Sander S Rensen
Affiliation: Maastricht University
Country: The Netherlands
- Activation of the complement system in human nonalcoholic fatty liver diseaseSander S Rensen
Department of Surgery, NUTRIM School for Nutrition, Toxicolgy, and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Hepatology 50:1809-17. 2009..This may have important implications for the pathogenesis and progression of NAFLD given the function of complement factors in clearance of apoptotic cells, hepatic fibrosis, and liver regeneration...
- Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray studyMarcel G M Wolfs
Department of Pathology and Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
BMC Med Genomics 3:34. 2010....
- Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitisSander S Rensen
Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
Am J Pathol 175:1473-82. 2009....
- Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosisKatrien H J Gaens
Department of Internal Medicine, Laboratory of Metabolism and Vascular Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
J Hepatol 56:647-55. 2012..The aim of the present study was to investigate the relationship between steatosis and CML and to study the role of CML in hepatic inflammation...
- Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivityMarten A Schults
Department of Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands
Mutat Res 736:75-81. 2012..These findings suggest a novel mechanism of liver cancer development in patients with nonalcoholic fatty liver disease...
- Total parenteral nutrition induces a shift in the Firmicutes to Bacteroidetes ratio in association with Paneth cell activation in ratsCaroline M Hodin
Department of Surgery, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
J Nutr 142:2141-7. 2012..75, P < 0.01). Further studies that include interventions with microbiota or nutrients that modulate them may yield information on the involvement of the microbiota and Paneth cells in TPN-associated intestinal compromise...
- The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in miceVeerle Bieghs
Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands
Gastroenterology 144:167-178.e1. 2013..We investigated whether 27HC can change the intracellular distribution cholesterol and reduce hepatic inflammation in mice...
- Liver manipulation during liver surgery in humans is associated with hepatocellular damage and hepatic inflammationMaartje A J van den Broek
Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
Liver Int 33:633-41. 2013..To date, information on this link in humans is lacking. As it is possible to modulate inflammation, it is clinically relevant to unravel this relationship...
- Novel evidence for chronic exposure to endotoxin in human nonalcoholic steatohepatitisFroukje J Verdam
Department of General Surgery, Faculty of Health, Medicine and Life Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
J Clin Gastroenterol 45:149-52. 2011..Furthermore, reliable measurement of the relatively low endotoxin levels in plasma of patients with liver disease and subsequent interpretation remain difficult...
- Neutrophil activation in morbid obesity, chronic activation of acute inflammationJeroen Nijhuis
Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of General Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
Obesity (Silver Spring) 17:2014-8. 2009..Moreover, because neutrophils have a short life span, this indicates that the chronic inflammatory condition associated with morbid obesity is characterized by a continuous activation of the innate immune system...
- Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient miceSander S Rensen
Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
PLoS ONE 7:e52411. 2012..We now investigated the hypothesis that MPO contributes to the development and progression of NASH...
- Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individualsCaroline M Hodin
NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
J Pathol 225:276-84. 2011..In addition, we show activation of the UPR in the intestine of obese subjects, which may underlie the observed Paneth cell compromise...
- Non-alcoholic steatohepatitis: a non-invasive diagnosis by analysis of exhaled breathFroukje J Verdam
Department of General Surgery, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
J Hepatol 58:543-8. 2013..Since analysis of volatile organic compounds in breath has been shown to accurately identify subjects with other chronic inflammatory diseases, we investigated its potential as a non-invasive tool to diagnose NASH...
- Lack of evidence for the role of human adenovirus-36 in obesity in a European cohortValère J Goossens
Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands
Obesity (Silver Spring) 19:220-1. 2011..In conclusion, this first Ad-36 study in the Netherlands and in Belgium indicates that Ad-36 does not play a role as a direct cause of BMI increase and obesity in humans in Western Europe...