Marco Mensink

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Lifestyle intervention and fatty acid metabolism in glucose-intolerant subjects
    Marco Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Obes Res 13:1354-62. 2005
  2. ncbi request reprint Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis?
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes Obes Metab 9:594-6. 2007
  3. ncbi request reprint Lifestyle intervention according to general recommendations improves glucose tolerance
    Marco Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, The Netherlands
    Obes Res 11:1588-96. 2003
  4. ncbi request reprint Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 31:1302-10. 2007
  5. ncbi request reprint Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance
    M Mensink
    Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Diabetologia 46:1082-9. 2003
  6. ncbi request reprint Study on lifestyle-intervention and impaired glucose tolerance Maastricht (SLIM): design and screening results
    Marco Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, Netherlands
    Diabetes Res Clin Pract 61:49-58. 2003
  7. ncbi request reprint Subscapular skinfold thickness distinguishes between transient and persistent impaired glucose tolerance: Study on Lifestyle-Intervention and Impaired Glucose Tolerance Maastricht (SLIM)
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabet Med 20:552-7. 2003
  8. ncbi request reprint Study on Lifestyle Intervention and Impaired Glucose Tolerance Maastricht (SLIM): preliminary results after one year
    M Mensink
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 27:377-84. 2003
  9. ncbi request reprint Plasma free Fatty Acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes 50:2548-54. 2001
  10. pmc Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance
    Joris Hoeks
    Department of Human Biology, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes 59:2117-25. 2010

Detail Information

Publications28

  1. ncbi request reprint Lifestyle intervention and fatty acid metabolism in glucose-intolerant subjects
    Marco Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Obes Res 13:1354-62. 2005
    ..Because exercise training is known to increase fatty acid (FA) oxidation, we investigated whether a combined diet and physical activity intervention program can improve FA oxidation in subjects with IGT...
  2. ncbi request reprint Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis?
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes Obes Metab 9:594-6. 2007
    ..Here we examined whether intervention programs known to improve insulin sensitivity are paralleled by an increase in skeletal muscle UCP3 protein levels...
  3. ncbi request reprint Lifestyle intervention according to general recommendations improves glucose tolerance
    Marco Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, The Netherlands
    Obes Res 11:1588-96. 2003
    ..We evaluated the impact of a 2-year combined diet and physical activity intervention program on glucose tolerance in Dutch subjects at increased risk for developing diabetes...
  4. ncbi request reprint Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 31:1302-10. 2007
    ....
  5. ncbi request reprint Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance
    M Mensink
    Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Diabetologia 46:1082-9. 2003
    ....
  6. ncbi request reprint Study on lifestyle-intervention and impaired glucose tolerance Maastricht (SLIM): design and screening results
    Marco Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, Netherlands
    Diabetes Res Clin Pract 61:49-58. 2003
    ..SLIM will address this topic in the Dutch population...
  7. ncbi request reprint Subscapular skinfold thickness distinguishes between transient and persistent impaired glucose tolerance: Study on Lifestyle-Intervention and Impaired Glucose Tolerance Maastricht (SLIM)
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabet Med 20:552-7. 2003
    ..To assess whether adding anthropometric measurements to an oral glucose tolerance test (OGTT) can help to distinguish between transient and persistent impaired glucose tolerance (IGT)...
  8. ncbi request reprint Study on Lifestyle Intervention and Impaired Glucose Tolerance Maastricht (SLIM): preliminary results after one year
    M Mensink
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 27:377-84. 2003
    ..The aim of this study is to evaluate the effect of a lifestyle-intervention programme on glucose tolerance in Dutch subjects with impaired glucose tolerance (IGT)...
  9. ncbi request reprint Plasma free Fatty Acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes 50:2548-54. 2001
    ....
  10. pmc Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance
    Joris Hoeks
    Department of Human Biology, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes 59:2117-25. 2010
    ..It is therefore anticipated that skeletal muscle mitochondrial function is maintained to accommodate increased fat oxidation unless factors secondary to insulin resistance exert negative effects on mitochondrial function...
  11. ncbi request reprint Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, P O Box 616, NL 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 91:1520-5. 2006
    ..Recent evidence points toward mitochondrial aberrations as a major contributor to the development of insulin resistance and diabetes, and UCP3 is reduced in diabetes...
  12. doi request reprint Impaired skeletal muscle substrate oxidation in glucose-intolerant men improves after weight loss
    Eva Corpeleijn
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Obesity (Silver Spring) 16:1025-32. 2008
    ....
  13. pmc Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity
    Ruth C R Meex
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes 59:572-9. 2010
    ..We examined whether exercise training could restore mitochondrial function and insulin sensitivity in patients with type 2 diabetes...
  14. doi request reprint Long- and medium-chain fatty acids induce insulin resistance to a similar extent in humans despite marked differences in muscle fat accumulation
    Joris Hoeks
    NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Human Biology, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 97:208-16. 2012
    ..Animal studies revealed that medium-chain fatty acids (MCFA), due to their metabolic characteristics, are not stored in skeletal muscle and may therefore not give rise to potentially hazardous lipid species impeding insulin signaling...
  15. doi request reprint The insulin-sensitizing effect of rosiglitazone in type 2 diabetes mellitus patients does not require improved in vivo muscle mitochondrial function
    Vera B Schrauwen-Hinderling
    Department of Radiology, Maastricht University Hospital, Maastricht, The Netherlands
    J Clin Endocrinol Metab 93:2917-21. 2008
    ..Our objective was to investigate whether improved in vivo mitochondrial function in skeletal muscle and intramyocellular lipids (IMCLs) contribute to the insulin-sensitizing effect of rosiglitazone...
  16. pmc Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients
    Esther Phielix
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Diabetes 57:2943-9. 2008
    ..The nature of this reduction is unknown. Here, we tested the hypothesis that a lower intrinsic mitochondrial respiratory capacity may underlie lower in vivo mitochondrial function observed in diabetic patients...
  17. ncbi request reprint Lifestyle intervention and adipokine levels in subjects at high risk for type 2 diabetes: the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM)
    Eva Corpeleijn
    Human Biology, Nutrition and Toxicology Research Institute, Maastricht, The Netherlands
    Diabetes Care 30:3125-7. 2007
    ....
  18. ncbi request reprint Intramyocellular lipids and insulin sensitivity: does size really matter?
    Matthijs K C Hesselink
    Departments of Movement Sciences, Maastricht University, Nutrition and Toxiology Research Institute Maastricht, The Netherlands
    Obes Res 12:741-2. 2004
  19. ncbi request reprint Human uncoupling protein-3 and obesity: an update
    Matthijs K C Hesselink
    Department of Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    Obes Res 11:1429-43. 2003
    ..Regardless of the origin of the fatty acid anions, this putative function of UCP3 might be of great importance in protecting mitochondria against fatty acid accumulation and may help to maintain muscular fat oxidative capacity...
  20. pmc Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Histochem Cell Biol 129:535-8. 2008
    ..Moreover, ATGL is exclusively expressed in type I (oxidative) muscle fibers, suggesting a pivotal role for ATGL in intramuscular fatty acid handling, lipid storage and breakdown...
  21. doi request reprint Type 2 diabetes mellitus and skeletal muscle metabolic function
    Esther Phielix
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Physiol Behav 94:252-8. 2008
    ....
  22. doi request reprint Impact of 3-year lifestyle intervention on postprandial glucose metabolism: the SLIM study
    C Roumen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabet Med 25:597-605. 2008
    ....
  23. ncbi request reprint Insulin acutely upregulates protein expression of the fatty acid transporter CD36 in human skeletal muscle in vivo
    E Corpeleijn
    From the Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Physiol Pharmacol 59:77-83. 2008
    ..We conclude that also in obese humans the FAT/CD36 protein content in skeletal muscle is dynamically regulated by insulin in vivo on the short term...
  24. ncbi request reprint Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects
    V B Schrauwen-Hinderling
    Department of Radiology, University Hospital Maastricht, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 50:113-20. 2007
    ..As obesity is an independent determinant of IMCL content, we examined mitochondrial function and IMCL content in overweight type 2 diabetes patients and BMI-matched normoglycaemic controls...
  25. ncbi request reprint Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids
    J Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Diabetologia 49:2419-26. 2006
    ..We examined whether lipid-induced insulin resistance was associated with downregulation of expression of skeletal muscle genes involved in oxidative metabolism and mitochondrial biogenesis in humans...
  26. ncbi request reprint Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study
    E Corpeleijn
    Department of Human Biology, The Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetologia 49:2392-401. 2006
    ....
  27. ncbi request reprint Impaired beta-adrenergically mediated lipolysis in skeletal muscle of obese subjects
    E E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, Maastricht, The Netherlands
    Diabetologia 47:1462-8. 2004
    ....
  28. ncbi request reprint Exogenous glucose oxidation during exercise in endurance-trained and untrained subjects
    A E Jeukendrup
    Department of Human Biology, Maastricht University, The Netherlands
    J Appl Physiol 82:835-40. 1997
    ....