A H V Remels
Affiliation: Maastricht University
Country: The Netherlands
- Remels A, Schrauwen P, Broekhuizen R, Willems J, Kersten S, Gosker H, et al. Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD. Eur Respir J. 2007;30:245-52 pubmed..Therefore, a disturbed expression of these regulatory factors may well underlie the disturbed skeletal muscle functioning in chronic obstructive pulmonary disease. ..
- Remels A, Gosker H, Schrauwen P, Langen R, Schols A. Peroxisome proliferator-activated receptors: a therapeutic target in COPD?. Eur Respir J. 2008;31:502-8 pubmed publisher..Proposed mechanisms will be outlined in the present article, as well as the therapeutic potential of peroxisome proliferator-activated receptor modulation in the treatment of skeletal muscle dysfunction. ..
- Remels A, Langen R, Schrauwen P, Schaart G, Schols A, Gosker H. Regulation of mitochondrial biogenesis during myogenesis. Mol Cell Endocrinol. 2010;315:113-20 pubmed publisher..In particular, PGC-1alpha and PPAR-alpha may be involved in the regulation of mitochondrial biogenesis during myogenesis. ..
- Remels A, Langen R, Gosker H, Russell A, Spaapen F, Voncken J, et al. PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle. Am J Physiol Endocrinol Metab. 2009;297:E174-83 pubmed publisher..These findings demonstrate that muscle-specific inhibition of NF-kappaB activation may be an interesting therapeutic avenue for treatment of several inflammation-associated skeletal muscle abnormalities. ..