Gunter Kenis

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Evidence that moment-to-moment variation in positive emotions buffer genetic risk for depression: a momentary assessment twin study
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Acta Psychiatr Scand 115:451-7. 2007
  2. ncbi request reprint Influence of antidepressants on intracellular levels of cyclic adenosine monophosphate in human peripheral blood mononuclear cells
    Gunter Kenis
    Department of Psychiatry and Neuropsychology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur Neuropsychopharmacol 13:53-6. 2003
  3. ncbi request reprint Stability of interleukin 6, soluble interleukin 6 receptor, interleukin 10 and CC16 in human serum
    Gunter Kenis
    Department of Psychiatry and Neuropsychology, University of Maastricht, Pb616, 6200MD Maastricht, The Netherlands
    Cytokine 19:228-35. 2002
  4. ncbi request reprint Effects of antidepressants on the production of cytokines
    Gunter Kenis
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Int J Neuropsychopharmacol 5:401-12. 2002
  5. doi request reprint Susceptibility to depression expressed as alterations in cortisol day curve: a cross-twin, cross-trait study
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdalseweg 1, Concorde Building, Maastricht, Netherlands
    Psychosom Med 70:314-8. 2008
  6. ncbi request reprint The psychology of psychiatric genetics: evidence that positive emotions in females moderate genetic sensitivity to social stress associated with the BDNF Val-sup-6-sup-6Met polymorphism
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    J Abnorm Psychol 117:699-704. 2008
  7. doi request reprint Transition from stress sensitivity to a depressive state: longitudinal twin study
    Marieke Wichers
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Vijverdalseweg 1, Concorde Building, Maastricht, The Netherlands
    Br J Psychiatry 195:498-503. 2009
  8. pmc Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction
    Leonidas Chouliaras
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neurobiol Aging 33:1672-81. 2012
  9. ncbi request reprint The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 33:3030-6. 2008
  10. ncbi request reprint Genetic risk of depression and stress-induced negative affect in daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdalseweg 1, Concorde Building, Maastricht, The Netherlands
    Br J Psychiatry 191:218-23. 2007

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Evidence that moment-to-moment variation in positive emotions buffer genetic risk for depression: a momentary assessment twin study
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Acta Psychiatr Scand 115:451-7. 2007
    ..It was investigated whether positive affect (PA) buffers negative affect (NA) reactivity in response to stress and whether PA moderates the genetic predisposition to negative affect reactivity...
  2. ncbi request reprint Influence of antidepressants on intracellular levels of cyclic adenosine monophosphate in human peripheral blood mononuclear cells
    Gunter Kenis
    Department of Psychiatry and Neuropsychology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur Neuropsychopharmacol 13:53-6. 2003
    ..However, pre-incubation with imipramine or paroxetine, did not influence this increase. These data do not support the hypothesis that cAMP may be related to the in vitro anti-inflammatory effects of antidepressants...
  3. ncbi request reprint Stability of interleukin 6, soluble interleukin 6 receptor, interleukin 10 and CC16 in human serum
    Gunter Kenis
    Department of Psychiatry and Neuropsychology, University of Maastricht, Pb616, 6200MD Maastricht, The Netherlands
    Cytokine 19:228-35. 2002
    ..We conclude that serum samples for the determination of IL-6, sIL-6R and CC16 can be stored at -20 degrees C for several years, but for IL-10 determinations, storage at -70 degrees C is recommended...
  4. ncbi request reprint Effects of antidepressants on the production of cytokines
    Gunter Kenis
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Int J Neuropsychopharmacol 5:401-12. 2002
    ..It is clear, however, that more research is warranted and we strongly argue the need for higher standardization in the methodology used to examine the cytokine network in depressed patients...
  5. doi request reprint Susceptibility to depression expressed as alterations in cortisol day curve: a cross-twin, cross-trait study
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdalseweg 1, Concorde Building, Maastricht, Netherlands
    Psychosom Med 70:314-8. 2008
    ..Alteration of diurnal secretion of cortisol is a possible endophenotype of depression, as depressed patients show alterations in cortisol dynamics over the day...
  6. ncbi request reprint The psychology of psychiatric genetics: evidence that positive emotions in females moderate genetic sensitivity to social stress associated with the BDNF Val-sup-6-sup-6Met polymorphism
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    J Abnorm Psychol 117:699-704. 2008
    ..Interdisciplinary research in psychology and psychiatric genetics may lead to the improvement of treatment choices in stress-related disorders...
  7. doi request reprint Transition from stress sensitivity to a depressive state: longitudinal twin study
    Marieke Wichers
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Vijverdalseweg 1, Concorde Building, Maastricht, The Netherlands
    Br J Psychiatry 195:498-503. 2009
    ..Daily-life stress sensitivity is associated with depression, but prospective data are lacking...
  8. pmc Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction
    Leonidas Chouliaras
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neurobiol Aging 33:1672-81. 2012
    ..These findings suggest a crucial role for DNA methylation in hippocampal aging and in the mediation of the beneficial effects of CR on aging...
  9. ncbi request reprint The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 33:3030-6. 2008
    ..Genetic moderation of ecological measures of reward experience is hypothesized to be of major relevance to the development of various behavioral disorders, including depression and addiction...
  10. ncbi request reprint Genetic risk of depression and stress-induced negative affect in daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Vijverdalseweg 1, Concorde Building, Maastricht, The Netherlands
    Br J Psychiatry 191:218-23. 2007
    ..A bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess...
  11. doi request reprint Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor?
    Gunter Kenis
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Int J Neuropsychopharmacol 14:247-53. 2011
    ..These findings suggest that the effect of IFN-α-induced immune activation on depression may be explained in part by alterations in neuroprotective capacity, reflected by decreases in serum BDNF following IFN-α treatment...
  12. pmc Histone deacetylase 2 in the mouse hippocampus: attenuation of age-related increase by caloric restriction
    Leonidas Chouliaras
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, PO BOX 616 VIJV, 6200 MD Maastricht, The Netherlands
    Curr Alzheimer Res 10:868-76. 2013
    ....
  13. pmc Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
    Leonidas Chouliaras
    School for Mental Health and NeuroScience MHeNS, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Neurobiol Aging 34:2091-9. 2013
    ....
  14. doi request reprint REVIEW: Genome-wide findings in schizophrenia and the role of gene-environment interplay
    Ruud van Winkel
    Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, The Netherlands
    CNS Neurosci Ther 16:e185-92. 2010
    ..Collaborative efforts that bring together expertise in statistics, genetics, epidemiology, experimental psychiatry, brain imaging, and clinical psychiatry will be required to succeed in this challenging task...
  15. ncbi request reprint Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: replication and extension of a gene-environment interaction
    Mark van Winkel
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO BOX 616 DRT 10, Maastricht 6200 MD, The Netherlands Riagg Maastricht, Parallelweg 45 47, 6221 BD, Maastricht, The Netherlands Electronic address
    Eur Neuropsychopharmacol 24:930-8. 2014
    ..Further, it shows that the generation of positive affect (PA) can buffer social stress sensitivity and partially undo the genetic susceptibility. ..
  16. ncbi request reprint Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, The Netherlands
    J Psychosom Res 62:207-14. 2007
    ..Therefore, the induction of depressive symptoms by interferon-alpha (IFN-alpha) may be mediated by changes in the cytokine network and the HPA axis...
  17. pmc Epigenetic genes and emotional reactivity to daily life events: a multi-step gene-environment interaction study
    Ehsan Pishva
    School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 9:e100935. 2014
    ..These data provide the first evidence that emotional responses to daily life stressors may be moderated by genetic variation in the genes involved in the epigenetic machinery. ..
  18. pmc Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction
    Leonidas Chouliaras
    School for Mental Health and NeuroScience MHeNS, Department of Psychiatry and Psychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Curr Alzheimer Res 9:536-44. 2012
    ..These findings indicate that the aging process in mice is connected with changes in epigenetic machinery in the hippocampus and suggest that CR acts by influencing epigenetic regulation...
  19. doi request reprint Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
    Odette L J Peerbooms
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University, Maastricht, The Netherlands
    Brain Behav Immun 25:1530-43. 2011
    ..This study provides evidence for shared genetic vulnerability for SZ, BPD and UDD mediated by MTHFR 677TT genotype, which is in line with epigenetic involvement in the pathophysiology of these psychiatric disorders...
  20. doi request reprint Genetic moderation of CO2-induced fear by 5-HTTLPR genotype
    Koen Schruers
    Academic Anxiety Center, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 25:37-42. 2011
    ..These results are in line with current theories on the role of 5-HT in both panic and respiration...
  21. doi request reprint The environment and schizophrenia
    Jim Van Os
    European Graduate School for Neuroscience, SEARCH, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
    Nature 468:203-12. 2010
    ..Longitudinal research is needed to uncover gene-environment interplay that determines how expression of vulnerability in the general population may give rise to more severe psychopathology...
  22. pmc Depressive symptoms in Crohn's disease: relationship with immune activation and tryptophan availability
    Sinan Guloksuz
    Department of Psychiatry and Psychology, Maastricht University Medical Centre, EURON, Maastricht, The Netherlands
    PLoS ONE 8:e60435. 2013
    ..Anti-TNF-α treatment in CD reduces depressive symptoms, in part independently of disease activity; there was no evidence that this effect was mediated by immune-induced changes in TRP availability...
  23. ncbi request reprint The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:120-3. 2008
    ..Higher order interaction effects involving BDNF Val(66)Met, 5-HTTLPR and childhood adversity may contribute to the etiology of depressive illness...
  24. doi request reprint Acute tryptophan depletion in C57BL/6 mice does not induce central serotonin reduction or affective behavioural changes
    Eva L Van Donkelaar
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neurochem Int 56:21-34. 2010
    ..Although in healthy mice no clear central serotonin or functional effects were observed, further research is indicated using mice with pre-existing serotonin dysfunction, as they might be more vulnerable to acute tryptophan depletion...
  25. doi request reprint Epigenetic regulation in the pathophysiology of Alzheimer's disease
    Leonidas Chouliaras
    School for Mental Health and NeuroScience MHeNS, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience EURON, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Prog Neurobiol 90:498-510. 2010
    ..Research on earlier stages of the disease could provide more insight into its underlying pathophysiology, possibly contributing to the establishment of early diagnosis and the development of more effective treatment strategies...
  26. pmc Brain-derived neurotrophic factor/FK506-binding protein 5 genotype by childhood trauma interactions do not impact on hippocampal volume and cognitive performance
    Dennis Hernaus
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands
    PLoS ONE 9:e92722. 2014
    ..The importance of appropriate statistical designs and inclusion of relevant covariates should be carefully considered. ..
  27. pmc Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex
    Jos Prickaerts
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    J Mol Neurosci 48:167-75. 2012
    ....
  28. ncbi request reprint Baseline immune activation as a risk factor for the onset of depression during interferon-alpha treatment
    Marieke C Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Biol Psychiatry 60:77-9. 2006
    ..This study prospectively investigated the hypothesis that baseline level of immune activation predicts the development of depression during interferon-alpha (IFN-alpha) treatment...
  29. ncbi request reprint Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines
    Rebecca Kuepper
    Department of Psychiatry and Psychology, EURON, Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands
    Schizophr Res 121:107-17. 2010
    ....
  30. doi request reprint Evidence for an association between tumor necrosis factor-alpha levels and lithium response
    Sinan Guloksuz
    Department of Psychiatry and Psychology, Maastricht University Medical Centre, EURON, Maastricht, The Netherlands
    J Affect Disord 143:148-52. 2012
    ..Tumor necrosis factor-alpha (TNF-α) modulation may represent a pathogenic molecular target and a biomarker for staging bipolar disorder. In this context, the possible association between lithium response and TNF-α level was examined...
  31. ncbi request reprint Maternal stress-induced reduction in birth weight as a marker for adult affective state
    Daniel L A van den Hove
    Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience, Universiteitssingel 50, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Front Biosci (Elite Ed) 2:43-6. 2010
    ..Female birth weight did not correlate to any of the studied outcome measures. These data suggest that male birth weight may represent a valuable indicative marker for variations in adult affective state with a developmental origin...
  32. pmc The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status
    Helen Vossen
    Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 5:e13641. 2010
    ..In order to obtain experimental confirmation and extension of findings, cortical processing of experimentally-induced pain was used...
  33. ncbi request reprint The epigenome and postnatal environmental influences in psychotic disorders
    Ehsan Pishva
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 49:337-48. 2014
    ....
  34. doi request reprint TrkB inhibition as a therapeutic target for CNS-related disorders
    Fabien Boulle
    Department of Psychiatry and Neuropsychology, Maastricht University, European Graduate School for Neuroscience EURON, Maastricht, The Netherlands
    Prog Neurobiol 98:197-206. 2012
    ..As such, the use of crystallography and in silico approaches to model BDNF-TrkB interaction and to generate relevant pharmacophores represent powerful tools to develop novel compounds targeting the TrkB receptor...
  35. ncbi request reprint The negative immunoregulatory effects of serotonin (5-HT) moduline, an endogenous 5-HT1B receptor antagonist with anti-anxiety properties
    Michael Maes
    Department of Psychiatry, University Hospital of Maastricht, Maastricht, The Netherlands
    Cytokine 19:308-11. 2002
    ..Leukocytes have functional 5-HT1B receptors. 5-HT moduline, an endogenous 5-HT1B receptor antagonist, may antagonize the 5-HT1B agonist-induced proliferation of immune cells...
  36. ncbi request reprint Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression
    Nele Jacobs
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, 6200 MD Maastricht, The Netherlands
    Arch Gen Psychiatry 63:989-96. 2006
    ....
  37. ncbi request reprint Stimulatory effect of antidepressants on the production of IL-6
    Marta Kubera
    Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Int Immunopharmacol 4:185-92. 2004
    ..We speculate that the therapeutic activity of these antidepressants is at least partly connected with their effect on the cytokine network and IL-6 production...
  38. ncbi request reprint Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6
    Marta Kubera
    Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Psychiatry Res 134:251-8. 2005
    ....
  39. ncbi request reprint Activation of the inflammatory response system in autism
    Jan Croonenberghs
    University Center of Child and Adolescent Psychiatry, Antwerp, Belgium
    Neuropsychobiology 45:1-6. 2002
    ..The main aim of the present study was to examine whether autism is accompanied by an activation of the IRS...
  40. ncbi request reprint The negative immunoregulatory effects of fluoxetine in relation to the cAMP-dependent PKA pathway
    Michael Maes
    Department of Psychiatry, University Hospital of Maastricht, Vijverdal P O Box 88, 6200 AB Maastricht, The Netherlands
    Int Immunopharmacol 5:609-18. 2005
    ....
  41. ncbi request reprint In humans, corticotropin releasing hormone antagonizes some of the negative immunoregulatory effects of serotonin
    Michael Maes
    Clinical Research Center for Mental Health, Limburg, Belgium
    Neuro Endocrinol Lett 24:420-4. 2003
    ....
  42. ncbi request reprint Inflammatory markers in depressed post-myocardial infarction patients
    Annique Schins
    Department of Psychiatry, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Psychiatr Res 39:137-44. 2005
    ..It was the aim of this study to test the hypothesis that depression in post-MI patients is associated with increased inflammation as compared to non-depressed post-MI patients...
  43. ncbi request reprint Increased serum interleukin-8 and interleukin-10 in schizophrenic patients resistant to treatment with neuroleptics and the stimulatory effects of clozapine on serum leukemia inhibitory factor receptor
    Michael Maes
    IRCCS, Istituto, Fatebenefratelli, Brescia
    Schizophr Res 54:281-91. 2002
    ....