprint Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms
    Connie Duckers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Blood 115:879-86. 2010
    ..In combination with low TFPI level, residual platelet FV allows sufficient thrombin generation to rescue these patients from fatal bleeding...
  8. doi request reprint Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera
    Marina Marchetti
    Department of Internal Medicine, Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Blood 112:4061-8. 2008
    ..In conclusion, these data indicate the occurrence of acquired APC resistance in ET and PV patients, probably because of a reduction in free PS levels. The APC-resistant phenotype is influenced by the JAK2(V617F) mutational load...
  9. pmc Inhibition of thrombin formation by active site mutated (S360A) activated protein C
    Gerry A F Nicolaes
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6200MD Maastricht, The Netherlands
    J Biol Chem 285:22890-900. 2010
    ..Because docking of APC to FVa and FVIIIa constitutes the first step in the inactivation of the cofactors, we hypothesize that the observed anticoagulant activity may be important for in vivo regulation of thrombin formation...
  10. ncbi request reprint Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation
    Lisbeth F A Maurissen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
    Blood 111:3034-41. 2008
    ..These results are of interest for carriers of the factor V(Leiden) mutation (R(506)Q), as protein S-C4BP effectively enhances APC-catalyzed factor Va (R(306)) inactivation in plasma containing factor V(Leiden)...
  11. ncbi request reprint Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels
    Jeroen M Brugge
    Department of Biochemistry, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Thromb Haemost 95:236-42. 2006
    ..These findings suggest that carriers of the prothrombin 20210 G/A mutation, who have a high prothrombin/protein S ratio, may experience a higher thrombosis risk than non-carriers with comparable prothrombin levels...
  12. pmc The role of thrombin exosites I and II in the activation of human coagulation factor V
    Kenneth Segers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Biol Chem 282:33915-24. 2007
    ..In addition, interactions between exosite I of thrombin and FV are primarily responsible for the different cleavage site specificity as compared with activation by RVV-V or LVV-V...
  13. doi request reprint Thrombin generation as an intermediate phenotype for venous thrombosis
    Olivier Segers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    Thromb Haemost 103:114-22. 2010
    ..These results indicate that the thrombin generation assay is sensitive to genetic variation in haemostasis-related genes, which makes it a promising tool to identify novel genetic risk factors of VTE...
  14. ncbi request reprint Advances in understanding the bleeding diathesis in factor V deficiency
    Connie Duckers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Br J Haematol 146:17-26. 2009
    ..The present review discusses and integrates these findings in the context of the biology of FV and the clinical features of FV deficiency...
  15. doi request reprint The Kunitz 1 and Kunitz 3 domains of tissue factor pathway inhibitor are required for efficient inhibition of factor Xa
    Sameera Peraramelli
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, The Netherlands
    Thromb Haemost 108:266-76. 2012
    ..This inhibitory activity is counteracted by K3 and C-terminus...
  16. pmc Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency
    Elisabetta Castoldi
    Department of Biochemistry, Maastricht University P O Box 616, 6200 Maastricht, The Netherlands
    Haematologica 95:1563-71. 2010
    ....
  17. ncbi request reprint Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography
    Svetlana N Tchaikovski
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Thromb Haemost 98:1350-6. 2007
    ..In conclusion, OC use increases thrombin generation, but differential effects of second and third generation OCs on the protein C system likely determine the differences in the risk of venous thrombosis between these kinds of OC...
  18. ncbi request reprint Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance
    Kristin M Seré
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, 6200 MD Maastricht, The Netherlands
    Blood 104:3624-30. 2004
    ....
  19. doi request reprint Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin
    Kenneth Segers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, 6200MD, The Netherlands
    J Biol Chem 283:22573-81. 2008
    ..Furthermore, mutations that were introduced near the Arg506 cleavage site had a significant but modest effect on the rate of APC-catalyzed FVa inactivation, suggesting an extended interaction surface between the FVa Arg506 site and APC...
  20. pmc Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor
    Tilman M Hackeng
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Proc Natl Acad Sci U S A 103:3106-11. 2006
    ..Our data suggest that protein S deficiency not only increases the risk of thrombosis by impairing the protein C system but also by reducing the ability of TFPI to down-regulate the extrinsic coagulation pathway...
  21. ncbi request reprint Activated protein C resistance determined with a thrombin generation-based test predicts for venous thrombosis in men and women
    Guido Tans
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Br J Haematol 122:465-70. 2003
    ..In addition, acquired APC resistance resulting from OC use predicts an increased risk for venous thrombosis independent of factor V Leiden...
  22. ncbi request reprint Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations
    Elisabetta Castoldi
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Blood 103:4173-9. 2004
    ....
  23. ncbi request reprint Coinheritance of Factor V (FV) Leiden enhances thrombin formation and is associated with a mild bleeding phenotype in patients homozygous for the FVII 9726+5G>A (FVII Lazio) mutation
    Elisabetta Castoldi
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Blood 102:4014-20. 2003
    ..We conclude that coinheritance of FV Leiden increases thrombin formation and can improve the clinical phenotype in patients with severe FVII deficiency...
  24. ncbi request reprint The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation
    Rory R Koenen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, 6200 MD Maastricht, The Netherlands
    Blood 102:1686-92. 2003
    ..47 +/- 0.21; n = 46). We propose that the decreased APC-independent anticoagulant activity of protein S in plasma with elevated prothrombin levels may contribute to the thrombotic risk associated with the prothrombin G20210A mutation...
  25. ncbi request reprint The Ser460Pro mutation in recombinant protein S Heerlen does not affect its APC-cofactor and APC-independent anticoagulant activities
    Rory R Koenen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, The Netherlands
    Thromb Haemost 91:1105-14. 2004
    ....
  26. ncbi request reprint Endogenous factor V synthesis in megakaryocytes contributes negligibly to the platelet factor V pool
    M Christella L G D Thomassen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Haematologica 88:1150-6. 2003
    ..Coagulation factor V (FV) is distributed between two pools: 80% circulates in plasma and 20% is stored in platelets. The aim of the study was to determine the origin of platelet FV...
  27. doi request reprint Protein S as cofactor for TFPI
    Tilman M Hackeng
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 29:2015-20. 2009
    ..The current review describes the background of the TFPI-cofactor activity of protein S as well as the rationale for the observation that the TFPI/protein S system particularly inhibits the TF pathway at low procoagulant stimuli...
  28. doi request reprint TFPI-dependent activities of protein S
    Sameera Peraramelli
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, University Maastricht, The Netherlands
    Thromb Res 129:S23-6. 2012
    ....
  29. ncbi request reprint Mechanisms of estrogen-induced venous thromboembolism
    Svetlana N Tchaikovski
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Thromb Res 126:5-11. 2010
    ....
  30. pmc Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V
    Kenneth Segers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 Maastricht, The Netherlands
    Proc Natl Acad Sci U S A 104:12697-702. 2007
    ..Seven drug-like hits were identified, indicating that therapeutic targets that bind transiently to the membrane surface can be investigated cost-effectively, and that inhibitors of protein-membrane interactions can be designed...
  31. ncbi request reprint Reduced factor V concentration and altered FV1/FV2 ratio do not fully explain R2-associated APC-resistance
    Jose W P Govers-Riemslag
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Thromb Haemost 88:444-9. 2002
    ..We conclude that the low FV levels and altered FV isoform ratio cannot fully explain R2-associated APC-resistance...
  32. ncbi request reprint Factor V Leiden: a disorder of factor V anticoagulant function
    Elisabetta Castoldi
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Curr Opin Hematol 11:176-81. 2004
    ..The present review covers the discovery, the physiological significance and the structural requirements of the APC-cofactor activity of FV...
  33. pmc Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency
    Connie Duckers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    Blood 112:3615-23. 2008
    ..Low TFPI levels decreased the FV requirement for minimal thrombin generation in FV-deficient plasma to less than 1% and might therefore protect FV-deficient patients from severe bleeding...
  34. ncbi request reprint Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test
    Joyce Curvers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Thromb Haemost 88:5-11. 2002
    ..To identify individuals at risk, functional tests are needed that estimate the risk to develop venous thrombosis...
  35. ncbi request reprint Changes of hemostatic variables during oral contraceptive use
    Guido Tans
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Semin Vasc Med 3:61-8. 2003
    ....
  36. ncbi request reprint Altered inactivation pathway of factor Va by activated protein C in the presence of heparin
    Gerry A F Nicolaes
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, The Netherlands
    Eur J Biochem 271:2724-36. 2004
    ..The modeling and experimental data suggest that heparin, when bound to APC, prevents optimal docking of APC at Arg506 and promotes association between FVa and APC at position Arg306...
  37. ncbi request reprint Effects of (pre-)analytical variables on activated protein C resistance determined via a thrombin generation-based assay
    Joyce Curvers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Thromb Haemost 87:483-92. 2002
    ..Multiple linear regression analysis showed that only the citrate concentration affected the nAPC-sr, which was higher in samples collected in 3.2% trisodiumcitrate than in samples collected in 3.8% trisodiumcitrate...
  38. ncbi request reprint Protein S multimers are generated in vitro and affect protein S structure-function analyses
    Kristin M Seré
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, The Netherlands
    Semin Hematol 43:S111-20. 2006
    ....
  39. doi request reprint Thrombin generation tests
    Elisabetta Castoldi
    Departement of Biochemistry, Maastricht University, Maastricht, The Netherlands
    Thromb Res 127:S21-5. 2011
    ..The present paper discusses these issues with particular reference to Calibrated Automated Thrombography...
  40. ncbi request reprint Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation
    Kristof Vanschoonbeek
    Department of Human Biology, Nutrition and Toxicology Research and Cardiovascular Research Institutes of Maastricht, Maastricht University, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 24:1734-40. 2004
    ..We studied how fish oil intake influenced thrombin generation in plasma and which factors were involved herein...
  41. pmc Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation
    Imke C A Munnix
    Department of Biochemistry, Maastricht University, CARIM, Maastricht University, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2484-90. 2007
    ..Platelets play a dual role in thrombosis by forming aggregates and stimulating coagulation. We investigated the commitment of platelets to these separate functions during collagen-induced thrombus formation in vitro and in vivo...
  42. ncbi request reprint Structural models of the snake venom factor V activators from Daboia russelli and Daboia lebetina
    Kenneth Segers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Proteins 64:968-84. 2006
    ..We propose that both FV activators achieve their exquisite substrate specificity for the Arg1545 site via interactions between these exosites and FV...
  43. pmc Protein S binds to and inhibits factor Xa
    M J Heeb
    Scripps Research Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 91:2728-32. 1994
    ..These data demonstrate mechanisms of anticoagulant action for protein S that are independent of activated protein C and that involve direct binding to factors Xa and Va and direct inhibition of factor Xa...
  44. ncbi request reprint Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia
    E Castoldi
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
    J Thromb Haemost 5:971-9. 2007
    ..Differently, in prothrombin G20210A carriers only prothrombin levels are elevated...
  45. ncbi request reprint Coagulation factors and the protein C system as determinants of thrombin generation in a normal population
    A W J H Dielis
    Department of Internal Medicine, Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Thromb Haemost 6:125-31. 2008
    ..Thrombin generation is a powerful tool to probe overall plasma coagulability...
  46. ncbi request reprint Determinants of the APTT- and ETP-based APC sensitivity tests
    M C H De Visser
    Department of Hematology, Hemostasis and Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 3:1488-94. 2005
    ..This risk has been demonstrated with two APC sensitivity tests, which quantify the effects of APC on the activated partial thromboplastin time (APTT) and the endogenous thrombin potential (ETP), respectively...
  47. ncbi request reprint Effect of in vitro fertilization treatment and subsequent pregnancy on the protein C pathway
    J Curvers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Br J Haematol 115:400-7. 2001
    ..Our findings demonstrate that IVF treatment is accompanied by the development of a mild prothrombotic condition...
  48. ncbi request reprint The risk of venous thrombosis associated with a high endogenous thrombin potential in the absence and presence of activated protein C
    A Brandts
    J Thromb Haemost 5:416-8. 2007
  49. ncbi request reprint Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity
    K M Seré
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Biochemistry 40:8852-60. 2001
    ..Multimeric protein S could not be identified in normal human plasma, and it is therefore unlikely that this form of protein S contributes to the APC-independent anticoagulant activity of protein S that is observed in plasma...
  50. ncbi request reprint Functional properties of factor V and factor Va encoded by the R2-gene
    L Hoekema
    Department of Biochemistry, Cardiovascular Research Institute, Maastricht, Maastricht University, The Netherlands
    Thromb Haemost 85:75-81. 2001
    ....
  51. ncbi request reprint Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C
    M J Heeb
    Committee on Vascular Biology, Scripps Research Institute, La Jolla, California 92037
    J Biol Chem 268:2872-7. 1993
    ..These data show that protein S has an anticoagulant function which is independent of activated protein C and, at least in part, that this is because of its competition with prothrombin for direct binding to Factor Va...
  52. ncbi request reprint Development of a calibrated automated thrombography based thrombin generation test in mouse plasma
    S N Tchaikovski
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherland
    J Thromb Haemost 5:2079-86. 2007
    ..Mouse models have become increasingly important in thrombosis research. However, only a limited number of assays are available for assessment of the coagulation system in mouse plasma...