Jg Ramaekers

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road tracking and car-following performance in actual traffic
    G Ramaekers
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Psychopharmacology (Berl) 159:203-10. 2002
  2. doi request reprint Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users
    J G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 23:266-77. 2009
  3. ncbi request reprint Stimulant effects of 3,4-methylenedioxymethamphetamine (MDMA) 75 mg and methylphenidate 20 mg on actual driving during intoxication and withdrawal
    J G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, The Netherlands
    Addiction 101:1614-21. 2006
  4. doi request reprint Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (ecstasy) intoxication: an event-related fMRI study
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 34:1641-8. 2009
  5. ncbi request reprint Cognition and motor control as a function of Delta9-THC concentration in serum and oral fluid: limits of impairment
    J G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Drug Alcohol Depend 85:114-22. 2006
  6. ncbi request reprint High-potency marijuana impairs executive function and inhibitory motor control
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:2296-303. 2006
  7. ncbi request reprint Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcohol
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:1048-55. 2006
  8. ncbi request reprint Dose related risk of motor vehicle crashes after cannabis use
    J G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, P O Box 616, MD 6200 Maastricht, The Netherlands
    Drug Alcohol Depend 73:109-19. 2004
  9. ncbi request reprint Antidepressants and driver impairment: empirical evidence from a standard on-the-road test
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Maastricht University, Maastricht, The Netherlands
    J Clin Psychiatry 64:20-9. 2003
  10. ncbi request reprint Actual driving performance and psychomotor function in healthy subjects after acute and subchronic treatment with escitalopram, mirtazapine, and placebo: a crossover trial
    Marleen Wingen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, University of Maastricht, Maastricht, The Netherlands
    J Clin Psychiatry 66:436-43. 2005

Detail Information

Publications28

  1. ncbi request reprint A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road tracking and car-following performance in actual traffic
    G Ramaekers
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Psychopharmacology (Berl) 159:203-10. 2002
    ..Antiepileptic drugs are known to produce side effects which may impair driving performance. Performance effects, however, may differ substantially between individual antiepileptic drugs...
  2. doi request reprint Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users
    J G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 23:266-77. 2009
    ..These data indicate that cannabis use history strongly determines the behavioural response to single doses of THC...
  3. ncbi request reprint Stimulant effects of 3,4-methylenedioxymethamphetamine (MDMA) 75 mg and methylphenidate 20 mg on actual driving during intoxication and withdrawal
    J G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, The Netherlands
    Addiction 101:1614-21. 2006
    ..The aims of the present study were to investigate the acute effects of MDMA on actual driving performance during the intoxication and withdrawal phase...
  4. doi request reprint Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (ecstasy) intoxication: an event-related fMRI study
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 34:1641-8. 2009
    ..It is concluded that the loss of deactivation in inferior parietal lobules may account for increments in memory failures observed during MDMA intoxication...
  5. ncbi request reprint Cognition and motor control as a function of Delta9-THC concentration in serum and oral fluid: limits of impairment
    J G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Drug Alcohol Depend 85:114-22. 2006
    ..It is concluded that serum THC concentrations between 2 and 5 ng/ml establish the lower and upper range of a THC limit for impairment...
  6. ncbi request reprint High-potency marijuana impairs executive function and inhibitory motor control
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:2296-303. 2006
    ..Use of higher doses of THC in controlled studies may offer a reliable indication of THC induced impairment as compared to lower doses of THC that have traditionally been used in performance studies...
  7. ncbi request reprint Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcohol
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:1048-55. 2006
    ..The lack of interaction indicated that the CNS stimulant effects of MDMA were never sufficient to overcome alcohol-induced impairment of impulse control or risk-taking behavior...
  8. ncbi request reprint Dose related risk of motor vehicle crashes after cannabis use
    J G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, P O Box 616, MD 6200 Maastricht, The Netherlands
    Drug Alcohol Depend 73:109-19. 2004
    ..Combined use of THC and alcohol produced severe impairment of cognitive, psychomotor, and actual driving performance in experimental studies and sharply increased the crash risk in epidemiological analyses...
  9. ncbi request reprint Antidepressants and driver impairment: empirical evidence from a standard on-the-road test
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Maastricht University, Maastricht, The Netherlands
    J Clin Psychiatry 64:20-9. 2003
    ..That test measures driving impairment from vehicular "weaving" (i.e., standard deviation of lateral position [SDLP]) during 1 hour of on-the-road driving in normal traffic...
  10. ncbi request reprint Actual driving performance and psychomotor function in healthy subjects after acute and subchronic treatment with escitalopram, mirtazapine, and placebo: a crossover trial
    Marleen Wingen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, University of Maastricht, Maastricht, The Netherlands
    J Clin Psychiatry 66:436-43. 2005
    ....
  11. ncbi request reprint The role of 5-HT1a and 5-HT2a receptors in attention and motor control: a mechanistic study in healthy volunteers
    Marleen Wingen
    Faculty of Psychology, Department of Neurocognition Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Psychopharmacology (Berl) 190:391-400. 2007
    ..Various studies have demonstrated a modulating role for serotonin in attention. Selective serotonin inhibitors have repeatedly been shown to impair performance in sustained attention tasks...
  12. ncbi request reprint Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg
    Tim R M Leufkens
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 191:951-9. 2007
    ..The effect of alprazolam XR on potentially dangerous daily activities, such as driving a car, is expected to be less as compared to alprazolam IR...
  13. ncbi request reprint Pharmacokinetic properties of delta9-tetrahydrocannabinol in serum and oral fluid
    Gerold F Kauert
    Institute of Forensic Toxicology, University of Frankfurt, Frankfurt, Main, Germany
    J Anal Toxicol 31:288-93. 2007
    ..The oral compartment and its kinetics for drugs, particularly THC, are not yet satisfactorily understood...
  14. ncbi request reprint Developing limits for driving under cannabis
    Franjo Grotenhermen
    Nova Institut, Hürth, Germany
    Addiction 102:1910-7. 2007
    ..Development of a rational and enforceable basis for controlling the impact of cannabis use on traffic safety...
  15. doi request reprint Sustained attention and serotonin: a pharmaco-fMRI study
    Marleen Wingen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, The Netherlands
    Hum Psychopharmacol 23:221-30. 2008
    ..The present study assessed the influence of increased serotonin levels on brain areas involved in sustained attention...
  16. ncbi request reprint Modulation of the critical flicker fusion effects of serotonin reuptake inhibitors by concomitant pupillary changes
    Jeroen A J Schmitt
    Department of Psychiatry and Neuropsychology, Universiteit Maastricht, Maastricht, The Netherlands
    Psychopharmacology (Berl) 160:381-6. 2002
    ..However, such an interpretation may be questioned since CFF elevations may also be due to SSRI-induced increases in pupil diameter...
  17. ncbi request reprint Effects of emedastine and cetirizine, alone and with alcohol, on actual driving of males and females
    Annemiek Vermeeren
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, The Netherlands
    J Psychopharmacol 16:57-64. 2002
    ..Emedastine, in oral doses of 2 mg and 4 mg twice daily, is sedating and impairs driving. The drug could therefore constitute a traffic hazard and its users should be warned accordingly...
  18. ncbi request reprint An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition
    Cecile Henquet
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:2748-57. 2006
    ..The association between cannabis and psychosis may represent higher order gene-environment and gene-gene interactions...
  19. ncbi request reprint Driving impairment in depressed patients receiving long-term antidepressant treatment
    Marleen Wingen
    Experimental Psychopharmacology Unit, Faculty of Psychology, Brain and Behaviour Institute, University of Maastricht, Maastricht, The Netherlands
    Psychopharmacology (Berl) 188:84-91. 2006
    ..Depression is a common mental disorder with cognitive deficits, but little information is available on the effects of antidepressant treatment on driving performance in depressed patients...
  20. ncbi request reprint A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performance
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 20:496-505. 2006
    ....
  21. pmc Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, The Netherlands
    Br J Clin Pharmacol 61:79-86. 2006
    ..It is unknown, however, whether acute sedation persists after repeated dosing. Therefore, this study assessed the effects of repeated dosing of these antihistamines on driving and psychomotor performance...
  22. ncbi request reprint Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected
    Kim P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 189:557-63. 2007
    ..Two factors may have confounded results in abstinent users: memory task characteristics and polydrug use...
  23. ncbi request reprint Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in man
    Jeroen A J Schmitt
    Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Universiteit Maastricht, The Netherlands
    J Psychopharmacol 16:207-14. 2002
    ..It is concluded that a serotonergically mediated reduction of dopamine activity plays an important role in the reduction of human vigilance following SSRI administration...
  24. ncbi request reprint Stimulating effects of H1-antagonists
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, The Netherlands
    Curr Pharm Des 12:2501-9. 2006
    ..In addition, it would be useful to determine whether terfenadine, ebastine, fexofenadine and desloratadine can return allergic patient's performance back to their preclinical level...
  25. ncbi request reprint Stimulating effects of the antihistamine fexofenadine: testing the dopamine transporter hypothesis
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Psychopharmacology (Berl) 187:95-102. 2006
    ..One hypothesis suggests that this is due to fexofenadine producing an increase in dopamine levels by blocking the dopamine transporter...
  26. ncbi request reprint Pitfalls in estimating drug-related crash risk
    Johannes G Ramaekers
    Trends Pharmacol Sci 24:114-5; author reply 115. 2003
  27. ncbi request reprint Time-resolved hair analysis of MDMA enantiomers by GC/MS-NCI
    Liliane Ferreira Martins
    National Laboratory of Health, Toxicology Division, University of Luxembourg, Luxembourg, Luxembourg
    Forensic Sci Int 172:150-5. 2007
    ..Furthermore, both enantiomers of amphetamine (AM) were also detected in hair segments of four volunteers and the R/S ratios ranged from 1.00 to 1.47...
  28. ncbi request reprint Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint
    Stefan W Toennes
    Institute of Forensic Toxicology, Institute for Legal Medicine, Goethe University of Frankfurt, Germany
    J Anal Toxicol 32:470-7. 2008
    ..From the results, it must be cautioned that cannabinoid blood concentrations from heavy users in a late elimination phase may be difficult to distinguish from concentrations measured in occasional users after acute cannabis use...