Sander S Rensen

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. doi request reprint Activation of the complement system in human nonalcoholic fatty liver disease
    Sander S Rensen
    Department of Surgery, NUTRIM School for Nutrition, Toxicolgy, and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Hepatology 50:1809-17. 2009
  2. pmc Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study
    Marcel G M Wolfs
    Department of Pathology and Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    BMC Med Genomics 3:34. 2010
  3. pmc Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    Sander S Rensen
    Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Pathol 175:1473-82. 2009
  4. doi request reprint Liver manipulation during liver surgery in humans is associated with hepatocellular damage and hepatic inflammation
    Maartje A J van den Broek
    Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
    Liver Int 33:633-41. 2013
  5. pmc Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice
    Sander S Rensen
    Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 7:e52411. 2012
  6. doi request reprint Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis
    Katrien H J Gaens
    Department of Internal Medicine, Laboratory of Metabolism and Vascular Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    J Hepatol 56:647-55. 2012
  7. doi request reprint Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity
    Marten A Schults
    Department of Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Mutat Res 736:75-81. 2012
  8. ncbi request reprint Nε-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance
    Katrien H J Gaens
    From the Department of Internal Medicine and the Laboratory of Metabolism and Vascular Medicine K H J G, P M N, M M v G, C J H v d K, C D A S, C G S, Cardiovascular Research Institute Maastricht K H J G, P M N, M M v G, C J H v d K, M A v Z, C D A S, C G S, Department of Human Biology G H G, E E B, NUTRIM School for Nutrition, Toxicology, and Metabolism G H G, S S R, W A B, J W M G, E E B, Department of General Surgery S S R, W A B, J W M G, and Department of Biomedical Engineering M A v Z, Maastricht University Medical Center, Maastricht, The Netherlands Department of Pathology and Cardiac Surgery, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands H W N and Department of Medicine and Clinical Chemistry, University of Heidelberg
    Arterioscler Thromb Vasc Biol 34:1199-208. 2014
  9. ncbi request reprint Non-alcoholic steatohepatitis: a non-invasive diagnosis by analysis of exhaled breath
    Froukje J Verdam
    Department of General Surgery, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Hepatol 58:543-8. 2013
  10. doi request reprint The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
    Veerle Bieghs
    Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands
    Gastroenterology 144:167-178.e1. 2013

Collaborators

Detail Information

Publications20

  1. doi request reprint Activation of the complement system in human nonalcoholic fatty liver disease
    Sander S Rensen
    Department of Surgery, NUTRIM School for Nutrition, Toxicolgy, and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Hepatology 50:1809-17. 2009
    ..Moreover, nonalcoholic steatohepatitis (NASH) was more prevalent in patients showing hepatic C9 or activated C3 deposition...
  2. pmc Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study
    Marcel G M Wolfs
    Department of Pathology and Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    BMC Med Genomics 3:34. 2010
    ....
  3. pmc Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    Sander S Rensen
    Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Pathol 175:1473-82. 2009
    ....
  4. doi request reprint Liver manipulation during liver surgery in humans is associated with hepatocellular damage and hepatic inflammation
    Maartje A J van den Broek
    Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
    Liver Int 33:633-41. 2013
    ..To date, information on this link in humans is lacking. As it is possible to modulate inflammation, it is clinically relevant to unravel this relationship...
  5. pmc Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice
    Sander S Rensen
    Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 7:e52411. 2012
    ..We now investigated the hypothesis that MPO contributes to the development and progression of NASH...
  6. doi request reprint Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis
    Katrien H J Gaens
    Department of Internal Medicine, Laboratory of Metabolism and Vascular Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    J Hepatol 56:647-55. 2012
    ..The aim of the present study was to investigate the relationship between steatosis and CML and to study the role of CML in hepatic inflammation...
  7. doi request reprint Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity
    Marten A Schults
    Department of Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Mutat Res 736:75-81. 2012
    ..These findings suggest a novel mechanism of liver cancer development in patients with nonalcoholic fatty liver disease...
  8. ncbi request reprint Nε-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance
    Katrien H J Gaens
    From the Department of Internal Medicine and the Laboratory of Metabolism and Vascular Medicine K H J G, P M N, M M v G, C J H v d K, C D A S, C G S, Cardiovascular Research Institute Maastricht K H J G, P M N, M M v G, C J H v d K, M A v Z, C D A S, C G S, Department of Human Biology G H G, E E B, NUTRIM School for Nutrition, Toxicology, and Metabolism G H G, S S R, W A B, J W M G, E E B, Department of General Surgery S S R, W A B, J W M G, and Department of Biomedical Engineering M A v Z, Maastricht University Medical Center, Maastricht, The Netherlands Department of Pathology and Cardiac Surgery, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands H W N and Department of Medicine and Clinical Chemistry, University of Heidelberg
    Arterioscler Thromb Vasc Biol 34:1199-208. 2014
    ....
  9. ncbi request reprint Non-alcoholic steatohepatitis: a non-invasive diagnosis by analysis of exhaled breath
    Froukje J Verdam
    Department of General Surgery, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Hepatol 58:543-8. 2013
    ..Since analysis of volatile organic compounds in breath has been shown to accurately identify subjects with other chronic inflammatory diseases, we investigated its potential as a non-invasive tool to diagnose NASH...
  10. doi request reprint The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
    Veerle Bieghs
    Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands
    Gastroenterology 144:167-178.e1. 2013
    ..We investigated whether 27HC can change the intracellular distribution cholesterol and reduce hepatic inflammation in mice...
  11. doi request reprint Endoscopic duodenal-jejunal bypass liner rapidly improves type 2 diabetes
    Charlotte de Jonge
    Department of General Surgery and NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, P Debyelaan 25, 6229 HX Maastricht, The Netherlands
    Obes Surg 23:1354-60. 2013
    ..To gain insight into the mediators involved, we investigated factors regulating glucose homeostasis in patients with type 2 diabetes treated with the novel endoscopic duodenal-jejunal bypass liner (DJBL)...
  12. doi request reprint Total parenteral nutrition induces a shift in the Firmicutes to Bacteroidetes ratio in association with Paneth cell activation in rats
    Caroline M Hodin
    Department of Surgery, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    J Nutr 142:2141-7. 2012
    ..75, P < 0.01). Further studies that include interventions with microbiota or nutrients that modulate them may yield information on the involvement of the microbiota and Paneth cells in TPN-associated intestinal compromise...
  13. doi request reprint Novel evidence for chronic exposure to endotoxin in human nonalcoholic steatohepatitis
    Froukje J Verdam
    Department of General Surgery, Faculty of Health, Medicine and Life Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
    J Clin Gastroenterol 45:149-52. 2011
    ..Furthermore, reliable measurement of the relatively low endotoxin levels in plasma of patients with liver disease and subsequent interpretation remain difficult...
  14. doi request reprint Neutrophil activation in morbid obesity, chronic activation of acute inflammation
    Jeroen Nijhuis
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of General Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Obesity (Silver Spring) 17:2014-8. 2009
    ..Moreover, because neutrophils have a short life span, this indicates that the chronic inflammatory condition associated with morbid obesity is characterized by a continuous activation of the innate immune system...
  15. doi request reprint Human intestinal microbiota composition is associated with local and systemic inflammation in obesity
    Froukje J Verdam
    Department of General Surgery, NUTRIM, Maastricht University Medical Center, Maastricht, the Netherlands Department of General Surgery, Atrium Medical Center Parkstad, Heerlen, The Netherlands
    Obesity (Silver Spring) 21:E607-15. 2013
    ..The relationship between microbiota composition, intestinal permeability, and inflammation in nonobese and obese subjects was investigated...
  16. doi request reprint Endoscopic duodenal-jejunal bypass liner rapidly improves plasma parameters of nonalcoholic fatty liver disease
    Charlotte de Jonge
    Department of General Surgery and NUTRIM School for Nutrition, Toxicology and Metabolism Research, Maastricht University Medical Center, Maastricht, the Netherlands Department of General Surgery, Atrium Medical Center Parkstad, Heerlen, The Netherlands
    Clin Gastroenterol Hepatol 11:1517-20. 2013
    ..5U/L) were still reduced (P < .05), whereas AST and L-FABP had returned to near baseline levels (P = not significant). Therefore, in obese subjects, DJBL reduces plasma parameters of NAFLD. ClinicalTrials.gov, Number: NCT00985114. ..
  17. doi request reprint Six months of treatment with the endoscopic duodenal-jejunal bypass liner does not lead to decreased systemic inflammation in obese patients with type 2 diabetes
    Charlotte de Jonge
    Department of General Surgery and NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, P Debyelaan 25, 6229 HX, Maastricht, The Netherlands
    Obes Surg 24:337-41. 2014
    ..0 ± 0.1 pg/mL; IL-6, 3.5 ± 0.5 pg/mL; MPO, 53.6 ± ng/mL; all p = ns compared to baseline). In the current study, 6 months of endoscopic DJBL treatment did not lead to decreased systemic inflammation. ..
  18. doi request reprint Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals
    Caroline M Hodin
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Pathol 225:276-84. 2011
    ..In addition, we show activation of the UPR in the intestine of obese subjects, which may underlie the observed Paneth cell compromise...
  19. doi request reprint Nicotine effect on inflammatory and growth factor responses in murine cutaneous wound healing
    Sofia Xanthoulea
    Department of Plastic Surgery, Maastricht University Medical Center, P O Box 5800, 6202 AZ, Maastricht, the Netherlands Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands Electronic address
    Int Immunopharmacol 17:1155-64. 2013
    ..Reduced growth factor expression by nicotine might contribute, at least in part, to the overall detrimental effects of tobacco use in wound healing and skin diseases. ..
  20. doi request reprint Lack of evidence for the role of human adenovirus-36 in obesity in a European cohort
    Valère J Goossens
    Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Obesity (Silver Spring) 19:220-1. 2011
    ..In conclusion, this first Ad-36 study in the Netherlands and in Belgium indicates that Ad-36 does not play a role as a direct cause of BMI increase and obesity in humans in Western Europe...