Frans C S Ramaekers

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint The cytoskeleton and disease
    Frans C S Ramaekers
    Department of Molecular Cell Biology, Research Institutes CARIM, GROW and EURON, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Pathol 204:351-4. 2004
  2. doi request reprint Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation
    Ronald B Driesen
    Department of Molecular Cell Biology, School for Cardiovascular Diseases CARIM, University of Maastricht, Maastricht, The Netherlands
    Cardiovasc Pathol 18:19-27. 2009
  3. ncbi request reprint Structural adaptation in adult rabbit ventricular myocytes: influence of dynamic physical interaction with fibroblasts
    Ronald B Driesen
    Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, Maastricht, The Netherlands
    Cell Biochem Biophys 44:119-28. 2006
  4. doi request reprint Human papillomavirus multiplex ligation-dependent probe amplification assay for the assessment of viral load, integration, and gain of telomerase-related genes in cervical malignancies
    Wendy Theelen
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht 6200MD, The Netherlands
    Hum Pathol 44:2410-8. 2013
  5. ncbi request reprint Structural remodelling of cardiomyocytes in the border zone of infarcted rabbit heart
    Ronald B Driesen
    Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Mol Cell Biochem 302:225-32. 2007
  6. doi request reprint Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels
    Paula J Jansen
    Department of Molecular Cell Biology, Research Institute Brain and Behaviour EURON, University of Maastricht, Maastricht, The Netherlands
    J Alzheimers Dis 18:319-29. 2009
  7. doi request reprint Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies
    Ronald B Driesen
    Department of Molecular Cell Biology, Maastricht University, Maastricht, The Netherlands
    J Cell Mol Med 13:896-908. 2009
  8. doi request reprint Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions
    Rogier J N T M Litjens
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    J Med Virol 85:1386-93. 2013
  9. doi request reprint CD44 and OTP are strong prognostic markers for pulmonary carcinoids
    Dorian R A Swarts
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Cancer Res 19:2197-207. 2013
  10. ncbi request reprint Laminopathies
    Jos L V Broers
    Department of Molecular Cell Biology, Research Institutes CARIM, GROW, and EURON, University of Maastricht, The Netherlands
    J Pathol 204:478-88. 2004

Collaborators

Detail Information

Publications45

  1. ncbi request reprint The cytoskeleton and disease
    Frans C S Ramaekers
    Department of Molecular Cell Biology, Research Institutes CARIM, GROW and EURON, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Pathol 204:351-4. 2004
    ..The advances in our understanding of the cytoskeleton and its function in disease will lead to new diagnostic and therapeutic applications in the foreseeable future...
  2. doi request reprint Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation
    Ronald B Driesen
    Department of Molecular Cell Biology, School for Cardiovascular Diseases CARIM, University of Maastricht, Maastricht, The Netherlands
    Cardiovasc Pathol 18:19-27. 2009
    ..In the present study, we provide evidence for the specific localization of cardiotin in cardiac mitochondria and for its down-regulation during adaptive remodeling (dedifferentiation) of cardiomyocytes...
  3. ncbi request reprint Structural adaptation in adult rabbit ventricular myocytes: influence of dynamic physical interaction with fibroblasts
    Ronald B Driesen
    Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, Maastricht, The Netherlands
    Cell Biochem Biophys 44:119-28. 2006
    ....
  4. doi request reprint Human papillomavirus multiplex ligation-dependent probe amplification assay for the assessment of viral load, integration, and gain of telomerase-related genes in cervical malignancies
    Wendy Theelen
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht 6200MD, The Netherlands
    Hum Pathol 44:2410-8. 2013
    ..In conclusion, the HPV MLPA assay can be performed on routinely processed cervical lesions for the detection of viral load and HPV integration. ..
  5. ncbi request reprint Structural remodelling of cardiomyocytes in the border zone of infarcted rabbit heart
    Ronald B Driesen
    Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Mol Cell Biochem 302:225-32. 2007
    ..It is suggested that the vacuoles represent plasma membrane invaginations and/or dilatations of T-tubular structures...
  6. doi request reprint Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels
    Paula J Jansen
    Department of Molecular Cell Biology, Research Institute Brain and Behaviour EURON, University of Maastricht, Maastricht, The Netherlands
    J Alzheimers Dis 18:319-29. 2009
    ..This increase is independent of the apoE-isoform, suggesting that the detrimental effect of apoE4 on the pathogenesis of AD is unlikely to be due to an apoE-isoform effect on brain cholesterol homeostasis...
  7. doi request reprint Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies
    Ronald B Driesen
    Department of Molecular Cell Biology, Maastricht University, Maastricht, The Netherlands
    J Cell Mol Med 13:896-908. 2009
    ....
  8. doi request reprint Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions
    Rogier J N T M Litjens
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    J Med Virol 85:1386-93. 2013
    ..However, for the implementation of the MLPA assay into clinical practice, additional HR-HPV types need to be included to increase the sensitivity of the assay, and thereby increase its negative predictive value...
  9. doi request reprint CD44 and OTP are strong prognostic markers for pulmonary carcinoids
    Dorian R A Swarts
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Cancer Res 19:2197-207. 2013
    ....
  10. ncbi request reprint Laminopathies
    Jos L V Broers
    Department of Molecular Cell Biology, Research Institutes CARIM, GROW, and EURON, University of Maastricht, The Netherlands
    J Pathol 204:478-88. 2004
    ..Which of these identities underlies the laminopathies, a myriad of genetic diseases caused by mutations in lamins or lamin-associated proteins, is a topic of intense debate...
  11. doi request reprint Molecular evidence for a clonal relationship between multiple lesions in patients with unknown primary adenocarcinoma
    Ernst Jan M Speel
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    Int J Cancer 123:1292-300. 2008
    ..Thus, other molecular mechanisms must underlie the common biology of these tumors...
  12. ncbi request reprint Bax expression and growth behavior of basal cell carcinomas
    Claudia M L Tilli
    Department of Dermatology, University Hospital Maastricht, The Netherlands
    J Cutan Pathol 29:79-87. 2002
    ..To understand the typical growth behavior of basal cell carcinoma (BCC) we searched for the correlation between proliferation and apoptosis and progression of BCC...
  13. ncbi request reprint Discrimination of DNA and RNA in cells by a vital fluorescent probe: lifetime imaging of SYTO13 in healthy and apoptotic cells
    Marc A M J van Zandvoort
    Department of Biophysics, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Cytometry 47:226-35. 2002
    ..We show that fluorescence lifetime imaging using two-photon excitation of SYTO13 allows differential and simultaneous imaging of DNA and RNA in living cells, as well as sequential and repetitive assessment of staining patterns...
  14. pmc Identification of chromosome 9 alterations and p53 accumulation in isolated carcinoma in situ of the urinary bladder versus carcinoma in situ associated with carcinoma
    Anton H N Hopman
    Department of Molecular Cell Biology, Research Institute of Growth and Development, University of Maastricht, Maastricht, The Netherlands
    Am J Pathol 161:1119-25. 2002
    ....
  15. ncbi request reprint HPV in situ hybridization: impact of different protocols on the detection of integrated HPV
    Anton H N Hopman
    Department of Molecular Cell Biology, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
    Int J Cancer 115:419-28. 2005
    ..001), this pattern was found. This indicates that, when robustly defined, a punctate HPV pattern in CIN II/III lesions is associated with the presence of an invasive carcinoma...
  16. ncbi request reprint Differential effects of Viscum album extract IscadorQu on cell cycle progression and apoptosis in cancer cells
    Marjan Harmsma
    Department of Molecular Cell Biology, Research Institute for Growth and Development GROW, University of Maastricht, The Netherlands
    Int J Oncol 25:1521-9. 2004
    ..Apoptosis was induced by activating the mitochondrial but not the death receptor-dependent pathway...
  17. ncbi request reprint Partial cleavage of A-type lamins concurs with their total disintegration from the nuclear lamina during apoptosis
    Jos L V Broers
    Department of Molecular Cell Biology, Research Institute Growth and Development GROW, University of Maastricht, Maastricht, The Netherlands
    Eur J Cell Biol 81:677-91. 2002
    ....
  18. ncbi request reprint Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities
    Anton H N Hopman
    Department of Molecular Cell Biology, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
    J Pathol 202:23-33. 2004
    ..These data indicate that integration of HPV 16/18 DNA is a pivotal step in the transition of CIN to micro-invasive carcinoma...
  19. ncbi request reprint Reverse structural and gap-junctional remodeling after prolonged atrial fibrillation in the goat
    Jannie Ausma
    Cardiovascular Research Institute Maastricht, The Netherlands
    Circulation 107:2051-8. 2003
    ..Prolonged atrial fibrillation (AF) results in electrical, structural, and gap-junctional remodeling. We examined the reversibility of the changes in (ultra)structure and gap junctions...
  20. ncbi request reprint Keratin 8/18 breakdown and reorganization during apoptosis
    Bert Schutte
    Department of Molecular Cell Biology Box 17, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
    Exp Cell Res 297:11-26. 2004
    ..At later stages of the apoptotic process, that is, when the integrity of the cytoplasmic membrane becomes compromised, keratin aggregates are shed from the cells...
  21. ncbi request reprint Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
    Monique Mulder
    Department of Molecular Cell Biology, Maastricht University and University Hospital Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 16:212-9. 2004
    ..A decrease in the number of presynaptic boutons may underlay these behavioral alterations. Therefore, the LDLR may be an important receptor for apoE in the central nervous system...
  22. doi request reprint An exploration of pathways involved in lung carcinoid progression using gene expression profiling
    Dorian R A Swarts
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
    Carcinogenesis 34:2726-37. 2013
    ..We have identified novel pathways underlying malignant progression and validated several genes as being strong prognostic indicators, some of which could serve as putative therapeutic targets. ..
  23. doi request reprint Molecular biomarkers in cervical cancer diagnosis: a critical appraisal
    Rogier J N T M Litjens
    Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology, Department of Obstetrics and Gynaecology, PO Box 616, 6200MD Maastricht, The Netherlands
    Expert Opin Med Diagn 7:365-77. 2013
    ..As a result, there is an urgent need for additional biomarkers that can detect these lesions and that can at the same time be applied to cytological specimens. This overview evaluates the most promising cytological biomarkers...
  24. doi request reprint Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies
    Winnok H De Vos
    Department of Molecular Cell Biology, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Hum Mol Genet 20:4175-86. 2011
    ..Our data suggest that nuclear rupture and loss of compartmentalization may add to cellular dysfunction and disease development in various laminopathies...
  25. ncbi request reprint Human apolipoprotein C-I expression in mice impairs learning and memory functions
    Karlygash Abildayeva
    Department of Molecular Cell Biology and Department of Basic Neurosciences, European Graduate School of Neuroscience, Institute Brain and Behavior, University of Maastricht, Maastricht, The Netherlands
    J Lipid Res 49:856-69. 2008
    ..In conclusion, human apoC-I expression impairs cognitive functions in mice independent of apoE expression, which supports the potential of a modulatory role for apoC-I during the development of AD...
  26. ncbi request reprint Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies
    Jos L V Broers
    Department of Moecular Cell Biology, Cardiovascular Research Institute Maastricht, University Maastricht, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Hum Mol Genet 13:2567-80. 2004
    ..e. lamins) and the cytoskeleton is causing more general cellular weakness and emphasizes a potential key function for lamins in maintaining cellular tensegrity...
  27. ncbi request reprint 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux
    Karlygash Abildayeva
    Department of Molecular Cell Biology, Institute of Brain and Behavior European Graduate School of Neuroscience, EURON, University of Maastricht, 6200 MD Maastricht, The Netherlands
    J Biol Chem 281:12799-808. 2006
    ..In conclusion, evidence is provided that 24(S)-hydroxycholesterol induces apoE-mediated efflux of cholesterol in astrocytes via an LXR-controlled pathway, which may be relevant for chronic and acute neurological diseases...
  28. doi request reprint Serum markers in small cell lung cancer: Opportunities for improvement
    Marjan Harmsma
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1836:255-72. 2013
    ..Finally, we discuss the possibility that detection of SCLC related autoantibodies in paraneoplastic disease can be used as a very early indicator of SCLC. ..
  29. doi request reprint Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities
    Dorian R A Swarts
    Department of Molecular Cell Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Biochim Biophys Acta 1826:255-71. 2012
    ..This implies the need to reconsider both diagnostic as well as therapeutic approaches for these different groups of malignancies...
  30. doi request reprint A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers
    Wendy Theelen
    Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    Int J Cancer 126:959-75. 2010
    ..Our study demonstrates that within a single MLPA-reaction viral type, load, integration and gain of TERC and TERT can be reliably determined, which will improve risk assessment for patients suspected for HPV infection...
  31. ncbi request reprint Dietary plant sterols accumulate in the brain
    Paula J Jansen
    Department of Molecular Cell Biology Box 17, Research Institute Brain and Behaviour EURON, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1761:445-53. 2006
    ..In conclusion, dietary plant sterols pass the blood-brain barrier and accumulate in the brain, where they may exert brain cell type-specific effects...
  32. ncbi request reprint DEDD association with cytokeratin filaments correlates with sensitivity to apoptosis
    Bert Schutte
    Department of Molecular Cell Biology, Research Institute Growth and Development, GROW, University of Maastricht, P O Box 616, 6200, MD, Maastricht, The Netherlands
    Apoptosis 11:1561-72. 2006
    ..Our data support the notion that DEDD-mediated accumulation of procaspases at the cytokeratin scaffold leads to an increase in the local concentration, which renders cells more apoptosis-prone...
  33. ncbi request reprint Partial cell fusion: a newly recognized type of communication between dedifferentiating cardiomyocytes and fibroblasts
    Ronald B Driesen
    Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Cardiovasc Res 68:37-46. 2005
    ..Our objective was to provide evidence for an additional type of heterocellular communication between fibroblasts and adult cardiomyocytes in vitro and in vivo...
  34. ncbi request reprint Primed in situ nucleic Acid labeling combined with immunocytochemistry to simultaneously localize DNA and proteins in cells and chromosomes
    Ernst J M Speel
    Department of Molecular Cell Biology, University of Maastricht, The Netherlands
    Methods Mol Biol 226:453-64. 2003
  35. ncbi request reprint PCR-based detection of nucleic acids in chromosomes, cells, and tissues: technical considerations on PRINS and in situ PCR and comparison with in situ hybridization
    Ernst J M Speel
    Department of Molecular Cell Biology, University of Maastricht, The Netherlands
    Methods Mol Biol 226:405-24. 2003
  36. pmc Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts
    Vanja Pekovic
    School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, England, UK
    J Cell Biol 176:163-72. 2007
    ..Our results suggest that LAP2alpha and lamin A/C are involved in controlling Rb localization and phosphorylation, and a lack or mislocalization of either protein leads to cell cycle arrest in HDFs...
  37. ncbi request reprint Effects of mistletoe (Viscum album L.) extracts Iscador on cell cycle and survival of tumor cells
    Marjan Harmsma
    MUbio Products B V, Maastricht, The Netherlands
    Arzneimittelforschung 56:474-82. 2006
    ..Iscador Malus also seemed to induce apoptosis via the death receptor route, which may explain the higher sensitivity of cancer and endothelial cells to this preparation...
  38. ncbi request reprint A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8
    Harriet C Hafkamp
    Research Institute GROW, Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Int J Cancer 107:394-400. 2003
    ..Evaluation of clinical data revealed a significant inverse relation between tobacco use with or without alcohol consumption, and HPV positivity of the tumors...
  39. ncbi request reprint 10q25.3 (DMBT1) copy number changes in astrocytoma grades II and IV
    Peter H Wessels
    Research Institute Growth and Development GROW, Maastricht, The Netherlands
    Genes Chromosomes Cancer 39:22-8. 2004
    ..These data indicate that selective loss of the 10q25.3 region, including the DMBT1 gene, is not an initiating event in the genesis of astrocytoma grade II...
  40. ncbi request reprint Gain of chromosome 7, as detected by in situ hybridization, strongly correlates with shorter survival in astrocytoma grade 2
    Peter H Wessels
    Department of Neurology, University Hospital Maastricht, Maastricht, Netherlands
    Genes Chromosomes Cancer 33:279-84. 2002
    ..Hence, as determined by ISH, trisomy/polysomy 7 is absent in non-neoplastic brain tissue and is frequently detected in A2, correlating with the malignant progression of the disease...
  41. ncbi request reprint Dual roles of intermediate filaments in apoptosis
    Normand Marceau
    Centre de recherche en cancérologie de l Université Laval and L Hôtel Dieu de Québec CHUQ, Quebec, Canada G1R 2J6
    Exp Cell Res 313:2265-81. 2007
    ..Clearly, the data accumulated in recent years provide new and significant insights into the multiple functions of IFs, particularly their dual roles in cell response to apoptotic insults...
  42. ncbi request reprint Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature
    Judy R van Beijnum
    Angiogenesis Laboratory, Department of Pathology, University Hospital Maastricht, PO Box 5800, 6202AZ Maastricht, The Netherlands
    Blood 108:2339-48. 2006
    ..Our results demonstrate the usefulness of the identification and subsequent targeting of specific tumor endothelial markers for anticancer therapy...
  43. ncbi request reprint Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation
    Valerie L R M Verstraeten
    Department of Dermatology, University Hospital Maastricht, P Debyelaan 25, 6202 AZ Maastricht, The Netherlands
    Hum Mol Genet 15:2509-22. 2006
    ..In contrast to earlier suggestions, we show that prelamin A accumulation is not the major determinant of the progeroid phenotype...
  44. pmc The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus
    Ewa Markiewicz
    Department of Biological Science, The School of Biological and Biomedical Sciences, The University of Durham, Durham, UK
    EMBO J 25:3275-85. 2006
    ..Our results support recent findings that suggest that INM proteins can influence signalling pathways by restricting access of transcription coactivators to the nucleus...
  45. ncbi request reprint Supratentorial grade II astrocytoma: biological features and clinical course
    Peter H Wessels
    Department of Neurology of the University Hospital of Maastricht, Netherlands
    Lancet Neurol 2:395-403. 2003
    ..Therefore these markers should be included in ongoing and future clinical studies of patients with astrocytoma grade II...