Sander S Rensen

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi Activation of the complement system in human nonalcoholic fatty liver disease
    Sander S Rensen
    Department of Surgery, NUTRIM School for Nutrition, Toxicolgy, and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Hepatology 50:1809-17. 2009
  2. ncbi Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study
    Marcel G M Wolfs
    Department of Pathology and Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    BMC Med Genomics 3:34. 2010
  3. ncbi Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    Sander S Rensen
    Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Pathol 175:1473-82. 2009
  4. ncbi Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis
    Katrien H J Gaens
    Department of Internal Medicine, Laboratory of Metabolism and Vascular Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    J Hepatol 56:647-55. 2012
  5. ncbi Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity
    Marten A Schults
    Department of Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Mutat Res 736:75-81. 2012
  6. ncbi Total parenteral nutrition induces a shift in the Firmicutes to Bacteroidetes ratio in association with Paneth cell activation in rats
    Caroline M Hodin
    Department of Surgery, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    J Nutr 142:2141-7. 2012
  7. ncbi The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
    Veerle Bieghs
    Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands
    Gastroenterology 144:167-178.e1. 2013
  8. ncbi Liver manipulation during liver surgery in humans is associated with hepatocellular damage and hepatic inflammation
    Maartje A J van den Broek
    Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
    Liver Int 33:633-41. 2013
  9. ncbi Novel evidence for chronic exposure to endotoxin in human nonalcoholic steatohepatitis
    Froukje J Verdam
    Department of General Surgery, Faculty of Health, Medicine and Life Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
    J Clin Gastroenterol 45:149-52. 2011
  10. ncbi Neutrophil activation in morbid obesity, chronic activation of acute inflammation
    Jeroen Nijhuis
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of General Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Obesity (Silver Spring) 17:2014-8. 2009

Collaborators

  • Jeroen Nijhuis
  • Johanne G Bloemen
  • Dieter Lutjohann
  • Ruben G J Visschers
  • Sofia Xanthoulea
  • Marco Peluso
  • Frederik J Van Schooten
  • Coen D A Stehouwer
  • Valère J Goossens
  • Marleen A van Baak
  • Froukje J Verdam
  • Wim A Buurman
  • Ann Driessen
  • Caroline M Hodin
  • Veerle Bieghs
  • Marten H Hofker
  • Marcel G M Wolfs
  • Jan Willem Greve
  • Maartje A J van den Broek
  • Ronit Shiri-Sverdlov
  • Jan Willem M Greve
  • Steven W M Olde Damink
  • Cornelis H C Dejong
  • Katrien H J Gaens
  • Marten A Schults
  • Kaatje Lenaerts
  • Edwin J C Moonen
  • Jogchum Plat
  • Patrick J van Gorp
  • Tim Hendrikx
  • Satish C Kalhan
  • Charlotte de Jonge
  • Nicole D Bouvy
  • Aalt Bast
  • Ger H Koek
  • Jakobus Luijk
  • Mike L J Jeurissen
  • Yasmin Dias Guichot
  • Joris J W Schreurs
  • Marion Gijbels
  • Jan W Dallinga
  • Eran Leitersdorf
  • Fons Verheyen
  • Sofie M A Walenbergh
  • Joep B N van Berkel
  • Cornelis H Dejong
  • Peter W Nagle
  • Roland K Chiu
  • Sandra M Claessen
  • Petra M G Niessen
  • Roger W Godschalk
  • Casper G Schalkwijk
  • Armelle Munnia
  • Bas Boonen
  • Jan W Greve
  • Willem A Buurman
  • Joep Grootjans
  • Fons K Verheyen
  • Lude Franke
  • Cisca Wijmenga
  • Bahram Sanjabi
  • Marcel Bruinenberg
  • Timon W van Haeften
  • Elinda J Bruin-Van Dijk

Detail Information

Publications14

  1. ncbi Activation of the complement system in human nonalcoholic fatty liver disease
    Sander S Rensen
    Department of Surgery, NUTRIM School for Nutrition, Toxicolgy, and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Hepatology 50:1809-17. 2009
    ..This may have important implications for the pathogenesis and progression of NAFLD given the function of complement factors in clearance of apoptotic cells, hepatic fibrosis, and liver regeneration...
  2. ncbi Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray study
    Marcel G M Wolfs
    Department of Pathology and Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    BMC Med Genomics 3:34. 2010
    ....
  3. ncbi Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    Sander S Rensen
    Department of Surgery, Maastricht University Medical Centre, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Pathol 175:1473-82. 2009
    ....
  4. ncbi Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis
    Katrien H J Gaens
    Department of Internal Medicine, Laboratory of Metabolism and Vascular Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    J Hepatol 56:647-55. 2012
    ..The aim of the present study was to investigate the relationship between steatosis and CML and to study the role of CML in hepatic inflammation...
  5. ncbi Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity
    Marten A Schults
    Department of Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Mutat Res 736:75-81. 2012
    ..These findings suggest a novel mechanism of liver cancer development in patients with nonalcoholic fatty liver disease...
  6. ncbi Total parenteral nutrition induces a shift in the Firmicutes to Bacteroidetes ratio in association with Paneth cell activation in rats
    Caroline M Hodin
    Department of Surgery, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    J Nutr 142:2141-7. 2012
    ..75, P < 0.01). Further studies that include interventions with microbiota or nutrients that modulate them may yield information on the involvement of the microbiota and Paneth cells in TPN-associated intestinal compromise...
  7. ncbi The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
    Veerle Bieghs
    Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands
    Gastroenterology 144:167-178.e1. 2013
    ..We investigated whether 27HC can change the intracellular distribution cholesterol and reduce hepatic inflammation in mice...
  8. ncbi Liver manipulation during liver surgery in humans is associated with hepatocellular damage and hepatic inflammation
    Maartje A J van den Broek
    Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
    Liver Int 33:633-41. 2013
    ..To date, information on this link in humans is lacking. As it is possible to modulate inflammation, it is clinically relevant to unravel this relationship...
  9. ncbi Novel evidence for chronic exposure to endotoxin in human nonalcoholic steatohepatitis
    Froukje J Verdam
    Department of General Surgery, Faculty of Health, Medicine and Life Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
    J Clin Gastroenterol 45:149-52. 2011
    ..Furthermore, reliable measurement of the relatively low endotoxin levels in plasma of patients with liver disease and subsequent interpretation remain difficult...
  10. ncbi Neutrophil activation in morbid obesity, chronic activation of acute inflammation
    Jeroen Nijhuis
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of General Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Obesity (Silver Spring) 17:2014-8. 2009
    ..Moreover, because neutrophils have a short life span, this indicates that the chronic inflammatory condition associated with morbid obesity is characterized by a continuous activation of the innate immune system...
  11. ncbi Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice
    Sander S Rensen
    Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 7:e52411. 2012
    ..We now investigated the hypothesis that MPO contributes to the development and progression of NASH...
  12. ncbi Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals
    Caroline M Hodin
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Pathol 225:276-84. 2011
    ..In addition, we show activation of the UPR in the intestine of obese subjects, which may underlie the observed Paneth cell compromise...
  13. ncbi Non-alcoholic steatohepatitis: a non-invasive diagnosis by analysis of exhaled breath
    Froukje J Verdam
    Department of General Surgery, Nutrition and Toxicology Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Hepatol 58:543-8. 2013
    ..Since analysis of volatile organic compounds in breath has been shown to accurately identify subjects with other chronic inflammatory diseases, we investigated its potential as a non-invasive tool to diagnose NASH...
  14. ncbi Lack of evidence for the role of human adenovirus-36 in obesity in a European cohort
    Valère J Goossens
    Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Obesity (Silver Spring) 19:220-1. 2011
    ..In conclusion, this first Ad-36 study in the Netherlands and in Belgium indicates that Ad-36 does not play a role as a direct cause of BMI increase and obesity in humans in Western Europe...