J W E Jocken
Affiliation: Maastricht University
Country: The Netherlands
Jocken J, Smit E, Goossens G, Essers Y, van Baak M, Mensink M, et al
. Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific. Histochem Cell Biol. 2008;129:535-8 pubmed publisher
..Moreover, ATGL is exclusively expressed in type I (oxidative) muscle fibers, suggesting a pivotal role for ATGL in intramuscular fatty acid handling, lipid storage and breakdown. ..
Jocken J, Moro C, Goossens G, Hansen D, Mairal A, Hesselink M, et al
. Skeletal muscle lipase content and activity in obesity and type 2 diabetes. J Clin Endocrinol Metab. 2010;95:5449-53 pubmed publisher
..017). TAG content did not differ between groups (84.7±18.9 vs. 70.4±12.4 ?mol/mg dry weight; P=0.543). Our data do not support an important role of total muscle DAG content in the development of insulin resistance in obese men. ..
Jocken J, Langin D, Smit E, Saris W, Valle C, Hul G, et al
. Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state. J Clin Endocrinol Metab. 2007;92:2292-9 pubmed
..Data on weight reduction indicated that also other factors (e.g. leptin) relate to ATGL and HSL protein expression. ..
Jocken J, Roepstorff C, Goossens G, van der Baan P, van Baak M, Saris W, et al
. Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation. Diabetes. 2008;57:1834-41 pubmed publisher
..Obesity is accompanied by impaired fasting glycerol release, lower HSL protein expression, and serine phosphorylation. It remains to be determined whether this is a primary factor or an adaptation to the obese insulin-resistant state. ..
Jocken J, Blaak E, Schiffelers S, Arner P, van Baak M, Saris W. Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation. Int J Obes (Lond). 2007;31:813-9 pubmed
Jocken J, Blaak E, van der Kallen C, van Baak M, Saris W. Blunted beta-adrenoceptor-mediated fat oxidation in overweight subjects: a role for the hormone-sensitive lipase gene. Metabolism. 2008;57:326-32 pubmed publisher
..In conclusion, our results suggest that variation in i7 and i6 of the HSL gene might be associated with a physiological effect on in vivo beta-adrenoceptor-mediated fat oxidation, at least in overweight-obese female subjects. ..