Rene Koopman

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers
    Rene Koopman
    Dept of Human Biology, Maastricht Univ, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 290:E1245-52. 2006
  2. ncbi request reprint Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males
    Rene Koopman
    Department of Human Biology, Maastricht University, P O Box 616, 6200, Maastricht, The Netherlands
    Eur J Appl Physiol 96:525-34. 2006
  3. ncbi request reprint Nutritional interventions to promote post-exercise muscle protein synthesis
    Rene Koopman
    Department of Movement Sciences, Maastricht University, Maastricht, The Netherlands
    Sports Med 37:895-906. 2007
  4. ncbi request reprint Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men
    Rene Koopman
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Br J Nutr 99:571-80. 2008
  5. ncbi request reprint A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men
    Rene Koopman
    Department of Human Biology, Maastricht University, The Netherlands
    Eur J Appl Physiol 94:180-7. 2005
  6. ncbi request reprint Protein ingestion further augments S6K1 phosphorylation in skeletal muscle following resistance type exercise in males
    Rene Koopman
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht 6200 MD, The Netherlands
    J Nutr 137:1880-6. 2007
  7. ncbi request reprint Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects
    Rene Koopman
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 288:E645-53. 2005
  8. ncbi request reprint Combined ingestion of protein and carbohydrate improves protein balance during ultra-endurance exercise
    Rene Koopman
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, The Netherlands
    Am J Physiol Endocrinol Metab 287:E712-20. 2004
  9. ncbi request reprint Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men
    Rene Koopman
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 84:623-32. 2006
  10. ncbi request reprint Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis
    Rene Koopman
    Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 293:E833-42. 2007

Detail Information

Publications31

  1. ncbi request reprint Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers
    Rene Koopman
    Dept of Human Biology, Maastricht Univ, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 290:E1245-52. 2006
    ..We conclude that resistance exercise effectively increases the phosphorylation of S6K1 on Thr421/Ser424, which is not associated with a substantial increase in S6 phosphorylation in a fasted state...
  2. ncbi request reprint Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males
    Rene Koopman
    Department of Human Biology, Maastricht University, P O Box 616, 6200, Maastricht, The Netherlands
    Eur J Appl Physiol 96:525-34. 2006
    ..We conclude that intramyocellular lipid and glycogen stores are readily used during resistance exercise and this is likely associated with the reported increase in whole-body insulin sensitivity following resistance exercise...
  3. ncbi request reprint Nutritional interventions to promote post-exercise muscle protein synthesis
    Rene Koopman
    Department of Movement Sciences, Maastricht University, Maastricht, The Netherlands
    Sports Med 37:895-906. 2007
    ..Exercise interventions combined with specific nutritional modulation provide an effective strategy to counteract or reduce the loss of skeletal muscle mass with aging...
  4. ncbi request reprint Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men
    Rene Koopman
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Br J Nutr 99:571-80. 2008
    ..Co-ingestion of leucine with carbohydrate and protein following physical activity does not further elevate muscle protein fractional synthetic rate in elderly men when ample protein is ingested...
  5. ncbi request reprint A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men
    Rene Koopman
    Department of Human Biology, Maastricht University, The Netherlands
    Eur J Appl Physiol 94:180-7. 2005
    ..05). This study shows that even a single session of resistance exercise improves whole-body insulin sensitivity for up to 24 h in healthy men, which is consistent with earlier observations following endurance exercise tasks...
  6. ncbi request reprint Protein ingestion further augments S6K1 phosphorylation in skeletal muscle following resistance type exercise in males
    Rene Koopman
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht 6200 MD, The Netherlands
    J Nutr 137:1880-6. 2007
    ..45 +/- 0.07, P < 0.01) and remained elevated during recovery (P < 0.05). We conclude that the availability of dietary protein further enhances phosphorylation of S6K1 during recovery from resistance type exercise...
  7. ncbi request reprint Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects
    Rene Koopman
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 288:E645-53. 2005
    ..0820 +/- 0.0104%/h). We conclude that coingestion of protein and leucine stimulates muscle protein synthesis and optimizes whole body protein balance compared with the intake of carbohydrate only...
  8. ncbi request reprint Combined ingestion of protein and carbohydrate improves protein balance during ultra-endurance exercise
    Rene Koopman
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, The Netherlands
    Am J Physiol Endocrinol Metab 287:E712-20. 2004
    ..Combined ingestion of protein and carbohydrate improves net protein balance at rest as well as during exercise and postexercise recovery...
  9. ncbi request reprint Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men
    Rene Koopman
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 84:623-32. 2006
    ..The progressive loss of skeletal muscle mass with aging is attributed to a disruption in the regulation of skeletal muscle protein turnover...
  10. ncbi request reprint Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis
    Rene Koopman
    Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 293:E833-42. 2007
    ..11 +/- 0.01%/h in the PRO, PRO + LCHO, and PRO + HCHO experiments, respectively. In conclusion, coingestion of carbohydrate during recovery does not further stimulate postexercise muscle protein synthesis when ample protein is ingested...
  11. pmc Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted state
    Luc J C van Loon
    Nutrition Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Physiol 553:611-25. 2003
    ....
  12. ncbi request reprint Significant intramyocellular lipid use during prolonged cycling in endurance-trained males as assessed by three different methodologies
    Trent Stellingwerff
    Department of Movement Science, Maastricht University, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 292:E1715-23. 2007
    ..In addition, this study shows differences in resting subcellular intramyocellular lipid deposit distribution and in the subsequent net use of these deposits during exercise...
  13. ncbi request reprint Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans
    Luc J C van Loon
    Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 289:E482-93. 2005
    ..This study confirms the hypothesis that plasma FFA availability regulates both intramuscular lipid and glycogen use in vivo in humans...
  14. ncbi request reprint The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetes
    Ralph J Manders
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Nutr 138:1079-85. 2008
    ..We conclude that the muscle protein synthetic response to CHO or CHO+PRO ingestion is not substantially impaired in longstanding, type 2 diabetes patients treated with oral blood glucose-lowering medication...
  15. doi request reprint Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men
    Rene Koopman
    Department of Human Movement Sciences, Maastricht University, Maastricht 6200 MD, The Netherlands
    J Nutr 139:1707-13. 2009
    ..27). We conclude that protein digestion and absorption kinetics and the subsequent muscle protein synthetic response following the ingestion of a large bolus of intact CAS are not substantially impaired in healthy, elderly men...
  16. doi request reprint Protein coingestion stimulates muscle protein synthesis during resistance-type exercise
    Milou Beelen
    Department of Human Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 295:E70-7. 2008
    ..012 and 0.060 +/- 0.004%/h in CHO + PRO vs. CHO treatment, respectively; P < 0.05). We conclude that, even in a fed state, protein coingestion stimulates whole body and muscle protein synthesis rates during resistance-type exercise...
  17. ncbi request reprint Substrate source use in older, trained males after decades of endurance training
    Hanneke Boon
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Med Sci Sports Exerc 39:2160-70. 2007
    ..The purpose of this study was to compare substrate source use in older, long-term exercising, endurance-trained males with sedentary controls...
  18. doi request reprint Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein
    Rene Koopman
    Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 90:106-15. 2009
    ..It has been suggested that a protein hydrolysate, as opposed to its intact protein, is more easily digested and absorbed from the gut, which results in greater plasma amino acid availability and a greater muscle protein synthetic response...
  19. doi request reprint Coingestion of carbohydrate and protein hydrolysate stimulates muscle protein synthesis during exercise in young men, with no further increase during subsequent overnight recovery
    Milou Beelen
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Nutr 138:2198-204. 2008
    ..Ingestion of protein with carbohydrate during and immediately after exercise improves whole-body protein synthesis but does not further augment muscle protein synthesis rates during 9 h of subsequent overnight recovery...
  20. ncbi request reprint Co-ingestion of a protein hydrolysate and amino acid mixture with carbohydrate improves plasma glucose disposal in patients with type 2 diabetes
    Ralph J F Manders
    Departments of Human Biology and Internal Medicine, Maastricht University Hospital, Maastricht, Netherlands
    Am J Clin Nutr 82:76-83. 2005
    ..Although insulin secretion after carbohydrate ingestion is severely impaired in patients with type 2 diabetes, amino acid and protein co-ingestion can substantially increase plasma insulin responses...
  21. ncbi request reprint Protein hydrolysate/leucine co-ingestion reduces the prevalence of hyperglycemia in type 2 diabetic patients
    Ralph J F Manders
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, Netherlands
    Diabetes Care 29:2721-2. 2006
  22. doi request reprint Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men
    Suzanne Verhoeven
    Department of Human Movement Sciences, Nutrition and Toxicology Research Institute, Maastricht, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 89:1468-75. 2009
    ..It has been reported that the blunted muscle protein synthetic response to food intake in the elderly can be normalized by increasing the leucine content of a meal...
  23. ncbi request reprint The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle
    Chamindie Punyadeera
    Department of Pathology, Research Institute GROW, Maastricht University, Maastricht, The Netherlands
    Eur J Endocrinol 152:427-36. 2005
    ..Furthermore, we aimed to detect and locate adiponectin in skeletal muscle tissue...
  24. ncbi request reprint Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained males
    Luc J C van Loon
    Department of Human Biology, Nutrition Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 285:E804-11. 2003
    ..Data obtained by quantitative fluorescence microscopy correspond well with MRS results, implying that both are valid methods to quantify IMTG content...
  25. ncbi request reprint A single session of resistance exercise induces oxidative damage in untrained men
    Saskia J Rietjens
    Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands
    Med Sci Sports Exerc 39:2145-51. 2007
    ..The aim of the present study was to investigate the effects of a single session of resistance exercise on antioxidant capacity, oxidative damage, and inflammation...
  26. pmc Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exercise
    Rene Koopman
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Eur J Appl Physiol 111:1871-8. 2011
    ..05), whereby rates of mixed muscle protein were 0.091 ± 0.005%/h. Muscle protein synthesis rates following resistance-type exercise are only marginally higher in type I compared with type II muscle fibres...
  27. ncbi request reprint Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in Type 2 diabetic men
    Ralph J Manders
    Department of Human Biology, Maastricht University, The Netherlands
    J Nutr 136:1294-9. 2006
    ....
  28. doi request reprint Aging, exercise, and muscle protein metabolism
    Rene Koopman
    Department of Human Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Appl Physiol (1985) 106:2040-8. 2009
    ..The latter is needed to define more effective strategies that will maximize the therapeutic benefits of lifestyle intervention in the elderly...
  29. ncbi request reprint Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
    Lex B Verdijk
    Dept of Movement Sciences, Faculty of Health Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 292:E151-7. 2007
    ..The decline in SC content might be an important factor in the etiology of type II muscle fiber atrophy, which accompanies the loss of skeletal muscle with aging...
  30. ncbi request reprint The use of the [1,2-13C]acetate recovery factor in metabolic research
    Luc J C van Loon
    Nutrition Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Appl Physiol 89:377-83. 2003
    ..Therefore, theoretical acetate recovery factors taken from previous literature are not generally applicable...
  31. ncbi request reprint Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes
    Luc J C van Loon
    Department of Movement Sciences, Nutrition Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 287:E558-65. 2004
    ..Because structural characteristics and intramyocellular distribution of lipid aggregates seem to be similar between groups, we conclude that elevated IMCL deposits are unlikely to be directly responsible for inducing insulin resistance...