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Species | Rene KoopmanSummaryAffiliation: Maastricht University Country: The Netherlands Publications
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Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesisRene Koopman
Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 293:E833-42. 2007..11 +/- 0.01%/h in the PRO, PRO + LCHO, and PRO + HCHO experiments, respectively. In conclusion, coingestion of carbohydrate during recovery does not further stimulate postexercise muscle protein synthesis when ample protein is ingested...- Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean menRene Koopman
Department of Human Biology, Maastricht University, Maastricht, Netherlands
Am J Clin Nutr 84:623-32. 2006..The progressive loss of skeletal muscle mass with aging is attributed to a disruption in the regulation of skeletal muscle protein turnover... - Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly menRene Koopman
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
Br J Nutr 99:571-80. 2008..Co-ingestion of leucine with carbohydrate and protein following physical activity does not further elevate muscle protein fractional synthetic rate in elderly men when ample protein is ingested... - Nutritional interventions to promote post-exercise muscle protein synthesisRene Koopman
Department of Movement Sciences, Maastricht University, Maastricht, The Netherlands
Sports Med 37:895-906. 2007..Exercise interventions combined with specific nutritional modulation provide an effective strategy to counteract or reduce the loss of skeletal muscle mass with aging... - Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibersRene Koopman
Dept of Human Biology, Maastricht Univ, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 290:E1245-52. 2006..We conclude that resistance exercise effectively increases the phosphorylation of S6K1 on Thr421/Ser424, which is not associated with a substantial increase in S6 phosphorylation in a fasted state... - Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy malesRene Koopman
Department of Human Biology, Maastricht University, P O Box 616, 6200, Maastricht, The Netherlands
Eur J Appl Physiol 96:525-34. 2006..We conclude that intramyocellular lipid and glycogen stores are readily used during resistance exercise and this is likely associated with the reported increase in whole-body insulin sensitivity following resistance exercise... - Protein ingestion further augments S6K1 phosphorylation in skeletal muscle following resistance type exercise in malesRene Koopman
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht 6200 MD, The Netherlands
J Nutr 137:1880-6. 2007..45 +/- 0.07, P < 0.01) and remained elevated during recovery (P < 0.05). We conclude that the availability of dietary protein further enhances phosphorylation of S6K1 during recovery from resistance type exercise... - A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy menRene Koopman
Department of Human Biology, Maastricht University, The Netherlands
Eur J Appl Physiol 94:180-7. 2005..05). This study shows that even a single session of resistance exercise improves whole-body insulin sensitivity for up to 24 h in healthy men, which is consistent with earlier observations following endurance exercise tasks... - Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjectsRene Koopman
Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 288:E645-53. 2005..0820 +/- 0.0104%/h). We conclude that coingestion of protein and leucine stimulates muscle protein synthesis and optimizes whole body protein balance compared with the intake of carbohydrate only... - Combined ingestion of protein and carbohydrate improves protein balance during ultra-endurance exerciseRene Koopman
Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, The Netherlands
Am J Physiol Endocrinol Metab 287:E712-20. 2004..Combined ingestion of protein and carbohydrate improves net protein balance at rest as well as during exercise and postexercise recovery... 
Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted stateLuc J C van Loon
Nutrition Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
J Physiol 553:611-25. 2003....- Significant intramyocellular lipid use during prolonged cycling in endurance-trained males as assessed by three different methodologiesTrent Stellingwerff
Department of Movement Science, Maastricht University, Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 292:E1715-23. 2007..In addition, this study shows differences in resting subcellular intramyocellular lipid deposit distribution and in the subsequent net use of these deposits during exercise... - The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetesRalph J Manders
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
J Nutr 138:1079-85. 2008..We conclude that the muscle protein synthetic response to CHO or CHO+PRO ingestion is not substantially impaired in longstanding, type 2 diabetes patients treated with oral blood glucose-lowering medication... - Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humansLuc J C van Loon
Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 289:E482-93. 2005..This study confirms the hypothesis that plasma FFA availability regulates both intramuscular lipid and glycogen use in vivo in humans... 
Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly menRene Koopman
Department of Human Movement Sciences, Maastricht University, Maastricht 6200 MD, The Netherlands
J Nutr 139:1707-13. 2009..27). We conclude that protein digestion and absorption kinetics and the subsequent muscle protein synthetic response following the ingestion of a large bolus of intact CAS are not substantially impaired in healthy, elderly men...- Protein coingestion stimulates muscle protein synthesis during resistance-type exerciseMilou Beelen
Department of Human Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 295:E70-7. 2008..012 and 0.060 +/- 0.004%/h in CHO + PRO vs. CHO treatment, respectively; P < 0.05). We conclude that, even in a fed state, protein coingestion stimulates whole body and muscle protein synthesis rates during resistance-type exercise... - Substrate source use in older, trained males after decades of endurance trainingHanneke Boon
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Med Sci Sports Exerc 39:2160-70. 2007..The purpose of this study was to compare substrate source use in older, long-term exercising, endurance-trained males with sedentary controls... - Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact proteinRene Koopman
Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht, Netherlands
Am J Clin Nutr 90:106-15. 2009..It has been suggested that a protein hydrolysate, as opposed to its intact protein, is more easily digested and absorbed from the gut, which results in greater plasma amino acid availability and a greater muscle protein synthetic response... - Coingestion of carbohydrate and protein hydrolysate stimulates muscle protein synthesis during exercise in young men, with no further increase during subsequent overnight recoveryMilou Beelen
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
J Nutr 138:2198-204. 2008..Ingestion of protein with carbohydrate during and immediately after exercise improves whole-body protein synthesis but does not further augment muscle protein synthesis rates during 9 h of subsequent overnight recovery... - Co-ingestion of a protein hydrolysate and amino acid mixture with carbohydrate improves plasma glucose disposal in patients with type 2 diabetesRalph J F Manders
Departments of Human Biology and Internal Medicine, Maastricht University Hospital, Maastricht, Netherlands
Am J Clin Nutr 82:76-83. 2005..Although insulin secretion after carbohydrate ingestion is severely impaired in patients with type 2 diabetes, amino acid and protein co-ingestion can substantially increase plasma insulin responses... - Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly menSuzanne Verhoeven
Department of Human Movement Sciences, Nutrition and Toxicology Research Institute, Maastricht, Maastricht University, Maastricht, Netherlands
Am J Clin Nutr 89:1468-75. 2009..It has been reported that the blunted muscle protein synthetic response to food intake in the elderly can be normalized by increasing the leucine content of a meal... - The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscleChamindie Punyadeera
Department of Pathology, Research Institute GROW, Maastricht University, Maastricht, The Netherlands
Eur J Endocrinol 152:427-36. 2005..Furthermore, we aimed to detect and locate adiponectin in skeletal muscle tissue... - Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained malesLuc J C van Loon
Department of Human Biology, Nutrition Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 285:E804-11. 2003..Data obtained by quantitative fluorescence microscopy correspond well with MRS results, implying that both are valid methods to quantify IMTG content... - Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in Type 2 diabetic menRalph J Manders
Department of Human Biology, Maastricht University, The Netherlands
J Nutr 136:1294-9. 2006.... - A single session of resistance exercise induces oxidative damage in untrained menSaskia J Rietjens
Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands
Med Sci Sports Exerc 39:2145-51. 2007..The aim of the present study was to investigate the effects of a single session of resistance exercise on antioxidant capacity, oxidative damage, and inflammation... - Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exerciseRene Koopman
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, The Netherlands
Eur J Appl Physiol 111:1871-8. 2011..05), whereby rates of mixed muscle protein were 0.091 ± 0.005%/h. Muscle protein synthesis rates following resistance-type exercise are only marginally higher in type I compared with type II muscle fibres... - Aging, exercise, and muscle protein metabolismRene Koopman
Department of Human Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
J Appl Physiol 106:2040-8. 2009..The latter is needed to define more effective strategies that will maximize the therapeutic benefits of lifestyle intervention in the elderly... - The use of the [1,2-13C]acetate recovery factor in metabolic researchLuc J C van Loon
Nutrition Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Eur J Appl Physiol 89:377-83. 2003..Therefore, theoretical acetate recovery factors taken from previous literature are not generally applicable... - Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderlyLex B Verdijk
Dept of Movement Sciences, Faculty of Health Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 292:E151-7. 2007..The decline in SC content might be an important factor in the etiology of type II muscle fiber atrophy, which accompanies the loss of skeletal muscle with aging... - Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletesLuc J C van Loon
Department of Movement Sciences, Nutrition Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
Am J Physiol Endocrinol Metab 287:E558-65. 2004..Because structural characteristics and intramyocellular distribution of lipid aggregates seem to be similar between groups, we conclude that elevated IMCL deposits are unlikely to be directly responsible for inducing insulin resistance... - Protein hydrolysate/leucine co-ingestion reduces the prevalence of hyperglycemia in type 2 diabetic patientsRalph J F Manders
Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands
Diabetes Care 29:2721-2. 2006