Olga A H Reneerkens
Affiliation: Maastricht University
Country: The Netherlands
- Selective phosphodiesterase inhibitors: a promising target for cognition enhancementOlga A H Reneerkens
Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Psychopharmacology (Berl) 202:419-43. 2009..However, recently phosphodiesterases (PDEs) have gained increased attention as a potential new target for cognition enhancement. Inhibition of PDEs increases the intracellular availability of the second messengers cGMP and/or cAMP...
- Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801Olga A H Reneerkens
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
Behav Brain Res 236:16-22. 2013..We concluded that since BAY 60-7550 and PQ10 reversed both scopolamine- and MK-801-induced memory deficits, this supports the notion that dual substrate PDE inhibitors might be suitable candidates for cognition enhancement...
- Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanismsOlga A H Reneerkens
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, The Netherlands
Neurobiol Learn Mem 97:370-9. 2012..To further elucidate the underlying mechanisms, the cellular and subcellular localization of PDE5 needs to be determined...
- EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptorsJos Prickaerts
Maastricht University, School for Mental Health and Neuroscience, 6200 MD Maastricht, The Netherlands
Neuropharmacology 62:1099-110. 2012..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...