Research Topics
| Jg RamaekersSummaryAffiliation: Maastricht University Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road tracking and car-following performance in actual trafficG Ramaekers
Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
Psychopharmacology (Berl) 159:203-10. 2002..Antiepileptic drugs are known to produce side effects which may impair driving performance. Performance effects, however, may differ substantially between individual antiepileptic drugs...
Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis usersJ G Ramaekers
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
J Psychopharmacol 23:266-77. 2009..These data indicate that cannabis use history strongly determines the behavioural response to single doses of THC...- Stimulant effects of 3,4-methylenedioxymethamphetamine (MDMA) 75 mg and methylphenidate 20 mg on actual driving during intoxication and withdrawalJ G Ramaekers
Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, The Netherlands
Addiction 101:1614-21. 2006..The aims of the present study were to investigate the acute effects of MDMA on actual driving performance during the intoxication and withdrawal phase... - Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (ecstasy) intoxication: an event-related fMRI studyJohannes G Ramaekers
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
Neuropsychopharmacology 34:1641-8. 2009..It is concluded that the loss of deactivation in inferior parietal lobules may account for increments in memory failures observed during MDMA intoxication... - Cognition and motor control as a function of Delta9-THC concentration in serum and oral fluid: limits of impairmentJ G Ramaekers
Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, 6200 MD Maastricht, The Netherlands
Drug Alcohol Depend 85:114-22. 2006..It is concluded that serum THC concentrations between 2 and 5 ng/ml establish the lower and upper range of a THC limit for impairment... - High-potency marijuana impairs executive function and inhibitory motor controlJohannes G Ramaekers
Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
Neuropsychopharmacology 31:2296-303. 2006..Use of higher doses of THC in controlled studies may offer a reliable indication of THC induced impairment as compared to lower doses of THC that have traditionally been used in performance studies... - Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcoholJohannes G Ramaekers
Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
Neuropsychopharmacology 31:1048-55. 2006..The lack of interaction indicated that the CNS stimulant effects of MDMA were never sufficient to overcome alcohol-induced impairment of impulse control or risk-taking behavior... - Dose related risk of motor vehicle crashes after cannabis useJ G Ramaekers
Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, P O Box 616, MD 6200 Maastricht, The Netherlands
Drug Alcohol Depend 73:109-19. 2004..Combined use of THC and alcohol produced severe impairment of cognitive, psychomotor, and actual driving performance in experimental studies and sharply increased the crash risk in epidemiological analyses... - Antidepressants and driver impairment: empirical evidence from a standard on-the-road testJohannes G Ramaekers
Experimental Psychopharmacology Unit, Brain and Behavior Institute, Maastricht University, Maastricht, The Netherlands
J Clin Psychiatry 64:20-9. 2003..That test measures driving impairment from vehicular "weaving" (i.e., standard deviation of lateral position [SDLP]) during 1 hour of on-the-road driving in normal traffic... - Actual driving performance and psychomotor function in healthy subjects after acute and subchronic treatment with escitalopram, mirtazapine, and placebo: a crossover trialMarleen Wingen
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, University of Maastricht, Maastricht, The Netherlands
J Clin Psychiatry 66:436-43. 2005.... - The role of 5-HT1a and 5-HT2a receptors in attention and motor control: a mechanistic study in healthy volunteersMarleen Wingen
Faculty of Psychology, Department of Neurocognition Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
Psychopharmacology (Berl) 190:391-400. 2007..Various studies have demonstrated a modulating role for serotonin in attention. Selective serotonin inhibitors have repeatedly been shown to impair performance in sustained attention tasks... - Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mgTim R M Leufkens
Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
Psychopharmacology (Berl) 191:951-9. 2007..The effect of alprazolam XR on potentially dangerous daily activities, such as driving a car, is expected to be less as compared to alprazolam IR... - Pharmacokinetic properties of delta9-tetrahydrocannabinol in serum and oral fluidGerold F Kauert
Institute of Forensic Toxicology, University of Frankfurt, Frankfurt, Main, Germany
J Anal Toxicol 31:288-93. 2007..The oral compartment and its kinetics for drugs, particularly THC, are not yet satisfactorily understood... - Developing limits for driving under cannabisFranjo Grotenhermen
Nova Institut, Hürth, Germany
Addiction 102:1910-7. 2007..Development of a rational and enforceable basis for controlling the impact of cannabis use on traffic safety... - Sustained attention and serotonin: a pharmaco-fMRI studyMarleen Wingen
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, The Netherlands
Hum Psychopharmacol 23:221-30. 2008..The present study assessed the influence of increased serotonin levels on brain areas involved in sustained attention... - Modulation of the critical flicker fusion effects of serotonin reuptake inhibitors by concomitant pupillary changesJeroen A J Schmitt
Department of Psychiatry and Neuropsychology, Universiteit Maastricht, Maastricht, The Netherlands
Psychopharmacology (Berl) 160:381-6. 2002..However, such an interpretation may be questioned since CFF elevations may also be due to SSRI-induced increases in pupil diameter... - Effects of emedastine and cetirizine, alone and with alcohol, on actual driving of males and femalesAnnemiek Vermeeren
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, The Netherlands
J Psychopharmacol 16:57-64. 2002..Emedastine, in oral doses of 2 mg and 4 mg twice daily, is sedating and impairs driving. The drug could therefore constitute a traffic hazard and its users should be warned accordingly... - An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognitionCecile Henquet
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
Neuropsychopharmacology 31:2748-57. 2006..The association between cannabis and psychosis may represent higher order gene-environment and gene-gene interactions... - Driving impairment in depressed patients receiving long-term antidepressant treatmentMarleen Wingen
Experimental Psychopharmacology Unit, Faculty of Psychology, Brain and Behaviour Institute, University of Maastricht, Maastricht, The Netherlands
Psychopharmacology (Berl) 188:84-91. 2006..Depression is a common mental disorder with cognitive deficits, but little information is available on the effects of antidepressant treatment on driving performance in depressed patients... - A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performanceEef L Theunissen
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
J Psychopharmacol 20:496-505. 2006.... 
Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performanceEef L Theunissen
Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, The Netherlands
Br J Clin Pharmacol 61:79-86. 2006..It is unknown, however, whether acute sedation persists after repeated dosing. Therefore, this study assessed the effects of repeated dosing of these antihistamines on driving and psychomotor performance...- Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffectedKim P C Kuypers
Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
Psychopharmacology (Berl) 189:557-63. 2007..Two factors may have confounded results in abstinent users: memory task characteristics and polydrug use... - Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in manJeroen A J Schmitt
Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Universiteit Maastricht, The Netherlands
J Psychopharmacol 16:207-14. 2002..It is concluded that a serotonergically mediated reduction of dopamine activity plays an important role in the reduction of human vigilance following SSRI administration... - Stimulating effects of H1-antagonistsEef L Theunissen
Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, The Netherlands
Curr Pharm Des 12:2501-9. 2006..In addition, it would be useful to determine whether terfenadine, ebastine, fexofenadine and desloratadine can return allergic patient's performance back to their preclinical level... - Stimulating effects of the antihistamine fexofenadine: testing the dopamine transporter hypothesisEef L Theunissen
Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
Psychopharmacology (Berl) 187:95-102. 2006..One hypothesis suggests that this is due to fexofenadine producing an increase in dopamine levels by blocking the dopamine transporter... - Pitfalls in estimating drug-related crash riskJohannes G Ramaekers
Trends Pharmacol Sci 24:114-5; author reply 115. 2003 - Time-resolved hair analysis of MDMA enantiomers by GC/MS-NCILiliane Ferreira Martins
National Laboratory of Health, Toxicology Division, University of Luxembourg, Luxembourg, Luxembourg
Forensic Sci Int 172:150-5. 2007..Furthermore, both enantiomers of amphetamine (AM) were also detected in hair segments of four volunteers and the R/S ratios ranged from 1.00 to 1.47... - Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo jointStefan W Toennes
Institute of Forensic Toxicology, Institute for Legal Medicine, Goethe University of Frankfurt, Germany
J Anal Toxicol 32:470-7. 2008..From the results, it must be cautioned that cannabinoid blood concentrations from heavy users in a late elimination phase may be difficult to distinguish from concentrations measured in occasional users after acute cannabis use...