R P Mensink

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Rationale and design of the TRANSFACT project phase I: a study to assess the effect of the two different dietary sources of trans fatty acids on cardiovascular risk factors in humans
    Jean Michel Chardigny
    INRA Université d Auvergne, Clermont Ferrand, France
    Contemp Clin Trials 27:364-73. 2006
  2. ncbi request reprint Post-genomic opportunities for understanding nutrition: the nutritionist's perspective
    Ronald P Mensink
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Proc Nutr Soc 61:401-4. 2002
  3. pmc Trans fatty acid intakes and food sources in the U.S. population: NHANES 1999-2002
    Penny M Kris-Etherton
    Department of Nutritional Sciences, 319 Chandlee Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    Lipids 47:931-40. 2012
  4. ncbi request reprint Effects of products made from a high-palmitic acid, trans-free semiliquid fat or a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile and on C-reactive protein concentrations in humans
    R P Mensink
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 62:617-24. 2008
  5. ncbi request reprint Effects of stearic acid on plasma lipid and lipoproteins in humans
    Ronald P Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Lipids 40:1201-5. 2005
  6. doi request reprint Diet and nonalcoholic fatty liver disease
    Ronald P Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Curr Opin Lipidol 19:25-9. 2008
  7. ncbi request reprint Metabolic and health effects of isomeric fatty acids
    Ronald P Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Curr Opin Lipidol 16:27-30. 2005
  8. ncbi request reprint Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d
    Ronald P Mensink
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 92:24-33. 2010
  9. ncbi request reprint Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials
    Ronald P Mensink
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 77:1146-55. 2003
  10. ncbi request reprint Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men
    Tine Tholstrup
    Research Department of Human Nutrition and the Center of Advanced Food Research, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 77:1125-32. 2003

Detail Information

Publications98

  1. ncbi request reprint Rationale and design of the TRANSFACT project phase I: a study to assess the effect of the two different dietary sources of trans fatty acids on cardiovascular risk factors in humans
    Jean Michel Chardigny
    INRA Université d Auvergne, Clermont Ferrand, France
    Contemp Clin Trials 27:364-73. 2006
    ..In fact, due to the naturally low level of TFA in milk fat, it is almost impossible to conduct a clinical trial with a limited number of subjects (<200)...
  2. ncbi request reprint Post-genomic opportunities for understanding nutrition: the nutritionist's perspective
    Ronald P Mensink
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Proc Nutr Soc 61:401-4. 2002
    ..These challenging questions can only be tackled through an integrated approach that combines the expertise from various disciplines...
  3. pmc Trans fatty acid intakes and food sources in the U.S. population: NHANES 1999-2002
    Penny M Kris-Etherton
    Department of Nutritional Sciences, 319 Chandlee Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    Lipids 47:931-40. 2012
    ....
  4. ncbi request reprint Effects of products made from a high-palmitic acid, trans-free semiliquid fat or a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile and on C-reactive protein concentrations in humans
    R P Mensink
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 62:617-24. 2008
    ..In general, however, fats were compared with different functional characteristics, which lower the practical applications of the results...
  5. ncbi request reprint Effects of stearic acid on plasma lipid and lipoproteins in humans
    Ronald P Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Lipids 40:1201-5. 2005
    ..Without doubt, the effects of stearic acid are more favorable than those of trans monounsaturated FA...
  6. doi request reprint Diet and nonalcoholic fatty liver disease
    Ronald P Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Curr Opin Lipidol 19:25-9. 2008
    ..The purpose of this review is to summarize recent findings from human studies on dietary effects on hepatic lipid accumulation...
  7. ncbi request reprint Metabolic and health effects of isomeric fatty acids
    Ronald P Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Curr Opin Lipidol 16:27-30. 2005
    ..The purpose of this review is to summarize recent findings from human studies on the metabolic and health effects of these two classes of isomeric fatty acids...
  8. ncbi request reprint Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d
    Ronald P Mensink
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 92:24-33. 2010
    ..It is unclear whether plant stanols lower serum LDL-cholesterol concentrations and cholesterol-standardized fat-soluble antioxidant concentrations dose-dependently when consumption exceeds the recommended daily intakes of 2.0-3.0 g...
  9. ncbi request reprint Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials
    Ronald P Mensink
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 77:1146-55. 2003
    ..Fats, however, also affect HDL cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is LDL cholesterol...
  10. ncbi request reprint Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men
    Tine Tholstrup
    Research Department of Human Nutrition and the Center of Advanced Food Research, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 77:1125-32. 2003
    ..Plasminogen activator inhibitor type 1 (PAI-1) is increased in the presence of hypertriglyceridemia. Free fatty acids (FFAs) in plasma may promote factor VII (FVII) activation...
  11. ncbi request reprint Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations
    Ronald P Mensink
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, Netherlands
    Atherosclerosis 160:205-13. 2002
    ..LDL-cholesterol standardised concentrations of tocopherol increased. The observed decrease in beta-carotene levels, as found in many other studies, appears not to be limited to the LDL fraction...
  12. ncbi request reprint A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations
    R P Mensink
    Department of Human Biology, Maastricht University, Netherlands
    Am J Clin Nutr 69:213-9. 1999
    ..Tocotrienols, lipid-soluble antioxidants with vitamin E activity, have been reported to lower LDL-cholesterol concentrations and platelet aggregation in men, but results are contradictory...
  13. ncbi request reprint Maternal and neonatal plasma antioxidant levels in normal pregnancy, and the relationship with fatty acid unsaturation
    G S Oostenbrug
    Department of Human Biology, Maastricht University, The Netherlands
    Br J Nutr 80:67-73. 1998
    ....
  14. ncbi request reprint Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters
    J Plat
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 54:671-7. 2000
    ..To examine in humans the effects on serum lipids, lipoproteins and fat-soluble antioxidants of a daily consumption of 2.5 g plant stanols, consumed either once per day at lunch or divided over the three meals...
  15. ncbi request reprint Effects of diets enriched with two different plant stanol ester mixtures on plasma ubiquinol-10 and fat-soluble antioxidant concentrations
    J Plat
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Metabolism 50:520-9. 2001
    ..However, for the most lipophylic carotenoids, some of the reduction was also related to the decrease in cholesterol absorption...
  16. ncbi request reprint Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment
    Arienne de Jong
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Br J Nutr 100:937-41. 2008
    ..We conclude that long-term consumption of both plant sterol and stanol esters effectively lowered LDL-cholesterol concentrations in statin users...
  17. ncbi request reprint Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects
    P L L Goyens
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 60:978-84. 2006
    ..To compare the effects of alpha-linolenic acid (ALA, C18:3n-3) to those of eicosapentaenoic acid (EPA, C20:5n-3) plus docosahexaenoic acid (DHA, C22:6n-3) on cardiovascular risk markers in healthy elderly subjects...
  18. ncbi request reprint Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state
    A Jellema
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Invest 34:766-73. 2004
    ..Sustained weight loss, however, is difficult to achieve and more insight into dietary approaches on anti-inflammatory responses in obese subjects is needed. In this respect, fish oil deserves attention...
  19. ncbi request reprint Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment
    A de Jong
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 62:263-73. 2008
    ....
  20. doi request reprint Consumption of oat beta-glucan with or without plant stanols did not influence inflammatory markers in hypercholesterolemic subjects
    Elke Theuwissen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Mol Nutr Food Res 53:370-6. 2009
    ..05) after consumption of PSE. Consumption of beta-glucan with or without PSE did not influence inflammatory parameters in mildly hypercholesterolemic subjects...
  21. ncbi request reprint The dietary alpha-linolenic acid to linoleic acid ratio does not affect the serum lipoprotein profile in humans
    Petra L L Goyens
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    J Nutr 135:2799-804. 2005
    ..044). We conclude that the ALA:LA ratio does not affect the serum lipoprotein profile. Compared with the control and LA diets, ALA lowered LDL cholesterol concentrations, possibly caused by the decrease in small VLDL...
  22. ncbi request reprint Dairy product consumption and the metabolic syndrome
    Leonie E C van Meijl
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Nutr Res Rev 21:148-57. 2008
    ..In conclusion, more research is warranted to better understand the physiological effects and the mechanisms involved of dairy products in the prevention and treatment of the metabolic syndrome...
  23. ncbi request reprint Functional food science and the cardiovascular system
    G Hornstra
    Department of Human Biology, Maastricht University, The Netherlands
    Br J Nutr 80:S113-46. 1998
    ..Finally, dietary supplements containing folate and vitamins B6 and/or B12 should be tested for their potential to reduce cardiovascular risk by lowering the plasma level of homocysteine...
  24. ncbi request reprint Interaction between a common variant of the cholesteryl ester transfer protein gene and the apolipoprotein E polymorphism: effects on plasma lipids and lipoproteins in a cohort of 7-year-old children
    P Rump
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Nutr Metab Cardiovasc Dis 12:317-24. 2002
    ..As both apo E and CETP contribute to the reverse transport of cholesterol to the liver, the effects of variations at the CETP locus may very well interact with the apo E genotype...
  25. ncbi request reprint Changes in serum concentrations of noncholesterol sterols and lipoproteins in healthy subjects do not depend on the ratio of plant sterols to stanols in the diet
    Elke Naumann
    Maastricht University, Department of Human Biology, Maastricht, The Netherlands
    J Nutr 133:2741-7. 2003
    ..Furthermore, both mixtures were equally effective in lowering serum LDL cholesterol concentrations...
  26. ncbi request reprint Beta-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations
    Elke Naumann
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 83:601-5. 2006
    ..beta-Glucan can reduce serum concentrations of total and LDL cholesterol. The mechanism of this action is not clear, however, and it is difficult to predict the cholesterol-lowering effect of a food product enriched with beta-glucan...
  27. doi request reprint Low-fat dairy consumption reduces systolic blood pressure, but does not improve other metabolic risk parameters in overweight and obese subjects
    L E C van Meijl
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Nutr Metab Cardiovasc Dis 21:355-61. 2011
    ..However, evidence from intervention studies is scarce. Our aim was to investigate the effects of daily consumption of low-fat dairy products on metabolic risk parameters in overweight and obese men and women...
  28. ncbi request reprint The metabolism of linoleic acid in healthy subjects after intake of a single dose of (13)C-linoleic acid
    S H Vermunt
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 55:321-6. 2001
    ..To investigate the in vivo oxidation of (13)C18:2n-6 and its conversion into longer-chain polyunsaturates (LCPs) in healthy subjects...
  29. ncbi request reprint Effects of plant sterols and stanols on lipid metabolism and cardiovascular risk
    J Plat
    Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
    Nutr Metab Cardiovasc Dis 11:31-40. 2001
    ..However, post-marketing surveillance for example for functional foods in general is necessary to monitor possible adverse effects and describe consumers and consumption patterns...
  30. ncbi request reprint Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment
    A de Jong
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 60:985-90. 2006
    ..To assess the effects of plant sterol or stanol ester consumption on their incorporation into erythrocytes and their effects on osmotic fragility of red blood cells...
  31. ncbi request reprint Stearic, oleic, and linoleic acids have comparable effects on markers of thrombotic tendency in healthy human subjects
    Myriam A M A Thijssen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, The Netherlands
    J Nutr 135:2805-11. 2005
    ..001) and by 0.35 fL compared with the linoleic acid diet (P < 0.001). In conclusion, our results do not suggest that stearic acid is highly thrombogenic compared with oleic and linoleic acids...
  32. ncbi request reprint Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects
    Elke Theuwissen
    Maastricht University, Department of Human Biology, 6200 MD Maastricht, The Netherlands
    J Nutr 137:583-8. 2007
    ..beta-Glucan muesli effectively lowered serum LDL cholesterol concentrations. The addition of plant stanol esters to beta-glucan-enriched muesli further lowered serum LDL cholesterol, although effects were slightly less than predicted...
  33. ncbi request reprint Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption
    J Plat
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Invest 32:242-50. 2002
    ..Identification of common variations in genes related to dietary responsiveness is therefore an attractive goal to be able to prescribe individually tailored diets for the treatment of dyslipidaemia...
  34. ncbi request reprint Essential fatty acid composition of plasma phospholipids and birth weight: a study in term neonates
    P Rump
    Department of Human Biology and the Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 73:797-806. 2001
    ..Essential fatty acids (EFAs) in umbilical cord blood samples are associated with attained birth weight in premature infants and low-birth-weight neonates...
  35. ncbi request reprint Effects of emulsified policosanols with different chain lengths on cholesterol metabolism in heterozygous LDL receptor-deficient mice
    Stefan P J Dullens
    Department of Human Biology, Nutrition and Toxicology, Maastricht Research Institute, Maastricht University, Maastricht, The Netherlands
    J Lipid Res 49:790-6. 2008
    ..Therefore, we conclude that the evaluated individual policosanols, as well as the natural policosanol mixture, have no potential for reducing coronary heart disease risk through effects on serum lipoprotein concentrations...
  36. ncbi request reprint Oxidized plant sterols in human serum and lipid infusions as measured by combined gas-liquid chromatography-mass spectrometry
    J Plat
    Maastricht University, Department of Human Biology, P O Box 616, 6200 MD, Maastricht, The Netherlands
    J Lipid Res 42:2030-8. 2001
    ..The relevance of these findings therefore deserves further exploration...
  37. ncbi request reprint Dietary trans alpha-linolenic acid from deodorised rapeseed oil and plasma lipids and lipoproteins in healthy men: the TransLinE Study
    S H Vermunt
    Maastricht University, Department of Human Biology, Maastricht, The Netherlands
    Br J Nutr 85:387-92. 2001
    ..In conclusion, trans alpha-linolenic acid may increase plasma LDL-:HDL-cholesterol and total cholesterol:HDL-cholesterol ratios. Whether diet-induced changes in these ratios truly affects the risk for CHD remains to be established...
  38. pmc TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols
    Florence Brüll
    Department of Human Biology, Maastricht University and School for Nutrition, Maastricht, The Netherlands
    J Biol Chem 285:2951-8. 2010
    ..In these cells, no Th1 shift was observed. Our results, therefore, indicate that TLR2 activation is essential to induce a Th1 shift in human PBMCs by plant stanols and plant sterols...
  39. doi request reprint Dietary (1-->3), (1-->4)-beta-D-glucans from oat activate nuclear factor-kappaB in intestinal leukocytes and enterocytes from mice
    Julia J Volman
    Department of Human Biology, Maastricht University Medical Centre, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
    Nutr Res 30:40-8. 2010
    ....
  40. ncbi request reprint Metabolic effects of plant sterols and stanols (Review)
    Arienne de Jong
    Department of Human Biology, University of Maastricht, The Netherlands
    J Nutr Biochem 14:362-9. 2003
    ..In conclusion, plant sterols and stanols effectively reduce serum LDL cholesterol and atherosclerotic risk. In addition potential effects of plant sterols and stanols on other metabolic processes remain to be elucidated...
  41. ncbi request reprint Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids
    J Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Diabetologia 49:2419-26. 2006
    ..We examined whether lipid-induced insulin resistance was associated with downregulation of expression of skeletal muscle genes involved in oxidative metabolism and mitochondrial biogenesis in humans...
  42. pmc Validating nutrient-related gene expression changes from microarrays using RT(2) PCR-arrays
    S Gaj
    Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands
    Genes Nutr 3:153-7. 2008
    ..We conclude that both techniques have their own (dis)advantages and specificities, and for less pronounced changes using both technologies may be useful as complementation rather than validation...
  43. ncbi request reprint Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies
    A Jellema
    Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Diabetologia 46:990-5. 2003
    ..Several case-control studies have examined the association between the Gly972Arg variant in the IRS-1 gene and Type 2 diabetes, but most had limited power and results could therefore be conflicting...
  44. doi request reprint Role of stearoyl-CoA desaturases in obesity and the metabolic syndrome
    H E Popeijus
    Nutrigenomics Consortium, Top Institute Food and Nutrition, Wageningen, The Netherlands
    Int J Obes (Lond) 32:1076-82. 2008
    ..Therefore, more human studies are needed at the molecular as well as at the physiological level to understand the true role of SCD1 during the development of obesity and the MS...
  45. doi request reprint Long-term plant stanol and sterol ester-enriched functional food consumption, serum lutein/zeaxanthin concentration and macular pigment optical density
    Tos T J M Berendschot
    University Eye Clinic Maastricht, PO Box 5800, NL 6202 AZ Maastricht, The Netherlands
    Br J Nutr 101:1607-10. 2009
    ..This shows that the observed reduction in serum carotenoid concentrations during 18 months consumption of these functional foods does not affect MPOD...
  46. doi request reprint A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients
    Jogchum Plat
    Maastricht University, Department of Human Biology, 6200 MD, Maastricht, The Netherlands
    J Nutr 139:1143-9. 2009
    ..Effects on TAG were also present in combination with statin treatment, illustrating an additional benefit of stanol esters in this CHD risk population...
  47. ncbi request reprint PASSCLAIM - Diet-related cardiovascular disease
    Ronald P Mensink
    Maastricht University, Department of Human Biology, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Nutr 42:I6-27. 2003
    ..Therefore, studies to further validate generic predictors for the CVD risk should be initiated...
  48. pmc The PPARgamma agonist rosiglitazone impairs colonic inflammation in mice with experimental colitis
    Julian D Ramakers
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Clin Immunol 27:275-83. 2007
    ..In conclusion, 16 days pretreatment with rosiglitazone impaired DSS-induced colitis in mice...
  49. pmc Arachidonic acid but not eicosapentaenoic acid (EPA) and oleic acid activates NF-kappaB and elevates ICAM-1 expression in Caco-2 cells
    Julian D Ramakers
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Lipids 42:687-98. 2007
    ..Finally, we suggest that the pro-inflammatory effects of ARA versus EPA and OA are not related to PPARgamma activation and/or eicosanoid formation...
  50. ncbi request reprint Effects of plant stanol esters on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase mRNA expression in mononuclear blood cells of healthy men and women
    Jogchum Plat
    Department of Human Biology, Maastricht University, 6200 MD, Maastricht, The Netherlands
    FASEB J 16:258-60. 2002
    ..Nor did it correlate significantly with changes in serum cholesterol-standardized lathosterol concentrations. This suggests that HMG-CoA reductase may be only partly regulated at a transcriptional level...
  51. ncbi request reprint Effects on the human serum lipoprotein profile of beta-glucan, soy protein and isoflavones, plant sterols and stanols, garlic and tocotrienols
    Daniëlle A J M Kerckhoffs
    Department of Human Biology and Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    J Nutr 132:2494-505. 2002
    ..It is not very likely that tocotrienols from palm oil or rice bran oil have favorable effects on the human serum lipoprotein profile...
  52. ncbi request reprint Preferential campesterol incorporation into various tissues in apolipoprotein E*3-Leiden mice consuming plant sterols or stanols
    Jogchum Plat
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Metabolism 57:1241-7. 2008
    ..We conclude that, in apolipoprotein E*3-Leiden mice, campesterol is preferentially incorporated into most tissues over sitosterol, which cannot be deduced from changes in serum concentrations...
  53. ncbi request reprint Weight loss, but not fish oil consumption, improves fasting and postprandial serum lipids, markers of endothelial function, and inflammatory signatures in moderately obese men
    Jogchum Plat
    Maastricht University, Department of Human Biology, 6200 MD Maastricht, The Netherlands
    J Nutr 137:2635-40. 2007
    ..001). This indicates that 1.1 g/d EPA+DHA supplied for 6 wk, in contrast to approximately 10 kg weight loss, does not improve markers of endothelial function and inflammation...
  54. ncbi request reprint Increased intestinal ABCA1 expression contributes to the decrease in cholesterol absorption after plant stanol consumption
    Jogchum Plat
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    FASEB J 16:1248-53. 2002
    ..If our hypothesis is correct, then the LXR pathway may be a target for dietary regulation of intestinal lipid metabolism...
  55. ncbi request reprint The baseline serum lipoprotein profile is related to plant stanol induced changes in serum lipoprotein cholesterol and triacylglycerol concentrations
    Elke Naumann
    Department of Human Biology, Maastricht University, PO Box 616, 6200 Maastricht, The Netherlands
    J Am Coll Nutr 27:117-26. 2008
    ....
  56. ncbi request reprint Food components and immune function
    Jogchum Plat
    Department of Human Biology, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Curr Opin Lipidol 16:31-7. 2005
    ..Enhancing immune function or alternatively dampening inflammatory processes by specific food components has received a lot of interest. The purpose of this review is to summarize recent findings with the emphasis on underlying mechanisms...
  57. doi request reprint Water-soluble dietary fibers and cardiovascular disease
    Elke Theuwissen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Physiol Behav 94:285-92. 2008
    ..Additionally, epidemiological studies suggest that a diet high in water-soluble fiber is inversely associated with the risk of CVD. These findings underlie current dietary recommendations to increase water-soluble fiber intake...
  58. ncbi request reprint Plant stanol and sterol esters in the control of blood cholesterol levels: mechanism and safety aspects
    Jogchum Plat
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Am J Cardiol 96:15D-22D. 2005
    ..Thus, plant stanols/sterols can be considered to be effective and safe cholesterol-lowering functional food ingredients...
  59. ncbi request reprint Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses
    Petra L L Goyens
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    J Lipid Res 46:1474-83. 2005
    ..The limited incorporation of dietary ALA into the hepatic phospholipid pool contributes to the low hepatic conversion of ALA into EPA. A low conversion of ALA-derived EPA into DPA might be an additional obstacle for DHA synthesis...
  60. ncbi request reprint Effects of specific CLA isomers on plasma fatty acid profile and expression of desaturases in humans
    Myriam A M A Thijssen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Lipids 40:137-45. 2005
    ..Effects on desaturation indices were, however, not reflected by changes at the transcriptional level for the various desaturases and elongase enzymes in PBMC...
  61. ncbi request reprint Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers
    Jogchum Plat
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    J Lipid Res 46:68-75. 2005
    ....
  62. ncbi request reprint Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation
    Jogchum Plat
    Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Lipid Res 46:2468-76. 2005
    ..Our findings indicate that the decreased intestinal absorption of cholesterol and carotenoids by plant sterols and stanols is caused by two distinct mechanisms...
  63. ncbi request reprint Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans
    Myriam A Thijssen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 82:510-6. 2005
    ..If so, then substituting these three 18-carbon fatty acids for each other would result in similar effects on the serum lipoprotein profile...
  64. ncbi request reprint Cis-9, trans- 11 and trans-10, cis-12 conjugated linoleic acid (CLA) do not affect the plasma lipoprotein profile in moderately overweight subjects with LDL phenotype B
    Elke Naumann
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Atherosclerosis 188:167-74. 2006
    ..Results of a pilot study suggested that cis-9, trans-11 conjugated linoleic acid (CLA) improved LDL phenotype in moderately overweight subjects with LDL phenotype B...
  65. doi request reprint Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells
    Leonie E C van Meijl
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Mol Nutr Food Res 54:1568-73. 2010
    ..Our results indicate that glutamine, leucine and proline attenuate IL-8 production, probably through inhibition of NF-κB, and that they increase Akt phosphorylation in HepG2 cells...
  66. doi request reprint Effects of low-fat dairy consumption on markers of low-grade systemic inflammation and endothelial function in overweight and obese subjects: an intervention study
    Leonie E C van Meijl
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Nutr 104:1523-7. 2010
    ....
  67. doi request reprint Plant stanol supplementation decreases serum triacylglycerols in subjects with overt hypertriglyceridemia
    Elke Theuwissen
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Lipids 44:1131-40. 2009
    ..Taken together, PSE supplementation not only lowered LDL cholesterol, but also serum TAG concentrations, especially in subjects with overt hypertriglyceridemia...
  68. ncbi request reprint Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome
    Ruth Vrolix
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, Netherlands
    Am J Clin Nutr 92:366-74. 2010
    ..Intervention studies are inconsistent, however, possibly due to differences in macronutrient and fiber compositions of the experimental diets...
  69. ncbi request reprint Cholesterol-lowering effect of beta-glucan from oat bran in mildly hypercholesterolemic subjects may decrease when beta-glucan is incorporated into bread and cookies
    Daniëlle A J M Kerckhoffs
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 78:221-7. 2003
    ..Findings about the effects of beta-glucan on serum lipoproteins are conflicting...
  70. pmc Plant stanol esters lower serum triacylglycerol concentrations via a reduced hepatic VLDL-1 production
    Jogchum Plat
    Department of Human Biology, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Lipids 44:1149-53. 2009
    ..Based on these findings, we hypothesize that the effect of plant stanol esters on serum TAG concentrations origins from a lowered hepatic production of large TAG-rich VLDL-1 particles...
  71. ncbi request reprint Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio
    Petra L L Goyens
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 84:44-53. 2006
    ..Human in vivo data on dietary determinants of alpha-linolenic acid (ALA; 18:3n-3) metabolism are scarce...
  72. ncbi request reprint Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols
    Jogchum Plat
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, 6229 ER, Maastricht, The Netherlands
    J Lipid Res 47:2762-71. 2006
    ....
  73. doi request reprint Variability of the glycemic response to single food products in healthy subjects
    Ruth Vrolix
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
    Contemp Clin Trials 31:5-11. 2010
    ..Many studies on the health effects of the glycemic index (GI) are confounded by differences in the intakes of other macronutrients and fibre. Little data exist about the within- and between-subject variability of the GI...
  74. doi request reprint Consuming functional foods enriched with plant sterol or stanol esters for 85 weeks does not affect neurocognitive functioning or mood in statin-treated hypercholesterolemic individuals
    Olga J G Schiepers
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Nutr 139:1368-73. 2009
    ..5 g/d does not affect neurocognitive functioning or mood in hypercholesterolemic individuals receiving statin treatment...
  75. doi request reprint An arachidonic acid-enriched diet does not result in more colonic inflammation as compared with fish oil- or oleic acid-enriched diets in mice with experimental colitis
    Julian D Ramakers
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Br J Nutr 100:347-54. 2008
    ..Future studies should further elucidate differential effects of fatty acids on colitis development in time...
  76. doi request reprint Effects of long term plant sterol and -stanol consumption on the retinal vasculature: a randomized controlled trial in statin users
    Elton R Kelly
    University Eye Clinic Maastricht, Maastricht, The Netherlands
    Atherosclerosis 214:225-30. 2011
    ..This may constitute an explanation for the suggested effects of plant sterols on vascular function. However, this novel finding needs confirmation and further study...
  77. doi request reprint Prolonged fasting and the effects on biomarkers of inflammation and on adipokines in healthy lean men
    N A van Herpen
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Horm Metab Res 45:378-82. 2013
    ..In healthy young lean men, fasting-induced increases in FFAs leading to insulin resistance do not cause changes in concentrations of the inflammatory cytokines. VEGF concentrations increased and those of chemerin decreased...
  78. doi request reprint Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure?
    Julia J Volman
    Department of Human Biology, Nutrition and Toxicology Institute Maastricht, Maastricht University, NL 6200 MD Maastricht, The Netherlands
    Mol Nutr Food Res 54:268-76. 2010
    ..bisporus activate BMM, without activating enterocytes. These characteristics make A. bisporus an attractive candidate as a nutritional compound to stimulate the immune response in depressed states of immunity...
  79. ncbi request reprint Fecal water from ileostomic patients consuming oat beta-glucan enhances immune responses in enterocytes
    Julian D Ramakers
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Mol Nutr Food Res 51:211-20. 2007
    ....
  80. ncbi request reprint Effects of the individual isomers cis-9,trans-11 vs. trans-10,cis-12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL-phenotype B
    Julian D Ramakers
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Lipids 40:909-18. 2005
    ..Inflammatory signatures in fasting, nonstimulated plasma as determined by an antibody array may indicate enhanced immune function by both CLA isomers...
  81. doi request reprint Effects of alpha-glucans from Agaricus bisporus on ex vivo cytokine production by LPS and PHA-stimulated PBMCs; a placebo-controlled study in slightly hypercholesterolemic subjects
    J J Volman
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Eur J Clin Nutr 64:720-6. 2010
    ..bisporus, consisting 90% of alpha-glucans, induced in vitro tumor necrosis factor (TNF)alpha and nitric oxide production. The purpose of this study was to evaluate the effects of consuming...
  82. ncbi request reprint Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine
    Stefan P J Dullens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Eur J Gastroenterol Hepatol 21:642-9. 2009
    ..Although there is quite some knowledge concerning regulatory effects in the liver, less is known concerning potential agents that could elevate de-novo apoA-I production in the small intestine...
  83. doi request reprint Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women
    F Brouns
    Faculty of Health, Medicine and Life Sciences, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Eur J Clin Nutr 66:591-9. 2012
    ....
  84. ncbi request reprint DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content
    Berber D Roorda
    Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Lipid Res 46:230-6. 2005
    ..14%; P <0.05). Our findings indicate that DGAT1 contributes to the storage of IMCL and that in vivo DNA electroporation is a promising tool to examine the functional consequences of altered gene expression in mature skeletal muscle...
  85. doi request reprint Trans fatty acid-induced NF-kappaB activation does not induce insulin resistance in cultured murine skeletal muscle cells
    Pascal P H Hommelberg
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Lipids 45:285-90. 2010
    ..We therefore conclude that FA-induced NF-kappaB activation is not sufficient for the induction of insulin resistance in skeletal muscle cells...
  86. ncbi request reprint Increasing apoA-I production as a target for CHD risk reduction
    Stefan P J Dullens
    Department of Human Biology, Maastricht University, Universiteitssingel 50, Maastricht, The Netherlands
    Nutr Metab Cardiovasc Dis 17:616-28. 2007
    ..This knowledge may ultimately be applied in developing dietary intervention strategies to elevate apoA-I production and serum HDL-C concentrations and consequently lower CHD risk...
  87. doi request reprint Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent
    Pascal P H Hommelberg
    Maastricht University, Dept of Human Biology, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 296:E114-20. 2009
    ..Collectively, these results demonstrate that SFA-induced NF-kappaB activation coincides with insulin resistance and depends on FA chain length...
  88. ncbi request reprint A fish oil diet does not reverse insulin resistance despite decreased adipose tissue TNF-alpha protein concentration in ApoE-3*Leiden mice
    Martin Muurling
    TNO Prevention and Health, Gaubius Laboratory Leiden, 2301 CE Leiden, The Netherlands
    J Nutr 133:3350-5. 2003
    ..05) in both groups. We conclude that partial replacement of saturated fat by fish oil does not improve preexisting high fat diet-induced insulin resistance, although it lowers TNF-alpha protein levels in WAT...
  89. ncbi request reprint Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance
    Martin Muurling
    Netherlands Organization for Applied Scientific Research Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    J Lipid Res 45:9-16. 2004
    ..We hypothesize that the different hepatic fat accumulation and/or decrease in FA intermediates has a major effect on the insulin sensitivity of the liver...
  90. ncbi request reprint Rosiglitazone improves muscle insulin sensitivity, irrespective of increased triglyceride content, in ob/ob mice
    Martin Muurling
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherland
    Metabolism 52:1078-83. 2003
    ..We conclude that rosiglitazone treatment leads to strong improvement of insulin sensitivity, irrespective of increased muscle TG content, in ob/ob mice...
  91. ncbi request reprint A low-fat diet has a higher potential than energy restriction to improve high-fat diet-induced insulin resistance in mice
    Martin Muurling
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Metabolism 51:695-701. 2002
    ..In summary, our data show that LF diet has a higher potential than ER to improve HF diet-induced insulin resistance, and that there is an association between improvement of insulin resistance and decrease of TG levels...
  92. ncbi request reprint Metabolic risk markers in an overweight and normal weight population with oversampling of carriers of the IRS-1 972Arg-variant
    Annemarie Jellema
    Centre for Nutrition and Health, National Institute for Public Health and the Environment, PO Box 1, 3720 BA, Bilthoven, The Netherlands
    Atherosclerosis 171:75-81. 2003
    ..The impact of this genotype and its modification by overweight may be smaller than suggested previously...
  93. ncbi request reprint Effects of two conjugated linoleic Acid isomers on body fat mass in overweight humans
    Corinne Malpuech-Brugère
    Unité du Métabolisme Protéino Energétique, Université d Auvergne Institut National de la Recherche Agronomique, Centre de Recherche en Nutrition Humaine Auvergne, Clermont Ferrand, France
    Obes Res 12:591-8. 2004
    ..To examine the effects of two different conjugated linoleic acid (CLA) isomers at two different intakes on body composition in overweight humans...
  94. ncbi request reprint Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study
    Jean Michel Chardigny
    Institut National de Recherche Agronomique and Food Science, UMR1019, Clermont Ferrand, France
    Am J Clin Nutr 87:558-66. 2008
    ..Putative differences between the effects of TFAs from industrially produced and natural sources on CVD risk markers were not previously investigated in healthy subjects...
  95. ncbi request reprint Plasma concentrations of plant sterols: physiology and relationship with coronary heart disease
    Yen Ming Chan
    School of Dietetics and Human Nutrition, McGill University, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Nutr Rev 64:385-402. 2006
    ..Since these factors may act as potential confounders, they must be controlled for before more solid conclusions can be reached...
  96. ncbi request reprint Customary use of plant sterol and plant stanol enriched margarine is associated with changes in serum plant sterol and stanol concentrations in humans
    Heidi P Fransen
    National Institute for Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    J Nutr 137:1301-6. 2007
    ..Whether the increased serum sterol concentrations result in adverse side effects needs to be investigated in future postlaunch monitoring studies...
  97. ncbi request reprint Biological effects of oxidized phytosterols: a review of the current knowledge
    Egbert Hovenkamp
    Unilever Food and Health Research Institute, 3130 AC Vlaardingen, The Netherlands
    Prog Lipid Res 47:37-49. 2008
    ..Therefore, the objective of this review is to summarise the current understanding of the biological effects, next to identifying future research needs that will help to clarify the possible impact of oxyphytosterols on human health...
  98. ncbi request reprint The plasminogen activator inhibitor-1 (PAI-1) promoter haplotype is related to PAI-1 plasma concentrations in lean individuals
    Maartje Verschuur
    Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 181:275-84. 2005
    ....