Research Topics
| W J RiedelSummaryAffiliation: Maastricht University Country: The Netherlands Publications
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Publications
Tryptophan depletion in normal volunteers produces selective impairment in memory consolidationW J Riedel
Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, European Graduate School for Neurosciences, Maastricht University, The Netherlands
Psychopharmacology (Berl) 141:362-9. 1999..On the basis of these results, it is concluded that tryptophan depletion specifically impairs long-term memory formation, presumably as a result of an acute decrease in 5-HT turnover in the brain...
Tryptophan modulation and cognitionWim J Riedel
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Universiteit Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
Adv Exp Med Biol 527:207-13. 2003..We conclude that experimental manipulations of tryptophan mediate temporal and frontal cognitive functions such as memory consolidation and working memory respectively, in an opposite manner...
Nutrients, age and cognitive functionW J Riedel
Experimental Psychopharmacology Unit, Maastricht University, The Netherlands
Curr Opin Clin Nutr Metab Care 1:579-85. 1998..The effects of nutritional supplements are modest but do not seem to be very different from those of medicinal or investigational cognition-enhancing or anti-dementia drugs...
Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteersJ A Schmitt
Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, European Graduate School for Neurosciences, Maastricht University, The Netherlands
J Psychopharmacol 14:21-9. 2000..Improvement of specific cognitive processes by lowered 5-HT function may be linked to the removal of inhibitory actions of 5-HT in the cortex...
40-Hz steady state response in Alzheimer's disease and mild cognitive impairmentJ A van Deursen
Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands
Neurobiol Aging 32:24-30. 2011..Furthermore a moderate correlation between 40-Hz SSR power and cognitive performance as measured by ADAS-cog was shown. The results suggest that 40-Hz SSR might be an interesting candidate marker of disease progression...
Histamine H1 receptor blockade predominantly impairs sensory processes in human sensorimotor performanceP van Ruitenbeek
Experimental Psychopharmacology Unit, Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
Br J Pharmacol 157:76-85. 2009..Better knowledge about the cognitive deficits associated with histamine dysfunction can contribute to better treatment of clinical disorders in which histamine hypofunction may be a contributing factor, such as in schizophrenia...
Memory impairments in humans after acute tryptophan depletion using a novel gelatin-based protein drinkA Sambeth
Faculty of Psychology and Neuroscience, Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
J Psychopharmacol 23:56-64. 2009..Our study provides further evidence that impairment in long-term episodic and elementary spatial memory after ATD is related to lowered tryptophan levels in plasma...
Pronounced cognitive deficits following an intravenous L-tryptophan challenge in first-degree relatives of bipolar patients compared to healthy controlsS Sobczak
Brain and Behavior Institute, Department of Psychiatry and Neuropsychology, Universiteit Maastricht, The Netherlands
Neuropsychopharmacology 28:711-9. 2003..In conclusions, cognitive deficits in FH following Trp may reflect a central 5-HT vulnerability in frontal brain areas. Independent of Trp, cognitive deficits in FH provide evidence for a trait marker for BD...
Histamine H1 receptor antagonist cetirizine impairs working memory processing speed, but not episodic memoryP van Ruitenbeek
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
Br J Pharmacol 161:456-66. 2010..The aim of the present study was to determine whether cetirizine can be used as a tool to model cognitive deficits associated with histaminergic hypofunction...
Memory in humans is unaffected by central H1-antagonism, while objectively and subjectively measured sedation is increasedP van Ruitenbeek
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
Eur Neuropsychopharmacol 20:226-35. 2010..The active control lorazepam impaired episodic- and working memory performance and increased sedation, while dexchlorpheniramine only increased sedation...
The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairmentB L Jorissen
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology, Maastricht, The Netherlands
Nutr Neurosci 4:121-34. 2001..There were also no significant interactions between treatment and 'severity of memory complaints'. In conclusion, a daily supplement of S-PS does not affect memory or other cognitive functions in older individuals with memory complaints...
Lower high-density lipoprotein cholesterol and increased omega-6 polyunsaturated fatty acids in first-degree relatives of bipolar patientsS Sobczak
Institute Brain and Behavior, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
Psychol Med 34:103-12. 2004..Changes in fatty acids show an association with central serotonergic parameters. It is suggested that these abnormalities in cholesterol and fatty acids may constitute a trait marker for bipolar disorders...
Effects of acute tryptophan depletion on mood and cortisol release in first-degree relatives of type I and type II bipolar patients and healthy matched controlsS Sobczak
Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology, Universiteit, Maastricht, The Netherlands
Neuropsychopharmacology 27:834-42. 2002..ATD was followed by a decrease in cortisol level in both FH subgroups, but not in the controls. The results suggest serotonergic vulnerability that affected mood in FH II subjects and cortisol release in both FH I and FH II subjects...
Increased EEG gamma band activity in Alzheimer's disease and mild cognitive impairmentJ A van Deursen
Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 Maastricht, The Netherlands
J Neural Transm 115:1301-11. 2008..The results suggest that elevated GBP is a reproducible and sensitive measure for cognitive dysfunction in AD in comparison with MCI and controls...
Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controlsT O C Kilkens
Maastricht University, Department of Psychiatry and Neuropsychology, Dr Tanslaan 10, 6229 ET, Maastricht, The Netherlands
Gut 53:1794-800. 2004..Serotonin, a key denominator of the brain-gut axis, is involved in the regulation of gastrointestinal motility, secretion, and perception as well as cognition and mood...
Dissociable hormonal, cognitive and mood responses to neuroendocrine challenge: evidence for receptor-specific serotonergic dysregulation in depressed moodW J Riedel
Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology, University Hospital, Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
Neuropsychopharmacology 26:358-67. 2002....
Cognition following acute tryptophan depletion: difference between first-degree relatives of bipolar disorder patients and matched healthy control volunteersS Sobczak
Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology, Universiteit Maastricht, The Netherlands
Psychol Med 32:503-15. 2002..Serotonin appears to be involved in speed of information processing, verbal and visual memory and learning processes...
Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteersA M W Linssen
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands
Psychopharmacology (Berl) 221:611-9. 2012..There are also observations of methylphenidate-induced cognition enhancement in healthy adults, although studies in this area are relatively sparse. We assessed the possible memory-enhancing properties of methylphenidate...
Memory functions and focussed attention in middle-aged and elderly subjects are unaffected by a low, acute dose of caffeineJ A J Schmitt
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Universiteit Maastricht, Maastricht, The Netherlands
J Nutr Health Aging 7:301-3. 2003..It is proposed that in middle-aged and elderly subjects cognitive effects may occur predominantly at higher caffeine dosages...
Response speed, contingent negative variation and P300 in Alzheimer's disease and MCIJ A van Deursen
Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
Brain Cogn 69:592-9. 2009..Insight into the psycho-physiological underpinnings of slowed RS can be provided by measuring the associated event-related potentials (ERP)...
Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitorsJ A Schmitt
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Universiteit Maastricht, The Netherlands
J Psychopharmacol 15:173-9. 2001..The impairing and facilitating cognitive effects of paroxetine and sertraline, respectively, may be more pronounced in the elderly depressed patient...
Dissociable effects of a single dose of ecstasy (MDMA) on psychomotor skills and attentional performanceC T J Lamers
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Maastricht University, Maastricht, The Netherlands
J Psychopharmacol 17:379-87. 2003..There was no effect of MDMA on visual search, planning or retrieval from semantic memory...
Mood congruent memory bias induced by tryptophan depletionT Klaassen
Brain and Behaviour Institute, Department of Psychiatry and Neuropsychology Maastricht University, The Netherlands
Psychol Med 32:167-72. 2002..CONCLUSION: Experimentally induced serotonergic depletion in normal individuals shifts affective memory bias towards negative affective valent verbal stimuli...
Higher, faster, stronger: the effect of dynamic stimuli on response preparation and CNV amplitudeA M W Linssen
Dept Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
Behav Brain Res 237:308-12. 2013..In conclusion, the dynamic task promotes response preparation. The new tasks may be especially valuable in groups with attention difficulties (i.e. elderly or ADHD patients)...
Safety of soy-derived phosphatidylserine in elderly peopleB L Jorissen
Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Universiteit Maastricht, The Netherlands
Nutr Neurosci 5:337-43. 2002..In conclusion, soy derived PS is a safe nutritional supplement for older persons if taken up to a dosage of 200 mg three times daily...
Cognitive domains affected by histamine H(1)-antagonism in humans: a literature reviewP van Ruitenbeek
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands, Maastricht, The Netherlands
Brain Res Rev 64:263-82. 2010..The importance of the sensitive cognitive domains to histaminergic dysfunction, as well as the relation between histamine related decrease in arousal and task performance deserve further research...
Effects of L-histidine depletion and L-tyrosine/L-phenylalanine depletion on sensory and motor processes in healthy volunteersP van Ruitenbeek
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
Br J Pharmacol 157:92-103. 2009..Here we evaluated whether depletion of L-histidine, the precursor of histamine, was effective in altering measures associated with histamine in humans and the behavioural and electrophysiological (event-related-potentials) effects...
Nutrients, age and cognitionB L Jorissen
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Universiteit Maastricht, Maastricht, The Netherlands
Clin Nutr 21:89-95. 2002..Contrary to epidemiological studies, experimental models mimic associations between nutrients and cognition by manipulating their presumed mechanisms of action and can eventually explain the causal nature of found associations...
Serotonergic vulnerability and depression: assumptions, experimental evidence and implicationsL A W Jans
Faculty of Psychology, Department of Neurocognition, Maastricht University, Maastricht, The Netherlands
Mol Psychiatry 12:522-43. 2007....
Cognitive changes after acute tryptophan depletion: what can they tell us?Wim J Riedel
Psychol Med 34:3-8. 2004
Tryptophan, mood, and cognitive functionWim J Riedel
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Universiteit Maastricht, The Netherlands
Brain Behav Immun 16:581-9. 2002..In conclusion, ATD is a model for impairment of memory, next to being a model of mood disorders in vulnerable subjects. Moreover, ATD could be used as a challenge to demonstrate individual vulnerability of the serotonergic system...
Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in manJeroen A J Schmitt
Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Universiteit Maastricht, The Netherlands
J Psychopharmacol 16:207-14. 2002..It is concluded that a serotonergically mediated reduction of dopamine activity plays an important role in the reduction of human vigilance following SSRI administration...
Plasma, oral fluid and sweat wipe ecstasy concentrations in controlled and real life conditionsNele Samyn
Drugs and Toxicology, Section Toxicology, National Institute of Criminalistics and Criminology, Vilvoordsesteenweg 100, 1120 Brussels, Belgium
Forensic Sci Int 128:90-7. 2002..Urine screening revealed the presence of combinations such as MDMA, MDEA, amph, cannabis, cocaine, LSD and psilocine in the multiple-drug condition...
Modulation of the critical flicker fusion effects of serotonin reuptake inhibitors by concomitant pupillary changesJeroen A J Schmitt
Department of Psychiatry and Neuropsychology, Universiteit Maastricht, Maastricht, The Netherlands
Psychopharmacology (Berl) 160:381-6. 2002..However, such an interpretation may be questioned since CFF elevations may also be due to SSRI-induced increases in pupil diameter...
Differential residual effects of zaleplon and zopiclone on actual driving: a comparison with a low dose of alcoholAnnemiek Vermeeren
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Maastricht University, The Netherlands
Sleep 25:224-31. 2002..To compare residual effects of zaleplon 10 mg, zopiclone 7.5 mg, and placebo, and a social dose of alcohol on car driving, memory, and psychomotor performance...
Cholinergic drugs affect novel object recognition in rats: relation with hippocampal EEG?Anke Sambeth
Faculty of Psychology and Brain and Behavior Institute, Maastricht University, The Netherlands
Eur J Pharmacol 572:151-9. 2007..However, there was a clear dissociation between memory performance and EEG after combined treatment with drugs, which makes additional research where EEG and performance measures are co-registered imperative...
Neuroendocrine response to meta-chlorophenylpiperazine and ipsapirone in relation to anxiety and aggressionTineke Klaassen
Departments of Psychiatry and Neuropsychology, University of Maastricht, PO Box 616, 6200 MD, Maastricht, The Netherlands
Psychiatry Res 113:29-40. 2002..Thus, in subjects with depressed mood, high levels of anxiety suggest a higher probability of 5-HT(2C) disturbances...
Specific serotonergic reuptake inhibition impairs vigilance performance acutely and after subchronic treatmentWim J Riedel
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Universiteit Maastricht, The Netherlands
J Psychopharmacol 19:12-20. 2005..Because citalopram is the most specific SSRI showing this effect, it is concluded that the SSRI-induced decrement of vigilance performance is specifically associated with serotonergic reuptake inhibition...
The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patientsLinda Booij
Department of Psychology, Leiden University, Leiden, The Netherlands and Psychomedical Center Parnassia, The Hague, The Netherlands
J Psychopharmacol 19:267-75. 2005..The comparison of the effects of high-dose and low-dose ATD is useful for those studies aiming to investigate the relationships among 5-HT, mood and cognition...
Acute tryptophan depletion in depressed patients treated with a selective serotonin-noradrenalin reuptake inhibitor: augmentation of antidepressant response?Linda Booij
Department of Psychology, Leiden University, Wassenaarseweg 52, Leiden 2333 AK, The Netherlands
J Affect Disord 86:305-11. 2005..In unmedicated depressed patients, ATD has no immediate effect on symptoms. The effects in currently depressed medicated patients have not been investigated...
Memory function in women with premenstrual complaints and the effect of serotonergic stimulation by acute administration of an alpha-lactalbumin proteinJeroen A J Schmitt
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Universiteit Maastricht, Maastricht, The Netherlands, Nestle Research Center, Lausanne, Switzerland
J Psychopharmacol 19:375-84. 2005..The data suggest that serotonergic hypofunction may play a role in premenstrual memory decline, but serotonergic mechanisms cannot fully account for observed cognitive changes in the premenstrual phase...
Effects of 5-HT on memory and the hippocampus: model and dataMartijn Meeter
Department of Cognitive Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Neuropsychopharmacology 31:712-20. 2006..The results suggest that the memory impairments in depressed subjects may be related to 5-HT undertransmission, and support the notion that 5-HT1A agonists ameliorate memory deficits in depression...
Human cognition assessment in drug researchWim J Riedel
Psychiatry Discovery Medicine, GlaxoSmithKline R and D, Cambridge, UK
Curr Pharm Des 12:2525-39. 2006..The associated factor analytical-, resource-strategy- and staged information processing models respectively are described. Finally a brief review is presented on possible physiological markers or biomarkers of human cognitive functions...
Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: a pooled analysis of nine studiesAnke Sambeth
Department of Neurocognition, Faculty of Psychology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Neurosci Biobehav Rev 31:516-29. 2007..The findings provide further support for a critical role of serotonin in declarative episodic memory...
Dopaminergic enhancement of cognitive functionMitul A Mehta
Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College, London, UK
Curr Pharm Des 12:2487-500. 2006....
Atypical cognitive profile in patients with depression after myocardial infarctionJeanette B Dijkstra
Department of Psychiatry and Neuropsychology, Maastricht University Hospital, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands
J Affect Disord 70:181-90. 2002..This may reflect a different etiology of post MI depression from non-cardiac-related depression...
Negative-ion chemical ionization gas chromatography-mass spectrometry assay for enantioselective measurement of amphetamines in oral fluid: application to a controlled study with MDMA and driving under the influence casesFrank T Peters
Department of Experimental and Clinical Toxicology, Saarland University, Homburg Saar, Germany
Clin Chem 53:702-10. 2007..Methods have been described for various matrices, but so far not for oral fluid, a matrix of increasing importance in testing for drugs of abuse, especially in the context of driving under the influence of drugs (DUID)...
Does ketamine mimic aspects of schizophrenic speech?Michael A Covington
CASPR, Artificial Intelligence Center, University of Georgia, Athens, GA 30602, USA
J Psychopharmacol 21:338-46. 2007..Reduced use of verbs apparently reflects a cognitive impairment of a different type than repetitiousness, and further investigation is needed to determine whether this impairment occurs in psychosis...
