Harald Moonen

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi CYP1A2 and NAT2 genotype/phenotype relations and urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a human dietary intervention study
    Harald J J Moonen
    Department of Health Risk Analysis and Toxicology, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Food Chem Toxicol 42:869-78. 2004
  2. ncbi The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans
    Harald Moonen
    Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Cancer Lett 229:25-31. 2005
  3. ncbi Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells
    Harald J J Moonen
    Department of Health Risk Analysis and Toxicology, University of Maastricht, Maastricht, The Netherlands
    Biochem Biophys Res Commun 338:1805-10. 2005
  4. ncbi Generation of free radicals and induction of DNA adducts by activation of heterocyclic aromatic amines via different metabolic pathways in vitro
    Harald J J Moonen
    Department of Health Risk Analysis and Toxicology, University of Maastricht, The Netherlands
    Mol Carcinog 35:196-203. 2002
  5. ncbi In vitro investigations into the interaction of beta-carotene with DNA: evidence for the role of carbon-centered free radicals
    Jos C S Kleinjans
    Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Carcinogenesis 25:1249-56. 2004
  6. ncbi Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations
    Liesbeth Geraets
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Biochem Pharmacol 72:902-10. 2006
  7. ncbi Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression
    Liesbeth Geraets
    Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Eur J Pharmacol 573:241-8. 2007
  8. ncbi Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells
    Liesbeth Geraets
    Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Nutr 137:2190-5. 2007
  9. ncbi Telomere length assessment: biomarker of chronic oxidative stress?
    Joyce M J Houben
    Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands
    Free Radic Biol Med 44:235-46. 2008

Detail Information

Publications9

  1. ncbi CYP1A2 and NAT2 genotype/phenotype relations and urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a human dietary intervention study
    Harald J J Moonen
    Department of Health Risk Analysis and Toxicology, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Food Chem Toxicol 42:869-78. 2004
    ....
  2. ncbi The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans
    Harald Moonen
    Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Cancer Lett 229:25-31. 2005
    ..Significant associations were found between the CYP1A2-164A-->C polymorphism (CYP1A2*1F) and the risk of colorectal adenomas, suggesting that the studied polymorphism plays an important role in CRC risk in humans...
  3. ncbi Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells
    Harald J J Moonen
    Department of Health Risk Analysis and Toxicology, University of Maastricht, Maastricht, The Netherlands
    Biochem Biophys Res Commun 338:1805-10. 2005
    ..These findings provide new mechanistic insights into the therapeutic effect of theophylline in oxidative stress-induced lung pathologies...
  4. ncbi Generation of free radicals and induction of DNA adducts by activation of heterocyclic aromatic amines via different metabolic pathways in vitro
    Harald J J Moonen
    Department of Health Risk Analysis and Toxicology, University of Maastricht, The Netherlands
    Mol Carcinog 35:196-203. 2002
    ....
  5. ncbi In vitro investigations into the interaction of beta-carotene with DNA: evidence for the role of carbon-centered free radicals
    Jos C S Kleinjans
    Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Carcinogenesis 25:1249-56. 2004
    ..We could, however, provide evidence of the occurrence of a carbon-centered beta-carotene radical which was found to be able to interact with B[a]P and to intercalate in DNA...
  6. ncbi Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations
    Liesbeth Geraets
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Biochem Pharmacol 72:902-10. 2006
    ..This inhibition could have important implications for nutritional treatment of acute and chronic inflammatory pathologies, like prevention of ischemia-reperfusion injury or vascular complications in diabetes...
  7. ncbi Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression
    Liesbeth Geraets
    Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Eur J Pharmacol 573:241-8. 2007
    ..PARP-1 inhibition could have beneficial effects in such diseases as Chronic Obstructive Pulmonary Disease (COPD) and diabetes, by preservation of cellular NAD(+) levels and attenuating inflammatory conditions...
  8. ncbi Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells
    Liesbeth Geraets
    Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Nutr 137:2190-5. 2007
    ..Furthermore, these results indicate possibilities to use food-derived flavonoids in the treatment of chronic inflammatory diseases...
  9. ncbi Telomere length assessment: biomarker of chronic oxidative stress?
    Joyce M J Houben
    Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands
    Free Radic Biol Med 44:235-46. 2008
    ..In this review several features of telomere length regulation, their relation with oxidative stress, and the potential application of measurement of telomere length as biomarker of chronic oxidative stress, will be discussed...