Research Topics
Genomes and Genes | Frans C S RamaekersSummaryAffiliation: Maastricht University Country: The Netherlands Publications
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Publications
The cytoskeleton and diseaseFrans C S Ramaekers
Department of Molecular Cell Biology, Research Institutes CARIM, GROW and EURON, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
J Pathol 204:351-4. 2004..The advances in our understanding of the cytoskeleton and its function in disease will lead to new diagnostic and therapeutic applications in the foreseeable future...
Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiationRonald B Driesen
Department of Molecular Cell Biology, School for Cardiovascular Diseases CARIM, University of Maastricht, Maastricht, The Netherlands
Cardiovasc Pathol 18:19-27. 2009..In the present study, we provide evidence for the specific localization of cardiotin in cardiac mitochondria and for its down-regulation during adaptive remodeling (dedifferentiation) of cardiomyocytes...- Structural adaptation in adult rabbit ventricular myocytes: influence of dynamic physical interaction with fibroblastsRonald B Driesen
Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht (CARIM, University of Maastricht, Maastricht, The Netherlands
Cell Biochem Biophys 44:119-28. 2006.... - Structural remodelling of cardiomyocytes in the border zone of infarcted rabbit heartRonald B Driesen
Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, P O Box 616, 6200 MD, Maastricht, The Netherlands
Mol Cell Biochem 302:225-32. 2007..It is suggested that the vacuoles represent plasma membrane invaginations and/or dilatations of T-tubular structures... - Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levelsPaula J Jansen
Department of Molecular Cell Biology, Research Institute Brain and Behaviour EURON, University of Maastricht, Maastricht, The Netherlands
J Alzheimers Dis 18:319-29. 2009..This increase is independent of the apoE-isoform, suggesting that the detrimental effect of apoE4 on the pathogenesis of AD is unlikely to be due to an apoE-isoform effect on brain cholesterol homeostasis... - Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologiesRonald B Driesen
Department of Molecular Cell Biology, Maastricht University, Maastricht, The Netherlands
J Cell Mol Med 13:896-908. 2009.... - LaminopathiesJos L V Broers
Department of Molecular Cell Biology, Research Institutes CARIM, GROW, and EURON, University of Maastricht, The Netherlands
J Pathol 204:478-88. 2004..Which of these identities underlies the laminopathies, a myriad of genetic diseases caused by mutations in lamins or lamin-associated proteins, is a topic of intense debate... - Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampusMonique Mulder
Department of Molecular Cell Biology, Maastricht University and University Hospital Maastricht, Maastricht, The Netherlands
Neurobiol Dis 16:212-9. 2004..A decrease in the number of presynaptic boutons may underlay these behavioral alterations. Therefore, the LDLR may be an important receptor for apoE in the central nervous system... - Differential effects of Viscum album extract IscadorQu on cell cycle progression and apoptosis in cancer cellsMarjan Harmsma
Department of Molecular Cell Biology, Research Institute for Growth and Development GROW, University of Maastricht, The Netherlands
Int J Oncol 25:1521-9. 2004..Apoptosis was induced by activating the mitochondrial but not the death receptor-dependent pathway... - HPV in situ hybridization: impact of different protocols on the detection of integrated HPVAnton H N Hopman
Department of Molecular Cell Biology, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
Int J Cancer 115:419-28. 2005..001), this pattern was found. This indicates that, when robustly defined, a punctate HPV pattern in CIN II/III lesions is associated with the presence of an invasive carcinoma... - Keratin 8/18 breakdown and reorganization during apoptosisBert Schutte
Department of Molecular Cell Biology Box 17, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
Exp Cell Res 297:11-26. 2004..At later stages of the apoptotic process, that is, when the integrity of the cytoplasmic membrane becomes compromised, keratin aggregates are shed from the cells... - Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalitiesAnton H N Hopman
Department of Molecular Cell Biology, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
J Pathol 202:23-33. 2004..These data indicate that integration of HPV 16/18 DNA is a pivotal step in the transition of CIN to micro-invasive carcinoma... - Molecular evidence for a clonal relationship between multiple lesions in patients with unknown primary adenocarcinomaErnst Jan M Speel
Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
Int J Cancer 123:1292-300. 2008..Thus, other molecular mechanisms must underlie the common biology of these tumors... - Discrimination of DNA and RNA in cells by a vital fluorescent probe: lifetime imaging of SYTO13 in healthy and apoptotic cellsMarc A M J van Zandvoort
Department of Biophysics, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
Cytometry 47:226-35. 2002..We show that fluorescence lifetime imaging using two-photon excitation of SYTO13 allows differential and simultaneous imaging of DNA and RNA in living cells, as well as sequential and repetitive assessment of staining patterns... - Bax expression and growth behavior of basal cell carcinomasClaudia M L Tilli
Department of Dermatology, University Hospital Maastricht, The Netherlands
J Cutan Pathol 29:79-87. 2002..To understand the typical growth behavior of basal cell carcinoma (BCC) we searched for the correlation between proliferation and apoptosis and progression of BCC... 
Identification of chromosome 9 alterations and p53 accumulation in isolated carcinoma in situ of the urinary bladder versus carcinoma in situ associated with carcinomaAnton H N Hopman
Department of Molecular Cell Biology, Research Institute of Growth and Development, University of Maastricht, Maastricht, The Netherlands
Am J Pathol 161:1119-25. 2002....- Partial cleavage of A-type lamins concurs with their total disintegration from the nuclear lamina during apoptosisJos L V Broers
Department of Molecular Cell Biology, Research Institute Growth and Development GROW, University of Maastricht, Maastricht, The Netherlands
Eur J Cell Biol 81:677-91. 2002.... - Reverse structural and gap-junctional remodeling after prolonged atrial fibrillation in the goatJannie Ausma
Cardiovascular Research Institute Maastricht, The Netherlands
Circulation 107:2051-8. 2003..Prolonged atrial fibrillation (AF) results in electrical, structural, and gap-junctional remodeling. We examined the reversibility of the changes in (ultra)structure and gap junctions... - Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathiesWinnok H De Vos
Department of Molecular Cell Biology, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, PO Box 616, NL 6200 MD Maastricht, The Netherlands
Hum Mol Genet 20:4175-86. 2011..Our data suggest that nuclear rupture and loss of compartmentalization may add to cellular dysfunction and disease development in various laminopathies... - Human apolipoprotein C-I expression in mice impairs learning and memory functionsKarlygash Abildayeva
Department of Molecular Cell Biology and Department of Basic Neurosciences, European Graduate School of Neuroscience, Institute Brain and Behavior, University of Maastricht, Maastricht, The Netherlands
J Lipid Res 49:856-69. 2008..In conclusion, human apoC-I expression impairs cognitive functions in mice independent of apoE expression, which supports the potential of a modulatory role for apoC-I during the development of AD... - Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathiesJos L V Broers
Department of Moecular Cell Biology, Cardiovascular Research Institute Maastricht, University Maastricht, PO Box 616, NL 6200 MD Maastricht, The Netherlands
Hum Mol Genet 13:2567-80. 2004..e. lamins) and the cytoskeleton is causing more general cellular weakness and emphasizes a potential key function for lamins in maintaining cellular tensegrity... - 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol effluxKarlygash Abildayeva
Department of Molecular Cell Biology, Institute of Brain and Behavior European Graduate School of Neuroscience, EURON, University of Maastricht, 6200 MD Maastricht, The Netherlands
J Biol Chem 281:12799-808. 2006..In conclusion, evidence is provided that 24(S)-hydroxycholesterol induces apoE-mediated efflux of cholesterol in astrocytes via an LXR-controlled pathway, which may be relevant for chronic and acute neurological diseases... - Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entitiesDorian R A Swarts
Department of Molecular Cell Biology, Maastricht University Medical Center, Maastricht, The Netherlands
Biochim Biophys Acta 1826:255-71. 2012..This implies the need to reconsider both diagnostic as well as therapeutic approaches for these different groups of malignancies... - A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancersWendy Theelen
Department of Molecular Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
Int J Cancer 126:959-75. 2010..Our study demonstrates that within a single MLPA-reaction viral type, load, integration and gain of TERC and TERT can be reliably determined, which will improve risk assessment for patients suspected for HPV infection... - DEDD association with cytokeratin filaments correlates with sensitivity to apoptosisBert Schutte
Department of Molecular Cell Biology, Research Institute Growth and Development, GROW, University of Maastricht, P O Box 616, 6200, MD, Maastricht, The Netherlands
Apoptosis 11:1561-72. 2006..Our data support the notion that DEDD-mediated accumulation of procaspases at the cytokeratin scaffold leads to an increase in the local concentration, which renders cells more apoptosis-prone... - Partial cell fusion: a newly recognized type of communication between dedifferentiating cardiomyocytes and fibroblastsRonald B Driesen
Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht (CARIM, University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Cardiovasc Res 68:37-46. 2005..CONCLUSION: Our results suggest that the partial cell fusion-type of heterocellular communication in our co-culture model and the contacts observed in vivo may lead to new insights in cardiovascular disease... - Dietary plant sterols accumulate in the brainPaula J Jansen
Department of Molecular Cell Biology Box 17, Research Institute Brain and Behaviour EURON, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
Biochim Biophys Acta 1761:445-53. 2006..In conclusion, dietary plant sterols pass the blood-brain barrier and accumulate in the brain, where they may exert brain cell type-specific effects... - Primed in situ nucleic Acid labeling combined with immunocytochemistry to simultaneously localize DNA and proteins in cells and chromosomesErnst J M Speel
Department of Molecular Cell Biology, University of Maastricht, The Netherlands
Methods Mol Biol 226:453-64. 2003 - PCR-based detection of nucleic acids in chromosomes, cells, and tissues: technical considerations on PRINS and in situ PCR and comparison with in situ hybridizationErnst J M Speel
Department of Molecular Cell Biology, University of Maastricht, The Netherlands
Methods Mol Biol 226:405-24. 2003 - Effects of mistletoe (Viscum album L.) extracts Iscador on cell cycle and survival of tumor cellsMarjan Harmsma
MUbio Products B.V, Maastricht, The Netherlands
Arzneimittelforschung 56:474-82. 2006..Iscador Malus also seemed to induce apoptosis via the death receptor route, which may explain the higher sensitivity of cancer and endothelial cells to this preparation... - Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblastsVanja Pekovic
School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, England, UK
J Cell Biol 176:163-72. 2007..Our results suggest that LAP2alpha and lamin A/C are involved in controlling Rb localization and phosphorylation, and a lack or mislocalization of either protein leads to cell cycle arrest in HDFs... - A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8Harriet C Hafkamp
Research Institute GROW, Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands
Int J Cancer 107:394-400. 2003..Evaluation of clinical data revealed a significant inverse relation between tobacco use with or without alcohol consumption, and HPV positivity of the tumors... - Supratentorial grade II astrocytoma: biological features and clinical coursePeter H Wessels
Department of Neurology of the University Hospital of Maastricht, Netherlands
Lancet Neurol 2:395-403. 2003..Therefore these markers should be included in ongoing and future clinical studies of patients with astrocytoma grade II... - 10q25.3 (DMBT1) copy number changes in astrocytoma grades II and IVPeter H Wessels
Research Institute Growth and Development GROW, Maastricht, The Netherlands
Genes Chromosomes Cancer 39:22-8. 2004..These data indicate that selective loss of the 10q25.3 region, including the DMBT1 gene, is not an initiating event in the genesis of astrocytoma grade II... - Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulationValerie L R M Verstraeten
Department of Dermatology, University Hospital Maastricht, P Debyelaan 25, 6202 AZ Maastricht, The Netherlands
Hum Mol Genet 15:2509-22. 2006..In contrast to earlier suggestions, we show that prelamin A accumulation is not the major determinant of the progeroid phenotype... - Dual roles of intermediate filaments in apoptosisNormand Marceau
Centre de recherche en cancérologie de l Université Laval and L Hôtel Dieu de Québec CHUQ, Quebec, Canada G1R 2J6
Exp Cell Res 313:2265-81. 2007..Clearly, the data accumulated in recent years provide new and significant insights into the multiple functions of IFs, particularly their dual roles in cell response to apoptotic insults... - Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculatureJudy R van Beijnum
Angiogenesis Laboratory, Department of Pathology, University Hospital Maastricht, PO Box 5800, 6202AZ Maastricht, The Netherlands
Blood 108:2339-48. 2006..Our results demonstrate the usefulness of the identification and subsequent targeting of specific tumor endothelial markers for anticancer therapy... - The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleusEwa Markiewicz
Department of Biological Science, The School of Biological and Biomedical Sciences, The University of Durham, Durham, UK
EMBO J 25:3275-85. 2006..Our results support recent findings that suggest that INM proteins can influence signalling pathways by restricting access of transcription coactivators to the nucleus... - Gain of chromosome 7, as detected by in situ hybridization, strongly correlates with shorter survival in astrocytoma grade 2Peter H Wessels
Department of Neurology, University Hospital Maastricht, Maastricht, Netherlands
Genes Chromosomes Cancer 33:279-84. 2002..Hence, as determined by ISH, trisomy/polysomy 7 is absent in non-neoplastic brain tissue and is frequently detected in A2, correlating with the malignant progression of the disease...