Research Topics
Genomes and Genes | J W M HeemskerkSummaryAffiliation: Maastricht University Country: The Netherlands Publications
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Publications
The Ca2+-mobilizing potency of alpha-thrombin and thrombin-receptor-activating peptide on human platelets -- concentration and time effects of thrombin-induced Ca2+ signalingJ W Heemskerk
Department of Biochemistry, Maastricht University, The Netherlands
Eur J Biochem 249:547-55. 1997..Thus, the high and prolonged Ca2+ signal induced by alpha-thrombin is due to continuous receptor cleavage without desensitizing effects of previously cleaved receptors...- Platelet activation and blood coagulationJohan W M Heemskerk
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
Thromb Haemost 88:186-93. 2002..In addition, platelets can support the initiation phase of coagulation by providing binding sites for prothrombin and factor XI. They thereby take over the initiating role of tissue factor and factor VIIa in coagulation activation... - Control of platelet activation by cyclic AMP turnover and cyclic nucleotide phosphodiesterase type-3Marion A H Feijge
Department of Biochemistry, University of Maastricht, P O Box 616, Maastricht, MD 6200, The Netherlands
Biochem Pharmacol 67:1559-67. 2004..This crucial role of PDE3, but not of PDE5, extends to all major processes in thrombus formation: assembly of platelets into aggregates, secretion of autocrine products, and procoagulant activity... 
Ragged spiking of free calcium in ADP-stimulated human platelets: regulation of puff-like calcium signals in vitro and ex vivoJ W Heemskerk
Department of Biochemistry, Maastricht University, The Netherlands
J Physiol 535:625-35. 2001..This platelet signal appears to be similar in an environment of non-physiological buffer medium and in flowing, whole blood...- Receptors and signalling mechanisms in the procoagulant response of plateletsJ W Heemskerk
Department of Biochemistry and Human Biology, University of Maastricht, The Netherlands
Platelets 11:301-6. 2000..Thus, platelets express high coagulation-promoting activity only after interacting with multiple receptors... - Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response of single, collagen-adherent plateletsJ W Heemskerk
Department of Biochemistry, University of Maastricht, The Netherlands
Thromb Haemost 81:782-92. 1999..Influx of Ca2+ is required for this response, and adhesion via integrin alpha2beta1 serves to potentiate the signaling effects of GpVI... 
Multiple ways to switch platelet integrins on and offJ M E M Cosemans
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
J Thromb Haemost 6:1253-61. 2008..Back-shifting of activated integrins towards their resting state may be a novel goal of antithrombotic medication...- Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoproteinR Nergiz-Unal
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
J Thromb Haemost 9:1835-46. 2011..Platelets abundantly express glycoprotein CD36 with thrombospondin-1 (TSP1) and oxidized low-density lipoprotein (oxLDL) as proposed ligands. How these agents promote platelet activation is still poorly understood... - Collagen-mimetic peptides mediate flow-dependent thrombus formation by high- or low-affinity binding of integrin alpha2beta1 and glycoprotein VII C A Munnix
Department of Biochemistry, CARIM, University of Maastricht, Maastricht, The Netherlands
J Thromb Haemost 6:2132-42. 2008.... - Perioperative dilutional coagulopathy treated with fresh frozen plasma and fibrinogen concentrate: a prospective randomized intervention trialM D Lancé
Department of Anesthesiology, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands
Vox Sang 103:25-34. 2012..This was tested in a controlled clinical intervention trial with patients experiencing massive bleeding during major surgery... - von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent plateletsJ J Briedé
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
J Thromb Haemost 1:559-65. 2003..6 micro mol L(-1). Taken together, these results demonstrate that thrombin-induced exposure of PS and high calcium response on fibrin-adherent platelets depends on shear- or botrocetin-induced VWF-platelet interaction... - Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgeryS E M Schols
Department of Biochemistry CARIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Thromb Haemost 103:318-28. 2010..In conclusion, the ability of thrombin generation and fibrin clot formation is independently reduced in acquired dilutional coagulopathy, while minimal levels of both are required for adequate haemostasis... - Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital modelM J E Kuijpers
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
J Thromb Haemost 7:152-61. 2009..Atherothrombosis is a major cause of cardiovascular events. However, animal models to study this process are scarce... - CD36 as a multiple-ligand signaling receptor in atherothrombosisR Nergiz-Unal
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
Cardiovasc Hematol Agents Med Chem 9:42-55. 2011..The new insights make CD36 attractive as a therapeutic target to suppress platelet and monocyte/macrophage function and thereby atherothrombosis... - Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilizationJ M E M Cosemans
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht, The Netherlands
J Thromb Haemost 8:1797-808. 2010..Interaction of murine Gas6 with the platelet Gas6 receptors Tyro3, Axl and Mer (TAM) plays an important role in arterial thrombus formation. However, a role for Gas6 in human platelet activation has been questioned... - Classification of venous thromboembolism (VTE). Platelets in venous thrombosisP E J Meijden
Department of Biochemistry, CARIM, University of Maastricht and University Hospital Maastricht, Maastricht, The Netherlands
J Thromb Haemost 3:2575-7. 2005 - Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y₁₂ antagonist ticagrelorMarijke J E Kuijpers
Dept of Biochemistry, CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Thromb Haemost 106:1179-88. 2011..This difference is masked by conventional platelet aggregation methods, but is revealed by thrombus formation measurement under flow. Juvenile platelets formed at later time points after clopidogrel treatment promoted thrombus formation... - Platelet-based coagulation: different populations, different functionsJ W M Heemskerk
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
J Thromb Haemost 11:2-16. 2013..Furthermore, we discuss the ligands, platelet receptors and downstream intracellular signaling pathways implicated in these coagulant functions. These insights lead to an adapted model of platelet-based coagulation... - Cyclic AMP raises intracellular Ca(2+) in human megakaryocytes independent of protein kinase AEls den Dekker
Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht, The Netherlands
Arterioscler Thromb Vasc Biol 22:179-86. 2002..These findings reveal a novel mechanism for elevating cytosolic Ca(2+) by cAMP, possibly via GTP-Rap1... - Role of murine integrin alpha2beta1 in thrombus stabilization and embolization: contribution of thromboxane A2Marijke J E Kuijpers
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
Thromb Haemost 98:1072-80. 2007..The increased embolization in alpha2-null mice may argue against the use of alpha2beta1 integrin inhibitors for antithrombotic therapy... - Fish oil consumption and reduction of arterial diseaseKristof Vanschoonbeek
Department of Human Biology, University of Maastricht, The Netherlands
J Nutr 133:657-60. 2003..In addition, we consider the possibility that the dietary effect on hemostatic and lipid factors involves transcription regulation of multiple genes, perhaps in a subject-dependent manner... - Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activationImke C A Munnix
Department of Biochemistry, Maastricht University, CARIM, Maastricht University, The Netherlands
Arterioscler Thromb Vasc Biol 27:2484-90. 2007..Platelets play a dual role in thrombosis by forming aggregates and stimulating coagulation. We investigated the commitment of platelets to these separate functions during collagen-induced thrombus formation in vitro and in vivo... - The quercetin paradoxAgnes W Boots
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
Toxicol Appl Pharmacol 222:89-96. 2007..Apparently, the potential toxicity of metabolites formed during the actual antioxidant activity of free radical scavengers should be considered in antioxidant supplementation... - Both ADP and thrombin regulate arteriolar thrombus stabilization and embolization, but are not involved in initial hemostasis as induced by micropunctureMiriam A van Gestel
Department of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
Microcirculation 14:193-205. 2007..Up to now, the relative importance of mediators involved is only partly known. It was the aim of this study to investigate the involvement of ADP and thrombin in subsequent phases of arteriolar hemostasis and thromboembolism in vivo... - Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in plateletsAmrei Strehl
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
J Biol Chem 282:7046-55. 2007..This platelet signaling protein is the first one identified to balance the pro-aggregatory and procoagulant functions of thrombi... - Plasma triacylglycerol and coagulation factor concentrations predict the anticoagulant effect of dietary fish oil in overweight subjectsKristof Vanschoonbeek
Department of Human Biology, Nutrition and Toxicology Research and Cardiovascular Research Institutes of Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
J Nutr 137:7-13. 2007..We conclude that high fasting triacylglycerol concentrations predict high procoagulant activity and a lowering of thrombin potential with dietary fish oil... - Novel methodology for assessment of prophylactic platelet transfusion therapy by measuring increased thrombus formation and thrombin generationSandra Cauwenberghs
Department of Biochemistry CARIM, Maastricht University, Maastricht, The Netherlands
Br J Haematol 136:480-90. 2007..We conclude that assessment of flow-induced adhesion and thrombin generation in acquired thrombocytopenia adequately determines the improved haemostatic activity by transfused platelets... - Activation of alphaIIbbeta3 is a sufficient but also an imperative prerequisite for activation of alpha2beta1 on plateletsGerlinde R Van De Walle
Laboratory for Thrombosis Research, Katholieke Universiteit Leuven, KU Leuven Campus Kortrijk, E Sabbelaan 53, B 8500 Kortrijk, Belgium, and Institut Fédératif No 4, Hopital Cardiologique, Pessac, France
Blood 109:595-602. 2007..In addition, analogous experiments with Glanzmann platelets lacking alphaIIbbeta3 confirmed the indispensability of alphaIIbbeta3 for alpha2beta1 activation... - Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activityPaola E J van der Meijden
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, Maastricht, The Netherlands
FEBS J 275:371-85. 2008..Taken together, these results demonstrate a dual P2Y(12)-dependent signaling mechanism, which increases the platelet-activating effect of thrombin by prolongation of Ca(2+) elevation, thereby facilitating the coagulation process... - Key role of platelet procoagulant activity in tissue factor-and collagen-dependent thrombus formation in arterioles and venules in vivo differential sensitivity to thrombin inhibitionMarijke J E Kuijpers
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Microcirculation 15:269-82. 2008..We investigated the interplay of these processes in vivo in a mouse model of arteriolar and venular thrombus formation... - Irregular spiking in free calcium concentration in single, human platelets. Regulation by modulation of the inositol trisphosphate receptorsRoosje M A van Gorp
Department of Biochemistry, University of Maastricht, The Netherlands
Eur J Biochem 269:1543-52. 2002..The observation that individual Ca2+ peaks were generated in various parts of a platelet at similar intervals and amplitudes points to effective cooperation of the various stores in the Ca2+-release process... - Development of platelet inhibition by cAMP during megakaryocytopoiesisEls den Dekker
Laboratory for Thrombosis and Haemostasis, Department of Haematology, University Medical Center Utrecht, Utrecht University, 3508 GA Utrecht, The Netherlands
J Biol Chem 277:29321-9. 2002..Thus, up-regulation of PKA-C appears to be a key step in the development of Ca2+ inhibition by prostacyclin in platelets... - Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotypeCecile Oury
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Blood 101:3969-76. 2003..Activation of the ERK2 pathway is instrumental in these processes... - Thrombin-induced hyperactivity of platelets of young stroke patients: involvement of thrombin receptors in the subject-dependent variability in Ca2+ signal generationKristof Vanschoonbeek
Dept of Human Biology, Cardiovascular Research Institute of Maastricht, University of Maastricht, Maastricht, The Netherlands
Thromb Haemost 88:931-7. 2002..Furthermore, the subject-dependent variation in thrombin-induced signalling is likely to involve PAR1-mediated platelet activation... - Real-time detection of activation patterns in individual platelets during thromboembolism in vivo: differences between thrombus growth and embolus formationMiriam A van Gestel
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, NL-6200 MD Maastricht, The Netherlands
J Vasc Res 39:534-43. 2002..These results show, for the first time, the relation between single platelet activation patterns, which are different during thrombus growth and embolus formation, and their behavior in a thromboembolic process in vivo... - Fibrillar type I collagens enhance platelet-dependent thrombin generation via glycoprotein VI with direct support of alpha2beta1 but not alphaIIbbeta3 integrinChristelle Lecut
Department Biochemistry, CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Thromb Haemost 94:107-14. 2005.... - Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in miceKristof Vanschoonbeek
Department of Biochemistry, CARIM and NUTRIM, Maastricht University, Maastricht, The Netherlands
Arterioscler Thromb Vasc Biol 28:2023-9. 2008..Using APOE2 knock-in mice, the relation of these fish-oil effects with altered gene expression was investigated... - Role of membrane cholesterol in platelet calcium signalling in response to VWF and collagen under stasis and flowMarjolijn van Lier
Department of Clinical Chemistry and Hematology and Cell Microscopy Center, UMCU, Utrecht, The Netherlands
Thromb Haemost 99:1068-78. 2008..Our data thus reveal a more critical role for membrane cholesterol in collagen-induced than in VWF-induced Ca(2+) signalling, and furthermore support the concept that secondary activation responses are dependent on intact CRDs... - Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivoMarijke J E Kuijpers
Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands
FASEB J 17:685-7. 2003.... - Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeletonSandra Cauwenberghs
Department of Biochemistry, CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
FEBS Lett 580:5313-20. 2006..After transfusion of stored platelet preparations to thrombocytopenic patients, the microparticles contribute to coagulant activity in vivo... - Synergistic effect of thrombin on collagen-induced platelet procoagulant activity is mediated through protease-activated receptor-1Jeffrey F W Keuren
Sanquin, Blood Bank region South-East, Maastricht, The Netherlands
Arterioscler Thromb Vasc Biol 25:1499-505. 2005..CONCLUSIONS: The interaction of thrombin with PAR-1 mediates a synergistic effect on collagen-induced procoagulant activity by inducing a sustained elevation in [Ca2+]i in a subpopulation of platelets... - Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formationChristelle Lecut
Department of Biochemistry, CARIM, Maastricht University, The Netherlands
Arterioscler Thromb Vasc Biol 24:1727-33. 2004..High-shear perfusion of blood over collagen results in rapid platelet adhesion, aggregation, and procoagulant activity. We studied regulation of alpha2beta1 and alphaIIbbeta3 integrin activation during thrombus formation on collagen... - Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generationKristof Vanschoonbeek
Department of Human Biology, Nutrition and Toxicology Research and Cardiovascular Research Institutes of Maastricht, Maastricht University, Maastricht, The Netherlands
Arterioscler Thromb Vasc Biol 24:1734-40. 2004..The effects on thrombin generation and fibrinogen clustered around subjects with high fibrinogen carrying alpha-chain fibrinogen polymorphism. Thus, dietary fish oil can provoke a hypocoagulant effect depending on the fibrinogen level... - Regulation of tissue factor-induced coagulation and platelet aggregation in flowing whole bloodMarijke J E Kuijpers
Department of Biochemistry, CARIM, University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Thromb Haemost 93:97-105. 2005..These platelet inhibitors thus maintain their aggregation-inhibiting effect at sites of thrombin formation... - Adhesion of human and mouse platelets to collagen under shear: a unifying modelJocelyn M Auger
Centre for Cardiovascular Sciences, Division of Medical Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK
FASEB J 19:825-7. 2005..These observations form the basis of a unifying two-state model of platelet adhesion and aggregate formation on collagen that is conserved between human and mouse platelets... - Facilitating roles of murine platelet glycoprotein Ib and alphaIIbbeta3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formationMarijke J E Kuijpers
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
J Physiol 558:403-15. 2004..Hence, these glycoproteins have an assistant procoagulant role in collagen-dependent thrombus formation, which is most prominent at reduced GPVI activity and is independent of the presence of thrombin... - Integrin alphaIIbbeta3 and shear-dependent action of glycoprotein Ibalpha stimulate platelet-dependent thrombin formation in stirred plasmaJeffrey F W Keuren
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
J Lab Clin Med 141:350-8. 2003..We conclude that thrombin formation and coagulation in stirred PRP depend, to a large extent, on platelet adhesion to integrin alpha(IIb)beta(3) and, in a shear-dependent way, on GP Ib... - Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic riskPaola E J van der Meijden
Department of Biochemistry, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
Thromb Haemost 93:1128-36. 2005..It is similarly active in platelets from control subjects and patients at thrombotic risk. Finally, the thrombogram method is useful for measuring incomplete P2Y(12) inhibition with clopidogrel... - Decreased responsiveness and development of activation markers of PLTs stored in plasmaJoyce Curvers
Sanquin Blood Bank Southeast Region, Maastricht, The Netherlands
Transfusion 44:49-58. 2004..PLTs collected for transfusion purposes preferably have retained these properties to restore impaired hemostasis with thrombocytopenia... - Store-mediated calcium entry in the regulation of phosphatidylserine exposure in blood cells from Scott patientsImke C A Munnix
Department of Biochemistry, CARIM, Maastricht University, P. O. Box 616, 6200 MD Maastricht, The Netherlands
Thromb Haemost 89:687-95. 2003..patient V.W. is a new case of Scott syndrome, ii. Ca(2+) entry in the platelets and lymphoblasts from both Scott patients is normal, and iii. elevated [Ca(2+)](i) as caused by SMCE is not sufficient to trigger PS exposure... - In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stabilityMiriam A van Gestel
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Arterioscler Thromb Vasc Biol 23:518-23. 2003..This may explain the beneficial effects of P2Y12 receptor antagonists in secondary prevention of ischemic events in patients with arterial thrombosis... - The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivoImke C A Munnix
Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands
Arterioscler Thromb Vasc Biol 25:2673-8. 2005..We investigated the signaling pathway of collagen-induced platelet activation in interaction with tissue factor-triggered coagulation during the thrombus-forming process... - Platelet inhibition by insulin is absent in type 2 diabetes mellitusIrlando Andrade Ferreira
Department of Hematology, University Medical Center Utrecht, Utrecht University, The Netherlands
Arterioscler Thromb Vasc Biol 26:417-22. 2006..CONCLUSIONS: The loss of responsiveness to insulin together with increased signaling through P2y12 might explain the hyperactivity of platelets in patients with DM2... - Platelet ADP response deteriorates in synthetic storage mediaJeffrey F W Keuren
Sanquin Blood Bank Southeast Region, Maastricht, The Netherlands
Transfusion 46:204-12. 2006..Higher plasma-to-AS ratios result in better preserved responses... - Plasma ectonucleotidases prevent desensitization of purinergic receptors in stored platelets: importance for platelet activity during thrombus formationSandra Cauwenberghs
Department of Biochemistry (CARIM, the Sanquin Blood Bank South-East, the Department of Health Risk Analysis and Toxicology (NUTRIM, Maastricht University, Maastricht, The Netherlands
Transfusion 46:1018-28. 2006..CONCLUSION: Ectonucleotidases in plasma preserve the functionality of P2X1 and P2Y receptors. Upon PLT storage, these plasma activities are essential to ensure adequate (shear-dependent) formation of aggregates and thrombi... - Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human bloodPia R M Siljander
Department of Biochemistry, University of Cambridge, Main Bldg, Downing Site, Tennis Court Rd, CB2 1QW Cambridge, United Kingdom
Blood 103:1333-41. 2004.... - Glutathione oxidation in calcium- and p38 MAPK-dependent membrane blebbing of endothelial cellsRoosje M A van Gorp
Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
Biochim Biophys Acta 1591:129-138. 2002.... - Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilizationJudith M E M Cosemans
Department of Biochemistry and Human Biology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
Blood 108:3045-52. 2006..This novel concept of intrinsic, dynamic thrombus instability gives possibilities for the use of antiplatelet therapy... - Antithrombin extends its jobJohan W M Heemskerk
Thromb Haemost 92:1171. 2004 - Measurement of the platelet procoagulant responseJohan W M Heemskerk
Department of Biochemistry, CARIM, Maastricht University, The Netherlands
Methods Mol Biol 272:135-44. 2004 - Increased thrombin generation and fibrinogen level after therapeutic plasma transfusion: relation to bleedingSaskia E M Schols
Department of Biochemistry CARIM, Maastricht University, Maastricht, The Netherlands
Thromb Haemost 99:64-70. 2008..Furthermore, the data suggest that thrombin generation and fibrinogen are independent determinants of the risk of perioperative bleeding in this patient group... - Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesionsJudith M E M Cosemans
Department of Human Biology, CARIM, University of Maastricht, The Netherlands
Atherosclerosis 181:19-27. 2005..Together, these results indicate that in advanced plaques collagen type I is a major trigger of thrombus formation and PS exposure, acting via GPVI and ADP release, while tissue factor directly enhances coagulation... - Platelet collagen receptors and coagulation. A characteristic platelet response as possible target for antithrombotic treatmentJohan W M Heemskerk
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, The Netherlands
Trends Cardiovasc Med 15:86-92. 2005..The main signaling receptor for collagen, glycoprotein VI, plays a key role in the platelet procoagulant response during thrombus formation; this is a reason why new anti-glycoprotein-VI antibodies are promising antithrombotic tools... - Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulationValery Daubie
Deparment of Biochemistry, CARIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Biochim Biophys Acta 1763:860-9. 2006..These data provide first evidence that these serine proteases trigger distinct signaling modules in endothelium that is activated by plasma coagulation... - Hemostatic and signaling functions of transfused plateletsSandra Cauwenberghs
Department of Biochemistry CARIM, Maastricht University and University Hospital, The Netherlands
Transfus Med Rev 21:287-94. 2007....